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Entry version 150 (05 Jun 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Dynamin-binding protein

Gene

DNMBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:19767742, PubMed:17015620). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Play a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynamin-binding proteinImported
Alternative name(s):
Scaffold protein Tuba1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNMBPImported
Synonyms:ARHGEF36Imported, KIAA10101 Publication, TUBA1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30373 DNMBP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611282 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6XZF7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Golgi apparatus, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in DNMBP may be involved in an autosomal recessive ocular disease characterized by bilateral infantile or early-childhood-onset cataracts.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1521V → R: Decreased interaction of SH3 domain 6 with L.monocytogenes InlC. 1 Publication1
Mutagenesisi1529P → A: Wild-type interaction of SH3 domain 6 with L.monocytogenes InlC. 1 Publication1
Mutagenesisi1569N → R: Decreased interaction of SH3 domain 6 with L.monocytogenes InlC. 1 Publication1

Keywords - Diseasei

Cataract

Organism-specific databases

DisGeNET

More...
DisGeNETi
23268

Open Targets

More...
OpenTargetsi
ENSG00000107554

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98994 Total early-onset cataract

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134950706

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DNMBP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56404535

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000799591 – 1577Dynamin-binding proteinAdd BLAST1577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei684PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6XZF7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6XZF7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6XZF7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6XZF7

PeptideAtlas

More...
PeptideAtlasi
Q6XZF7

PRoteomics IDEntifications database

More...
PRIDEi
Q6XZF7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67829
67830 [Q6XZF7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6XZF7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6XZF7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in heart, brain, lung, liver, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000107554 Expressed in 222 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6XZF7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6XZF7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037878
HPA058216

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNM1 via its N-terminal SH3 domains. The C-terminal SH3 domain binds a complex containing actin, tubulin, Hsp70 and actin-regulatory proteins, such as ENAH, EVL, WIRE, CR16, WAVE1 and NAP1L1 (By similarity). Interacts with FASLG (PubMed:19807924). Interacts (via SH3 domain 6) with WASL (PubMed:19767742, PubMed:24332715, PubMed:17015620). Interacts (via SH3 domain 6) interacts with ENAH (PubMed:24332715). Interacts (via C-terminal domain) with TJP1; required for the apical cell-cell junction localization of DNMBP (PubMed:17015620).By similarity4 Publications
(Microbial infection) Interacts (via SH3 domain 6) with L.monocytogenes InlC.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116869, 30 interactors

Database of interacting proteins

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DIPi
DIP-53822N

Protein interaction database and analysis system

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IntActi
Q6XZF7, 17 interactors

Molecular INTeraction database

More...
MINTi
Q6XZF7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000315659

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11577
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6XZF7

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q6XZF7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 61SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini66 – 126SH3 2PROSITE-ProRule annotationAdd BLAST61
Domaini145 – 204SH3 3PROSITE-ProRule annotationAdd BLAST60
Domaini243 – 302SH3 4PROSITE-ProRule annotationAdd BLAST60
Domaini784 – 967DHPROSITE-ProRule annotationAdd BLAST184
Domaini1008 – 1217BARPROSITE-ProRule annotationAdd BLAST210
Domaini1285 – 1348SH3 5PROSITE-ProRule annotationAdd BLAST64
Domaini1513 – 1576SH3 6PROSITE-ProRule annotationAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili693 – 757Sequence analysisAdd BLAST65
Coiled coili1136 – 1173Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi610 – 649Pro-richAdd BLAST40
Compositional biasi1351 – 1449Ser-richAdd BLAST99

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3519 Eukaryota
KOG4225 Eukaryota
ENOG410XT9S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183088

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112243

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6XZF7

KEGG Orthology (KO)

More...
KOi
K20705

Database of Orthologous Groups

More...
OrthoDBi
207472at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6XZF7

