UniProtKB - Q6Y1S1 (MYD88_RAT)
Myeloid differentiation primary response protein MyD88
Myd88
Functioni
GO - Molecular functioni
- identical protein binding Source: RGD
- interleukin-1 receptor binding Source: RGD
- protein self-association Source: RGD
- signaling receptor binding Source: RGD
- TIR domain binding Source: RGD
- Toll binding Source: RGD
- Toll-like receptor binding Source: RGD
GO - Biological processi
- 3'-UTR-mediated mRNA stabilization Source: RGD
- apoptotic process Source: RGD
- cell surface receptor signaling pathway Source: RGD
- cellular response to lipopolysaccharide Source: RGD
- cellular response to mechanical stimulus Source: RGD
- cellular response to oxidised low-density lipoprotein particle stimulus Source: RGD
- cytokine-mediated signaling pathway Source: RGD
- defense response to bacterium Source: RGD
- defense response to Gram-positive bacterium Source: UniProtKB
- defense response to protozoan Source: RGD
- establishment of endothelial intestinal barrier Source: RGD
- immunoglobulin mediated immune response Source: RGD
- induced systemic resistance Source: RGD
- inflammatory response Source: RGD
- innate immune response Source: GO_Central
- interleukin-1-mediated signaling pathway Source: RGD
- JNK cascade Source: RGD
- lipopolysaccharide-mediated signaling pathway Source: RGD
- MyD88-dependent toll-like receptor signaling pathway Source: RGD
- phagocytosis Source: RGD
- positive regulation of chemokine biosynthetic process Source: RGD
- positive regulation of cytokine production involved in inflammatory response Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
- positive regulation of interleukin-17 production Source: RGD
- positive regulation of interleukin-23 production Source: RGD
- positive regulation of interleukin-6 production Source: RGD
- positive regulation of interleukin-8 production Source: RGD
- positive regulation of JNK cascade Source: RGD
- positive regulation of lymphocyte proliferation Source: RGD
- positive regulation of NF-kappaB transcription factor activity Source: RGD
- positive regulation of smooth muscle cell proliferation Source: RGD
- positive regulation of tumor necrosis factor production Source: RGD
- positive regulation of type I interferon production Source: RGD
- regulation of cell population proliferation Source: RGD
- regulation of chemokine (C-X-C motif) ligand 1 production Source: RGD
- regulation of chemokine (C-X-C motif) ligand 2 production Source: RGD
- regulation of gene expression Source: RGD
- regulation of inflammatory response Source: RGD
- regulation of interleukin-6 production Source: RGD
- regulation of neutrophil migration Source: RGD
- regulation of tumor necrosis factor production Source: RGD
- response to interleukin-1 Source: RGD
- response to lipopolysaccharide Source: RGD
- response to molecule of fungal origin Source: RGD
- response to peptidoglycan Source: RGD
- response to virus Source: RGD
- Toll signaling pathway Source: RGD
- type I interferon production Source: RGD
- type I interferon signaling pathway Source: RGD
Keywordsi
Biological process | Immunity, Inflammatory response, Innate immunity |
Enzyme and pathway databases
Reactomei | R-RNO-1257604, PIP3 activates AKT signaling R-RNO-1810476, RIP-mediated NFkB activation via ZBP1 R-RNO-209543, p75NTR recruits signalling complexes R-RNO-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-RNO-9020702, Interleukin-1 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Myeloid differentiation primary response protein MyD88 |
Gene namesi | Name:Myd88 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 735043, Myd88 |
Subcellular locationi
Cytosol
- cytosol Source: RGD
Nucleus
- nucleus Source: RGD
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- cytoplasm Source: RGD
- postsynaptic density Source: RGD
- protein-containing complex Source: RGD
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000393138 | 1 – 296 | Myeloid differentiation primary response protein MyD88Add BLAST | 296 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 244 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q6Y1S1 |
PRIDEi | Q6Y1S1 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000013634, Expressed in spleen and 22 other tissues |
Genevisiblei | Q6Y1S1, RN |
Interactioni
Subunit structurei
Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains.
Interacts with IL18R1.
Interacts with BMX, IL1RL1, IKBKE and IRF7.
Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist.
Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding.
Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1.
Interacts (via TIR domain) with DHX9 (via H2A and OB-fold regions); this interaction is direct.
Interacts with OTUD4 deubiquitinase; the interaction is direct.
