Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 143 (17 Jun 2020)
Sequence version 2 (25 Nov 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

Gene

TPTE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate.1 Publication
Shows no phosphoinositide phosphatase activity.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei320Phosphocysteine intermediateCurated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000884 [Q6XPS3-3]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC:3.1.3.671 Publication)
Alternative name(s):
Lipid phosphatase TPIP
TPTE and PTEN homologous inositol lipid phosphatase1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPTE2
Synonyms:TPIP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000132958.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17299 TPTE2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606791 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6XPS3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi320C → S: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
93492

Open Targets

More...
OpenTargetsi
ENSG00000132958

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134917664

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6XPS3 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TPTE2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273973

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002241871 – 522Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2Add BLAST522

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6XPS3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6XPS3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6XPS3

PeptideAtlas

More...
PeptideAtlasi
Q6XPS3

PRoteomics IDEntifications database

More...
PRIDEi
Q6XPS3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
2297
67806 [Q6XPS3-1]
67807 [Q6XPS3-2]
67808 [Q6XPS3-3]
67809 [Q6XPS3-4]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q6XPS3

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6XPS3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6XPS3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be testis-specific.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132958 Expressed in right testis and 61 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6XPS3 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000132958 Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125031, 81 interactors

Protein interaction database and analysis system

More...
IntActi
Q6XPS3, 26 interactors

Molecular INTeraction database

More...
MINTi
Q6XPS3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000383089

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6XPS3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6XPS3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini210 – 386Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST177
Domaini393 – 522C2 tensin-typePROSITE-ProRule annotationAdd BLAST130

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2283 Eukaryota
COG2453 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154335

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020105_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6XPS3

KEGG Orthology (KO)

More...
KOi
K18079

Identification of Orthologs from Complete Genome Data

More...
OMAi
NCRIFHD

Database of Orthologous Groups

More...
OrthoDBi
639380at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6XPS3

TreeFam database of animal gene trees

More...
TreeFami
TF354329

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
IPR027359 Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01326 PTEN_C2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6XPS3-1) [UniParc]FASTAAdd to basket
Also known as: TPIP gamma

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNESPQTNEF KGTTEEAPAK ESPHTSEFKG AALVSPISKS MLERLSKFEV
60 70 80 90 100
EDAENVASYD SKIKKIVHSI VSSFAFGIFG VFLVLLDVTL LLADLIFTDS
110 120 130 140 150
KLYIPLEYRS ISLAIGLFFL MDVLLRVFVE GRQQYFSDLF NILDTAIIVI
160 170 180 190 200
PLLVDVIYIF FDIKLLRNIP RWTHLVRLLR LIILIRIFHL LHQKRQLEKL
210 220 230 240 250
MRRLVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS FYRNPIEEVV
260 270 280 290 300
RFLDKKHRNH YRVYNLCSER AYDPKHFHNR VSRIMIDDHN VPTLHEMVVF
310 320 330 340 350
TKEVNEWMAQ DLENIVAIHC KGGKGRTGTM VCALLIASEI FLTAEESLYY
360 370 380 390 400
FGERRTNKTH SNKFQGVETP SQNRYVGYFA QVKHLYNWNL PPRRILFIKR
410 420 430 440 450
FIIYSIRGDV CDLKVQVVME KKVVFSSTSL GNCSILHDIE TDKILINVYD
460 470 480 490 500
GPPLYDDVKV QFFSSNLPKY YDNCPFFFWF NTSFIQNNRL CLPRNELDNP
510 520
HKQKAWKIYP PEFAVEILFG EK
Length:522
Mass (Da):61,112
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CC42349355EDA9F
GO
Isoform 2 (identifier: Q6XPS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-171: Missing.

Show »
Length:482
Mass (Da):56,320
Checksum:i7AC9220C5EAA8E7F
GO
Isoform 3 (identifier: Q6XPS3-3) [UniParc]FASTAAdd to basket
Also known as: TPIP alpha

The sequence of this isoform differs from the canonical sequence as follows:
     40-77: SMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFG → R
     132-171: Missing.

Show »
Length:445
Mass (Da):52,231
Checksum:i9808843A147E838D
GO
Isoform 4 (identifier: Q6XPS3-4) [UniParc]FASTAAdd to basket
Also known as: TPIP beta

The sequence of this isoform differs from the canonical sequence as follows:
     40-170: Missing.
     435-522: ILHDIETDKI...FAVEILFGEK → REEGSTLRRANWKGEPSRRPVLD

Show »
Length:326
Mass (Da):38,263
Checksum:iE4E36B37921D7C7F
GO
Isoform 5 (identifier: Q6XPS3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-171: DSKIKKIVHS...DIKLLRNIPR → E

Show »
Length:411
Mass (Da):48,386
Checksum:iDBC2F0E1B072AFCE
GO
Isoform 6 (identifier: Q6XPS3-6) [UniParc]FASTAAdd to basket
Also known as: TPIP-C2

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: Missing.

Note: Expressed in testis, strongly inhibits cell growth in HeLa cells.Curated
Show »
Length:193
Mass (Da):22,746
Checksum:i9F5DC594BF968538
GO
Isoform 7 (identifier: Q6XPS3-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-522: NLPKYYDNCP...FAVEILFGEK → REEGSTLRRANWKGEPSRRPVLD

Show »
Length:488
Mass (Da):56,839
Checksum:iEAE72803045303C0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V171G3V171_HUMAN
Phosphatidylinositol 3,4,5-trisphos...
TPTE2 hCG_2020790
337Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti521E → K in CAD13144 (PubMed:11716755).Curated1
Sequence conflicti521E → K in AAP45146 (PubMed:14659893).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047501367V → I. Corresponds to variant dbSNP:rs2497218Ensembl.1
Natural variantiVAR_057349444I → V4 PublicationsCorresponds to variant dbSNP:rs2497218Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0475691 – 329Missing in isoform 6. 2 PublicationsAdd BLAST329
Alternative sequenceiVSP_01732240 – 170Missing in isoform 4. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_01732340 – 77SMLER…SFAFG → R in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_04450660 – 171DSKIK…RNIPR → E in isoform 5. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_017324132 – 171Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_017325435 – 522ILHDI…LFGEK → REEGSTLRRANWKGEPSRRP VLD in isoform 4. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_053978466 – 522NLPKY…LFGEK → REEGSTLRRANWKGEPSRRP VLD in isoform 7. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ421032 mRNA Translation: CAD13144.1
AJ421033 mRNA Translation: CAD13145.1
AY219890 mRNA Translation: AAP45146.1
FJ969729 mRNA Translation: ACT21090.1
AK301741 mRNA Translation: BAG63204.1
AL590076 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08219.1
BC128146 mRNA Translation: AAI28147.1
BC128147 mRNA Translation: AAI28148.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45013.1 [Q6XPS3-5]
CCDS45014.1 [Q6XPS3-1]
CCDS9285.1 [Q6XPS3-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001135440.1, NM_001141968.1 [Q6XPS3-5]
NP_001258779.1, NM_001271850.1 [Q6XPS3-6]
NP_570141.3, NM_130785.3 [Q6XPS3-3]
NP_954863.2, NM_199254.2 [Q6XPS3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000255310; ENSP00000255310; ENSG00000132958 [Q6XPS3-3]
ENST00000382978; ENSP00000372438; ENSG00000132958 [Q6XPS3-2]
ENST00000390680; ENSP00000375098; ENSG00000132958 [Q6XPS3-3]
ENST00000400103; ENSP00000382974; ENSG00000132958 [Q6XPS3-5]
ENST00000400230; ENSP00000383089; ENSG00000132958 [Q6XPS3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
93492

