Myeloid differentiation primary response protein MyD88

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• identical protein binding Source: RGD
• interleukin-1 receptor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1beta and NMDA stimulation."
    Gardoni F., Boraso M., Zianni E., Corsini E., Galli C.L., Cattabeni F., Marinovich M., Di Luca M., Viviani B.
    J Neuroinflammation 8:14-14(2011) [PubMed] [Europe PMC] [Abstract]
• protein self-association Source: RGD
• signaling receptor binding Source: RGDInferred from physical interactionⁱ
  • "Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection."
    Li C., Ha T., Kelley J., Gao X., Qiu Y., Kao R.L., Browder W., Williams D.L.
    Cardiovasc Res 61:538-547(2004) [PubMed] [Europe PMC] [Abstract]
• TIR domain binding Source: RGD
• Toll binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection."
    Li C., Ha T., Kelley J., Gao X., Qiu Y., Kao R.L., Browder W., Williams D.L.
    Cardiovasc Res 61:538-547(2004) [PubMed] [Europe PMC] [Abstract]
• Toll-like receptor binding Source: RGD

GO - Biological processⁱ

• 3'-UTR-mediated mRNA stabilization Source: RGD
• apoptotic process Source: RGD
• cell surface receptor signaling pathway Source: RGD
• cellular response to lipopolysaccharide Source: RGD
• cellular response to mechanical stimulus Source: RGD
• cellular response to oxidised low-density lipoprotein particle stimulus Source: RGD
• cytokine-mediated signaling pathway Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-Jun N-terminal kinase, and activator protein-1 signaling."
    Chandrasekar B., Mummidi S., Valente A.J., Patel D.N., Bailey S.R., Freeman G.L., Hatano M., Tokuhisa T., Jensen L.E.
    J. Biol. Chem. 280:26263-26277(2005) [PubMed] [Europe PMC] [Abstract]
• defense response to bacterium Source: RGD
• defense response to Gram-positive bacterium Source: UniProtKB
• defense response to protozoan Source: RGD
• establishment of endothelial intestinal barrier Source: RGD
• immunoglobulin mediated immune response Source: RGD
• induced systemic resistance Source: RGD
• inflammatory response Source: RGD
• innate immune response Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• interleukin-1-mediated signaling pathway Source: RGD
• JNK cascade Source: RGDInferred from mutant phenotypeⁱ
  • "The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-Jun N-terminal kinase, and activator protein-1 signaling."
    Chandrasekar B., Mummidi S., Valente A.J., Patel D.N., Bailey S.R., Freeman G.L., Hatano M., Tokuhisa T., Jensen L.E.
    J. Biol. Chem. 280:26263-26277(2005) [PubMed] [Europe PMC] [Abstract]
• lipopolysaccharide-mediated signaling pathway Source: RGD
• MyD88-dependent toll-like receptor signaling pathway Source: RGD
• phagocytosis Source: RGD
• positive regulation of chemokine biosynthetic process Source: RGD
• positive regulation of cytokine production involved in inflammatory response Source: RGD
• positive regulation of gene expression Source: RGD
• positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
• positive regulation of interleukin-17 production Source: RGD
• positive regulation of interleukin-23 production Source: RGD
• positive regulation of interleukin-6 production Source: RGD
• positive regulation of interleukin-8 production Source: RGD
• positive regulation of JNK cascade Source: RGD
• positive regulation of lymphocyte proliferation Source: RGD
• positive regulation of NF-kappaB transcription factor activity Source: RGD
• positive regulation of smooth muscle cell proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-Jun N-terminal kinase, and activator protein-1 signaling."
    Chandrasekar B., Mummidi S., Valente A.J., Patel D.N., Bailey S.R., Freeman G.L., Hatano M., Tokuhisa T., Jensen L.E.
    J. Biol. Chem. 280:26263-26277(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of tumor necrosis factor production Source: RGD
• positive regulation of type I interferon production Source: RGD
• regulation of cell population proliferation Source: RGD
• regulation of chemokine (C-X-C motif) ligand 1 production Source: RGD
• regulation of chemokine (C-X-C motif) ligand 2 production Source: RGD
• regulation of gene expression Source: RGD
• regulation of inflammatory response Source: RGD
• regulation of interleukin-6 production Source: RGD
• regulation of neutrophil migration Source: RGD
• regulation of tumor necrosis factor production Source: RGD
• response to interleukin-1 Source: RGD
• response to lipopolysaccharide Source: RGD
• response to molecule of fungal origin Source: RGD
• response to peptidoglycan Source: RGD
• response to virus Source: RGD
• Toll signaling pathway Source: RGDInferred from direct assayⁱ
  • "Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection."
    Li C., Ha T., Kelley J., Gao X., Qiu Y., Kao R.L., Browder W., Williams D.L.
    Cardiovasc Res 61:538-547(2004) [PubMed] [Europe PMC] [Abstract]
• type I interferon production Source: RGD
• type I interferon signaling pathway Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• identical protein binding Source: RGD
• interleukin-1 receptor binding Source: RGDInferred from physical interactionⁱ
  • "Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1beta and NMDA stimulation."
    Gardoni F., Boraso M., Zianni E., Corsini E., Galli C.L., Cattabeni F., Marinovich M., Di Luca M., Viviani B.
    J Neuroinflammation 8:14-14(2011) [PubMed] [Europe PMC] [Abstract]
• protein self-association Source: RGD
• signaling receptor binding Source: RGDInferred from physical interactionⁱ
  • "Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection."
    Li C., Ha T., Kelley J., Gao X., Qiu Y., Kao R.L., Browder W., Williams D.L.
    Cardiovasc Res 61:538-547(2004) [PubMed] [Europe PMC] [Abstract]
• TIR domain binding Source: RGD
• Toll binding Source: RGDInferred from direct assayⁱ
  • "Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection."
    Li C., Ha T., Kelley J., Gao X., Qiu Y., Kao R.L., Browder W., Williams D.L.
    Cardiovasc Res 61:538-547(2004) [PubMed] [Europe PMC] [Abstract]
• Toll-like receptor binding Source: RGD

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSAGGPRVGS VSVDSYLFSL PLVALNVGVR RRLSLFLNPR TTAAADWTSL 
        60         70         80         90        100
AEEMGFEYLE IREFETRPDP TRSLLDAWQG RSGSSVGRLL ELLALLDRED 
       110        120        130        140        150
ILYELKDRIE EDCQKYIRNQ QKQESEKPLQ VARVESSVPQ TKELGGITTL 
       160        170        180        190        200
DDPLGQTPEL FDAFICYCPS DIEFVQEMIR QLEQTDYRLK LCVSDRDVLP 
       210        220        230        240        250
GTCVWSIASE LIEKRCRRMV VVVSDDYLQS KECDFQTKFA LSLSPGVQQK 
       260        270        280        290 
RLIPIKYKAM KKDFPSILRF ITICDYTNPC TKSWFWTRLA KALSLP     

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