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Entry version 140 (07 Apr 2021)
Sequence version 2 (15 Jan 2008)
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Protein

Nicotinate phosphoribosyltransferase

Gene

NAPRT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication, Mn2+1 PublicationNote: Activity is highest with Mn2+.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=44.3 µM for nicotinic acid (in the presence of 3 mM ATP)1 Publication
  2. KM=22.1 µM for 5-phosphoribosyl-1-pyrophosphate (in the presence of 3 mM ATP)1 Publication
  3. KM=27.3 µM for nicotinic acid (in the presence of inorganic phosphate)1 Publication
  4. KM=38.2 µM for 5-phosphoribosyl-1-pyrophosphate (in the presence of inorganic phosphate)1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: NAD(+) biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.3 Publications
    Proteins known to be involved in this subpathway in this organism are:
    1. Nicotinate phosphoribosyltransferase (NAPRT), Nicotinate phosphoribosyltransferase (NAPRT), Nicotinate phosphoribosyltransferase, Nicotinate phosphoribosyltransferase (NAPRT), Nicotinate phosphoribosyltransferase (NAPRT), Nicotinate phosphoribosyltransferase (NAPRT), Nicotinate phosphoribosyltransferase (NAPRT)
    This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei21NicotinateBy similarity1
    Binding sitei210NicotinateBy similarity1
    Binding sitei318NicotinateBy similarity1
    Binding sitei380PhosphoribosylpyrophosphateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLigase, Transferase
    Biological processPyridine nucleotide biosynthesis
    LigandMagnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    6.3.4.21, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q6XQN6

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-197264, Nicotinamide salvaging
    R-HSA-6798695, Neutrophil degranulation

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00253;UER00457

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferase (EC:6.3.4.213 Publications)
    Short name:
    NAPRTase
    Alternative name(s):
    FHA-HIT-interacting protein
    Nicotinate phosphoribosyltransferase domain-containing protein 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:NAPRT
    Synonyms:FHIP, NAPRT1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:30450, NAPRT

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    611552, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q6XQN6

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    HostDB:ENSG00000147813.15

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi19D → A: Complete loss of activity. 1 Publication1
    Mutagenesisi21Y → A: Partial loss of activity in the presence of ATP, complete loss in the absence of ATP. 1 Publication1
    Mutagenesisi169G → A: Partial loss of activity. 1 Publication1
    Mutagenesisi209G → A: Partial loss of activity. 1 Publication1
    Mutagenesisi213H → A: Partial loss of activity. 1 Publication1
    Mutagenesisi288D → A: Partial loss of activity. 1 Publication1
    Mutagenesisi318R → A: Partial loss of activity in the presence of ATP, almost complete loss in the absence of ATP. 1 Publication1
    Mutagenesisi357N → A: Small loss of activity. 1 Publication1
    Mutagenesisi379G → A: Complete loss of activity. 1 Publication1
    Mutagenesisi380T → A: Partial loss of activity. 1 Publication1
    Mutagenesisi381S → A: Partial loss of activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    93100

    Open Targets

    More...
    OpenTargetsi
    ENSG00000147813

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA142671293

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q6XQN6, Tbio

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    NAPRT

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    166221824

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003156811 – 538Nicotinate phosphoribosyltransferaseAdd BLAST538

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei213PhosphohistidineBy similarity1
    Modified residuei537PhosphoserineCombined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q6XQN6

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q6XQN6

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q6XQN6

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q6XQN6

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q6XQN6

    PeptideAtlas

    More...
    PeptideAtlasi
    Q6XQN6

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q6XQN6

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    67810 [Q6XQN6-1]
    67811 [Q6XQN6-2]
    67812 [Q6XQN6-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q6XQN6

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q6XQN6

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000147813, Expressed in muscle tissue and 203 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q6XQN6, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q6XQN6, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000147813, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    125001, 39 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q6XQN6, 9 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000401508

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q6XQN6, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1538
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q6XQN6

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the NAPRTase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2511, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000153456

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q6XQN6

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    NPHIYKV

    Database of Orthologous Groups

    More...
    OrthoDBi
    577034at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q6XQN6

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314732

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.20.20.70, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013785, Aldolase_TIM
    IPR041619, NAPRTase_C
    IPR040727, NAPRTase_N
    IPR007229, Nic_PRibTrfase-Fam
    IPR006405, Nic_PRibTrfase_pncB
    IPR036068, Nicotinate_pribotase-like_C

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11098, PTHR11098, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF17956, NAPRTase_C, 1 hit
    PF17767, NAPRTase_N, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000484, NAPRT, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51690, SSF51690, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01513, NAPRTase_put, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q6XQN6-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAAEQDPEAR AAARPLLTDL YQATMALGYW RAGRARDAAE FELFFRRCPF
    60 70 80 90 100
    GGAFALAAGL RDCVRFLRAF RLRDADVQFL ASVLPPDTDP AFFEHLRALD
    110 120 130 140 150
    CSEVTVRALP EGSLAFPGVP LLQVSGPLLV VQLLETPLLC LVSYASLVAT
    160 170 180 190 200
    NAARLRLIAG PEKRLLEMGL RRAQGPDGGL TASTYSYLGG FDSSSNVLAG
    210 220 230 240 250
    QLRGVPVAGT LAHSFVTSFS GSEVPPDPML APAAGEGPGV DLAAKAQVWL
    260 270 280 290 300
    EQVCAHLGLG VQEPHPGERA AFVAYALAFP RAFQGLLDTY SVWRSGLPNF
    310 320 330 340 350
    LAVALALGEL GYRAVGVRLD SGDLLQQAQE IRKVFRAAAA QFQVPWLESV
    360 370 380 390 400
    LIVVSNNIDE EALARLAQEG SEVNVIGIGT SVVTCPQQPS LGGVYKLVAV
    410 420 430 440 450
    GGQPRMKLTE DPEKQTLPGS KAAFRLLGSD GSPLMDMLQL AEEPVPQAGQ
    460 470 480 490 500
    ELRVWPPGAQ EPCTVRPAQV EPLLRLCLQQ GQLCEPLPSL AESRALAQLS
    510 520 530
    LSRLSPEHRR LRSPAQYQVV LSERLQALVN SLCAGQSP
    Length:538
    Mass (Da):57,578
    Last modified:January 15, 2008 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26DF39885CBB1C9B
    GO
    Isoform 2 (identifier: Q6XQN6-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         517-517: Y → YQVGGGGPPCHSALCAPALTLPTAPVLCSL

    Show »
    Length:567
    Mass (Da):60,291
    Checksum:i3FFE59FEFD270DF9
    GO
    Isoform 3 (identifier: Q6XQN6-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         469-481: Missing.

    Show »
    Length:525
    Mass (Da):56,099
    Checksum:iE18F7E02CB00ABF4
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    C9J8U2C9J8U2_HUMAN
    Nicotinate phosphoribosyltransferas...
    NAPRT NAPRT1, hCG_32062
    490Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    G5E977G5E977_HUMAN
    Nicotinate phosphoribosyltransferas...
    NAPRT NAPRT1, hCG_32062
    584Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YF31H0YF31_HUMAN
    Nicotinate phosphoribosyltransferas...
    NAPRT
    163Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YDA6H0YDA6_HUMAN
    Nicotinate phosphoribosyltransferas...
    NAPRT
    128Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A087WUT5A0A087WUT5_HUMAN
    Nicotinate phosphoribosyltransferas...
    NAPRT
    232Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH06284 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
    The sequence AAH32466 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti155L → V in AAP69603 (Ref. 2) Curated1
    Sequence conflicti155L → V in AAP69604 (Ref. 2) Curated1
    Sequence conflicti155L → V in AAP69605 (Ref. 2) Curated1
    Sequence conflicti224V → A in BAF75377 (PubMed:17604275).Curated1
    Sequence conflicti246A → T in BAF75377 (PubMed:17604275).Curated1
    Sequence conflicti375V → A in BAF75377 (PubMed:17604275).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03827557A → V. Corresponds to variant dbSNP:rs896950Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030610469 – 481Missing in isoform 3. 1 PublicationAdd BLAST13
    Alternative sequenceiVSP_030612517Y → YQVGGGGPPCHSALCAPALT LPTAPVLCSL in isoform 2. 1 Publication1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB242230 mRNA Translation: BAF75377.1
    AY214325 mRNA Translation: AAP69603.1
    AY214326 mRNA Translation: AAP69604.1
    AY214327 mRNA Translation: AAP69605.1
    BC006284 mRNA Translation: AAH06284.2 Different initiation.
    BC032466 mRNA Translation: AAH32466.1 Different initiation.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS6403.2 [Q6XQN6-1]
    CCDS69555.1 [Q6XQN6-3]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001273758.1, NM_001286829.1 [Q6XQN6-3]
    NP_660202.3, NM_145201.5 [Q6XQN6-1]
    XP_016869469.1, XM_017013980.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000426292; ENSP00000390949; ENSG00000147813 [Q6XQN6-3]
    ENST00000449291; ENSP00000401508; ENSG00000147813 [Q6XQN6-1]
    ENST00000621955; ENSP00000480017; ENSG00000278488 [Q6XQN6-1]
    ENST00000632139; ENSP00000488794; ENSG00000278488 [Q6XQN6-3]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    93100

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:93100

    UCSC genome browser

    More...
    UCSCi
    uc003yym.6, human [Q6XQN6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB242230 mRNA Translation: BAF75377.1
    AY214325 mRNA Translation: AAP69603.1
    AY214326 mRNA Translation: AAP69604.1
    AY214327 mRNA Translation: AAP69605.1
    BC006284 mRNA Translation: AAH06284.2 Different initiation.
    BC032466 mRNA Translation: AAH32466.1 Different initiation.
    CCDSiCCDS6403.2 [Q6XQN6-1]
    CCDS69555.1 [Q6XQN6-3]
    RefSeqiNP_001273758.1, NM_001286829.1 [Q6XQN6-3]
    NP_660202.3, NM_145201.5 [Q6XQN6-1]
    XP_016869469.1, XM_017013980.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4YUBX-ray2.90A/B1-538[»]
    SMRiQ6XQN6
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi125001, 39 interactors
    IntActiQ6XQN6, 9 interactors
    STRINGi9606.ENSP00000401508

    PTM databases

    iPTMnetiQ6XQN6
    PhosphoSitePlusiQ6XQN6

    Genetic variation databases

    BioMutaiNAPRT
    DMDMi166221824

    Proteomic databases

    EPDiQ6XQN6
    jPOSTiQ6XQN6
    MassIVEiQ6XQN6
    MaxQBiQ6XQN6
    PaxDbiQ6XQN6
    PeptideAtlasiQ6XQN6
    PRIDEiQ6XQN6
    ProteomicsDBi67810 [Q6XQN6-1]
    67811 [Q6XQN6-2]
    67812 [Q6XQN6-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    14617, 180 antibodies

    Genome annotation databases

    EnsembliENST00000426292; ENSP00000390949; ENSG00000147813 [Q6XQN6-3]
    ENST00000449291; ENSP00000401508; ENSG00000147813 [Q6XQN6-1]
    ENST00000621955; ENSP00000480017; ENSG00000278488 [Q6XQN6-1]
    ENST00000632139; ENSP00000488794; ENSG00000278488 [Q6XQN6-3]
    GeneIDi93100
    KEGGihsa:93100
    UCSCiuc003yym.6, human [Q6XQN6-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    93100
    DisGeNETi93100

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    NAPRT
    HGNCiHGNC:30450, NAPRT
    HPAiENSG00000147813, Low tissue specificity
    MIMi611552, gene
    neXtProtiNX_Q6XQN6
    OpenTargetsiENSG00000147813
    PharmGKBiPA142671293
    VEuPathDBiHostDB:ENSG00000147813.15

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2511, Eukaryota
    GeneTreeiENSGT00940000153456
    InParanoidiQ6XQN6
    OMAiNPHIYKV
    OrthoDBi577034at2759
    PhylomeDBiQ6XQN6
    TreeFamiTF314732

    Enzyme and pathway databases

    UniPathwayiUPA00253;UER00457
    BRENDAi6.3.4.21, 2681
    PathwayCommonsiQ6XQN6
    ReactomeiR-HSA-197264, Nicotinamide salvaging
    R-HSA-6798695, Neutrophil degranulation

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    93100, 9 hits in 996 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    NAPRT, human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    93100
    PharosiQ6XQN6, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q6XQN6
    RNActiQ6XQN6, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000147813, Expressed in muscle tissue and 203 other tissues
    ExpressionAtlasiQ6XQN6, baseline and differential
    GenevisibleiQ6XQN6, HS

    Family and domain databases

    Gene3Di3.20.20.70, 1 hit
    InterProiView protein in InterPro
    IPR013785, Aldolase_TIM
    IPR041619, NAPRTase_C
    IPR040727, NAPRTase_N
    IPR007229, Nic_PRibTrfase-Fam
    IPR006405, Nic_PRibTrfase_pncB
    IPR036068, Nicotinate_pribotase-like_C
    PANTHERiPTHR11098, PTHR11098, 1 hit
    PfamiView protein in Pfam
    PF17956, NAPRTase_C, 1 hit
    PF17767, NAPRTase_N, 1 hit
    PIRSFiPIRSF000484, NAPRT, 1 hit
    SUPFAMiSSF51690, SSF51690, 1 hit
    TIGRFAMsiTIGR01513, NAPRTase_put, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPNCB_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XQN6
    Secondary accession number(s): A7BFI3
    , Q6PJL1, Q6XQN4, Q6XQN5, Q8N5E8, Q9BRG0
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: April 7, 2021
    This is version 140 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with genetic variants
      List of human entries with genetic variants
    3. Human variants curated from literature reports
      Index of human variants curated from literature reports
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families
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