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Protein

DnaJ homolog subfamily C member 14

Gene

DNAJC14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processProtein transport, Transport

Enzyme and pathway databases

SIGNORiQ6Y2X3

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 14
Alternative name(s):
DnaJ protein homolog 3
Dopamine receptor-interacting protein of 78 kDa
Short name:
DRIP78
Human DnaJ protein 3
Short name:
hDj-3
Gene namesi
Name:DNAJC14
Synonyms:DRIP78, HDJ3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135392.15
HGNCiHGNC:24581 DNAJC14
MIMi606092 gene
neXtProtiNX_Q6Y2X3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi85406
OpenTargetsiENSG00000135392
PharmGKBiPA134940402

Polymorphism and mutation databases

BioMutaiDNAJC14
DMDMi110808200

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474931 – 702DnaJ homolog subfamily C member 14Add BLAST702

Proteomic databases

EPDiQ6Y2X3
MaxQBiQ6Y2X3
PaxDbiQ6Y2X3
PeptideAtlasiQ6Y2X3
PRIDEiQ6Y2X3
ProteomicsDBi67835

PTM databases

iPTMnetiQ6Y2X3
PhosphoSitePlusiQ6Y2X3

Expressioni

Tissue specificityi

Highly expressed in pancreas and selectively expressed in brain, lung, liver, skeletal muscle and kidney.1 Publication

Gene expression databases

BgeeiENSG00000135392 Expressed in 166 organ(s), highest expression level in leukocyte
CleanExiHS_DNAJC14
ExpressionAtlasiQ6Y2X3 baseline and differential
GenevisibleiQ6Y2X3 HS

Organism-specific databases

HPAiHPA017653

Interactioni

Subunit structurei

Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal domain.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124515, 7 interactors
CORUMiQ6Y2X3
IntActiQ6Y2X3, 1 interactor
STRINGi9606.ENSP00000316240

Structurei

3D structure databases

ProteinModelPortaliQ6Y2X3
SMRiQ6Y2X3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini443 – 507JPROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi673 – 676Poly-Ala4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0720 Eukaryota
ENOG410Z2TP LUCA
GeneTreeiENSGT00930000150905
HOGENOMiHOG000290199
HOVERGENiHBG059561
InParanoidiQ6Y2X3
KOiK09534
OMAiFRVWVGV
OrthoDBiEOG091G038N
PhylomeDBiQ6Y2X3
TreeFamiTF105173

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
IPR032843 Jiv
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF14901 Jiv90, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q6Y2X3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQKHPGERG LYGAHHSGGA SLRTLGPSVD PEIPSFSGLR DSAGTAPNGT
60 70 80 90 100
RCLTEHSGPK HTQHPNPAHW LDPSHGPPGG PGPPRDAEDP DQSETSSEEE
110 120 130 140 150
SGVDQELSKE NETGNQKDGN SFLSIPSACN CQGTPGIPEG PYSEGGNGSS
160 170 180 190 200
SNFCHHCTSP ALGEDELEEE YDDEESLKFP SDFSRVSSGK KPPSRRQRHR
210 220 230 240 250
FPTKEDTREG GRRDPRSPGR HRLGRKRSQA DKRKGLGLWG AEELCQLGQA
260 270 280 290 300
GFWWLIELLV LVGEYVETCG HLIYACRQLK SSDLDLFRVW MGVWTGRLGG
310 320 330 340 350
WAQVMFQFLS QGFYCGVGLF TRFLKLLGAL LLLALALFLG FLQLGWRFLV
360 370 380 390 400
GLGDRLGWRD KATWLFSWLD SPALQRCLTL LRDSRPWQRL VRIVQWGWLE
410 420 430 440 450
LPWVKQNINR QGNAPVASGR YCQPEEEVAR LLTMAGVPED ELNPFHVLGV
460 470 480 490 500
EATASDVELK KAYRQLAVMV HPDKNHHPRA EEAFKVLRAA WDIVSNAEKR
510 520 530 540 550
KEYEMKRMAE NELSRSVNEF LSKLQDDLKE AMNTMMCSRC QGKHRRFEMD
560 570 580 590 600
REPKSARYCA ECNRLHPAEE GDFWAESSML GLKITYFALM DGKVYDITEW
610 620 630 640 650
AGCQRVGISP DTHRVPYHIS FGSRIPGTRG RQRATPDAPP ADLQDFLSRI
660 670 680 690 700
FQVPPGQMPN GNFFAAPQPA PGAAAASKPN STVPKGEAKP KRRKKVRRPF

