Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 126 (31 Jul 2019)
Sequence version 2 (02 Nov 2010)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Zinc transporter 10

Gene

SLC30A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death (PubMed:22341972, PubMed:22341971, PubMed:25319704, PubMed:27226609, PubMed:27307044). Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells (PubMed:22706290, PubMed:22427991, PubMed:26728129).1 Publication5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandManganese, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-425410 Metal ion SLC transporters

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.4.2.5 the cation diffusion facilitator (cdf) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc transporter 10
Short name:
ZnT-10
Alternative name(s):
Manganese transporter SLC30A10
Solute carrier family 30 member 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC30A10
Synonyms:ZNT10, ZNT8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25355 SLC30A10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611146 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6XR72

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 10CytoplasmicSequence analysis10
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 40ExtracellularSequence analysis9
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Topological domaini62 – 81CytoplasmicSequence analysisAdd BLAST20
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 113ExtracellularSequence analysisAdd BLAST11
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 244CytoplasmicSequence analysisAdd BLAST110
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 278ExtracellularSequence analysisAdd BLAST13
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 485CytoplasmicSequence analysisAdd BLAST186

Keywords - Cellular componenti

Cell membrane, Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypermanganesemia with dystonia 1 (HMNDYT1)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic autosomal recessive disorder characterized by dystonia, parkinsonism, extrapyramidal signs, severe hypermanganesemia, polycythemia, and chronic hepatic disease, including steatosis and cirrhosis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07257389L → P in HMNDYT1; abolishes cell surface localization. 2 PublicationsCorresponds to variant dbSNP:rs281860284EnsemblClinVar.1
Natural variantiVAR_072574105 – 107Missing in HMNDYT1; abolishes cell surface localization; decreases manganese efflux; decreases protection against manganese-induced neurotoxity. 2 Publications3
Natural variantiVAR_072576256Missing in HMNDYT1. 1 Publication1
Natural variantiVAR_072577349L → P in HMNDYT1. 1 PublicationCorresponds to variant dbSNP:rs281860291EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi4Y → F: Decreases interaction with SLC30A3; no effect on self-association; decreases zinc transport; decreases EGF-induced ERK1/2 phosphorylation. 1 Publication1
Mutagenesisi25E → A: Abolishes manganese efflux activity. 1 Publication1
Mutagenesisi40D → A: Abolishes manganese efflux activity. 1 Publication1
Mutagenesisi127N → A: Abolishes manganese efflux activity; when associated with A-244. 1 Publication1
Mutagenesisi196T → P: Abolishes cell surface localization. 1 Publication1
Mutagenesisi244H → A: Abolishes manganese efflux activity; when associated with A-127. 1 Publication1
Mutagenesisi248D → A: Abolishes manganese efflux activity. 1 Publication1
Mutagenesisi333H → A: Decreases manganese efflux activity. 1 Publication1
Mutagenesisi350H → A: Decreases manganese efflux activity. 1 Publication1

Keywords - Diseasei

Disease mutation, Dystonia, Neurodegeneration, Parkinsonism

Organism-specific databases

DisGeNET

More...
DisGeNETi
55532

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SLC30A10

MalaCards human disease database

More...
MalaCardsi
SLC30A10
MIMi613280 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000196660

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
309854 Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670903

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC30A10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033506

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003125801 – 485Zinc transporter 10Add BLAST485

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6XR72

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6XR72

PeptideAtlas

More...
PeptideAtlasi
Q6XR72

PRoteomics IDEntifications database

More...
PRIDEi
Q6XR72

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67813 [Q6XR72-4]
67814 [Q6XR72-2]
67815 [Q6XR72-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6XR72

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6XR72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in fetal liver and fetal brain (PubMed:15154973). Expressed in adult tissues with relative levels small intestine > liver > testes > brain > ovary > colon > cervix > prostate > placenta (PubMed:22706290).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by ZNF658 in response to zinc. Down-regulated by angiotensin-2.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196660 Expressed in 82 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6XR72 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA064547

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers. Forms heterodimers and high-molecular weight oligomers with SLC30A3, SLC30A2 and SLC30A4; heterodimerization is mediated by covalent-bound tyrosine residues and occurs probably in a tissue-specific manner.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120703, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q6XR72, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355893

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni308 – 485Required for plasma membrane localization1 PublicationAdd BLAST178

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi253 – 256Poly-Val4
Compositional biasi396 – 399Poly-Leu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1483 Eukaryota
COG1230 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159967

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000166089

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6XR72

KEGG Orthology (KO)

More...
KOi
K14697

Identification of Orthologs from Complete Genome Data

More...
OMAi
HEVHVWE

Database of Orthologous Groups

More...
OrthoDBi
820567at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6XR72