TreeFam database of animal gene trees

More...
TreeFami
TF330015

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit
cd11798 SH3_DNMBP_C1, 1 hit
cd11794 SH3_DNMBP_N1, 1 hit
cd11795 SH3_DNMBP_N2, 1 hit
cd11796 SH3_DNMBP_N3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.60, 1 hit
1.20.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR004148 BAR_dom
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR035469 DNMBP
IPR035820 DNMBP_SH3_C1
IPR035817 DNMBP_SH3_N1
IPR035818 DNMBP_SH3_N2
IPR035819 DNMBP_SH3_N3
IPR001331 GDS_CDC24_CS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR22834:SF19 PTHR22834:SF19, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03114 BAR, 1 hit
PF00621 RhoGEF, 1 hit
PF00018 SH3_1, 3 hits
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00721 BAR, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657 SSF103657, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51021 BAR, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50002 SH3, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6XZF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAGSVVRAI FDFCPSVSEE LPLFVGDIIE VLAVVDEFWL LGKKEDVTGQ
60 70 80 90 100
FPSSFVEIVT IPSLKEGERL FVCICEFTSQ ELDNLPLHRG DLVILDGIPT
110 120 130 140 150
AGWLQGRSCW GARGFFPSSC VRELCLSSQS RQWHSQSALF QIPEYSMGQA
160 170 180 190 200
RALMGLSAQL DEELDFREGD VITIIGVPEP GWFEGELEGR RGIFPEGFVE
210 220 230 240 250
LLGPLRTVDE SVSSGNQDDC IVNGEVDTPV GEEEIGPDED EEEPGTYGVA
260 270 280 290 300
LYRFQALEPN ELDFEVGDKI RILATLEDGW LEGSLKGRTG IFPYRFVKLC
310 320 330 340 350
PDTRVEETMA LPQEGSLARI PETSLDCLEN TLGVEEQRHE TSDHEAEEPD
360 370 380 390 400
CIISEAPTSP LGHLTSEYDT DRNSYQDEDT AGGPPRSPGV EWEMPLATDS
410 420 430 440 450
PTSDPTEVVN GISSQPQVPF HPNLQKSQYY STVGGSHPHS EQYPDLLPLE
460 470 480 490 500
ARTRDYASLP PKRMYSQLKT LQKPVLPLYR GSSVSASRVV KPRQSSPQLH
510 520 530 540 550
NLASYTKKHH TSSVYSISER LEMKPGPQAQ GLVMEAATHS QGDGSTDLDS
560 570 580 590 600
KLTQQLIEFE KSLAGPGTEP DKILRHFSIM DFNSEKDIVR GSSKLITEQE
610 620 630 640 650
LPERRKALRP PPPRPCTPVS TSPHLLVDQN LKPAPPLVVR PSRPAPLPPS
660 670 680 690 700
AQQRTNAVSP KLLSRHRPTC ETLEKEGPGH MGRSLDQTSP CPLVLVRIEE
710 720 730 740 750
MERDLDMYSR AQEELNLMLE EKQDESSRAE TLEDLKFCES NIESLNMELQ
760 770 780 790 800
QLREMTLLSS QSSSLVAPSG SVSAENPEQR MLEKRAKVIE ELLQTERDYI
810 820 830 840 850
RDLEMCIERI MVPMQQAQVP NIDFEGLFGN MQMVIKVSKQ LLAALEISDA
860 870 880 890 900
VGPVFLGHRD ELEGTYKIYC QNHDEAIALL EIYEKDEKIQ KHLQDSLADL
910 920 930 940 950
KSLYNEWGCT NYINLGSFLI KPVQRVMRYP LLLMELLNST PESHPDKVPL
960 970 980 990 1000
TNAVLAVKEI NVNINEYKRR KDLVLKYRKG DEDSLMEKIS KLNIHSIIKK
1010 1020 1030 1040 1050
SNRVSSHLKH LTGFAPQIKD EVFEETEKNF RMQERLIKSF IRDLSLYLQH
1060 1070 1080 1090 1100
IRESACVKVV AAVSMWDVCM ERGHRDLEQF ERVHRYISDQ LFTNFKERTE
1110 1120 1130 1140 1150
RLVISPLNQL LSMFTGPHKL VQKRFDKLLD FYNCTERAEK LKDKKTLEEL
1160 1170 1180 1190 1200
QSARNNYEAL NAQLLDELPK FHQYAQGLFT NCVHGYAEAH CDFVHQALEQ
1210 1220 1230 1240 1250
LKPLLSLLKV AGREGNLIAI FHEEHSRVLQ QLQVFTFFPE SLPATKKPFE
1260 1270 1280 1290 1300
RKTIDRQSAR KPLLGLPSYM LQSEELRASL LARYPPEKLF QAERNFNAAQ
1310 1320 1330 1340 1350
DLDVSLLEGD LVGVIKKKDP MGSQNRWLID NGVTKGFVYS SFLKPYNPRR
1360 1370 1380 1390 1400
SHSDASVGSH SSTESEHGSS SPRFPRQNSG STLTFNPSSM AVSFTSGSCQ
1410 1420 1430 1440 1450
KQPQDASPPP KECDQGTLSA SLNPSNSESS PSRCPSDPDS TSQPRSGDSA
1460 1470 1480 1490 1500
DVARDVKQPT ATPRSYRNFR HPEIVGYSVP GRNGQSQDLV KGCARTAQAP
1510 1520 1530 1540 1550
EDRSTEPDGS EAEGNQVYFA VYTFKARNPN ELSVSANQKL KILEFKDVTG
1560 1570
NTEWWLAEVN GKKGYVPSNY IRKTEYT
Length:1,577
Mass (Da):177,347
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A1FDCB06124F627
GO
Isoform 2 (identifier: Q6XZF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-754: Missing.