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:93492

UCSC genome browser

More...
UCSCi
uc001ume.4 human [Q6XPS3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ421032 mRNA Translation: CAD13144.1
AJ421033 mRNA Translation: CAD13145.1
AY219890 mRNA Translation: AAP45146.1
FJ969729 mRNA Translation: ACT21090.1
AK301741 mRNA Translation: BAG63204.1
AL590076 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08219.1
BC128146 mRNA Translation: AAI28147.1
BC128147 mRNA Translation: AAI28148.1
CCDSiCCDS45013.1 [Q6XPS3-5]
CCDS45014.1 [Q6XPS3-1]
CCDS9285.1 [Q6XPS3-3]
RefSeqiNP_001135440.1, NM_001141968.1 [Q6XPS3-5]
NP_001258779.1, NM_001271850.1 [Q6XPS3-6]
NP_570141.3, NM_130785.3 [Q6XPS3-3]
NP_954863.2, NM_199254.2 [Q6XPS3-1]

3D structure databases

SMRiQ6XPS3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125031, 81 interactors
IntActiQ6XPS3, 26 interactors
MINTiQ6XPS3
STRINGi9606.ENSP00000383089

Chemistry databases

SwissLipidsiSLP:000000884 [Q6XPS3-3]

PTM databases

DEPODiQ6XPS3
iPTMnetiQ6XPS3
PhosphoSitePlusiQ6XPS3

Polymorphism and mutation databases

BioMutaiTPTE2
DMDMi215273973

Proteomic databases

MassIVEiQ6XPS3
MaxQBiQ6XPS3
PaxDbiQ6XPS3
PeptideAtlasiQ6XPS3
PRIDEiQ6XPS3
ProteomicsDBi2297
67806 [Q6XPS3-1]
67807 [Q6XPS3-2]
67808 [Q6XPS3-3]
67809 [Q6XPS3-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22226 52 antibodies

Genome annotation databases

EnsembliENST00000255310; ENSP00000255310; ENSG00000132958 [Q6XPS3-3]
ENST00000382978; ENSP00000372438; ENSG00000132958 [Q6XPS3-2]
ENST00000390680; ENSP00000375098; ENSG00000132958 [Q6XPS3-3]
ENST00000400103; ENSP00000382974; ENSG00000132958 [Q6XPS3-5]
ENST00000400230; ENSP00000383089; ENSG00000132958 [Q6XPS3-1]
GeneIDi93492
KEGGihsa:93492
UCSCiuc001ume.4 human [Q6XPS3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
93492
DisGeNETi93492
EuPathDBiHostDB:ENSG00000132958.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TPTE2
HGNCiHGNC:17299 TPTE2
HPAiENSG00000132958 Tissue enriched (testis)
MIMi606791 gene
neXtProtiNX_Q6XPS3
OpenTargetsiENSG00000132958
PharmGKBiPA134917664

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2283 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00940000154335
HOGENOMiCLU_020105_3_0_1
InParanoidiQ6XPS3
KOiK18079
OMAiNCRIFHD
OrthoDBi639380at2759
PhylomeDBiQ6XPS3
TreeFamiTF354329

Enzyme and pathway databases

ReactomeiR-HSA-1660514 Synthesis of PIPs at the Golgi membrane

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
93492 21 hits in 778 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TPTE2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
93492
PharosiQ6XPS3 Tbio

Protein Ontology

More...
PROi
PR:Q6XPS3
RNActiQ6XPS3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132958 Expressed in right testis and 61 other tissues
ExpressionAtlasiQ6XPS3 baseline and differential

Family and domain databases

Gene3Di1.20.120.350, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit
SMARTiView protein in SMART
SM01326 PTEN_C2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPTE2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XPS3
Secondary accession number(s): A1A4X0
, A1A4X1, A8MX64, B1AQ16, B4DWZ2, Q5VUH2, Q8WWL4, Q8WWL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 25, 2008
Last modified: June 17, 2020
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again