UniProtKB - Q6XZF7 (DNMBP_HUMAN)
Dynamin-binding protein
DNMBP
Functioni
Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:19767742, PubMed:17015620).
Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467).
Plays a role in ciliogenesis (By similarity).
May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).
By similarity3 PublicationsGO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: UniProtKB
GO - Biological processi
- aging Source: Ensembl
- intracellular signal transduction Source: InterPro
- regulation of cell shape Source: UniProtKB
- regulation of small GTPase mediated signal transduction Source: Reactome
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Enzyme and pathway databases
PathwayCommonsi | Q6XZF7 |
Reactomei | R-HSA-9013148, CDC42 GTPase cycle |
SignaLinki | Q6XZF7 |
SIGNORi | Q6XZF7 |
Names & Taxonomyi
Protein namesi | Recommended name: Dynamin-binding proteinImportedAlternative name(s): Scaffold protein Tuba1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30373, DNMBP |
MIMi | 611282, gene |
neXtProti | NX_Q6XZF7 |
VEuPathDBi | HostDB:ENSG00000107554 |
Subcellular locationi
Golgi apparatus
- Golgi stack By similarity
Cytoskeleton
- cytoskeleton By similarity
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- synapse By similarity
- Cell junction 1 Publication
Note: Localizes to the apical junction, colocalizes with TJP1.1 Publication
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi stack Source: UniProtKB-SubCell
Other locations
- cell-cell junction Source: UniProtKB
- presynapse Source: UniProtKB
- synapse Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoskeleton, Golgi apparatus, SynapsePathology & Biotechi
Involvement in diseasei
Cataract 48 (CTRCT48)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081450 | 271 – 1577 | Missing in CTRCT48. 1 PublicationAdd BLAST | 1307 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1521 | V → R: Decreased interaction of SH3 domain 6 with L.monocytogenes InlC. 1 Publication | 1 | |
Mutagenesisi | 1529 | P → A: Wild-type interaction of SH3 domain 6 with L.monocytogenes InlC. 1 Publication | 1 | |
Mutagenesisi | 1569 | N → R: Decreased interaction of SH3 domain 6 with L.monocytogenes InlC. 1 Publication | 1 |
Keywords - Diseasei
Cataract, Disease variantOrganism-specific databases
DisGeNETi | 23268 |
MalaCardsi | DNMBP |
MIMi | 618415, phenotype |
OpenTargetsi | ENSG00000107554 |
Orphaneti | 98994, Total early-onset cataract |
PharmGKBi | PA134950706 |
Miscellaneous databases
Pharosi | Q6XZF7, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295871 |
Genetic variation databases
BioMutai | DNMBP |
DMDMi | 56404535 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079959 | 1 – 1577 | Dynamin-binding proteinAdd BLAST | 1577 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 496 | PhosphoserineCombined sources | 1 | |
Modified residuei | 684 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q6XZF7 |
jPOSTi | Q6XZF7 |
MassIVEi | Q6XZF7 |
MaxQBi | Q6XZF7 |
PaxDbi | Q6XZF7 |
PeptideAtlasi | Q6XZF7 |
PRIDEi | Q6XZF7 |
ProteomicsDBi | 67829 [Q6XZF7-1] 67830 [Q6XZF7-2] |
PTM databases
iPTMneti | Q6XZF7 |
MetOSitei | Q6XZF7 |
PhosphoSitePlusi | Q6XZF7 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000107554, Expressed in female gonad and 233 other tissues |
ExpressionAtlasi | Q6XZF7, baseline and differential |
Genevisiblei | Q6XZF7, HS |
Organism-specific databases
HPAi | ENSG00000107554, Low tissue specificity |
Interactioni
Subunit structurei
Binds DNM1 via its N-terminal SH3 domains. The C-terminal SH3 domain binds a complex containing actin, tubulin, Hsp70 and actin-regulatory proteins, such as ENAH, EVL, WIRE, CR16, WAVE1 and NAP1L1 (By similarity).
Interacts with FASLG (PubMed:19807924).