TreeFam database of animal gene trees

More...
TreeFami
TF313924

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1510.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002524 Cation_efflux
IPR027469 Cation_efflux_TMD_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01545 Cation_efflux, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161111 SSF161111, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01297 CDF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6XR72-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRYSGKTCR LLFMLVLTVA FFVAELVSGY LGNSIALLSD SFNMLSDLIS
60 70 80 90 100
LCVGLSAGYI ARRPTRGFSA TYGYARAEVV GALSNAVFLT ALCFTIFVEA
110 120 130 140 150
VLRLARPERI DDPELVLIVG VLGLLVNVVG LLIFQDCAAW FACCLRGRSR
160 170 180 190 200
RLQQRQQLAE GCVPGAFGGP QGAEDPRRAA DPTAPGSDSA VTLRGTSVER
210 220 230 240 250
KREKGATVFA NVAGDSFNTQ NEPEDMMKKE KKSEALNIRG VLLHVMGDAL
260 270 280 290 300
GSVVVVITAI IFYVLPLKSE DPCNWQCYID PSLTVLMVII ILSSAFPLIK
310 320 330 340 350
ETAAILLQMV PKGVNMEELM SKLSAVPGIS SVHEVHIWEL VSGKIIATLH
360 370 380 390 400
IKYPKDRGYQ DASTKIREIF HHAGIHNVTI QFENVDLKEP LEQKDLLLLC
410 420 430 440 450
NSPCISKGCA KQLCCPPGAL PLAHVNGCAE HNGGPSLDTY GSDGLSRRDA
460 470 480
REVAIEVSLD SCLSDHGQSL NKTQEDQCYV NRTHF
Length:485
Mass (Da):52,684
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i96A3495EF026DE94
GO
Isoform 2 (identifier: Q6XR72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:240
Mass (Da):26,289
Checksum:i8D3C17D391E719E6
GO
Isoform 3 (identifier: Q6XR72-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-223: GDSFNTQNEP → ELIHNTRFLL
     224-485: Missing.

Note: No experimental confirmation available.
Show »
Length:223
Mass (Da):24,009
Checksum:i3A7FDB2E11FF9459
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAP44332 differs from that shown. Contaminating sequence. Sequence of unknown origin in position 427.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07257389L → P in HMNDYT1; abolishes cell surface localization. 2 PublicationsCorresponds to variant dbSNP:rs281860284EnsemblClinVar.1
Natural variantiVAR_072574105 – 107Missing in HMNDYT1; abolishes cell surface localization; decreases manganese efflux; decreases protection against manganese-induced neurotoxity. 2 Publications3
Natural variantiVAR_072575167F → S1 PublicationCorresponds to variant dbSNP:rs281860286EnsemblClinVar.1
Natural variantiVAR_072576256Missing in HMNDYT1. 1 Publication1
Natural variantiVAR_072577349L → P in HMNDYT1. 1 PublicationCorresponds to variant dbSNP:rs281860291EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0298631 – 245Missing in isoform 2. 1 PublicationAdd BLAST245
Alternative sequenceiVSP_029864214 – 223GDSFNTQNEP → ELIHNTRFLL in isoform 3. 1 Publication10
Alternative sequenceiVSP_029865224 – 485Missing in isoform 3. 1 PublicationAdd BLAST262

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY212919 mRNA Translation: AAP44332.1 Sequence problems.
AL359609 mRNA Translation: CAB94880.1
AC093562 Genomic DNA No translation available.
BC036078 mRNA Translation: AAH36078.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31026.1 [Q6XR72-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
T50628

NCBI Reference Sequences

More...
RefSeqi
NP_061183.2, NM_018713.2 [Q6XR72-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356609; ENSP00000349018; ENSG00000196660 [Q6XR72-3]
ENST00000366926; ENSP00000355893; ENSG00000196660 [Q6XR72-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55532

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55532

UCSC genome browser

More...
UCSCi
uc001hlw.4 human [Q6XR72-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY212919 mRNA Translation: AAP44332.1 Sequence problems.
AL359609 mRNA Translation: CAB94880.1
AC093562 Genomic DNA No translation available.
BC036078 mRNA Translation: AAH36078.1
CCDSiCCDS31026.1 [Q6XR72-4]
PIRiT50628
RefSeqiNP_061183.2, NM_018713.2 [Q6XR72-4]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120703, 6 interactors
IntActiQ6XR72, 4 interactors
STRINGi9606.ENSP00000355893

Protein family/group databases

TCDBi2.A.4.2.5 the cation diffusion facilitator (cdf) family

PTM databases

iPTMnetiQ6XR72
PhosphoSitePlusiQ6XR72

Polymorphism and mutation databases

BioMutaiSLC30A10
DMDMi311033506

Proteomic databases

jPOSTiQ6XR72
PaxDbiQ6XR72
PeptideAtlasiQ6XR72
PRIDEiQ6XR72
ProteomicsDBi67813 [Q6XR72-4]
67814 [Q6XR72-2]
67815 [Q6XR72-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55532
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356609; ENSP00000349018; ENSG00000196660 [Q6XR72-3]
ENST00000366926; ENSP00000355893; ENSG00000196660 [Q6XR72-4]
GeneIDi55532
KEGGihsa:55532
UCSCiuc001hlw.4 human [Q6XR72-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55532
DisGeNETi55532

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC30A10
GeneReviewsiSLC30A10
HGNCiHGNC:25355 SLC30A10
HPAiHPA064547
MalaCardsiSLC30A10
MIMi611146 gene
613280 phenotype
neXtProtiNX_Q6XR72
OpenTargetsiENSG00000196660
Orphaneti309854 Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome
PharmGKBiPA142670903

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1483 Eukaryota
COG1230 LUCA
GeneTreeiENSGT00940000159967
HOGENOMiHOG000166089
InParanoidiQ6XR72
KOiK14697
OMAiHEVHVWE
OrthoDBi820567at2759
PhylomeDBiQ6XR72
TreeFamiTF313924

Enzyme and pathway databases

ReactomeiR-HSA-425410 Metal ion SLC transporters

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC30A10 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55532

Protein Ontology

More...
PROi
PR:Q6XR72

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196660 Expressed in 82 organ(s), highest expression level in liver
GenevisibleiQ6XR72 HS

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNT10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XR72
Secondary accession number(s): Q49AL9, Q9NPW0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 2, 2010
Last modified: July 31, 2019
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again