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Entry version 142 (29 Sep 2021)
Sequence version 2 (15 Jan 2008)
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Protein

Nicotinate phosphoribosyltransferase

Gene

NAPRT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198).

Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication, Mn2+1 PublicationNote: Activity is highest with Mn2+.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=44.3 µM for nicotinic acid (in the presence of 3 mM ATP)1 Publication
  2. KM=22.1 µM for 5-phosphoribosyl-1-pyrophosphate (in the presence of 3 mM ATP)1 Publication
  3. KM=27.3 µM for nicotinic acid (in the presence of inorganic phosphate)1 Publication
  4. KM=38.2 µM for 5-phosphoribosyl-1-pyrophosphate (in the presence of inorganic phosphate)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.3 Publications This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei21NicotinateBy similarity1
Binding sitei210NicotinateBy similarity1
Binding sitei318NicotinateBy similarity1
Binding sitei380PhosphoribosylpyrophosphateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • NAD salvage Source: GO_Central
  • response to oxidative stress Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.3.4.21, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6XQN6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-197264, Nicotinamide salvaging
R-HSA-6798695, Neutrophil degranulation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00253;UER00457

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.213 Publications)
Short name:
NAPRTase
Alternative name(s):
FHA-HIT-interacting protein
Nicotinate phosphoribosyltransferase domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NAPRT
Synonyms:FHIP, NAPRT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30450, NAPRT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611552, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6XQN6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000147813

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi19D → A: Complete loss of activity. 1 Publication1
Mutagenesisi21Y → A: Partial loss of activity in the presence of ATP, complete loss in the absence of ATP. 1 Publication1
Mutagenesisi169G → A: Partial loss of activity. 1 Publication1
Mutagenesisi209G → A: Partial loss of activity. 1 Publication1
Mutagenesisi213H → A: Partial loss of activity. 1 Publication1
Mutagenesisi288D → A: Partial loss of activity. 1 Publication1
Mutagenesisi318R → A: Partial loss of activity in the presence of ATP, almost complete loss in the absence of ATP. 1 Publication1
Mutagenesisi357N → A: Small loss of activity. 1 Publication1
Mutagenesisi379G → A: Complete loss of activity. 1 Publication1
Mutagenesisi380T → A: Partial loss of activity. 1 Publication1
Mutagenesisi381S → A: Partial loss of activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
93100

Open Targets

More...
OpenTargetsi
ENSG00000147813

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671293

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6XQN6, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4523354

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NAPRT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166221824

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003156811 – 538Nicotinate phosphoribosyltransferaseAdd BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei213PhosphohistidineBy similarity1
Modified residuei537PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6XQN6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6XQN6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6XQN6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6XQN6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6XQN6

PeptideAtlas

More...
PeptideAtlasi
Q6XQN6

PRoteomics IDEntifications database

More...
PRIDEi
Q6XQN6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67810 [Q6XQN6-1]
67811 [Q6XQN6-2]
67812 [Q6XQN6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6XQN6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6XQN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147813, Expressed in muscle tissue and 204 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6XQN6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6XQN6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000147813, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125001, 39 interactors

Protein interaction database and analysis system

More...
IntActi
Q6XQN6, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000401508

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6XQN6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1538
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6XQN6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NAPRTase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2511, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153456

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6XQN6

Identification of Orthologs from Complete Genome Data

More...
OMAi
VYFPGSP

Database of Orthologous Groups

More...
OrthoDBi
577034at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6XQN6

TreeFam database of animal gene trees

More...
TreeFami
TF314732

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785, Aldolase_TIM
IPR041619, NAPRTase_C
IPR040727, NAPRTase_N
IPR007229, Nic_PRibTrfase-Fam
IPR006405, Nic_PRibTrfase_pncB
IPR036068, Nicotinate_pribotase-like_C