Interacts (via SH3 domain 6) with WASL (PubMed:19767742, PubMed:24332715, PubMed:17015620).
Interacts (via SH3 domain 6) interacts with ENAH (PubMed:24332715).
Interacts (via C-terminal domain) with TJP1; required for the apical cell-cell junction localization of DNMBP (PubMed:17015620).
By similarity4 Publications(Microbial infection) Interacts (via SH3 domain 6) with L.monocytogenes InlC.
2 PublicationsBinary interactionsi
Q6XZF7
With | #Exp. | IntAct |
---|---|---|
BIN3 [Q9NQY0] | 2 | EBI-2483419,EBI-2653038 |
Dnm1 [P21575] from Rattus norvegicus. | 3 | EBI-2483419,EBI-80070 |
Isoform 1 [Q6XZF7-1]
Protein-protein interaction databases
BioGRIDi | 116869, 111 interactors |
DIPi | DIP-53822N |
IntActi | Q6XZF7, 32 interactors |
MINTi | Q6XZF7 |
STRINGi | 9606.ENSP00000315659 |
Miscellaneous databases
RNActi | Q6XZF7, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q6XZF7 |
SMRi | Q6XZF7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q6XZF7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 61 | SH3 1PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 66 – 126 | SH3 2PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 145 – 204 | SH3 3PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 243 – 302 | SH3 4PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 784 – 967 | DHPROSITE-ProRule annotationAdd BLAST | 184 | |
Domaini | 1008 – 1217 | BARPROSITE-ProRule annotationAdd BLAST | 210 | |
Domaini | 1285 – 1348 | SH3 5PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 1513 – 1576 | SH3 6PROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 211 – 244 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 335 – 395 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 591 – 624 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 639 – 659 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1348 – 1487 | DisorderedSequence analysisAdd BLAST | 140 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 693 – 757 | Sequence analysisAdd BLAST | 65 | |
Coiled coili | 1136 – 1173 | Sequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 335 – 351 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 591 – 610 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1352 – 1405 | Polar residuesSequence analysisAdd BLAST | 54 | |
Compositional biasi | 1414 – 1448 | Polar residuesSequence analysisAdd BLAST | 35 |
Keywords - Domaini
Coiled coil, Repeat, SH3 domainPhylogenomic databases
eggNOGi | KOG3519, Eukaryota KOG4225, Eukaryota |
GeneTreei | ENSGT00950000183088 |
HOGENOMi | CLU_252350_0_0_1 |
InParanoidi | Q6XZF7 |
OrthoDBi | 207472at2759 |
PhylomeDBi | Q6XZF7 |
TreeFami | TF330015 |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit cd11798, SH3_DNMBP_C1, 1 hit cd11794, SH3_DNMBP_N1, 1 hit cd11795, SH3_DNMBP_N2, 1 hit cd11796, SH3_DNMBP_N3, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit 1.20.900.10, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR004148, BAR_dom IPR035899, DBL_dom_sf IPR000219, DH-domain IPR035469, DNMBP IPR035820, DNMBP_SH3_C1 IPR035817, DNMBP_SH3_N1 IPR035818, DNMBP_SH3_N2 IPR035819, DNMBP_SH3_N3 IPR001331, GDS_CDC24_CS IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR22834:SF19, PTHR22834:SF19, 1 hit |