QR
Length:702
Mass (Da):78,569
Last modified:July 25, 2006 - v2
Checksum:iDAECF48B7196C7F2
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VNT6F8VNT6_HUMAN
DnaJ homolog subfamily C member 14
DNAJC14
151Annotation score:
F8VYY5F8VYY5_HUMAN
DnaJ homolog subfamily C member 14
DNAJC14
79Annotation score:
A0A2R8Y716A0A2R8Y716_HUMAN
DnaJ homolog subfamily C member 14
DNAJC14
191Annotation score:

Sequence cautioni

The sequence BAB71050 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti285D → N in AAO73451 (PubMed:12768437).Curated1
Sequence conflicti460K → R in AAO73451 (PubMed:12768437).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY188447 mRNA Translation: AAO73451.1
EF560741 mRNA Translation: ABQ59051.1
CH471054 Genomic DNA Translation: EAW96833.1
BC080655 mRNA Translation: AAH80655.1
BC117146 mRNA Translation: AAI17147.1
BC117148 mRNA Translation: AAI17149.1
AK055945 mRNA Translation: BAB71050.1 Different initiation.
AF351784 mRNA Translation: AAK56241.1
CCDSiCCDS8894.1
RefSeqiNP_115740.5, NM_032364.5
UniGeneiHs.709320

Genome annotation databases

EnsembliENST00000317269; ENSP00000316240; ENSG00000135392
ENST00000317287; ENSP00000317500; ENSG00000135392
ENST00000357606; ENSP00000350223; ENSG00000135392
GeneIDi85406
KEGGihsa:85406
UCSCiuc001shx.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY188447 mRNA Translation: AAO73451.1
EF560741 mRNA Translation: ABQ59051.1
CH471054 Genomic DNA Translation: EAW96833.1
BC080655 mRNA Translation: AAH80655.1
BC117146 mRNA Translation: AAI17147.1
BC117148 mRNA Translation: AAI17149.1
AK055945 mRNA Translation: BAB71050.1 Different initiation.
AF351784 mRNA Translation: AAK56241.1
CCDSiCCDS8894.1
RefSeqiNP_115740.5, NM_032364.5
UniGeneiHs.709320

3D structure databases

ProteinModelPortaliQ6Y2X3
SMRiQ6Y2X3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124515, 7 interactors
CORUMiQ6Y2X3
IntActiQ6Y2X3, 1 interactor
STRINGi9606.ENSP00000316240

PTM databases

iPTMnetiQ6Y2X3
PhosphoSitePlusiQ6Y2X3

Polymorphism and mutation databases

BioMutaiDNAJC14
DMDMi110808200

Proteomic databases

EPDiQ6Y2X3
MaxQBiQ6Y2X3
PaxDbiQ6Y2X3
PeptideAtlasiQ6Y2X3
PRIDEiQ6Y2X3
ProteomicsDBi67835

Protocols and materials databases

DNASUi85406
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317269; ENSP00000316240; ENSG00000135392
ENST00000317287; ENSP00000317500; ENSG00000135392
ENST00000357606; ENSP00000350223; ENSG00000135392
GeneIDi85406
KEGGihsa:85406
UCSCiuc001shx.1 human

Organism-specific databases

CTDi85406
DisGeNETi85406
EuPathDBiHostDB:ENSG00000135392.15
GeneCardsiDNAJC14
HGNCiHGNC:24581 DNAJC14
HPAiHPA017653
MIMi606092 gene
neXtProtiNX_Q6Y2X3
OpenTargetsiENSG00000135392
PharmGKBiPA134940402
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0720 Eukaryota
ENOG410Z2TP LUCA
GeneTreeiENSGT00930000150905
HOGENOMiHOG000290199
HOVERGENiHBG059561
InParanoidiQ6Y2X3
KOiK09534
OMAiFRVWVGV
OrthoDBiEOG091G038N
PhylomeDBiQ6Y2X3
TreeFamiTF105173

Enzyme and pathway databases

SIGNORiQ6Y2X3

Miscellaneous databases

ChiTaRSiDNAJC14 human
GeneWikiiDNAJC14
GenomeRNAii85406
PROiPR:Q6Y2X3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135392 Expressed in 166 organ(s), highest expression level in leukocyte
CleanExiHS_DNAJC14
ExpressionAtlasiQ6Y2X3 baseline and differential
GenevisibleiQ6Y2X3 HS

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
IPR032843 Jiv
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF14901 Jiv90, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDJC14_HUMAN
AccessioniPrimary (citable) accession number: Q6Y2X3
Secondary accession number(s): A5YM67
, Q17RY2, Q66K17, Q96N59, Q96T63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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