The PANTHER Classification System

More...
PANTHERi
PTHR11098, PTHR11098, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17956, NAPRTase_C, 1 hit
PF17767, NAPRTase_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000484, NAPRT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51690, SSF51690, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01513, NAPRTase_put, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6XQN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAEQDPEAR AAARPLLTDL YQATMALGYW RAGRARDAAE FELFFRRCPF
60 70 80 90 100
GGAFALAAGL RDCVRFLRAF RLRDADVQFL ASVLPPDTDP AFFEHLRALD
110 120 130 140 150
CSEVTVRALP EGSLAFPGVP LLQVSGPLLV VQLLETPLLC LVSYASLVAT
160 170 180 190 200
NAARLRLIAG PEKRLLEMGL RRAQGPDGGL TASTYSYLGG FDSSSNVLAG
210 220 230 240 250
QLRGVPVAGT LAHSFVTSFS GSEVPPDPML APAAGEGPGV DLAAKAQVWL
260 270 280 290 300
EQVCAHLGLG VQEPHPGERA AFVAYALAFP RAFQGLLDTY SVWRSGLPNF
310 320 330 340 350
LAVALALGEL GYRAVGVRLD SGDLLQQAQE IRKVFRAAAA QFQVPWLESV
360 370 380 390 400
LIVVSNNIDE EALARLAQEG SEVNVIGIGT SVVTCPQQPS LGGVYKLVAV
410 420 430 440 450
GGQPRMKLTE DPEKQTLPGS KAAFRLLGSD GSPLMDMLQL AEEPVPQAGQ
460 470 480 490 500
ELRVWPPGAQ EPCTVRPAQV EPLLRLCLQQ GQLCEPLPSL AESRALAQLS
510 520 530
LSRLSPEHRR LRSPAQYQVV LSERLQALVN SLCAGQSP
Length:538
Mass (Da):57,578
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26DF39885CBB1C9B
GO
Isoform 2 (identifier: Q6XQN6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     517-517: Y → YQVGGGGPPCHSALCAPALTLPTAPVLCSL

Show »
Length:567
Mass (Da):60,291
Checksum:i3FFE59FEFD270DF9
GO
Isoform 3 (identifier: Q6XQN6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     469-481: Missing.

Show »
Length:525
Mass (Da):56,099
Checksum:iE18F7E02CB00ABF4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J8U2C9J8U2_HUMAN
Nicotinate phosphoribosyltransferas...
NAPRT NAPRT1, hCG_32062
490Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E977G5E977_HUMAN
Nicotinate phosphoribosyltransferas...
NAPRT NAPRT1, hCG_32062
584Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDA6H0YDA6_HUMAN
Nicotinate phosphoribosyltransferas...
NAPRT
128Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF31H0YF31_HUMAN
Nicotinate phosphoribosyltransferas...
NAPRT
163Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUT5A0A087WUT5_HUMAN
Nicotinate phosphoribosyltransferas...
NAPRT
232Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH06284 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH32466 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti155L → V in AAP69603 (Ref. 2) Curated1
Sequence conflicti155L → V in AAP69604 (Ref. 2) Curated1
Sequence conflicti155L → V in AAP69605 (Ref. 2) Curated1
Sequence conflicti224V → A in BAF75377 (PubMed:17604275).Curated1
Sequence conflicti246A → T in BAF75377 (PubMed:17604275).Curated1
Sequence conflicti375V → A in BAF75377 (PubMed:17604275).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03827557A → V. Corresponds to variant dbSNP:rs896950Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030610469 – 481Missing in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_030612517Y → YQVGGGGPPCHSALCAPALT LPTAPVLCSL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB242230 mRNA Translation: BAF75377.1
AY214325 mRNA Translation: AAP69603.1
AY214326 mRNA Translation: AAP69604.1
AY214327 mRNA Translation: AAP69605.1
BC006284 mRNA Translation: AAH06284.2 Different initiation.
BC032466 mRNA Translation: AAH32466.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS6403.2 [Q6XQN6-1]
CCDS69555.1 [Q6XQN6-3]

NCBI Reference Sequences

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RefSeqi
NP_001273758.1, NM_001286829.1 [Q6XQN6-3]
NP_660202.3, NM_145201.5 [Q6XQN6-1]
XP_016869469.1, XM_017013980.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000426292; ENSP00000390949; ENSG00000147813 [Q6XQN6-3]
ENST00000449291; ENSP00000401508; ENSG00000147813 [Q6XQN6-1]
ENST00000621955; ENSP00000480017; ENSG00000278488 [Q6XQN6-1]
ENST00000632139; ENSP00000488794; ENSG00000278488 [Q6XQN6-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
93100