Pfami | View protein in Pfam PF03114, BAR, 1 hit PF00621, RhoGEF, 1 hit PF00018, SH3_1, 3 hits PF07653, SH3_2, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00721, BAR, 1 hit SM00325, RhoGEF, 1 hit SM00326, SH3, 6 hits |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 6 hits |
PROSITEi | View protein in PROSITE PS51021, BAR, 1 hit PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50002, SH3, 6 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEAGSVVRAI FDFCPSVSEE LPLFVGDIIE VLAVVDEFWL LGKKEDVTGQ
60 70 80 90 100
FPSSFVEIVT IPSLKEGERL FVCICEFTSQ ELDNLPLHRG DLVILDGIPT
110 120 130 140 150
AGWLQGRSCW GARGFFPSSC VRELCLSSQS RQWHSQSALF QIPEYSMGQA
160 170 180 190 200
RALMGLSAQL DEELDFREGD VITIIGVPEP GWFEGELEGR RGIFPEGFVE
210 220 230 240 250
LLGPLRTVDE SVSSGNQDDC IVNGEVDTPV GEEEIGPDED EEEPGTYGVA
260 270 280 290 300
LYRFQALEPN ELDFEVGDKI RILATLEDGW LEGSLKGRTG IFPYRFVKLC
310 320 330 340 350
PDTRVEETMA LPQEGSLARI PETSLDCLEN TLGVEEQRHE TSDHEAEEPD
360 370 380 390 400
CIISEAPTSP LGHLTSEYDT DRNSYQDEDT AGGPPRSPGV EWEMPLATDS
410 420 430 440 450
PTSDPTEVVN GISSQPQVPF HPNLQKSQYY STVGGSHPHS EQYPDLLPLE
460 470 480 490 500
ARTRDYASLP PKRMYSQLKT LQKPVLPLYR GSSVSASRVV KPRQSSPQLH
510 520 530 540 550
NLASYTKKHH TSSVYSISER LEMKPGPQAQ GLVMEAATHS QGDGSTDLDS
560 570 580 590 600
KLTQQLIEFE KSLAGPGTEP DKILRHFSIM DFNSEKDIVR GSSKLITEQE
610 620 630 640 650
LPERRKALRP PPPRPCTPVS TSPHLLVDQN LKPAPPLVVR PSRPAPLPPS
660 670 680 690 700
AQQRTNAVSP KLLSRHRPTC ETLEKEGPGH MGRSLDQTSP CPLVLVRIEE
710 720 730 740 750
MERDLDMYSR AQEELNLMLE EKQDESSRAE TLEDLKFCES NIESLNMELQ
760 770 780 790 800
QLREMTLLSS QSSSLVAPSG SVSAENPEQR MLEKRAKVIE ELLQTERDYI
810 820 830 840 850
RDLEMCIERI MVPMQQAQVP NIDFEGLFGN MQMVIKVSKQ LLAALEISDA
860 870 880 890 900
VGPVFLGHRD ELEGTYKIYC QNHDEAIALL EIYEKDEKIQ KHLQDSLADL
910 920 930 940 950
KSLYNEWGCT NYINLGSFLI KPVQRVMRYP LLLMELLNST PESHPDKVPL
960 970 980 990 1000
TNAVLAVKEI NVNINEYKRR KDLVLKYRKG DEDSLMEKIS KLNIHSIIKK
1010 1020 1030 1040 1050
SNRVSSHLKH LTGFAPQIKD EVFEETEKNF RMQERLIKSF IRDLSLYLQH
1060 1070 1080 1090 1100
IRESACVKVV AAVSMWDVCM ERGHRDLEQF ERVHRYISDQ LFTNFKERTE
1110 1120 1130 1140 1150
RLVISPLNQL LSMFTGPHKL VQKRFDKLLD FYNCTERAEK LKDKKTLEEL
1160 1170 1180 1190 1200
QSARNNYEAL NAQLLDELPK FHQYAQGLFT NCVHGYAEAH CDFVHQALEQ
1210 1220 1230 1240 1250
LKPLLSLLKV AGREGNLIAI FHEEHSRVLQ QLQVFTFFPE SLPATKKPFE
1260 1270 1280 1290 1300
RKTIDRQSAR KPLLGLPSYM LQSEELRASL LARYPPEKLF QAERNFNAAQ
1310 1320 1330 1340 1350
DLDVSLLEGD LVGVIKKKDP MGSQNRWLID NGVTKGFVYS SFLKPYNPRR
1360 1370 1380 1390 1400
SHSDASVGSH SSTESEHGSS SPRFPRQNSG STLTFNPSSM AVSFTSGSCQ
1410 1420 1430 1440 1450
KQPQDASPPP KECDQGTLSA SLNPSNSESS PSRCPSDPDS TSQPRSGDSA
1460 1470 1480 1490 1500
