UniProtKB - Q6XUZ5 (IDHC_SHEEP)
Protein
Isocitrate dehydrogenase [NADP] cytoplasmic
Gene
IDH1
Organism
Ovis aries (Sheep)
Status
Functioni
Catalytic activityi
- EC:1.1.1.42By similarity
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 77 | SubstrateBy similarity | 1 | |
Binding sitei | 82 | NADPBy similarity | 1 | |
Binding sitei | 109 | SubstrateBy similarity | 1 | |
Binding sitei | 132 | SubstrateBy similarity | 1 | |
Sitei | 139 | Critical for catalysisBy similarity | 1 | |
Binding sitei | 212 | Substrate; shared with neighboring subunitBy similarity | 1 | |
Sitei | 212 | Critical for catalysisBy similarity | 1 | |
Metal bindingi | 252 | Magnesium or manganese; shared with neighboring subunitBy similarity | 1 | |
Binding sitei | 260 | NADPBy similarity | 1 | |
Metal bindingi | 275 | Magnesium or manganeseBy similarity | 1 | |
Metal bindingi | 279 | Magnesium or manganeseBy similarity | 1 | |
Binding sitei | 328 | NADP; via amide nitrogen and carbonyl oxygenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 75 – 77 | NADPBy similarity | 3 | |
Nucleotide bindingi | 310 – 315 | NADPBy similarity | 6 |
GO - Molecular functioni
- isocitrate dehydrogenase (NADP+) activity Source: UniProtKB
- magnesium ion binding Source: UniProtKB
- NAD binding Source: InterPro
GO - Biological processi
- 2-oxoglutarate metabolic process Source: UniProtKB
- glyoxylate cycle Source: UniProtKB-KW
- isocitrate metabolic process Source: UniProtKB
- tricarboxylic acid cycle Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Glyoxylate bypass, Tricarboxylic acid cycle |
Ligand | Magnesium, Manganese, Metal-binding, NADP |
Names & Taxonomyi
Protein namesi | Recommended name: Isocitrate dehydrogenase [NADP] cytoplasmic (EC:1.1.1.42By similarity)Short name: IDH Alternative name(s): Cytosolic NADP-isocitrate dehydrogenase IDP NADP(+)-specific ICDH Oxalosuccinate decarboxylase |
Gene namesi | Name:IDH1 |
Organismi | Ovis aries (Sheep) |
Taxonomic identifieri | 9940 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- cytosol By similarity
Cytosol
- cytosol Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000236189 | 2 – 414 | Isocitrate dehydrogenase [NADP] cytoplasmicAdd BLAST | 413 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 42 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 81 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 126 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 224 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 233 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 321 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 389 | PhosphoserineBy similarity | 1 | |
Modified residuei | 400 | N6-succinyllysineBy similarity | 1 |
Post-translational modificationi
Acetylation at Lys-374 dramatically reduces catalytic activity.By similarity
Keywords - PTMi
Acetylation, PhosphoproteinInteractioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 9940.ENSOARP00000020383 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 94 – 100 | Substrate bindingBy similarity | 7 |
Sequence similaritiesi
Belongs to the isocitrate and isopropylmalate dehydrogenases family.Curated
Phylogenomic databases
eggNOGi | KOG1526, Eukaryota |
OrthoDBi | 769322at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR019818, IsoCit/isopropylmalate_DH_CS IPR004790, Isocitrate_DH_NADP IPR024084, IsoPropMal-DH-like_dom |
PANTHERi | PTHR11822, PTHR11822, 1 hit |
Pfami | View protein in Pfam PF00180, Iso_dh, 1 hit |
PIRSFi | PIRSF000108, IDH_NADP, 1 hit |
SMARTi | View protein in SMART SM01329, Iso_dh, 1 hit |
TIGRFAMsi | TIGR00127, nadp_idh_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00470, IDH_IMDH, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6XUZ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHKIQGGSV VEMQGDEMTR IIWELIKEKL IFPYVDLDLH SYDLSIENRD
60 70 80 90 100
ATNDQVTKDA AEAIKKYNVG VKCATITPDE KRVEEFKLKQ MWKSPNGTIR
110 120 130 140 150
NILGGTVFRE AIICKNIPRL VSGWVKPIII GRHAYGDQYR ATDFVVPGPG
160 170 180 190 200
KVEICYTPSD GSPKTVYLVH NFTESGGVAM GMFNQDKSIE DFAHSSFQMA
210 220 230 240 250
LSKNWPLYLS TKNTILKKYD GRFKDIFQEI YDKQYKSQFE AQNIWYEHRL
260 270 280 290 300
IDDMVAQAMK SEGGFIWACK NYDGDVQSDS VAQGYGSLGM MTSVLVCPDG
310 320 330 340 350
KTVEAEAAHG TVTRHYRMYQ KGQETSTNPI ASIFAWTRGL AHRAKLDNNK
360 370 380 390 400
ELSFFAKALE EVCIETIEAG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK
410
LGENLQLKLA QAKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY208678 mRNA Translation: AAP41947.1 |
RefSeqi | NP_001009276.1, NM_001009276.1 |
Genome annotation databases
GeneIDi | 443257 |
KEGGi | oas:443257 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY208678 mRNA Translation: AAP41947.1 |
RefSeqi | NP_001009276.1, NM_001009276.1 |
3D structure databases
SMRi | Q6XUZ5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9940.ENSOARP00000020383 |
Genome annotation databases
GeneIDi | 443257 |
KEGGi | oas:443257 |
Organism-specific databases
CTDi | 3417 |
Phylogenomic databases
eggNOGi | KOG1526, Eukaryota |
OrthoDBi | 769322at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR019818, IsoCit/isopropylmalate_DH_CS IPR004790, Isocitrate_DH_NADP IPR024084, IsoPropMal-DH-like_dom |
PANTHERi | PTHR11822, PTHR11822, 1 hit |
Pfami | View protein in Pfam PF00180, Iso_dh, 1 hit |
PIRSFi | PIRSF000108, IDH_NADP, 1 hit |
SMARTi | View protein in SMART SM01329, Iso_dh, 1 hit |
TIGRFAMsi | TIGR00127, nadp_idh_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00470, IDH_IMDH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IDHC_SHEEP | |
Accessioni | Q6XUZ5Primary (citable) accession number: Q6XUZ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families