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Entry version 83 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Genome polyprotein

Gene
N/A
Organism
Petunia vein clearing virus (isolate Hohn) (PVCV)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Encodes presumably for at least four polypeptides: Movement protein (MP), capsid protein (CP), Protease (PR), and reverse transcriptase (RT).

Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1227For protease activity; shared with dimeric partnerBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1480Magnesium; catalyticPROSITE-ProRule annotation1
Metal bindingi1543Magnesium; catalyticPROSITE-ProRule annotation1
Metal bindingi1544Magnesium; catalyticPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1113 – 1126CCHC-typePROSITE-ProRule annotationAdd BLAST14

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAspartyl protease, DNA-binding, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase, Viral movement protein
Biological processTransport
LigandMagnesium, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Including the following 2 domains:
Aspartic protease (EC:3.4.23.-)
Short name:
PR
Reverse transcriptase (EC:2.7.7.49PROSITE-ProRule annotation, EC:2.7.7.7PROSITE-ProRule annotation)
Short name:
RT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPetunia vein clearing virus (isolate Hohn) (PVCV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri492095 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaPararnaviraeArtverviricotaRevtraviricetesOrterviralesCaulimoviridaePetuvirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiPetunia [TaxID: 4101]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008483 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003180631 – 2180Genome polyproteinAdd BLAST2180

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni507 – 529DisorderedSequence analysisAdd BLAST23
Regioni624 – 679DisorderedSequence analysisAdd BLAST56
Regioni703 – 809DisorderedSequence analysisAdd BLAST107
Regioni822 – 848DisorderedSequence analysisAdd BLAST27
Regioni1824 – 1848DisorderedSequence analysisAdd BLAST25
Regioni2115 – 2145DisorderedSequence analysisAdd BLAST31
Regioni2161 – 2180DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili573 – 624Sequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi627 – 679Polar residuesSequence analysisAdd BLAST53
Compositional biasi703 – 722Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi723 – 739Polar residuesSequence analysisAdd BLAST17
Compositional biasi756 – 809Polar residuesSequence analysisAdd BLAST54
Compositional biasi2120 – 2145Basic residuesSequence analysisAdd BLAST26
Compositional biasi2162 – 2180Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1113 – 1126CCHC-typePROSITE-ProRule annotationAdd BLAST14

