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Protein

Lipase member I

Gene

LIPI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).1 Publication

Activity regulationi

Inhibited by sodium vanadate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei159Nucleophile1
Active sitei183Charge relay systemBy similarity1
Active sitei253Charge relay systemBy similarity1

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: InterPro
  • heparin binding Source: UniProtKB
  • phospholipase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Hydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.1.32 2681
ReactomeiR-HSA-1483166 Synthesis of PA

Protein family/group databases

ESTHERihuman-LIPI Phospholipase

Chemistry databases

SwissLipidsiSLP:000000626

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase member I (EC:3.1.1.-)
Short name:
LIPI
Alternative name(s):
Cancer/testis antigen 17
Short name:
CT17
LPD lipase
Membrane-associated phosphatidic acid-selective phospholipase A1-beta
Short name:
mPA-PLA1 beta
Gene namesi
Name:LIPI
Synonyms:LPDL
ORF Names:PRED5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000188992.11
HGNCiHGNC:18821 LIPI
MIMi609252 gene
neXtProtiNX_Q6XZB0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Hypertriglyceridemia, familial (FHTR)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis.
See also OMIM:145750
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02376055C → Y in FHTR. 1 PublicationCorresponds to variant dbSNP:rs11909217Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi159S → A: No activity. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi149998
MalaCardsiLIPI
MIMi145750 phenotype
OpenTargetsiENSG00000188992
Orphaneti413 NON RARE IN EUROPE: Hyperlipoproteinemia type 4
PharmGKBiPA38695

Polymorphism and mutation databases

BioMutaiLIPI
DMDMi81170675

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000004277916 – 460Lipase member IAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi238 ↔ 251By similarity
Disulfide bondi275 ↔ 286By similarity
Disulfide bondi289 ↔ 297By similarity
Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi436 ↔ 455By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6XZB0
PeptideAtlasiQ6XZB0
PRIDEiQ6XZB0
ProteomicsDBi67826
67827 [Q6XZB0-2]

PTM databases

iPTMnetiQ6XZB0
PhosphoSitePlusiQ6XZB0

Expressioni

Tissue specificityi

Expressed in testis. Expressed exclusively at the connecting piece of the sperm.2 Publications

Gene expression databases

BgeeiENSG00000188992 Expressed in 52 organ(s), highest expression level in caput epididymis
CleanExiHS_LIPI
ExpressionAtlasiQ6XZB0 baseline and differential
GenevisibleiQ6XZB0 HS

Interactioni

Subunit structurei

Interacts with heparin with a high affinity.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000343331

Structurei

3D structure databases

ProteinModelPortaliQ6XZB0
SMRiQ6XZB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKYJ Eukaryota
ENOG4111AHY LUCA
GeneTreeiENSGT00760000119069
HOGENOMiHOG000234386
HOVERGENiHBG080640
InParanoidiQ6XZB0
KOiK19404
OMAiMGSTPSW
OrthoDBiEOG091G0680
PhylomeDBiQ6XZB0
TreeFamiTF324997

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00821 TAGLIPASE
SUPFAMiSSF53474 SSF53474, 1 hit

Sequences (8+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6XZB0-1) [UniParc]FASTAAdd to basket
Also known as: mPA-PLA1beta1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVYIFLCLM CWVRSDNKRP CLEFSQLSVK DSFRDLFIPR IETILMMYTR
60 70 80 90 100
NNLNCAEPLF EQNNSLNVNF NTQKKTVWLI HGYRPVGSIP LWLQNFVRIL
110 120 130 140 150
LNEEDMNVIV VDWSRGATTF IYNRAVKNTR KVAVSLSVHI KNLLKHGASL
160 170 180 190 200
DNFHFIGVSL GAHISGFVGK IFHGQLGRIT GLDPAGPRFS RKPPYSRLDY
210 220 230 240 250
TDAKFVDVIH SDSNGLGIQE PLGHIDFYPN GGNKQPGCPK SIFSGIQFIK
260 270 280 290 300
CNHQRAVHLF MASLETNCNF ISFPCRSYKD YKTSLCVDCD CFKEKSCPRL
310 320 330 340 350
GYQAKLFKGV LKERMEGRPL RTTVFLDTSG TYPFCTYYFV LSIIVPDKTM
360 370 380 390 400
MDGSFSFKLL NQLGMIEEPR LYEKNKPFYK LQEVKILAQF YNDFVNISSI
410 420 430 440 450
GLTYFQSSNL QCSTCTYKIQ SLMLKSLTYP ERPPLCRYNI VLKDREEVFL
460
NPNTCTPKNT
Length:460
Mass (Da):52,922
Last modified:March 28, 2018 - v3
Checksum:iD83A76050DBB6D24
GO
Isoform 2 (identifier: Q6XZB0-2) [UniParc]FASTAAdd to basket
Also known as: mPA-PLA1alpha1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MRVYIFLCLMCWV → MLLKCLHNNLCQKYSAHAFQFSPRNVLWLLVVCL

Show »
Length:481
Mass (Da):55,249
Checksum:i5079323132EB8999
GO
Isoform 3 (identifier: Q6XZB0-3) [UniParc]FASTAAdd to basket
Also known as: deltaE7.2

The sequence of this isoform differs from the canonical sequence as follows:
     330-336: GTYPFCT → A

Show »
Length:454
Mass (Da):52,224
Checksum:i53BAF0EB5FE591A5
GO
Isoform 4 (identifier: Q6XZB0-4) [UniParc]FASTAAdd to basket
Also known as: deltaE6.1

The sequence of this isoform differs from the canonical sequence as follows:
     245-279: Missing.

Show »
Length:425
Mass (Da):48,836
Checksum:i843576AB346A9CD8
GO
Isoform 5 (identifier: Q6XZB0-5) [UniParc]FASTAAdd to basket
Also known as: deltaE5

The sequence of this isoform differs from the canonical sequence as follows:
     215-244: Missing.

Show »
Length:430
Mass (Da):49,769
Checksum:i744BE8220143281B
GO
Isoform 6 (identifier: Q6XZB0-6) [UniParc]FASTAAdd to basket
Also known as: deltaE8-9

The sequence of this isoform differs from the canonical sequence as follows:
     336-375: TYYFVLSIIV...IEEPRLYEKN → NHHFAGIILY...MPSSIKCTCL
     376-460: Missing.

Show »
Length:375
Mass (Da):43,005
Checksum:i02E18ECA4D84E285
GO
Isoform 7 (identifier: Q6XZB0-7) [UniParc]FASTAAdd to basket
Also known as: 7B+

The sequence of this isoform differs from the canonical sequence as follows:
     336-368: TYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEE → NKPVFRIYLFNTSPYPLLAGRLFHLSCLRVVKN
     369-460: Missing.

Show »
Length:368
Mass (Da):42,135
Checksum:i0D5DC5B861667854
GO
Isoform 8 (identifier: Q6XZB0-8) [UniParc]FASTAAdd to basket
Also known as: deltaE2-3

The sequence of this isoform differs from the canonical sequence as follows:
     16-180: Missing.

Show »
Length:295
Mass (Da):34,041
Checksum:i5BDFF655BA7D2716
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZG8A0A087WZG8_HUMAN
Lipase member I
LIPI
421Annotation score:
A0A2Q2TCK2A0A2Q2TCK2_HUMAN
Lipase member I
LIPI
451Annotation score:
H0Y3S0H0Y3S0_HUMAN
Lipase member I
LIPI
141Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti421S → R in AAP37476 (PubMed:12963729).1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02376055C → Y in FHTR. 1 PublicationCorresponds to variant dbSNP:rs11909217Ensembl.1
Natural variantiVAR_023761364G → E1 PublicationCorresponds to variant dbSNP:rs74369337Ensembl.1
Natural variantiVAR_023762431E → K1 PublicationCorresponds to variant dbSNP:rs2822432Ensembl.1
Natural variantiVAR_023763444D → E1 PublicationCorresponds to variant dbSNP:rs7278737Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0160901 – 13MRVYI…LMCWV → MLLKCLHNNLCQKYSAHAFQ FSPRNVLWLLVVCL in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_05389616 – 180Missing in isoform 8. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_053897215 – 244Missing in isoform 5. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_053898245 – 279Missing in isoform 4. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_053899330 – 336GTYPFCT → A in isoform 3. 1 Publication7
Alternative sequenceiVSP_053900336 – 375TYYFV…LYEKN → NHHFAGIILYLKNERKCFLI QTHVHQRTHKMPSSIKCTCL in isoform 6. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_053901336 – 368TYYFV…GMIEE → NKPVFRIYLFNTSPYPLLAG RLFHLSCLRVVKN in isoform 7. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_053902369 – 460Missing in isoform 7. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_053903376 – 460Missing in isoform 6. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY197607 mRNA Translation: AAP37476.1
JN387910 mRNA Translation: AEL12688.1
JN387911 mRNA Translation: AEL12689.1
JN387912 mRNA Translation: AEL12690.1
JN387913 mRNA Translation: AEL12691.1
JN387914 mRNA Translation: AEL12692.1
JN387915 mRNA Translation: AEL12693.1
JN387916 mRNA Translation: AEL12694.1
AF130358 Genomic DNA No translation available.
AL078615 Genomic DNA No translation available.
AP001347 Genomic DNA No translation available.
CCDSiCCDS13564.1 [Q6XZB0-2]
RefSeqiNP_001289927.1, NM_001302998.1 [Q6XZB0-1]
NP_001289928.1, NM_001302999.1 [Q6XZB0-5]
NP_001289929.1, NM_001303000.1 [Q6XZB0-3]
NP_001289930.1, NM_001303001.1
NP_945347.2, NM_198996.3 [Q6XZB0-2]
UniGeneiHs.139907

