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Entry version 106 (07 Oct 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Genome polyprotein

Gene
N/A
Organism
Beet mosaic virus (BtMV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
an RNA-dependent RNA polymerase that plays an essential role in the virus replication.
required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).By similarity
has helicase activity. It may be involved in replication (By similarity).By similarity
Both 6K peptides are indispensable for virus replication.By similarity
has RNA-binding and proteolytic activities.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. EC:3.4.22.44
  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein. EC:3.4.22.45

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei224For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei233For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei266For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei656For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei729For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei2092For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2127For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2198For nuclear inclusion protein A activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1254 – 1261ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Serine protease, Suppressor of RNA silencing, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C06.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 10 chains:
P1 proteinase (EC:3.4.-.-)
Alternative name(s):
N-terminal protein
Helper component proteinase (EC:3.4.22.45)
Short name:
HC-pro
6 kDa protein 1
Short name:
6K1
Cytoplasmic inclusion protein (EC:3.6.4.-)
Short name:
CI
6 kDa protein 2
Short name:
6K2
Alternative name(s):
VPg
Nuclear inclusion protein A (EC:3.4.22.44)
Short name:
NI-a
Short name:
NIa
Alternative name(s):
49 kDa proteinase
Short name:
49 kDa-Pro
NIa-pro
Nuclear inclusion protein B (EC:2.7.7.48)
Short name:
NI-b
Short name:
NIb
Alternative name(s):
RNA-directed RNA polymerase
Capsid protein
Short name:
CP
Alternative name(s):
Coat protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBeet mosaic virus (BtMV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri114921 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaStelpaviricetesPatataviralesPotyviridaePotyvirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiAmaranthus retroflexus (Redroot amaranth) (American pigweed) [TaxID: 124763]
Beta vulgaris subsp. maritima (Sea beet) (Beta maritima) [TaxID: 350892]
Beta vulgaris subsp. vulgaris [TaxID: 3555]
Chenopodium album (Fat-hen) [TaxID: 3559]
Melilotus indicus (Sourclover) (Yellow sweet clover) [TaxID: 200951]
Sonchus arvensis (Perennial sowthistle) [TaxID: 50192]
Spinacia oleracea (Spinach) [TaxID: 3562]
Trifolium incarnatum (Crimson clover) [TaxID: 60916]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007617 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004199941 – 3085Genome polyproteinAdd BLAST3085
ChainiPRO_00000402461 – 313P1 proteinaseSequence analysisAdd BLAST313
ChainiPRO_0000040247314 – 770Helper component proteinaseSequence analysisAdd BLAST457
ChainiPRO_0000040248771 – 1117Protein P3Sequence analysisAdd BLAST347
ChainiPRO_00000402491118 – 11696 kDa protein 1By similarityAdd BLAST52
ChainiPRO_00000402501170 – 1803Cytoplasmic inclusion proteinBy similarityAdd BLAST634
ChainiPRO_00000402511804 – 18556 kDa protein 2By similarityAdd BLAST52
ChainiPRO_00000402521856 – 2046Viral genome-linked proteinBy similarityAdd BLAST191
ChainiPRO_00000402532047 – 2293Nuclear inclusion protein ABy similarityAdd BLAST247
ChainiPRO_00000402542294 – 2809Nuclear inclusion protein BBy similarityAdd BLAST516
ChainiPRO_00000402552810 – 3085Capsid proteinAdd BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1919O-(5'-phospho-RNA)-tyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity
Genome polyprotein of potyviruses undergoes post-translational proteolytic processing by the main proteinase NIa-pro resulting in the production of at least ten individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei313 – 314Cleavage; by P1 proteinasePROSITE-ProRule annotation2
Sitei770 – 771Cleavage; by autolysisPROSITE-ProRule annotation2
Sitei1117 – 1118Cleavage; by NIa-proBy similarity2
Sitei1169 – 1170Cleavage; by NIa-proBy similarity2
Sitei1803 – 1804Cleavage; by NIa-proBy similarity2
Sitei1855 – 1856Cleavage; by NIa-proBy similarity2
Sitei2046 – 2047Cleavage; by NIa-proBy similarity2
Sitei2293 – 2294Cleavage; by NIa-proBy similarity2
Sitei2809 – 2810Cleavage; by NIa-proBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6XW15

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini170 – 313Peptidase S30PROSITE-ProRule annotationAdd BLAST144
Domaini648 – 770Peptidase C6PROSITE-ProRule annotationAdd BLAST123
Domaini1241 – 1393Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST153
Domaini1412 – 1571Helicase C-terminalPROSITE-ProRule annotationAdd BLAST160
Domaini2047 – 2266Peptidase C4PROSITE-ProRule annotationAdd BLAST220
Domaini2535 – 2659RdRp catalyticPROSITE-ProRule annotationAdd BLAST125

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi365 – 368Involved in interaction with stylet and aphid transmissionBy similarity4
Motifi622 – 624Involved in virions binding and aphid transmissionBy similarity3
Motifi1343 – 1346DESH box4
Motifi1895 – 1904Nuclear localization signalSequence analysis10

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus of helper component proteinase is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR039560, Potyvirid-P3
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF01577, Peptidase_S30, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF13608, Potyvirid-P3, 1 hit
PF00680, RdRP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00966, NIAPOTYPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Genome polyprotein (identifier: Q6XW15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATMMHFGQF PSNIPLRAAT CCTKVHSTLV TKEMMASSVK PAESSSVARP
60 70 80 90 100
IIYSSAATDG YEKAQRAFEA SFREKYSGKL EAMKYGKMVK KGGLTYVKRA
110 120 130 140 150
GPQAIAKGIE MDAAIEKFNT AFNAGELENV TLEGDITAGI SVARGESVWL
160 170 180 190 200
RSVFWSRSLK KQARKKTPKL VAKSDFDDLF NKVLKVASLG NIPVEIVGKK
210 220 230 240 250
ANKILRCGYR RVNTSTIPYF HLPHHNSNYI CRELHPQRVR WLVPLLVRHR
260 270 280 290 300
KIRDQFSDSM IARGWSGLIL PKYIASTCGR RYDEVIVRGR LYGRVEDART
310 320 330 340 350
KLPAGDVGRT MHYSSGEERF FAGWKEGFEK LVPAQKEHIC KIVQDNKFCG
360 370 380 390 400
KLAASIVQIA FPCHKMACDV CRNKFNEMTP EAYSELIDKH IDQRMNEINE
410 420 430 440 450
AIVRFPGLKQ VVSNFRSKHI ASTNIKDNLE VAKLTQGHKA NQMMQLARIN
460 470 480 490 500
SILIKGNTAT PSEISDASGL LLEITRWFNN HLSVIDKGSL RAFRNKRSSK
510 520 530 540 550
ALVNPSLLCD NQRDKNGNFI WGERGYHSKR FFASHFDEVT PGDGYKEYII
560 570 580 590 600
RKGPQGQRKL AIGNLIVSFD LEKTRQALKG EEVEKLPLSN SCVSKRNGNY
610 620 630 640 650
VYTSCCVTLD DGTPLYSNIK NPTKRHLVVG TTGDPKIVDL PATDTDKMYI
660 670 680 690 700
AKEGYCYLNI FLAMLINVNE NEAKAFTKMV RDIIIPMLGT WPTMQDLATA
710 720 730 740 750
CFMMTAFFPE TSSAELPRIL VDHTNQTMHV IDSFGSLTTG YHVLKAGTAA
760 770 780 790 800
QLIDFASTEL EGEMKWYRVG GHGLPVKEKM ISALITSIFR PKKLVYLIEE
810 820 830 840 850
DPYVLIMAMC SPRLIISLFN NGALELAAKH WISRDKNVSA IFAMLMDLST
860 870 880 890 900
EMSKAELLIE QHRMINECAK RVHDTQNYLD EVGPHQQEVR TFLALISDEL
910 920 930 940 950
EADKELHKTG FANFSERFHS LTEKMYVDAL EEEWRGLSLL DRFSYATFVY
960 970 980 990 1000
KHKPRSTSVL PPKKSEDIDA KFVISPSWFV GKTKEHLSGG RKYVTSQITQ
1010 1020 1030 1040 1050
FTSYIKRATL DRAMRIMCSC LKDLAYFMNV ALVTHLLISM IAAVYNMLND
1060 1070 1080 1090 1100
HRIAKRRLYI LEMQETNTAI WHLYDTWKTV NQRDPTHEEF RKYVAKVNKN
1110 1120 1130 1140 1150
LLRHLPEEED KAEVEYQANK VYEKKLEKAV ALMALFTMIF DTEKSGAVFS
1160 1170 1180 1190 1200
ILRNIKSVFS TLGEEVKYQS LDEIQSIEDE KKLTIDFDLD TEITAEHTTM
1210 1220 1230 1240 1250
DVQFEKWWDK QLSQNRVVPH YRVGGTFIEF TRHTAASVCN TICASSEQEF
1260 1270 1280 1290 1300
VVRGAVGSGK STGLPSHLSR KGRVLLLEPT RPLAENVCKQ LRKEPFHLSP
1310 1320 1330 1340 1350
TLRMRGLTTF GSSNISVMTS GYALHFHANN PQRLEEFDFI MIDESHTMDS
1360 1370 1380 1390 1400
STMAFYCLLR EYEFKGKILK VSATPPGREC EFKTQHDVLI KIEESLSYNS
1410 1420 1430 1440 1450
FVTAQGTGSN ADVVQNGDNI LVYVPSYNDV DQLSKGLMEK GHLVTKVDGR
1460 1470 1480 1490 1500
TMKMGNVEIP TKGTSSKKHF IVATNIIENG VTLDIDVVVD FGLKVVAELD
1510 1520 1530 1540 1550
SDSRCMRYKK VSISYGERLQ RLGRVGRVKQ GTALRIGHTE TGMTEIPVAI
1560 1570 1580 1590 1600
ATEAAFICFA YNLPVMTHNV TSSLLSRCTN RQARTMMQYE LSPFFMVELV
1610 1620 1630 1640 1650
HFNGCVHPQI ESKLKAYKLR DSETQLSTLA IPNSGTSRWK TVGEYKKLGV
1660 1670 1680 1690 1700
RIEADDNVRV PFAANGVPDR LYADLWETIQ QHKSDAGFGR LTSACASKIS
1710 1720 1730 1740 1750
YTLTTQPNAI PRTLAIIEHL LREEQQKKAY FESLNDTLCA TSFSLAGMVN
1760 1770 1780 1790 1800
NIRRRYLKDH SAHNINVLQN AKSQLNEFNS KAIDPERVGD IMGYGVLDTV
1810 1820 1830 1840 1850
QYQSATDVQK RLKLKGRWNG SLAATDLLIA GAVFAGGCWM LWEYTKSGNE
1860 1870 1880 1890 1900
IVQYQGKRRQ MQKLKFRNAR DNKVGREVYG DDGTIEHFFG AAYTERGKRK
1910 1920 1930 1940 1950
GNNSTKGMGT KTRRFVHMYG FDPTEYSFVR FVDPLTGYSK DESVQTDISL
1960 1970 1980 1990 2000
VQSEIGEYRQ KCMEDDDELI DFIKQKPGIQ AYFMKNGSDK ALQVDLTPHI
2010 2020 2030 2040 2050
PLLSCAKTAT IAGFPERESE LRQTGTPIVV NKNVVPGEHK EVVREEGKSI
2060 2070 2080 2090 2100
VKGLRNYNPI SSVVCRLTND SNGNAQTLYG VGFGPLIITN SHLFKMNNGT
2110 2120 2130 2140 2150
LFVRSHQGEF TVQNTTQLQI YHVKDKDMIL IRMPKDFPPF PMKLKFRAPH
2160 2170 2180 2190 2200
SEERACLVGS RFQQKSLSSE VSDSTLIRPT DSGSGYWKHW VSTKEGDCGL
2210 2220 2230 2240 2250
PMVALKDGSL IGIHGLTSVR SELNYFVPFT DDFQSKYLSN IESLEWVKHW
2260 2270 2280 2290 2300
RHTPDKVAWN GMTLRENGPA SEFSVSKLIA DLTHGYVDEV VEQGYSSKWV
2310 2320 2330 2340 2350
ANRLDGNLKA VASSSSQLVT KHVVKGPCVL FQEFLATHEE AARYFVPRMG
2360 2370 2380 2390 2400
EYGPSRLNKE AFLKDFLKYA GPITVGVVNT NSFEDAVASV INMLEDLDYG
2410 2420 2430 2440 2450
ECAYVTDPDS IFDSLNMKAA VGALYKGKKK EYFEQLNTTE REDLLRLSCE
2460 2470 2480 2490 2500
RLYEGKMGVW NGSLKAELRP KEKLEQNKTR TFTAAPIDTL LGGKVCVDDF