Keywords - Domaini

Coiled coil, Zinc-finger

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.270, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR000477, RT_dom
IPR041577, RT_RNaseH_2
IPR028919, Viral_movement
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01107, MP, 1 hit
PF17919, RT_RNaseH_2, 1 hit
PF00078, RVT_1, 1 hit
PF00098, zf-CCHC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00343, ZnF_C2HC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56672, SSF56672, 1 hit
SSF57756, SSF57756, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50878, RT_POL, 1 hit
PS50158, ZF_CCHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6XKE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMTSPSDYQS NSSLATTYSN APKLSKALSN KYDYLYEVDI LKENQKISDT
60 70 80 90 100
YLPLLNPYSA FAKRSVTPWS QIRSLVQSKP RHVKEYVAAS KLDQHPVFAT
110 120 130 140 150
GEEQFVTLHI PEEFASHWKS HQFTHIHFGA VKIALTYHGR KGQPVVARLA
160 170 180 190 200
LLDTRYLEYQ HANLGTAEIT LNAGTVFITL FPNFTMSLSD ANLSTALKIQ
210 220 230 240 250
VQIQGAPLTK DSIQATLHYQ IAWRVQNHAM DLTLPGGEEA LFLKIDAGNG
260 270 280 290 300
ATQCTQVPRQ LSKEDLIKIL PDSWVTNYEK LKEPEEPLRS TEVSMSKRHD
310 320 330 340 350
KSVAISFDHS HYKKLRNTHH FMGMISDDVI VLDDPETFSK TLPSLMQTHD
360 370 380 390 400
WIHHFQLDGR AVSWYKDPFD GHCPWDIDCQ CYSCLYSEDE EDFEDGFPTK
410 420 430 440 450
YKGIPRPGSI AERKMQEEAN LKKLYEDKDP FVGSLSRPGK YEYLVRYDAP
460 470 480 490 500
SWAKDPHLTV EPTGWDSDEP ILPNQPFITR NTLPKIYMFN PLNYENNFPP
510 520 530 540 550
LSSFSKDGAD HTPKIPKRNV VLPSGAKDPT GDLEATVNWQ TENALAQNRM
560 570 580 590 600
LTTIDRTLKE TVTKVDRVSD QSSKNQGLIR VLEQQLQDLN KRICPPGTSL
610 620 630 640 650
FHFFDQQKSE MASLKEQIRL LKEQPQKNET DTPSYQSSYQ PFHNFSSPYM
660 670 680 690 700
PSNPPNSPFT NFANTPQPQP SLFSQYPIQP KSPNTFDLAK LVWEKKDAIA
710 720 730 740 750
EEKRAKKKLQ KDEVKQKTSL PPESKRPDPQ SSSHLGDQFM ISDPTLPKVY
760 770 780 790 800
ELNEPSVPSE DTSSQSYIST EESVEDTDSF SVVSEESTQL SQLSSSSNDS
810 820 830 840 850
PENNENTLPQ TFMVRPTEPE ISEVEDEVDG MTEEPIPERR PEITPPKMVG
860 870 880 890 900
TGFHTFSLDD ISITKWPERI QDFHTWMLTK QLVEREPFLI LSEFTARLSG
910 920 930 940 950
TLREWWNSVG PDDKNRFLTS QDFTWNIRIL YSYFCGDQSQ NKEELRRQIF
960 970 980 990 1000
EMKCLSYDRK KIDRHFQRMI KLFYHIGGDI SLKQAFISSL PPILSERISA
1010 1020 1030 1040 1050
LIKERGTSGT QMHVGDIRQT GFYVLDDLCS KRKFFNQMKK MSRDLEKACT
1060 1070 1080 1090 1100
KSDLIIKGDK GCSGYCNPSR RRKYKRFKLP SFKERDGRQY RKRRRFFRKS
1110 1120 1130 1140 1150
KTSKAMRQKP RSCFTCGKIG HFSRNCPQNK KSIKLISEIQ KYTGIDIEDD
1160 1170 1180 1190 1200
LESVFSIEDE PSEDTLFSLE FYEEYAGEQY QITSYEAPKT ENPPLPKIHT
1210 1220 1230 1240 1250
IVEIPQTEVK VYTSKWDKPI SVIAFYDTGA AYSIMDPAIL PSEYWIPHFR
1260 1270 1280 1290 1300
HFGTADDGIL TTTVKTKHPI TIEFFPGFKY TTKLLGSDIP GKDLLIGFDI
1310 1320 1330 1340 1350
YRQLNNKLRI GADGIRWKNQ FKRYTEIPRL FQLTTSNELQ QLEDVIKNQL
1360 1370 1380 1390 1400
CAESHVDFLS KCSHPLWLNQ DFFIQLPFKR NENINPTKAS HSGMNPEHLQ
1410 1420 1430 1440 1450
LALKECDELQ QFDLIEPSDS QWACEAFYVN KRSEQVRGKL RLVINYQPLN
1460 1470 1480 1490 1500
HFLQDDKFPI PNKLTLFSHL SKAKLFSKFD LKSGFWQLGI HPNERPKTGF
1510 1520 1530 1540 1550
CIPDRHFQWK VMPFGLKTAP SLFQKAMIKI FQPILFSALV YIDDILLFSE
1560 1570 1580 1590 1600
TLEDHIKLLN QFISLVKKFG VMLSAKKMIL AQNKIQFLGM DFADGTFSPA
1610 1620 1630 1640 1650
GHISLELQKF PDTNLSVKQI QQFLGIVNYI RDFIPEVTEH ISPLSDMLKK
1660 1670 1680 1690 1700
KPPAWGKCQD NAVKQLKQLA QQVKSLHIPS EGKKILQTDA SDQYWSAVLL
1710 1720 1730 1740 1750
EEHNGKRKIC GFASGKFKVS EQHYHSTFKE ILAVKNGIKK FNFFLIHTNF
1760 1770 1780 1790 1800
LVEMDMRAFP KMIRLNPKIV PNSQLLRWAQ WFSPYQFEVK HLKGKDNILA
1810 1820 1830 1840 1850
DFLSRPHEFS QRLKNSPKVL MFQRRTRSNS TKSKADSSQS TGSSYKLSHN
1860 1870 1880 1890 1900
LPENPPEAFD LDYPWDTSVF LERRTFYELQ VFKKYGGSIL RPFGVDPEYP
1910 1920 1930 1940 1950
FAHIFIPNPT DFSEDLLWMF WYLLNHFHIL MEFRCSKFSK FDQVNPWMMK
1960 1970 1980 1990 2000
FLLWFNNHNY WASLFKCMKG IKKYVVIWFY RPVNYYQGKL CALPHSSIVK
2010 2020 2030 2040 2050
WNHVSVLNDE DEYSELQRFI FQENKCIPKE IWPGSLGSWN YGNSDHPHGQ
2060 2070 2080 2090 2100
WIRDALREYR EMNDYFQDAQ DPYPAYSKVD LTQEELNTLR ITRSYGSSSE
2110 2120 2130 2140 2150
DADMVKRSIY TVQSNIVKNS PRKRKGKAKS KSSTRNEKRR AKNKCKYRSL
2160 2170 2180
HGEDWWIELG YSTKPSTPSW TQDSSSEPCI
Length:2,180
Mass (Da):252,579
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i064C7E35DEE22E13
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY228106 Genomic DNA Translation: AAO67368.1
AY228106 Genomic DNA Translation: AAO67369.1 Sequence problems.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228106 Genomic DNA Translation: AAO67368.1
AY228106 Genomic DNA Translation: AAO67369.1 Sequence problems.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di3.30.70.270, 2 hits
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR000477, RT_dom
IPR041577, RT_RNaseH_2
IPR028919, Viral_movement
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf
PfamiView protein in Pfam
PF01107, MP, 1 hit
PF17919, RT_RNaseH_2, 1 hit
PF00078, RVT_1, 1 hit
PF00098, zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343, ZnF_C2HC, 1 hit
SUPFAMiSSF56672, SSF56672, 1 hit
SSF57756, SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50878, RT_POL, 1 hit
PS50158, ZF_CCHC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_PVCV2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XKE6
Secondary accession number(s): Q6XKE5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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