Genome annotation databases

EnsembliENST00000344577; ENSP00000343331; ENSG00000188992 [Q6XZB0-2]
GeneIDi149998
KEGGihsa:149998
UCSCiuc002yjm.4 human [Q6XZB0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY197607 mRNA Translation: AAP37476.1
JN387910 mRNA Translation: AEL12688.1
JN387911 mRNA Translation: AEL12689.1
JN387912 mRNA Translation: AEL12690.1
JN387913 mRNA Translation: AEL12691.1
JN387914 mRNA Translation: AEL12692.1
JN387915 mRNA Translation: AEL12693.1
JN387916 mRNA Translation: AEL12694.1
AF130358 Genomic DNA No translation available.
AL078615 Genomic DNA No translation available.
AP001347 Genomic DNA No translation available.
CCDSiCCDS13564.1 [Q6XZB0-2]
RefSeqiNP_001289927.1, NM_001302998.1 [Q6XZB0-1]
NP_001289928.1, NM_001302999.1 [Q6XZB0-5]
NP_001289929.1, NM_001303000.1 [Q6XZB0-3]
NP_001289930.1, NM_001303001.1
NP_945347.2, NM_198996.3 [Q6XZB0-2]
UniGeneiHs.139907

3D structure databases

ProteinModelPortaliQ6XZB0
SMRiQ6XZB0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000343331

Chemistry databases

SwissLipidsiSLP:000000626

Protein family/group databases

ESTHERihuman-LIPI Phospholipase

PTM databases

iPTMnetiQ6XZB0
PhosphoSitePlusiQ6XZB0

Polymorphism and mutation databases

BioMutaiLIPI
DMDMi81170675

Proteomic databases

PaxDbiQ6XZB0
PeptideAtlasiQ6XZB0
PRIDEiQ6XZB0
ProteomicsDBi67826
67827 [Q6XZB0-2]

Protocols and materials databases

DNASUi149998
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344577; ENSP00000343331; ENSG00000188992 [Q6XZB0-2]
GeneIDi149998
KEGGihsa:149998
UCSCiuc002yjm.4 human [Q6XZB0-1]

Organism-specific databases

CTDi149998
DisGeNETi149998
EuPathDBiHostDB:ENSG00000188992.11
GeneCardsiLIPI
HGNCiHGNC:18821 LIPI
MalaCardsiLIPI
MIMi145750 phenotype
609252 gene
neXtProtiNX_Q6XZB0
OpenTargetsiENSG00000188992
Orphaneti413 NON RARE IN EUROPE: Hyperlipoproteinemia type 4
PharmGKBiPA38695
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKYJ Eukaryota
ENOG4111AHY LUCA
GeneTreeiENSGT00760000119069
HOGENOMiHOG000234386
HOVERGENiHBG080640
InParanoidiQ6XZB0
KOiK19404
OMAiMGSTPSW
OrthoDBiEOG091G0680
PhylomeDBiQ6XZB0
TreeFamiTF324997

Enzyme and pathway databases

BRENDAi3.1.1.32 2681
ReactomeiR-HSA-1483166 Synthesis of PA

Miscellaneous databases

ChiTaRSiLIPI human
GenomeRNAii149998
PROiPR:Q6XZB0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188992 Expressed in 52 organ(s), highest expression level in caput epididymis
CleanExiHS_LIPI
ExpressionAtlasiQ6XZB0 baseline and differential
GenevisibleiQ6XZB0 HS

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00821 TAGLIPASE
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIPI_HUMAN
AccessioniPrimary (citable) accession number: Q6XZB0
Secondary accession number(s): G1JSG3
, G1JSG4, G1JSG5, G1JSG6, G1JSG7, G1JSG8, G1JSG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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