2510 2520 2530 2540 2550
NNRFYSLNLK GPWSVGMTKF YGGWNELLQK LPDGWIYCDA DGSQFDSSLT
2560 2570 2580 2590 2600
PYLINAVVQI REHFMEDWEI GRTMLRNFYT EIVYTPILTP DGTIVKKFKG
2610 2620 2630 2640 2650
NNSGQPSTVV DNTLMVILAM HYAMHQQCWK EEEMKEKIRF FANGDDLLIA
2660 2670 2680 2690 2700
IYPSKEKFLN VLSEYFHELG LKYDFSSRST VRETLWFMSH RGLYLDDMYI
2710 2720 2730 2740 2750
PKLEEERIVS ILEWDRSNEA THRAEAICAA MIEAWGYPEL LKYIREFYLW
2760 2770 2780 2790 2800
MMQHECYRDL VRDGKLPYIA ETALRKLYTD KSVDENELVK YWKALAPEED
2810 2820 2830 2840 2850
DGPDIVTYQG DEKPSKSSQP QSSSPQVPQQ VDAGASSQGR DKQSVIKHDS
2860 2870 2880 2890 2900
TKSKDVGQSS TAVPRLKQIS KMRMPVSKGR QVLALDHLLD YKPEQVDLSN
2910 2920 2930 2940 2950
TRATKEQFDN WYEAVMREYD VSDSQMGVIM NGLMVWCIEN GTSPNLSGDW
2960 2970 2980 2990 3000
VMMDGEEQVS FPLKPIVENA KPSFRQIMHH FSDAAEAYIE MRNRERPYMP
3010 3020 3030 3040 3050
RYGAQRNLRD KTLARYAFDF YEVTSRTTDR AREAHFQMKA AALASVSNKL
3060 3070 3080
FGLDGSVATT SEDTERHTAT DVNAHMHHMM GVRQG
Note: Produced by conventional translation.
Length:3,085
Mass (Da):349,731
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i918576B242794C0D
GO
Isoform P3N-PIPO polyprotein (identifier: P0CJ96-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0CJ96.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,038
Mass (Da):117,627
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY206394 Genomic RNA Translation: AAP41071.1

NCBI Reference Sequences

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RefSeqi
NP_954611.1, NC_005304.1 [Q6XW15-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
2943205

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
vg:2943205

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY206394 Genomic RNA Translation: AAP41071.1
RefSeqiNP_954611.1, NC_005304.1 [Q6XW15-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC06.001

Proteomic databases

PRIDEiQ6XW15

Genome annotation databases

GeneIDi2943205
KEGGivg:2943205

Family and domain databases

Gene3Di2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit
InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR039560, Potyvirid-P3
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF01577, Peptidase_S30, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF13608, Potyvirid-P3, 1 hit
PF00680, RdRP_1, 1 hit
PRINTSiPR00966, NIAPOTYPTASE
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_BTMV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XW15
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: October 7, 2020
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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