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Protein

Transcription factor LBX2

Gene

LBX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative transcription factor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi85 – 144HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor LBX2
Alternative name(s):
Ladybird homeobox protein homolog 2
Gene namesi
Name:LBX2
ORF Names:LP3727
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000179528.15
HGNCiHGNC:15525 LBX2
MIMi607164 gene
neXtProtiNX_Q6XYB7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179528
PharmGKBiPA30305

Polymorphism and mutation databases

DMDMi74749508

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113281 – 198Transcription factor LBX2Add BLAST198

Proteomic databases

EPDiQ6XYB7
PaxDbiQ6XYB7
PeptideAtlasiQ6XYB7
PRIDEiQ6XYB7
ProteomicsDBi67822
67823 [Q6XYB7-2]

PTM databases

iPTMnetiQ6XYB7

Expressioni

Gene expression databases

BgeeiENSG00000179528
CleanExiHS_LBX2
ExpressionAtlasiQ6XYB7 baseline and differential

Organism-specific databases

HPAiHPA044257

Interactioni

Protein-protein interaction databases

IntActiQ6XYB7, 2 interactors
STRINGi9606.ENSP00000417116

Structurei

3D structure databases

ProteinModelPortaliQ6XYB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000007247
HOVERGENiHBG006244
InParanoidiQ6XYB7
KOiK09353
OMAiDILAPRM
OrthoDBiEOG091G09CY
PhylomeDBiQ6XYB7
TreeFamiTF325047

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6XYB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSGREPRTP RTLLSIADIL APRMVPRAPS APQLPESGPG PTSPLCALEE
60 70 80 90 100
LTSKTFRGLD ARALQPSEGR AGPDALGPGP FGRKRRKSRT AFTAQQVLEL
110 120 130 140 150
ERRFVFQKYL APSERDGLAT RLGLANAQVV TWFQNRRAKL KRDVEEMRAD
160 170 180 190
VASLRALSPE VLCSLALPEG APDPGLCLGP AGPDSRPHLS DEEIQVDD
Length:198
Mass (Da):21,482
Last modified:July 5, 2004 - v1
Checksum:iFF0796EB344F5C26
GO
Isoform 2 (identifier: Q6XYB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MNSGREPRTP...DARALQPSEG → MGKRTSLEVS...NNSQACRPQR

Note: No experimental confirmation available.
Show »
Length:194
Mass (Da):21,356
Checksum:i12F3B61B90422810
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037227158S → F. Corresponds to variant dbSNP:rs17009998Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0295221 – 69MNSGR…QPSEG → MGKRTSLEVSLGELGGEKCR GGRRSFPPLAASRPARPGGW RWARRDLCKTASRAENNSQA CRPQR in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY305861 mRNA Translation: AAP74384.1
AY203953 mRNA Translation: AAP34476.1
CH471053 Genomic DNA Translation: EAW99636.1
BC150517 mRNA Translation: AAI50518.1
CCDSiCCDS33228.1 [Q6XYB7-2]
CCDS62938.1 [Q6XYB7-1]
RefSeqiNP_001009812.1, NM_001009812.1 [Q6XYB7-2]
NP_001269359.1, NM_001282430.1 [Q6XYB7-1]
UniGeneiHs.516124

Genome annotation databases

EnsembliENST00000377566; ENSP00000366789; ENSG00000179528 [Q6XYB7-1]
ENST00000460508; ENSP00000417116; ENSG00000179528 [Q6XYB7-2]
GeneIDi85474
KEGGihsa:85474
UCSCiuc002slv.6 human [Q6XYB7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLBX2_HUMAN
AccessioniPrimary (citable) accession number: Q6XYB7
Secondary accession number(s): Q7Z5Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: July 18, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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