DVARDVKQPT ATPRSYRNFR HPEIVGYSVP GRNGQSQDLV KGCARTAQAP
1510 1520 1530 1540 1550
EDRSTEPDGS EAEGNQVYFA VYTFKARNPN ELSVSANQKL KILEFKDVTG
1560 1570
NTEWWLAEVN GKKGYVPSNY IRKTEYT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GTX1 | A0A1B0GTX1_HUMAN | Dynamin-binding protein | DNMBP | 1,209 | Annotation score: | ||
A0A1C7CYY6 | A0A1C7CYY6_HUMAN | Dynamin-binding protein | DNMBP | 865 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 831 | M → T in AAH41628 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050955 | 81 | E → D. Corresponds to variant dbSNP:rs12267912Ensembl. | 1 | |
Natural variantiVAR_081450 | 271 – 1577 | Missing in CTRCT48. 1 PublicationAdd BLAST | 1307 | |
Natural variantiVAR_050956 | 373 | N → K. Corresponds to variant dbSNP:rs35924554Ensembl. | 1 | |
Natural variantiVAR_050957 | 914 | N → K. Corresponds to variant dbSNP:rs7919507Ensembl. | 1 | |
Natural variantiVAR_024339 | 1413 | C → W1 PublicationCorresponds to variant dbSNP:rs11190305Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012079 | 1 – 754 | Missing in isoform 2. 1 PublicationAdd BLAST | 754 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY196211 mRNA Translation: AAP34307.1 AB023227 mRNA Translation: BAA76854.1 BC041628 mRNA Translation: AAH41628.1 |
CCDSi | CCDS7485.1 [Q6XZF7-1] |
RefSeqi | NP_001305255.1, NM_001318326.1 NP_001305256.1, NM_001318327.1 NP_056036.1, NM_015221.3 [Q6XZF7-1] XP_011537861.1, XM_011539559.2 [Q6XZF7-1] |
Genome annotation databases
Ensembli | ENST00000324109.9; ENSP00000315659.4; ENSG00000107554.17 |
GeneIDi | 23268 |
KEGGi | hsa:23268 |
MANE-Selecti | ENST00000324109.9; ENSP00000315659.4; NM_015221.4; NP_056036.1 |
UCSCi | uc001kqg.3, human [Q6XZF7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY196211 mRNA Translation: AAP34307.1 AB023227 mRNA Translation: BAA76854.1 BC041628 mRNA Translation: AAH41628.1 |
CCDSi | CCDS7485.1 [Q6XZF7-1] |
RefSeqi | NP_001305255.1, NM_001318326.1 NP_001305256.1, NM_001318327.1 NP_056036.1, NM_015221.3 [Q6XZF7-1] XP_011537861.1, XM_011539559.2 [Q6XZF7-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UG1 | NMR | - | A | 1278-1355 | [»] | |
1UHC | NMR | - | A | 1510-1575 | [»] | |
4CC2 | X-ray | 1.55 | A/C | 1513-1577 | [»] | |
4CC3 | X-ray | 1.97 | A/C/E/G | 1513-1577 | [»] | |
4CC4 | X-ray | 2.60 | B/D/F | 1513-1577 | [»] | |
4CC7 | X-ray | 1.97 | A/C/E/G/I/K/M | 1513-1577 | [»] | |
4GLM | X-ray | 1.90 | A/B/C/D | 246-301 | [»] | |
AlphaFoldDBi | Q6XZF7 | |||||
SMRi | Q6XZF7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116869, 111 interactors |
DIPi | DIP-53822N |
IntActi | Q6XZF7, 32 interactors |
MINTi | Q6XZF7 |
STRINGi | 9606.ENSP00000315659 |
Chemistry databases
ChEMBLi | CHEMBL4295871 |
PTM databases
iPTMneti | Q6XZF7 |
MetOSitei | Q6XZF7 |
PhosphoSitePlusi | Q6XZF7 |
Genetic variation databases
BioMutai | DNMBP |
DMDMi | 56404535 |
Proteomic databases
EPDi | Q6XZF7 |
jPOSTi | Q6XZF7 |
MassIVEi | Q6XZF7 |
MaxQBi | Q6XZF7 |
PaxDbi | Q6XZF7 |
