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Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Macrobrachium rosenbergii nodavirus (MrNV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RdRp
Alternative name(s):
RNA replicase
OrganismiMacrobrachium rosenbergii nodavirus (MrNV)
Taxonomic identifieri222557 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNodaviridaeunclassified Nodaviridae
Virus hostiMacrobrachium rosenbergii (Giant fresh water prawn) [TaxID: 79674]
Proteomesi
  • UP000203150 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002236871 – 1045RNA-directed RNA polymeraseAdd BLAST1045

Structurei

3D structure databases

ProteinModelPortaliQ6XNL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini593 – 718RdRp catalyticAdd BLAST126

Sequence similaritiesi

Belongs to the nodaviridae RNA polymerase family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR001205 RNA-dir_pol_C
IPR020237 vRNA-dir_pol_C
PfamiView protein in Pfam
PF00680 RdRP_1, 1 hit
PF17501 Viral_RdRp_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q6XNL5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKCNNLLYGV ELPMCLQSSM GMVVVTGLAI VYLVIYILIY SFTHGPRLSR
60 70 80 90 100
RLASYVVIGP YEAIAKSRPA MALQRAMVDL TRRDVRTDWY PLNNLLMNKP
110 120 130 140 150
HRLSENGHKT SGAVRDAARN LITSAITSLG MDKYEISPGG HTVDEQLASH
160 170 180 190 200
RHYAVNDLHR ASADDAVKEN AVIVAIDTDY YLRDPSIYFS NNNPFILHTF
210 220 230 240 250
QPITVAGKDG DVRFTISDNQ VDYRVDGGGR WQHKVWNWCD YGEFLYLKNI
260 270 280 290 300
LGILSINWWL SFFGIRKVIY QKIQHARPWV DCPNRALVWG LPQFTRYMIT
310 320 330 340 350
WLPIEMNARE LSRVNYQCAS RPGWNCLVDH TSTKLVASIG REGNDCHVEL
360 370 380 390 400
AKEDLDVVLG LSTMQSVTSR LLQMGYKQPQ TLATVCQFYN SAAYDILSCS
410 420 430 440 450
IVARPSQPPV HWPLASEIDQ PTTSFRNYSN NIVTCGNLCP QLKRWEVLSN
460 470 480 490 500
SLEHRVTMVA NNKVPTPRIA RFAEEYVRLV VPEANVGVPY SLEDARKELD
510 520 530 540 550
KPTQVNAVNQ IWETVDMEVR RLIEAFVKNE PTNKSGRIIS SFADSRFLLK
560 570 580 590 600
FSTYTLAFRD EVLHAEHNRH WFCPGLTPNE IADKVCDYVR GVATPAEGDF
610 620 630 640 650
SNFDGRVSAW CQENVMNAVY HRWFNRKFSK ELQKYTSMLV SCPARAKRFG
660 670 680 690 700
FQYEPGVGVK SGSPTTCDLN SVLNNFTQYA AVRLTKPDLS PQEAFEQTGL
710 720 730 740 750
SFGDDSLFDK QYQLRWNYVV EQLGMELKVE PFDPSNGVTF LARVFPDPYS
760 770 780 790 800
TNTSFQDPLR TWRKLNMTSR TCVPVESAAL DRVSGYLVTD KYSPVTSEYC
810 820 830 840 850
HMIERCYMNT AESVTRRRQR KDCDREKPYW LVSGGAWPQR EGDYELMMRV
860 870 880 890 900
TAARTGFEES KLINLISQFQ SVHDPWDIKP LDYQEPSPYK DTLDIDGQPV
910 920 930 940 950
DAVDERQYQN ERNTVNLRAG AAISQMPVPS VPGGEDCNRQ SADMPGPKSS
960 970 980 990 1000
EGSEQLQGLP EQDGSNRLQC HRQPTFKAKG GSNTKGRSRK SRNGGRSISS
1010 1020 1030 1040
KTANPTTHEV GGGNGKTRVT IAKRSGPKRP HNVVSNAWET LNDNR
Length:1,045
Mass (Da):118,394
Last modified:July 5, 2004 - v1
Checksum:i229E7D36C9376032
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY222839 Genomic RNA Translation: AAO60068.1
RefSeqiNP_919036.1, NC_005094.1

Genome annotation databases

GeneIDi2943295
KEGGivg:2943295

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY222839 Genomic RNA Translation: AAO60068.1
RefSeqiNP_919036.1, NC_005094.1

3D structure databases

ProteinModelPortaliQ6XNL5
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2943295
KEGGivg:2943295

Family and domain databases

InterProiView protein in InterPro
IPR001205 RNA-dir_pol_C
IPR020237 vRNA-dir_pol_C
PfamiView protein in Pfam
PF00680 RdRP_1, 1 hit
PF17501 Viral_RdRp_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRDRP_MRNV
AccessioniPrimary (citable) accession number: Q6XNL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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