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Entry version 147 (17 Jun 2020)
Sequence version 2 (18 May 2010)
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Protein

Dual serine/threonine and tyrosine protein kinase

Gene

DSTYK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei681ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei777Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi658 – 666ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q6XUX3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dual serine/threonine and tyrosine protein kinase (EC:2.7.12.1)
Alternative name(s):
Dusty protein kinase
Short name:
Dusty PK
RIP-homologous kinase
Receptor-interacting serine/threonine-protein kinase 5
Sugen kinase 496
Short name:
SgK496
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSTYK
Synonyms:KIAA0472, RIP5, RIPK5, SGK496
ORF Names:HDCMD38P
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000133059.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29043 DSTYK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612666 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6XUX3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital anomalies of the kidney and urinary tract 1 (CAKUT1)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. Congenital anomalies of kidney and urinary tract are the commonest cause of chronic kidney disease in children.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07132429R → Q in CAKUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200780796EnsemblClinVar.1
Natural variantiVAR_071325200D → G in CAKUT1. 1 Publication1
Natural variantiVAR_071326843S → L in CAKUT1. 1 PublicationCorresponds to variant dbSNP:rs778586547EnsemblClinVar.1
Spastic paraplegia 23, autosomal recessive (SPG23)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG23 is an autosomal recessive form characterized by childhood-onset of gait difficulties and pigmentary abnormalities, including premature graying of the hair and vitiligo-like or hyperpigmented skin lesions.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi681K → Q: No change. 1 Publication1

Keywords - Diseasei

Disease mutation, Hereditary spastic paraplegia, Neurodegeneration

Organism-specific databases

DisGeNET

More...
DisGeNETi
25778

MalaCards human disease database

More...
MalaCardsi
DSTYK
MIMi270750 phenotype
610805 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000133059

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
101003 Autosomal recessive spastic paraplegia type 23
93100 Renal agenesis, unilateral

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164718861

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6XUX3 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1908386

DrugCentral

More...
DrugCentrali
Q6XUX3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DSTYK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434486

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002331181 – 929Dual serine/threonine and tyrosine protein kinaseAdd BLAST929

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6XUX3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6XUX3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6XUX3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6XUX3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6XUX3

PeptideAtlas

More...
PeptideAtlasi
Q6XUX3

PRoteomics IDEntifications database

More...
PRIDEi
Q6XUX3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67816 [Q6XUX3-1]
67817 [Q6XUX3-2]
67818 [Q6XUX3-3]
67819 [Q6XUX3-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6XUX3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6XUX3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. Expressed in the skin (PubMed:28157540).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133059 Expressed in parietal lobe and 238 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6XUX3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000133059 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
117313, 48 interactors

Protein interaction database and analysis system

More...
IntActi
Q6XUX3, 23 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000356130

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q6XUX3

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6XUX3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6XUX3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini652 – 906Protein kinasePROSITE-ProRule annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili189 – 215Sequence analysisAdd BLAST27
Coiled coili395 – 431Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 22Poly-Gly8
Compositional biasi69 – 72Poly-Gly4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0192 Eukaryota
COG0515 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00840000129948

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014116_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6XUX3

KEGG Orthology (KO)

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KOi
K16288

Identification of Orthologs from Complete Genome Data

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OMAi
CIFILGQ

Database of Orthologous Groups

More...
OrthoDBi
254886at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6XUX3

TreeFam database of animal gene trees

More...
TreeFami
TF331821

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714 Pkinase_Tyr, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6XUX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGDGVPWGS EPVSGPGPGG GGMIRELCRG FGRYRRYLGR LRQNLRETQK
60 70 80 90 100
FFRDIKCSHN HTCLSSLTGG GGAERGPAGD VAETGLQAGQ LSCISFPPKE
110 120 130 140 150
EKYLQQIVDC LPCILILGQD CNVKCQLLNL LLGVQVLPTT KLGSEESCKL
160 170 180 190 200
RRLRFTYGTQ TRVSLALPGQ YELVHTLVAH QGNWETIPEE DLEVQENNED
210 220 230 240 250
AAHVLAELEV TMHHALLQEV DVVVAPCQGL RPTVDVLGDL VNDFLPVITY
260 270 280 290 300
ALHKDELSER DEQELQEIRK YFSFPVFFFK VPKLGSEIID SSTRRMESER
310 320 330 340 350
SPLYRQLIDL GYLSSSHWNC GAPGQDTKAQ SMLVEQSEKL RHLSTFSHQV
360 370 380 390 400
LQTRLVDAAK ALNLVHCHCL DIFINQAFDM QRDLQITPKR LEYTRKKENE
410 420 430 440 450
LYESLMNIAN RKQEEMKDMI VETLNTMKEE LLDDATNMEF KDVIVPENGE
460 470 480 490 500
PVGTREIKCC IRQIQELIIS RLNQAVANKL ISSVDYLRES FVGTLERCLQ
510 520 530 540 550
SLEKSQDVSV HITSNYLKQI LNAAYHVEVT FHSGSSVTRM LWEQIKQIIQ
560 570 580 590 600
RITWVSPPAI TLEWKRKVAQ EAIESLSASK LAKSICSQFR TRLNSSHEAF
610 620 630 640 650
AASLRQLEAG HSGRLEKTED LWLRVRKDHA PRLARLSLES CSLQDVLLHR
660 670 680 690 700
KPKLGQELGR GQYGVVYLCD NWGGHFPCAL KSVVPPDEKH WNDLALEFHY
710 720 730 740 750
MRSLPKHERL VDLHGSVIDY NYGGGSSIAV LLIMERLHRD LYTGLKAGLT
760 770 780 790 800
LETRLQIALD VVEGIRFLHS QGLVHRDIKL KNVLLDKQNR AKITDLGFCK
810 820 830 840 850
PEAMMSGSIV GTPIHMAPEL FTGKYDNSVD VYAFGILFWY ICSGSVKLPE
860 870 880 890 900
AFERCASKDH LWNNVRRGAR PERLPVFDEE CWQLMEACWD GDPLKRPLLG
910 920
IVQPMLQGIM NRLCKSNSEQ PNRGLDDST
Length:929
Mass (Da):105,206
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8DDAAC289DE21EE7
GO
Isoform 2 (identifier: Q6XUX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     824-868: Missing.

Show »
Length:884
Mass (Da):99,968
Checksum:i89E487C2D3CDD2FA
GO
Isoform 3 (identifier: Q6XUX3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-792: Missing.

Show »
Length:587
Mass (Da):66,302
Checksum:i6C7E99A983B9BA58
GO
Isoform 4 (identifier: Q6XUX3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-539: Missing.
     703-718: SLPKHERLVDLHGSVI → WVLASFISMRKIQRRI
     719-929: Missing.

Show »
Length:179
Mass (Da):20,769
Checksum:i67DB6F18452BB99F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti247V → A in AAH72406 (PubMed:15489334).Curated1
Sequence conflicti449G → R in AAH60870 (PubMed:15489334).Curated1
Sequence conflicti641C → R in AAP42418 (PubMed:17123648).Curated1
Sequence conflicti641C → R in AAS55390 (PubMed:17123648).Curated1
Sequence conflicti641C → R in AAF65505 (Ref. 2) Curated1
Sequence conflicti641C → R in AAH53627 (PubMed:15489334).Curated1
Sequence conflicti641C → R in AAH72406 (PubMed:15489334).Curated1
Sequence conflicti641C → R in AAI17412 (PubMed:15489334).Curated1
Sequence conflicti641C → R in AAI43604 (PubMed:15489334).Curated1
Sequence conflicti641C → R in BAA32317 (PubMed:9455484).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07132429R → Q in CAKUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200780796EnsemblClinVar.1
Natural variantiVAR_071325200D → G in CAKUT1. 1 Publication1
Natural variantiVAR_057101432L → V. Corresponds to variant dbSNP:rs35845538Ensembl.1
Natural variantiVAR_071326843S → L in CAKUT1. 1 PublicationCorresponds to variant dbSNP:rs778586547EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0180301 – 539Missing in isoform 4. 1 PublicationAdd BLAST539
Alternative sequenceiVSP_018031451 – 792Missing in isoform 3. 1 PublicationAdd BLAST342
Alternative sequenceiVSP_018032703 – 718SLPKH…HGSVI → WVLASFISMRKIQRRI in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_018033719 – 929Missing in isoform 4. 1 PublicationAdd BLAST211
Alternative sequenceiVSP_018034824 – 868Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY208850 mRNA Translation: AAP42418.1
AY429674 mRNA Translation: AAS55390.1
AF068286 mRNA Translation: AAF65505.1
AC093422 Genomic DNA No translation available.
BC048204 mRNA Translation: AAH48204.1
BC053627 mRNA Translation: AAH53627.1
BC060870 mRNA Translation: AAH60870.2
BC072406 mRNA Translation: AAH72406.1
BC117411 mRNA Translation: AAI17412.1
BC143603 mRNA Translation: AAI43604.1
AB007941 mRNA Translation: BAA32317.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1451.1 [Q6XUX3-1]
CCDS1452.1 [Q6XUX3-2]