By similarityGO - Molecular functioni
- identical protein binding Source: RGD
- interleukin-1 receptor binding Source: RGD
- protein self-association Source: RGD
- signaling receptor binding Source: RGD
- TIR domain binding Source: RGD
- Toll binding Source: RGD
- Toll-like receptor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000018341 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 109 | DeathPROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 159 – 293 | TIRPROSITE-ProRule annotationAdd BLAST | 135 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 110 – 155 | Intermediate domainBy similarityAdd BLAST | 46 |
Domaini
Phylogenomic databases
eggNOGi | ENOG502QWKI, Eukaryota |
GeneTreei | ENSGT00510000048324 |
HOGENOMi | CLU_045884_0_0_1 |
InParanoidi | Q6Y1S1 |
OMAi | RCKRMVV |
OrthoDBi | 890418at2759 |
PhylomeDBi | Q6Y1S1 |
TreeFami | TF326264 |
Family and domain databases
CDDi | cd08312, Death_MyD88, 1 hit |
Gene3Di | 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR034249, MyD88_Death IPR017281, Myelin_different_resp_MyD88 IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR15079, PTHR15079, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF01582, TIR, 1 hit |
PIRSFi | PIRSF037756, MyD88, 1 hit |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00255, TIR, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS50104, TIR, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSAGGPRVGS VSVDSYLFSL PLVALNVGVR RRLSLFLNPR TTAAADWTSL
60 70 80 90 100
AEEMGFEYLE IREFETRPDP TRSLLDAWQG RSGSSVGRLL ELLALLDRED
110 120 130 140 150
ILYELKDRIE EDCQKYIRNQ QKQESEKPLQ VARVESSVPQ TKELGGITTL
160 170 180 190 200
DDPLGQTPEL FDAFICYCPS DIEFVQEMIR QLEQTDYRLK LCVSDRDVLP
210 220 230 240 250
GTCVWSIASE LIEKRCRRMV VVVSDDYLQS KECDFQTKFA LSLSPGVQQK
260 270 280 290
RLIPIKYKAM KKDFPSILRF ITICDYTNPC TKSWFWTRLA KALSLP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 170 | S → N in AAO91937 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY191270 mRNA Translation: AAO91937.1 BC097266 mRNA Translation: AAH97266.1 |
RefSeqi | NP_937763.1, NM_198130.1 XP_006244149.1, XM_006244087.3 |
Genome annotation databases
Ensembli | ENSRNOT00000018341; ENSRNOP00000018341; ENSRNOG00000013634 |
GeneIDi | 301059 |
KEGGi | rno:301059 |
UCSCi | RGD:735043, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY191270 mRNA Translation: AAO91937.1 BC097266 mRNA Translation: AAH97266.1 |
RefSeqi | NP_937763.1, NM_198130.1 XP_006244149.1, XM_006244087.3 |
3D structure databases
SMRi | Q6Y1S1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000018341 |
Proteomic databases
PaxDbi | Q6Y1S1 |
PRIDEi | Q6Y1S1 |
Genome annotation databases
Ensembli | ENSRNOT00000018341; ENSRNOP00000018341; ENSRNOG00000013634 |
GeneIDi | 301059 |
KEGGi | rno:301059 |
UCSCi | RGD:735043, rat |
Organism-specific databases
CTDi | 4615 |
RGDi | 735043, Myd88 |
Phylogenomic databases
eggNOGi | ENOG502QWKI, Eukaryota |
GeneTreei | ENSGT00510000048324 |
HOGENOMi | CLU_045884_0_0_1 |
InParanoidi | Q6Y1S1 |
OMAi | RCKRMVV |
OrthoDBi | 890418at2759 |
PhylomeDBi | Q6Y1S1 |
TreeFami | TF326264 |
Enzyme and pathway databases
Reactomei | R-RNO-1257604, PIP3 activates AKT signaling R-RNO-1810476, RIP-mediated NFkB activation via ZBP1 R-RNO-209543, p75NTR recruits signalling complexes R-RNO-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-RNO-9020702, Interleukin-1 signaling |
Miscellaneous databases
PROi | PR:Q6Y1S1 |
Gene expression databases
Bgeei | ENSRNOG00000013634, Expressed in spleen and 22 other tissues |
Genevisiblei | Q6Y1S1, RN |
Family and domain databases
CDDi | cd08312, Death_MyD88, 1 hit |
Gene3Di | 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR034249, MyD88_Death IPR017281, Myelin_different_resp_MyD88 IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR15079, PTHR15079, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF01582, TIR, 1 hit |
PIRSFi | PIRSF037756, MyD88, 1 hit |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00255, TIR, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS50104, TIR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYD88_RAT | |
Accessioni | Q6Y1S1Primary (citable) accession number: Q6Y1S1 Secondary accession number(s): Q4QRC0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 23, 2010 |
Last sequence update: | March 23, 2010 | |
Last modified: | December 2, 2020 | |
This is version 120 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |