UniProtKB - Q6XUX2 (DUSTY_RAT)
Protein
Dual serine/threonine and tyrosine protein kinase
Gene
Dstyk
Organism
Rattus norvegicus (Rat)
Status
Functioni
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 679 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 775 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 656 – 664 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
- protein serine/threonine kinase activity Source: UniProtKB-KW
- protein tyrosine kinase activity Source: UniProtKB-KW
GO - Biological processi
- cellular response to fibroblast growth factor stimulus Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of fibroblast growth factor receptor signaling pathway Source: UniProtKB
- positive regulation of kinase activity Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Dual serine/threonine and tyrosine protein kinase (EC:2.7.12.1)Alternative name(s): Dusty protein kinase Short name: Dusty PK Receptor-interacting serine/threonine-protein kinase 5 |
Gene namesi | Name:Dstyk Synonyms:Ripk5 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 735051, Dstyk |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
- Apical cell membrane By similarity
- Basolateral cell membrane By similarity
Other locations
- Cytoplasm By similarity
- Cell junction By similarity
Note: Detected in basolateral and apical membranes of all tubular epithelia. Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane.By similarity
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- basolateral plasma membrane Source: UniProtKB
Other locations
- cell junction Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233121 | 1 – 927 | Dual serine/threonine and tyrosine protein kinaseAdd BLAST | 927 |
Proteomic databases
jPOSTi | Q6XUX2 |
PaxDbi | Q6XUX2 |
PRIDEi | Q6XUX2 |
Expressioni
Tissue specificityi
Expressed in many regions of the adult brain.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000021298, Expressed in cerebellum and 19 other tissues |
Genevisiblei | Q6XUX2, RN |
Interactioni
Protein-protein interaction databases
BioGRIDi | 257980, 1 interactor |
STRINGi | 10116.ENSRNOP00000004810 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 650 – 904 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 255 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 393 – 429 | Sequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 15 – 22 | Poly-Gly | 8 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0192, Eukaryota |
GeneTreei | ENSGT00840000129948 |
HOGENOMi | CLU_014116_0_0_1 |
InParanoidi | Q6XUX2 |
OMAi | CIFILGQ |
OrthoDBi | 254886at2759 |
PhylomeDBi | Q6XUX2 |
TreeFami | TF331821 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6XUX2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEADGQSWSG ESVSGPGPGG GGMIRELCRG FGRYRRYLGR LRQNLRETQK
60 70 80 90 100
FFRDIKCSHS HSCPSSPAGG GAAELGPAGD VAAAPLPAGQ LSCISFPPME
110 120 130 140 150
EKYLQQIVDH LPCILILGQD CNAKCQLLNL LLAVRVLPTL KLDSDESCKL
160 170 180 190 200
RRLRFTYGTR TQVSLALPGQ YELVHTLASH QDNWETIPEE DLEVQEDSED
210 220 230 240 250
TARVLADLEV TMHHALLQEV DIVVAPCHSH RPAVDVLSDL ANDFLPVITY
260 270 280 290 300
ALHKDELSER DEQELQEIRK YFSFPVFFFK VPTLEIIRSS SGRADSERSP
310 320 330 340 350
LSGQLMDLGY LSSSHRNCMA SDQDCRAQSM LVEQSEKLRQ LSTFSHQLLQ
360 370 380 390 400
TRLVDAAKAL NAVHSHCLDI FINQAFDMQR DLQITPKRLE YTRKKENELY
410 420 430 440 450
ESLMNIANRK QEEMKDMIVE TLNTMKEELL DDAANMEFKD VIVPENGETV
460 470 480 490 500
GTREIKSCIR QIQELIISRL NQAVANKLIS SVDYLRESFV GTLERCLQSL
510 520 530 540 550
EKSQDVSVHI TSNYLKQILN AAYHVEVTFH SGSSVTRMLW EQIKQIIQRI
560 570 580 590 600
TWVNPPTITL EWKRKVAQEA IDSLSASKLA KSICSQFRTR LNSSHEAFAA
610 620 630 640 650
SLRQLEAGHS GRLEKTEDLW LKVRKDHAPR LARLSLESRS LQDVLLHRKP
660 670 680 690 700
KLGQELGRGQ YGVVYLCDNW GGHFPCALKS VVPPDEKHWN DLALEFHYMR
710 720 730 740 750
SLPKHERLVD LHGSVIDYNY GGGSSVAVLL IMERLHRDLY TGLKAGLSLE
760 770 780 790 800
TRLQIALDVV EGIRFLHSQG LVHRDIKLKN VLLDKQNRAK ITDLGFCKPE
810 820 830 840 850
AMMSGSIVGT PIHMAPELFT GKYDNSVDVY AFGILFWYIC SGSIKLPEAF
860 870 880 890 900
ERCASKDHLW NNVRRGTRPE RLPVFDEECW QLMEACWDGD PSKRPLLGIV
910 920
QPILRSIMDR LCKCDSERPS RGLDDST
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY208851 mRNA Translation: AAP42419.1 AY429675 mRNA Translation: AAS55391.1 |
RefSeqi | NP_955750.1, NM_199463.2 |
Genome annotation databases
Ensembli | ENSRNOT00000004810; ENSRNOP00000004810; ENSRNOG00000021298 |
GeneIDi | 304791 |
KEGGi | rno:304791 |
UCSCi | RGD:735051, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY208851 mRNA Translation: AAP42419.1 AY429675 mRNA Translation: AAS55391.1 |
RefSeqi | NP_955750.1, NM_199463.2 |
3D structure databases
SMRi | Q6XUX2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 257980, 1 interactor |
STRINGi | 10116.ENSRNOP00000004810 |
Proteomic databases
jPOSTi | Q6XUX2 |
PaxDbi | Q6XUX2 |
PRIDEi | Q6XUX2 |
Genome annotation databases
Ensembli | ENSRNOT00000004810; ENSRNOP00000004810; ENSRNOG00000021298 |
GeneIDi | 304791 |
KEGGi | rno:304791 |
UCSCi | RGD:735051, rat |
Organism-specific databases
CTDi | 25778 |
RGDi | 735051, Dstyk |
Phylogenomic databases
eggNOGi | KOG0192, Eukaryota |
GeneTreei | ENSGT00840000129948 |
HOGENOMi | CLU_014116_0_0_1 |
InParanoidi | Q6XUX2 |
OMAi | CIFILGQ |
OrthoDBi | 254886at2759 |
PhylomeDBi | Q6XUX2 |
TreeFami | TF331821 |
Miscellaneous databases
PROi | PR:Q6XUX2 |
Gene expression databases
Bgeei | ENSRNOG00000021298, Expressed in cerebellum and 19 other tissues |
Genevisiblei | Q6XUX2, RN |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DUSTY_RAT | |
Accessioni | Q6XUX2Primary (citable) accession number: Q6XUX2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families