UniProtKB - Q6XYB7 (LBX2_HUMAN)
Protein
Transcription factor LBX2
Gene
LBX2
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 85 – 144 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- muscle cell differentiation Source: UniProtKB
- positive regulation of convergent extension involved in gastrulation Source: UniProtKB
- positive regulation of non-canonical Wnt signaling pathway Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q6XYB7 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor LBX2Alternative name(s): Ladybird homeobox 21 Publication Ladybird homeobox protein homolog 2 |
Gene namesi | Name:LBX2 ORF Names:LP3727 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15525, LBX2 |
MIMi | 607164, gene |
neXtProti | NX_Q6XYB7 |
VEuPathDBi | HostDB:ENSG00000179528.15 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 85474 |
OpenTargetsi | ENSG00000179528 |
PharmGKBi | PA30305 |
Miscellaneous databases
Pharosi | Q6XYB7, Tbio |
Genetic variation databases
BioMutai | LBX2 |
DMDMi | 74749508 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311328 | 1 – 198 | Transcription factor LBX2Add BLAST | 198 |
Proteomic databases
EPDi | Q6XYB7 |
MassIVEi | Q6XYB7 |
PaxDbi | Q6XYB7 |
PeptideAtlasi | Q6XYB7 |
PRIDEi | Q6XYB7 |
ProteomicsDBi | 67822 [Q6XYB7-1] 67823 [Q6XYB7-2] |
PTM databases
iPTMneti | Q6XYB7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000179528, Expressed in right lobe of liver and 108 other tissues |
ExpressionAtlasi | Q6XYB7, baseline and differential |
Organism-specific databases
HPAi | ENSG00000179528, Tissue enhanced (liver) |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 124550, 1 interactor |
IntActi | Q6XYB7, 2 interactors |
STRINGi | 9606.ENSP00000366789 |
Miscellaneous databases
RNActi | Q6XYB7, protein |
Family & Domainsi
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0488, Eukaryota |
GeneTreei | ENSGT00940000162295 |
HOGENOMi | CLU_086390_0_0_1 |
InParanoidi | Q6XYB7 |
OMAi | MNSGRQP |
OrthoDBi | 1472248at2759 |
PhylomeDBi | Q6XYB7 |
TreeFami | TF325047 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6XYB7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNSGREPRTP RTLLSIADIL APRMVPRAPS APQLPESGPG PTSPLCALEE
60 70 80 90 100
LTSKTFRGLD ARALQPSEGR AGPDALGPGP FGRKRRKSRT AFTAQQVLEL
110 120 130 140 150
ERRFVFQKYL APSERDGLAT RLGLANAQVV TWFQNRRAKL KRDVEEMRAD
160 170 180 190
VASLRALSPE VLCSLALPEG APDPGLCLGP AGPDSRPHLS DEEIQVDD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V218 | G3V218_HUMAN | HCG1641699, isoform CRA_b | LBX2 hCG_1641699 | 57 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083939 | 139 | K → E Found in a patient with atrial septal defects; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs753669213Ensembl. | 1 | |
Natural variantiVAR_037227 | 158 | S → F. Corresponds to variant dbSNP:rs17009998Ensembl. | 1 | |
Natural variantiVAR_083940 | 171 | A → P Found in a patient with atrial septal defects; unknown pathological significance. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029522 | 1 – 69 | MNSGR…QPSEG → MGKRTSLEVSLGELGGEKCR GGRRSFPPLAASRPARPGGW RWARRDLCKTASRAENNSQA CRPQR in isoform 2. 1 PublicationAdd BLAST | 69 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY305861 mRNA Translation: AAP74384.1 AY203953 mRNA Translation: AAP34476.1 CH471053 Genomic DNA Translation: EAW99636.1 BC150517 mRNA Translation: AAI50518.1 |
CCDSi | CCDS33228.1 [Q6XYB7-2] CCDS62938.1 [Q6XYB7-1] |
RefSeqi | NP_001009812.1, NM_001009812.1 [Q6XYB7-2] NP_001269359.1, NM_001282430.1 [Q6XYB7-1] |
Genome annotation databases
Ensembli | ENST00000377566; ENSP00000366789; ENSG00000179528 [Q6XYB7-1] ENST00000460508; ENSP00000417116; ENSG00000179528 [Q6XYB7-2] |
GeneIDi | 85474 |
KEGGi | hsa:85474 |
UCSCi | uc002slv.6, human [Q6XYB7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY305861 mRNA Translation: AAP74384.1 AY203953 mRNA Translation: AAP34476.1 CH471053 Genomic DNA Translation: EAW99636.1 BC150517 mRNA Translation: AAI50518.1 |
CCDSi | CCDS33228.1 [Q6XYB7-2] CCDS62938.1 [Q6XYB7-1] |
RefSeqi | NP_001009812.1, NM_001009812.1 [Q6XYB7-2] NP_001269359.1, NM_001282430.1 [Q6XYB7-1] |
3D structure databases
SMRi | Q6XYB7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124550, 1 interactor |
IntActi | Q6XYB7, 2 interactors |
STRINGi | 9606.ENSP00000366789 |
PTM databases
iPTMneti | Q6XYB7 |
Genetic variation databases
BioMutai | LBX2 |
DMDMi | 74749508 |
Proteomic databases
EPDi | Q6XYB7 |
MassIVEi | Q6XYB7 |
PaxDbi | Q6XYB7 |
PeptideAtlasi | Q6XYB7 |
PRIDEi | Q6XYB7 |
ProteomicsDBi | 67822 [Q6XYB7-1] 67823 [Q6XYB7-2] |
Protocols and materials databases
Antibodypediai | 31549, 121 antibodies |
DNASUi | 85474 |
Genome annotation databases
Ensembli | ENST00000377566; ENSP00000366789; ENSG00000179528 [Q6XYB7-1] ENST00000460508; ENSP00000417116; ENSG00000179528 [Q6XYB7-2] |
GeneIDi | 85474 |
KEGGi | hsa:85474 |
UCSCi | uc002slv.6, human [Q6XYB7-1] |
Organism-specific databases
CTDi | 85474 |
DisGeNETi | 85474 |
GeneCardsi | LBX2 |
HGNCi | HGNC:15525, LBX2 |
HPAi | ENSG00000179528, Tissue enhanced (liver) |
MIMi | 607164, gene |
neXtProti | NX_Q6XYB7 |
OpenTargetsi | ENSG00000179528 |
PharmGKBi | PA30305 |
VEuPathDBi | HostDB:ENSG00000179528.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0488, Eukaryota |
GeneTreei | ENSGT00940000162295 |
HOGENOMi | CLU_086390_0_0_1 |
InParanoidi | Q6XYB7 |
OMAi | MNSGRQP |
OrthoDBi | 1472248at2759 |
PhylomeDBi | Q6XYB7 |
TreeFami | TF325047 |
Enzyme and pathway databases
PathwayCommonsi | Q6XYB7 |
Miscellaneous databases
BioGRID-ORCSi | 85474, 2 hits in 895 CRISPR screens |
GenomeRNAii | 85474 |
Pharosi | Q6XYB7, Tbio |
PROi | PR:Q6XYB7 |
RNActi | Q6XYB7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179528, Expressed in right lobe of liver and 108 other tissues |
ExpressionAtlasi | Q6XYB7, baseline and differential |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LBX2_HUMAN | |
Accessioni | Q6XYB7Primary (citable) accession number: Q6XYB7 Secondary accession number(s): Q7Z5Y8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot