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Protein

Cytochrome P450 2C54

Gene

Cyp2c54

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metabolizes arachidonic acid mainly to 12-hydroxyeicosatetraenoic acid (HETE).1 Publication

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • arachidonic acid epoxygenase activity Source: MGI
  • aromatase activity Source: UniProtKB-EC
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • linoleic acid epoxygenase activity Source: MGI
  • steroid hydroxylase activity Source: GO_Central

GO - Biological processi

  • arachidonic acid metabolic process Source: MGI
  • epoxygenase P450 pathway Source: GO_Central
  • linoleic acid metabolic process Source: MGI

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C54 (EC:1.14.14.11 Publication)
Alternative name(s):
CYPIIC54
Gene namesi
Name:Cyp2c54Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:3642960 Cyp2c54

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002829581 – 490Cytochrome P450 2C54Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127PhosphoserineBy similarity1
Modified residuei252N6-acetyllysineBy similarity1
Modified residuei375N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6XVG2
PaxDbiQ6XVG2
PeptideAtlasiQ6XVG2
PRIDEiQ6XVG2

PTM databases

iPTMnetiQ6XVG2
PhosphoSitePlusiQ6XVG2
SwissPalmiQ6XVG2

Expressioni

Tissue specificityi

Expressed in liver.1 Publication

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.Curated

Gene expression databases

BgeeiENSMUSG00000067225
GenevisibleiQ6XVG2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048284

Structurei

3D structure databases

ProteinModelPortaliQ6XVG2
SMRiQ6XVG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiQ6XVG2
KOiK07413
OMAiALADWAC
OrthoDBiEOG091G0BT8
PhylomeDBiQ6XVG2
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q6XVG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPILVLVLT LSCLFLLSLW RQSYERGKLP PGPTPLPIIG NILQIDVKDI
60 70 80 90 100
CQSFTNLSRV YGPVYTLYLG RKPTVVLHGY EAVKEALVDH GDVFAGRGRL
110 120 130 140 150
PVFDKATNGM GIGFSNGSVW KNTRHFSLMT LRNLGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTN GSPCDPTFIL GCAPCNVICS IIFQDRFDYK DRDFLNLLEK
210 220 230 240 250
LDEISKILST PWLQVCNTFP ALLDYCPGSH NQFFKNYAYI KNFLLEKIRE
260 270 280 290 300
HKESLDVTIP RDFIDYFLIK GAQEDDNHPL KNNFEHLAIT VTDLFIGGTE
310 320 330 340 350
SMSTTLRYAL LLLLKYPHVT AKVQEEIEHV IGKHRRPCMQ DRSHMPYTNA
360 370 380 390 400
MIHEVQRFID LVPNNLPHEV TCDIKFRNYF IPKGTTVITS LSSVLRDSKE
410 420 430 440 450
FPNPEKFDPG HFLDENGKFK KSDYFMPFST GKRICAGEGL ARMELFLFLT
460 470 480 490
SILQNFNLKP LVHPKDIDIT PMLIGLGSVP PAFQLCFIPS
Length:490
Mass (Da):55,858
Last modified:July 5, 2004 - v1
Checksum:iC226BBBB734DE29D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY206874 mRNA Translation: AAO52737.1
CCDSiCCDS29800.1
RefSeqiNP_996260.1, NM_206537.2
UniGeneiMm.379575

Genome annotation databases

EnsembliENSMUST00000048959; ENSMUSP00000048284; ENSMUSG00000067225
GeneIDi404195
KEGGimmu:404195
UCSCiuc012bln.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCP254_MOUSE
AccessioniPrimary (citable) accession number: Q6XVG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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