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Entry version 144 (16 Oct 2019)
Sequence version 3 (28 Mar 2018)
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Protein

Lipase member I

Gene

LIPI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by sodium vanadate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei159Nucleophile1
Active sitei183Charge relay systemBy similarity1
Active sitei253Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding, Hydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.1.32 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1483166 Synthesis of PA

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-LIPI Phospholipase

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000626

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lipase member I (EC:3.1.1.-)
Short name:
LIPI
Alternative name(s):
Cancer/testis antigen 17
Short name:
CT17
LPD lipase
Membrane-associated phosphatidic acid-selective phospholipase A1-beta
Short name:
mPA-PLA1 beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LIPI
Synonyms:LPDL
ORF Names:PRED5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18821 LIPI

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609252 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6XZB0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypertriglyceridemia, familial (FHTR)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02376055C → Y in FHTR. 1 PublicationCorresponds to variant dbSNP:rs11909217Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi159S → A: No activity. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
149998

MalaCards human disease database

More...
MalaCardsi
LIPI
MIMi145750 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000188992

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
413 NON RARE IN EUROPE: Hyperlipoproteinemia type 4

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38695

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6XZB0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LIPI

Domain mapping of disease mutations (DMDM)

More...
DMDMi
81170675

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 15Sequence analysisAdd BLAST15
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004277916 – 460Lipase member IAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi238 ↔ 251By similarity
Disulfide bondi275 ↔ 286By similarity
Disulfide bondi289 ↔ 297By similarity
Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi436 ↔ 455By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6XZB0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6XZB0

PeptideAtlas

More...
PeptideAtlasi
Q6XZB0

PRoteomics IDEntifications database

More...
PRIDEi
Q6XZB0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67826 [Q6XZB0-1]
67827 [Q6XZB0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6XZB0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6XZB0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis. Expressed exclusively at the connecting piece of the sperm.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188992 Expressed in 52 organ(s), highest expression level in caput epididymis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6XZB0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6XZB0 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with heparin with a high affinity.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000343331

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IKYJ Eukaryota
ENOG4111AHY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161940

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234386

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6XZB0

KEGG Orthology (KO)

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KOi
K19404

Identification of Orthologs from Complete Genome Data

More...
OMAi
YIKCDHQ

Database of Orthologous Groups

More...
OrthoDBi
534956at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6XZB0

TreeFam database of animal gene trees

More...
TreeFami
TF324997

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00707 Pancreat_lipase_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR000734 TAG_lipase

The PANTHER Classification System

More...
PANTHERi
PTHR11610 PTHR11610, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00151 Lipase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000865 Lipoprotein_lipase_LIPH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00821 TAGLIPASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6XZB0-1) [UniParc]FASTAAdd to basket
Also known as: mPA-PLA1beta1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVYIFLCLM CWVRSDNKRP CLEFSQLSVK DSFRDLFIPR IETILMMYTR
60 70 80 90 100
NNLNCAEPLF EQNNSLNVNF NTQKKTVWLI HGYRPVGSIP LWLQNFVRIL
110 120 130 140 150
LNEEDMNVIV VDWSRGATTF IYNRAVKNTR KVAVSLSVHI KNLLKHGASL
160 170 180 190 200
DNFHFIGVSL GAHISGFVGK IFHGQLGRIT GLDPAGPRFS RKPPYSRLDY
210 220 230 240 250
TDAKFVDVIH SDSNGLGIQE PLGHIDFYPN GGNKQPGCPK SIFSGIQFIK
260 270 280 290 300
CNHQRAVHLF MASLETNCNF ISFPCRSYKD YKTSLCVDCD CFKEKSCPRL
310 320 330 340 350
GYQAKLFKGV LKERMEGRPL RTTVFLDTSG TYPFCTYYFV LSIIVPDKTM
360 370 380 390 400
MDGSFSFKLL NQLGMIEEPR LYEKNKPFYK LQEVKILAQF YNDFVNISSI
410 420 430 440 450
GLTYFQSSNL QCSTCTYKIQ SLMLKSLTYP ERPPLCRYNI VLKDREEVFL
460
NPNTCTPKNT
Length:460
Mass (Da):52,922
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD83A76050DBB6D24
GO
Isoform 2 (identifier: Q6XZB0-2) [UniParc]FASTAAdd to basket
Also known as: mPA-PLA1alpha1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MRVYIFLCLMCWV → MLLKCLHNNLCQKYSAHAFQFSPRNVLWLLVVCL