NCBI Reference Sequences

More...
RefSeqi
NP_056190.1, NM_015375.2 [Q6XUX3-1]
NP_955749.1, NM_199462.2 [Q6XUX3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367161; ENSP00000356129; ENSG00000133059 [Q6XUX3-2]
ENST00000367162; ENSP00000356130; ENSG00000133059 [Q6XUX3-1]
ENST00000615388; ENSP00000478016; ENSG00000133059 [Q6XUX3-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25778

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25778

UCSC genome browser

More...
UCSCi
uc001hbw.4 human [Q6XUX3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208850 mRNA Translation: AAP42418.1
AY429674 mRNA Translation: AAS55390.1
AF068286 mRNA Translation: AAF65505.1
AC093422 Genomic DNA No translation available.
BC048204 mRNA Translation: AAH48204.1
BC053627 mRNA Translation: AAH53627.1
BC060870 mRNA Translation: AAH60870.2
BC072406 mRNA Translation: AAH72406.1
BC117411 mRNA Translation: AAI17412.1
BC143603 mRNA Translation: AAI43604.1
AB007941 mRNA Translation: BAA32317.1
CCDSiCCDS1451.1 [Q6XUX3-1]
CCDS1452.1 [Q6XUX3-2]
RefSeqiNP_056190.1, NM_015375.2 [Q6XUX3-1]
NP_955749.1, NM_199462.2 [Q6XUX3-2]

3D structure databases

SMRiQ6XUX3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117313, 48 interactors
IntActiQ6XUX3, 23 interactors
STRINGi9606.ENSP00000356130

Chemistry databases

BindingDBiQ6XUX3
ChEMBLiCHEMBL1908386
DrugCentraliQ6XUX3

PTM databases

iPTMnetiQ6XUX3
PhosphoSitePlusiQ6XUX3

Polymorphism and mutation databases

BioMutaiDSTYK
DMDMi296434486

Proteomic databases

EPDiQ6XUX3
jPOSTiQ6XUX3
MassIVEiQ6XUX3
MaxQBiQ6XUX3
PaxDbiQ6XUX3
PeptideAtlasiQ6XUX3
PRIDEiQ6XUX3
ProteomicsDBi67816 [Q6XUX3-1]
67817 [Q6XUX3-2]
67818 [Q6XUX3-3]
67819 [Q6XUX3-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34564 171 antibodies

The DNASU plasmid repository

More...
DNASUi
25778

Genome annotation databases

EnsembliENST00000367161; ENSP00000356129; ENSG00000133059 [Q6XUX3-2]
ENST00000367162; ENSP00000356130; ENSG00000133059 [Q6XUX3-1]
ENST00000615388; ENSP00000478016; ENSG00000133059 [Q6XUX3-4]
GeneIDi25778
KEGGihsa:25778
UCSCiuc001hbw.4 human [Q6XUX3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25778
DisGeNETi25778
EuPathDBiHostDB:ENSG00000133059.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DSTYK
HGNCiHGNC:29043 DSTYK
HPAiENSG00000133059 Low tissue specificity
MalaCardsiDSTYK
MIMi270750 phenotype
610805 phenotype
612666 gene
neXtProtiNX_Q6XUX3
OpenTargetsiENSG00000133059
Orphaneti101003 Autosomal recessive spastic paraplegia type 23
93100 Renal agenesis, unilateral
PharmGKBiPA164718861

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00840000129948
HOGENOMiCLU_014116_0_0_1
InParanoidiQ6XUX3
KOiK16288
OMAiCIFILGQ
OrthoDBi254886at2759
PhylomeDBiQ6XUX3
TreeFamiTF331821

Enzyme and pathway databases

SignaLinkiQ6XUX3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
25778 4 hits in 816 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DSTYK human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RIPK5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25778
PharosiQ6XUX3 Tchem

Protein Ontology

More...
PROi
PR:Q6XUX3
RNActiQ6XUX3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000133059 Expressed in parietal lobe and 238 other tissues
GenevisibleiQ6XUX3 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDUSTY_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XUX3
Secondary accession number(s): B7ZL64
, O75060, Q17R94, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: June 17, 2020
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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