UniProtKB - Q6XXX9 (5HT1A_CANLF)
Protein
5-hydroxytryptamine receptor 1A
Gene
HTR1A
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli (By similarity).By similarity
GO - Molecular functioni
- G protein-coupled serotonin receptor activity Source: UniProtKB
- neurotransmitter receptor activity Source: GO_Central
- serotonin binding Source: GO_Central
GO - Biological processi
- adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: UniProtKB
- behavioral fear response Source: UniProtKB
- chemical synaptic transmission Source: GO_Central
- exploration behavior Source: UniProtKB
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
- regulation of behavior Source: InterPro
- regulation of dopamine metabolic process Source: UniProtKB
- regulation of hormone secretion Source: InterPro
- regulation of serotonin secretion Source: UniProtKB
- regulation of vasoconstriction Source: InterPro
- serotonin metabolic process Source: UniProtKB
- serotonin receptor signaling pathway Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Behavior |
Names & Taxonomyi
Protein namesi | Recommended name: 5-hydroxytryptamine receptor 1AShort name: 5-HT-1A Short name: 5-HT1A Alternative name(s): Serotonin receptor 1A |
Gene namesi | Name:HTR1A |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- dendrite By similarity
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 36 | ExtracellularBy similarityAdd BLAST | 36 | |
Transmembranei | 37 – 62 | Helical; Name=1By similarityAdd BLAST | 26 | |
Topological domaini | 63 – 73 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 74 – 98 | Helical; Name=2By similarityAdd BLAST | 25 | |
Topological domaini | 99 – 110 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 111 – 132 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 133 – 152 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 153 – 178 | Helical; Name=4By similarityAdd BLAST | 26 | |
Topological domaini | 179 – 191 | ExtracellularBy similarityAdd BLAST | 13 | |
Transmembranei | 192 – 217 | Helical; Name=5By similarityAdd BLAST | 26 | |
Topological domaini | 218 – 345 | CytoplasmicBy similarityAdd BLAST | 128 | |
Transmembranei | 346 – 367 | Helical; Name=6By similarityAdd BLAST | 22 | |
Topological domaini | 368 – 378 | ExtracellularBy similarityAdd BLAST | 11 | |
Transmembranei | 379 – 403 | Helical; Name=7By similarityAdd BLAST | 25 | |
Topological domaini | 404 – 423 | CytoplasmicBy similarityAdd BLAST | 20 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068901 | 1 – 423 | 5-hydroxytryptamine receptor 1AAdd BLAST | 423 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 10 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 24 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 109 ↔ 187 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q6XXX9 |
Interactioni
Subunit structurei
Heterodimer; heterodimerizes with GPER1 (By similarity).
Interacts with YIF1B (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9612.ENSCAFP00000037035 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 112 – 121 | Agonist bindingBy similarity | 10 | |
Regioni | 358 – 362 | Agonist bindingBy similarity | 5 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 133 – 135 | DRY motif; important for ligand-induced conformation changesBy similarity | 3 | |
Motifi | 396 – 400 | NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity | 5 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | Q6XXX9 |
OrthoDBi | 703991at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000610, 5HT1A_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF20, PTHR24247:SF20, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00512, 5HT1ARECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6XXX9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGLSPRQGN NTTSSEGPFG TLGNATGISD VTFSYQVITS LLLGTLIFCA
60 70 80 90 100
VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN
110 120 130 140 150
KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP
160 170 180 190 200
RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST
210 220 230 240 250
FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKAERKGADA RSGVSPAPQP
260 270 280 290 300
RKSVNGEPGG REWRQGPGSQ AGGPLCTNGA VRRGDDGAAL EVIEVHRVGS
310 320 330 340 350
SKEHLPLPCE AGAIPCAPAS FEKKNERNAE AKRKMALARE RKTVKTLGII
360 370 380 390 400
MGTFILCWLP FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY
410 420
AYFNKDFQNA FKKIVRCKFC RRR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY204570 Genomic DNA Translation: AAP12467.1 |
RefSeqi | NP_001012397.1, NM_001012397.1 |
Genome annotation databases
GeneIDi | 487230 |
KEGGi | cfa:487230 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY204570 Genomic DNA Translation: AAP12467.1 |
RefSeqi | NP_001012397.1, NM_001012397.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000037035 |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
PaxDbi | Q6XXX9 |
Genome annotation databases
GeneIDi | 487230 |
KEGGi | cfa:487230 |
Organism-specific databases
CTDi | 3350 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | Q6XXX9 |
OrthoDBi | 703991at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000610, 5HT1A_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF20, PTHR24247:SF20, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00512, 5HT1ARECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 5HT1A_CANLF | |
Accessioni | Q6XXX9Primary (citable) accession number: Q6XXX9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 12, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families