Show »
Length:481
Mass (Da):55,249
Checksum:i5079323132EB8999
GO
Isoform 3 (identifier: Q6XZB0-3) [UniParc]FASTAAdd to basket
Also known as: deltaE7.2

The sequence of this isoform differs from the canonical sequence as follows:
     330-336: GTYPFCT → A

Show »
Length:454
Mass (Da):52,224
Checksum:i53BAF0EB5FE591A5
GO
Isoform 4 (identifier: Q6XZB0-4) [UniParc]FASTAAdd to basket
Also known as: deltaE6.1

The sequence of this isoform differs from the canonical sequence as follows:
     245-279: Missing.

Show »
Length:425
Mass (Da):48,836
Checksum:i843576AB346A9CD8
GO
Isoform 5 (identifier: Q6XZB0-5) [UniParc]FASTAAdd to basket
Also known as: deltaE5

The sequence of this isoform differs from the canonical sequence as follows:
     215-244: Missing.

Show »
Length:430
Mass (Da):49,769
Checksum:i744BE8220143281B
GO
Isoform 6 (identifier: Q6XZB0-6) [UniParc]FASTAAdd to basket
Also known as: deltaE8-9

The sequence of this isoform differs from the canonical sequence as follows:
     336-375: TYYFVLSIIV...IEEPRLYEKN → NHHFAGIILY...MPSSIKCTCL
     376-460: Missing.

Show »
Length:375
Mass (Da):43,005
Checksum:i02E18ECA4D84E285
GO
Isoform 7 (identifier: Q6XZB0-7) [UniParc]FASTAAdd to basket
Also known as: 7B+

The sequence of this isoform differs from the canonical sequence as follows:
     336-368: TYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEE → NKPVFRIYLFNTSPYPLLAGRLFHLSCLRVVKN
     369-460: Missing.

Show »
Length:368
Mass (Da):42,135
Checksum:i0D5DC5B861667854
GO
Isoform 8 (identifier: Q6XZB0-8) [UniParc]FASTAAdd to basket
Also known as: deltaE2-3

The sequence of this isoform differs from the canonical sequence as follows:
     16-180: Missing.

Show »
Length:295
Mass (Da):34,041
Checksum:i5BDFF655BA7D2716
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZG8A0A087WZG8_HUMAN
Lipase member I
LIPI
421Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Q2TCK2A0A2Q2TCK2_HUMAN
Lipase member I
LIPI
451Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3S0H0Y3S0_HUMAN
Lipase member I
LIPI
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti421S → R in AAP37476 (PubMed:12963729).1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02376055C → Y in FHTR. 1 PublicationCorresponds to variant dbSNP:rs11909217Ensembl.1
Natural variantiVAR_023761364G → E1 PublicationCorresponds to variant dbSNP:rs74369337Ensembl.1
Natural variantiVAR_023762431E → K1 PublicationCorresponds to variant dbSNP:rs2822432Ensembl.1
Natural variantiVAR_023763444D → E1 PublicationCorresponds to variant dbSNP:rs7278737Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0160901 – 13MRVYI…LMCWV → MLLKCLHNNLCQKYSAHAFQ FSPRNVLWLLVVCL in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_05389616 – 180Missing in isoform 8. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_053897215 – 244Missing in isoform 5. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_053898245 – 279Missing in isoform 4. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_053899330 – 336GTYPFCT → A in isoform 3. 1 Publication7
Alternative sequenceiVSP_053900336 – 375TYYFV…LYEKN → NHHFAGIILYLKNERKCFLI QTHVHQRTHKMPSSIKCTCL in isoform 6. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_053901336 – 368TYYFV…GMIEE → NKPVFRIYLFNTSPYPLLAG RLFHLSCLRVVKN in isoform 7. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_053902369 – 460Missing in isoform 7. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_053903376 – 460Missing in isoform 6. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY197607 mRNA Translation: AAP37476.1
JN387910 mRNA Translation: AEL12688.1
JN387911 mRNA Translation: AEL12689.1
JN387912 mRNA Translation: AEL12690.1
JN387913 mRNA Translation: AEL12691.1
JN387914 mRNA Translation: AEL12692.1
JN387915 mRNA Translation: AEL12693.1
JN387916 mRNA Translation: AEL12694.1
AF130358 Genomic DNA No translation available.
AL078615 Genomic DNA No translation available.
AP001347 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS13564.1 [Q6XZB0-2]

NCBI Reference Sequences

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RefSeqi
NP_001289927.1, NM_001302998.1 [Q6XZB0-1]
NP_001289928.1, NM_001302999.1 [Q6XZB0-5]
NP_001289929.1, NM_001303000.1 [Q6XZB0-3]
NP_001289930.1, NM_001303001.1
NP_945347.2, NM_198996.3 [Q6XZB0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000344577; ENSP00000343331; ENSG00000188992 [Q6XZB0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
149998

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:149998

UCSC genome browser

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UCSCi
uc002yjm.4 human [Q6XZB0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY197607 mRNA Translation: AAP37476.1
JN387910 mRNA Translation: AEL12688.1
JN387911 mRNA Translation: AEL12689.1
JN387912 mRNA Translation: AEL12690.1
JN387913 mRNA Translation: AEL12691.1
JN387914 mRNA Translation: AEL12692.1
JN387915 mRNA Translation: AEL12693.1
JN387916 mRNA Translation: AEL12694.1
AF130358 Genomic DNA No translation available.
AL078615 Genomic DNA No translation available.
AP001347 Genomic DNA No translation available.
CCDSiCCDS13564.1 [Q6XZB0-2]
RefSeqiNP_001289927.1, NM_001302998.1 [Q6XZB0-1]
NP_001289928.1, NM_001302999.1 [Q6XZB0-5]
NP_001289929.1, NM_001303000.1 [Q6XZB0-3]
NP_001289930.1, NM_001303001.1
NP_945347.2, NM_198996.3 [Q6XZB0-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000343331

Chemistry databases

SwissLipidsiSLP:000000626

Protein family/group databases

ESTHERihuman-LIPI Phospholipase

PTM databases

iPTMnetiQ6XZB0
PhosphoSitePlusiQ6XZB0

Polymorphism and mutation databases

BioMutaiLIPI
DMDMi81170675

Proteomic databases

MassIVEiQ6XZB0
PaxDbiQ6XZB0
PeptideAtlasiQ6XZB0
PRIDEiQ6XZB0
ProteomicsDBi67826 [Q6XZB0-1]
67827 [Q6XZB0-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
149998

Genome annotation databases

EnsembliENST00000344577; ENSP00000343331; ENSG00000188992 [Q6XZB0-2]
GeneIDi149998
KEGGihsa:149998
UCSCiuc002yjm.4 human [Q6XZB0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
149998
DisGeNETi149998

GeneCards: human genes, protein and diseases

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GeneCardsi
LIPI
HGNCiHGNC:18821 LIPI
MalaCardsiLIPI
MIMi145750 phenotype
609252 gene
neXtProtiNX_Q6XZB0
OpenTargetsiENSG00000188992
Orphaneti413 NON RARE IN EUROPE: Hyperlipoproteinemia type 4
PharmGKBiPA38695

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKYJ Eukaryota
ENOG4111AHY LUCA
GeneTreeiENSGT00940000161940
HOGENOMiHOG000234386
InParanoidiQ6XZB0
KOiK19404
OMAiYIKCDHQ
OrthoDBi534956at2759
PhylomeDBiQ6XZB0
TreeFamiTF324997

Enzyme and pathway databases

BRENDAi3.1.1.32 2681
ReactomeiR-HSA-1483166 Synthesis of PA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LIPI human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
149998
PharosiQ6XZB0

Protein Ontology

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PROi
PR:Q6XZB0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000188992 Expressed in 52 organ(s), highest expression level in caput epididymis
ExpressionAtlasiQ6XZB0 baseline and differential
GenevisibleiQ6XZB0 HS

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00821 TAGLIPASE
SUPFAMiSSF53474 SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIPI_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XZB0
Secondary accession number(s): G1JSG3
, G1JSG4, G1JSG5, G1JSG6, G1JSG7, G1JSG8, G1JSG9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 28, 2018
Last modified: October 16, 2019
This is version 144 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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