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:93100

UCSC genome browser

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UCSCi
uc003yym.6, human [Q6XQN6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB242230 mRNA Translation: BAF75377.1
AY214325 mRNA Translation: AAP69603.1
AY214326 mRNA Translation: AAP69604.1
AY214327 mRNA Translation: AAP69605.1
BC006284 mRNA Translation: AAH06284.2 Different initiation.
BC032466 mRNA Translation: AAH32466.1 Different initiation.
CCDSiCCDS6403.2 [Q6XQN6-1]
CCDS69555.1 [Q6XQN6-3]
RefSeqiNP_001273758.1, NM_001286829.1 [Q6XQN6-3]
NP_660202.3, NM_145201.5 [Q6XQN6-1]
XP_016869469.1, XM_017013980.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YUBX-ray2.90A/B1-538[»]
SMRiQ6XQN6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi125001, 39 interactors
IntActiQ6XQN6, 9 interactors
STRINGi9606.ENSP00000401508

Chemistry databases

ChEMBLiCHEMBL4523354

PTM databases

iPTMnetiQ6XQN6
PhosphoSitePlusiQ6XQN6

Genetic variation databases

BioMutaiNAPRT
DMDMi166221824

Proteomic databases

EPDiQ6XQN6
jPOSTiQ6XQN6
MassIVEiQ6XQN6
MaxQBiQ6XQN6
PaxDbiQ6XQN6
PeptideAtlasiQ6XQN6
PRIDEiQ6XQN6
ProteomicsDBi67810 [Q6XQN6-1]
67811 [Q6XQN6-2]
67812 [Q6XQN6-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
14617, 187 antibodies

The DNASU plasmid repository

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DNASUi
93100

Genome annotation databases

EnsembliENST00000426292; ENSP00000390949; ENSG00000147813 [Q6XQN6-3]
ENST00000449291; ENSP00000401508; ENSG00000147813 [Q6XQN6-1]
ENST00000621955; ENSP00000480017; ENSG00000278488 [Q6XQN6-1]
ENST00000632139; ENSP00000488794; ENSG00000278488 [Q6XQN6-3]
GeneIDi93100
KEGGihsa:93100
UCSCiuc003yym.6, human [Q6XQN6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
93100
DisGeNETi93100

GeneCards: human genes, protein and diseases

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GeneCardsi
NAPRT
HGNCiHGNC:30450, NAPRT
HPAiENSG00000147813, Low tissue specificity
MIMi611552, gene
neXtProtiNX_Q6XQN6
OpenTargetsiENSG00000147813
PharmGKBiPA142671293
VEuPathDBiHostDB:ENSG00000147813

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2511, Eukaryota
GeneTreeiENSGT00940000153456
InParanoidiQ6XQN6
OMAiVYFPGSP
OrthoDBi577034at2759
PhylomeDBiQ6XQN6
TreeFamiTF314732

Enzyme and pathway databases

UniPathwayiUPA00253;UER00457
BRENDAi6.3.4.21, 2681
PathwayCommonsiQ6XQN6
ReactomeiR-HSA-197264, Nicotinamide salvaging
R-HSA-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
93100, 10 hits in 1019 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NAPRT, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
93100
PharosiQ6XQN6, Tbio

Protein Ontology

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PROi
PR:Q6XQN6
RNActiQ6XQN6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147813, Expressed in muscle tissue and 204 other tissues
ExpressionAtlasiQ6XQN6, baseline and differential
GenevisibleiQ6XQN6, HS

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785, Aldolase_TIM
IPR041619, NAPRTase_C
IPR040727, NAPRTase_N
IPR007229, Nic_PRibTrfase-Fam
IPR006405, Nic_PRibTrfase_pncB
IPR036068, Nicotinate_pribotase-like_C
PANTHERiPTHR11098, PTHR11098, 1 hit
PfamiView protein in Pfam
PF17956, NAPRTase_C, 1 hit
PF17767, NAPRTase_N, 1 hit
PIRSFiPIRSF000484, NAPRT, 1 hit
SUPFAMiSSF51690, SSF51690, 1 hit
TIGRFAMsiTIGR01513, NAPRTase_put, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPNCB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XQN6
Secondary accession number(s): A7BFI3
, Q6PJL1, Q6XQN4, Q6XQN5, Q8N5E8, Q9BRG0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 29, 2021
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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