PeptideAtlasi | Q6XZF7 |
PRIDEi | Q6XZF7 |
ProteomicsDBi | 67829 [Q6XZF7-1] 67830 [Q6XZF7-2] |
Protocols and materials databases
ABCDi | Q6XZF7, 6 sequenced antibodies |
Antibodypediai | 31117, 144 antibodies from 25 providers |
DNASUi | 23268 |
Genome annotation databases
Ensembli | ENST00000324109.9; ENSP00000315659.4; ENSG00000107554.17 |
GeneIDi | 23268 |
KEGGi | hsa:23268 |
MANE-Selecti | ENST00000324109.9; ENSP00000315659.4; NM_015221.4; NP_056036.1 |
UCSCi | uc001kqg.3, human [Q6XZF7-1] |
Organism-specific databases
CTDi | 23268 |
DisGeNETi | 23268 |
GeneCardsi | DNMBP |
HGNCi | HGNC:30373, DNMBP |
HPAi | ENSG00000107554, Low tissue specificity |
MalaCardsi | DNMBP |
MIMi | 611282, gene 618415, phenotype |
neXtProti | NX_Q6XZF7 |
OpenTargetsi | ENSG00000107554 |
Orphaneti | 98994, Total early-onset cataract |
PharmGKBi | PA134950706 |
VEuPathDBi | HostDB:ENSG00000107554 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3519, Eukaryota KOG4225, Eukaryota |
GeneTreei | ENSGT00950000183088 |
HOGENOMi | CLU_252350_0_0_1 |
InParanoidi | Q6XZF7 |
OrthoDBi | 207472at2759 |
PhylomeDBi | Q6XZF7 |
TreeFami | TF330015 |
Enzyme and pathway databases
PathwayCommonsi | Q6XZF7 |
Reactomei | R-HSA-9013148, CDC42 GTPase cycle |
SignaLinki | Q6XZF7 |
SIGNORi | Q6XZF7 |
Miscellaneous databases
BioGRID-ORCSi | 23268, 14 hits in 1078 CRISPR screens |
ChiTaRSi | DNMBP, human |
EvolutionaryTracei | Q6XZF7 |
GenomeRNAii | 23268 |
Pharosi | Q6XZF7, Tbio |
PROi | PR:Q6XZF7 |
RNActi | Q6XZF7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000107554, Expressed in female gonad and 233 other tissues |
ExpressionAtlasi | Q6XZF7, baseline and differential |
Genevisiblei | Q6XZF7, HS |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit cd11798, SH3_DNMBP_C1, 1 hit cd11794, SH3_DNMBP_N1, 1 hit cd11795, SH3_DNMBP_N2, 1 hit cd11796, SH3_DNMBP_N3, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit 1.20.900.10, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR004148, BAR_dom IPR035899, DBL_dom_sf IPR000219, DH-domain IPR035469, DNMBP IPR035820, DNMBP_SH3_C1 IPR035817, DNMBP_SH3_N1 IPR035818, DNMBP_SH3_N2 IPR035819, DNMBP_SH3_N3 IPR001331, GDS_CDC24_CS IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR22834:SF19, PTHR22834:SF19, 1 hit |
Pfami | View protein in Pfam PF03114, BAR, 1 hit PF00621, RhoGEF, 1 hit PF00018, SH3_1, 3 hits PF07653, SH3_2, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00721, BAR, 1 hit SM00325, RhoGEF, 1 hit SM00326, SH3, 6 hits |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 6 hits |
PROSITEi | View protein in PROSITE PS51021, BAR, 1 hit PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50002, SH3, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | DNMBP_HUMAN | |
Accessioni | Q6XZF7Primary (citable) accession number: Q6XZF7 Secondary accession number(s): Q8IVY3, Q9Y2L3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 7, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references