Show »
Length:823
Mass (Da):93,498
Checksum:i535FFA230587539F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GTX1A0A1B0GTX1_HUMAN
Dynamin-binding protein
DNMBP
1,209Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1C7CYY6A0A1C7CYY6_HUMAN
Dynamin-binding protein
DNMBP
865Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti831M → T in AAH41628 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05095581E → D. Corresponds to variant dbSNP:rs12267912Ensembl.1
Natural variantiVAR_081450271 – 1577Missing Probable disease-associated mutation found in one family affected by early-childhood-onset cataract. 1 PublicationAdd BLAST1307
Natural variantiVAR_050956373N → K. Corresponds to variant dbSNP:rs35924554Ensembl.1
Natural variantiVAR_050957914N → K. Corresponds to variant dbSNP:rs7919507Ensembl.1
Natural variantiVAR_081451938 – 1577Missing Probable disease-associated mutation found in one family affected by bilateral infantile or early-childhood-onset cataract. 1 PublicationAdd BLAST640
Natural variantiVAR_0243391413C → W1 PublicationCorresponds to variant dbSNP:rs11190305Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0120791 – 754Missing in isoform 2. 1 PublicationAdd BLAST754

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY196211 mRNA Translation: AAP34307.1
AB023227 mRNA Translation: BAA76854.1
BC041628 mRNA Translation: AAH41628.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7485.1 [Q6XZF7-1]

NCBI Reference Sequences

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RefSeqi
NP_001305255.1, NM_001318326.1
NP_001305256.1, NM_001318327.1
NP_056036.1, NM_015221.3 [Q6XZF7-1]
XP_011537861.1, XM_011539559.2 [Q6XZF7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000324109; ENSP00000315659; ENSG00000107554 [Q6XZF7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23268

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23268

UCSC genome browser

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UCSCi
uc001kqg.3 human [Q6XZF7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY196211 mRNA Translation: AAP34307.1
AB023227 mRNA Translation: BAA76854.1
BC041628 mRNA Translation: AAH41628.1
CCDSiCCDS7485.1 [Q6XZF7-1]
RefSeqiNP_001305255.1, NM_001318326.1
NP_001305256.1, NM_001318327.1
NP_056036.1, NM_015221.3 [Q6XZF7-1]
XP_011537861.1, XM_011539559.2 [Q6XZF7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UG1NMR-A1278-1355[»]
1UHCNMR-A1510-1575[»]
4CC2X-ray1.55A/C1513-1577[»]
4CC3X-ray1.97A/C/E/G1513-1577[»]
4CC4X-ray2.60B/D/F1513-1577[»]
4CC7X-ray1.97A/C/E/G/I/K/M1513-1577[»]
4GLMX-ray1.90A/B/C/D246-301[»]
SMRiQ6XZF7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116869, 30 interactors
DIPiDIP-53822N
IntActiQ6XZF7, 17 interactors
MINTiQ6XZF7
STRINGi9606.ENSP00000315659

PTM databases

iPTMnetiQ6XZF7
PhosphoSitePlusiQ6XZF7

Polymorphism and mutation databases

BioMutaiDNMBP
DMDMi56404535

Proteomic databases

EPDiQ6XZF7
jPOSTiQ6XZF7
MaxQBiQ6XZF7
PaxDbiQ6XZF7
PeptideAtlasiQ6XZF7
PRIDEiQ6XZF7
ProteomicsDBi67829
67830 [Q6XZF7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324109; ENSP00000315659; ENSG00000107554 [Q6XZF7-1]
GeneIDi23268
KEGGihsa:23268
UCSCiuc001kqg.3 human [Q6XZF7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23268
DisGeNETi23268

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DNMBP
HGNCiHGNC:30373 DNMBP
HPAiHPA037878
HPA058216
MIMi611282 gene
neXtProtiNX_Q6XZF7
OpenTargetsiENSG00000107554
Orphaneti98994 Total early-onset cataract
PharmGKBiPA134950706

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3519 Eukaryota
KOG4225 Eukaryota
ENOG410XT9S LUCA
GeneTreeiENSGT00950000183088
HOGENOMiHOG000112243
InParanoidiQ6XZF7
KOiK20705
OrthoDBi207472at2759
PhylomeDBiQ6XZF7
TreeFamiTF330015

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DNMBP human
EvolutionaryTraceiQ6XZF7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23268

Protein Ontology

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PROi
PR:Q6XZF7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000107554 Expressed in 222 organ(s), highest expression level in female gonad
ExpressionAtlasiQ6XZF7 baseline and differential
GenevisibleiQ6XZF7 HS

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd11798 SH3_DNMBP_C1, 1 hit
cd11794 SH3_DNMBP_N1, 1 hit
cd11795 SH3_DNMBP_N2, 1 hit
cd11796 SH3_DNMBP_N3, 1 hit
Gene3Di1.20.1270.60, 1 hit
1.20.900.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR004148 BAR_dom
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR035469 DNMBP
IPR035820 DNMBP_SH3_C1
IPR035817 DNMBP_SH3_N1
IPR035818 DNMBP_SH3_N2
IPR035819 DNMBP_SH3_N3
IPR001331 GDS_CDC24_CS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR22834:SF19 PTHR22834:SF19, 1 hit
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PF00621 RhoGEF, 1 hit
PF00018 SH3_1, 3 hits
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 6 hits
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 6 hits
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50002 SH3, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNMBP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XZF7
Secondary accession number(s): Q8IVY3, Q9Y2L3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: June 5, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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