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Entry version 112 (26 Feb 2020)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Toll-like receptor 9

Gene

Tlr9

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Toll-like receptor 9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tlr9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

Rat genome database

More...
RGDi
631352 Tlr9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500428239624 – 1032Sequence analysisAdd BLAST1009

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q6Y1S0, 1 interactor

Molecular INTeraction database

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MINTi
Q6Y1S0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6Y1S0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini868 – 1016TIRInterPro annotationAdd BLAST149

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4641 Eukaryota
COG4886 LUCA

KEGG Orthology (KO)

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KOi
K10161

Database of Orthologous Groups

More...
OrthoDBi
263937at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10140, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR041283 LRR_12
IPR000157 TIR_dom
IPR027181 TLR9
IPR035897 Toll_tir_struct_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR47410:SF3 PTHR47410:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18837 LRR_12, 1 hit
PF13516 LRR_6, 1 hit
PF13855 LRR_8, 3 hits
PF01582 TIR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 14 hits
SM00255 TIR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52200 SSF52200, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 19 hits
PS50104 TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6Y1S0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLCSRTLHP LSLLVQAAVL AEALALGTLP AFLPCELKPH GLVDCNWLFL
60 70 80 90 100
KSVPHFSAAE PRSNITSLSL IANRIHHLHN LDFVHLPNVR QLNLKWNCPP
110 120 130 140 150
PGLSPLHFSC RMTIEPKTFL AMRMLEELNL SYNGITTVPR LPSSLTNLSL
160 170 180 190 200
SHTNILVLDA SSLAGLHSLR VLFMDGNCYY KNPCNGAVNV TPDAFLGLSN
210 220 230 240 250
LTHLSLKYNN LTEVPRQLPP SLEYLLLSYN LIVKLGPEDL ANLTSLRVLD
260 270 280 290 300
VGGNCRRCDH APDLCTECRQ KSLDLHPQTF HHLSHLEGLV LKDSSLHSLN
310 320 330 340 350
SKWFQGLVNL SVLDLSENFL YESINKTSAF QNLTRLRKLD LSFNYCKKVS
360 370 380 390 400
FARLHLASSF KSLVSLQELN MNGIFFRLLN KNTLRWLAGL PKLHTLHLQM
410 420 430 440 450
NFINQAQLSV FSTFRALRFV DLSNNRISGP PTLSRVAPEK ADEAEKGVPW
460 470 480 490 500
PASLTPALPS TPVSKNFMVR CKNLRFTMDL SRNNLVTIKP EMFVNLSHLQ
510 520 530 540 550
CLSLSHNCIA QAVNGSQFLP LTNLKVLDLS YNKLDLYHSK SFSELPQLQA
560 570 580 590 600
LDLSYNSQPF SMQGIGHNFS FLANLSRLQN LSLAHNDIHS RVSSRLYSTS
610 620 630 640 650
VEYLDFSGNG VGRMWDEEDL YLYFFQDLRS LIHLDLSQNK LHILRPQNLN
660 670 680 690 700
YLPKSLTKLS FRDNHLSFFN WSSLAFLPNL RDLDLAGNLL KALTNGTLPN
710 720 730 740 750
GTLLQKLDVS SNSIVFVVPA FFALAVELKE VNLSHNILKT VDRSWFGPIV
760 770 780 790 800
MNLTVLDVSS NPLHCACGAP FVDLLLEVQT KVPGLANGVK CGSPRQLQGR
810 820 830 840 850
SIFAQDLRLC LDDVLSRDCF GLSLLAVAVG TVLPLLQHLC GWDVWYCFHL
860 870 880 890 900
CLAWLPLLTR GRRSAQALPY DAFVVFDKAQ SAVADWVYNE LRVRLEERRG
910 920 930 940 950
RRALRLCLED RDWLPGQTLF ENLWASIYGS RKTLFVLAHT DKVSGLLRTS
960 970 980 990 1000
FLLAQQRLLE DRKDVVVLVI LRPDAHRSRY VRLRQRLCRQ SVLFWPHQPN
1010 1020 1030
GQGSFWAQLS TALTRDNHHF YNRNFCRGPT AE
Length:1,032
Mass (Da):116,607
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D27941212F00C15
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY191271 mRNA Translation: AAO91938.1

NCBI Reference Sequences

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RefSeqi
NP_937764.1, NM_198131.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
338457

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:338457

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191271 mRNA Translation: AAO91938.1
RefSeqiNP_937764.1, NM_198131.1

3D structure databases

SMRiQ6Y1S0
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ6Y1S0, 1 interactor
MINTiQ6Y1S0

Genome annotation databases

GeneIDi338457
KEGGirno:338457

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54106
RGDi631352 Tlr9

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
KOiK10161
OrthoDBi263937at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6Y1S0

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR041283 LRR_12
IPR000157 TIR_dom
IPR027181 TLR9
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR47410:SF3 PTHR47410:SF3, 1 hit
PfamiView protein in Pfam
PF18837 LRR_12, 1 hit
PF13516 LRR_6, 1 hit
PF13855 LRR_8, 3 hits
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 14 hits
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 19 hits
PS50104 TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6Y1S0_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6Y1S0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 26, 2020
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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