Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prostaglandin D2 receptor 2

Gene

Ptgdr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391908 Prostanoid ligand receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor 2
Alternative name(s):
G protein-coupled receptor 44
Gene namesi
Name:Ptgdr2
Synonyms:Crth2, Gpr44
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311986 Ptgdr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini56 – 71CytoplasmicSequence analysisAdd BLAST16
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 104ExtracellularSequence analysisAdd BLAST12
Transmembranei105 – 125Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini126 – 147CytoplasmicSequence analysisAdd BLAST22
Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini169 – 209ExtracellularSequence analysisAdd BLAST41
Transmembranei210 – 230Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini231 – 245CytoplasmicSequence analysisAdd BLAST15
Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini267 – 284ExtracellularSequence analysisAdd BLAST18
Transmembranei285 – 305Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini306 – 403CytoplasmicSequence analysisAdd BLAST98

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075112
GuidetoPHARMACOLOGYi339

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004159261 – 403Prostaglandin D2 receptor 2Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 198PROSITE-ProRule annotation
Modified residuei330PhosphoserineCombined sources1
Modified residuei349PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6XKD3
PRIDEiQ6XKD3

PTM databases

iPTMnetiQ6XKD3
PhosphoSitePlusiQ6XKD3

Expressioni

Gene expression databases

BgeeiENSRNOG00000036631
GenevisibleiQ6XKD3 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066082

Chemistry databases

BindingDBiQ6XKD3

Structurei

3D structure databases

ProteinModelPortaliQ6XKD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi329 – 332Involved in the recycling of CRTH2By similarity4

Domaini

The 329-DSEL-332 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for GRK2 and GPRK5/GRK5 to promote agonist-induced internalization (By similarity). Thr-351 is a major site for PKC-induced internalization of the receptor (By similarity).By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IV6V Eukaryota
ENOG410YAX7 LUCA
GeneTreeiENSGT00760000118990
HOVERGENiHBG099857
InParanoidiQ6XKD3
KOiK06715
OMAiQTVVTTW
OrthoDBiEOG091G0FTA
PhylomeDBiQ6XKD3

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6XKD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANITLKPLC PLLEEMVQLP NHSNSSLRYI DHVSVLLHGL ASLLGLVENG
60 70 80 90 100
LILFVVGCRM RQTVVTTWVL HLALSDLLAA ASLPFFTYFL AVGHSWELGT
110 120 130 140 150
TFCKLHSSVF FLNMFASGFL LSAISLDRCL QVVRPVWAQN HRTVAAAHRV
160 170 180 190 200
CLMLWALAVL NTVPYFVFRD TIPRRDGRIM CYYNMLLLNP GSDRDTTCDY
210 220 230 240 250
RQKALAVSKF LLAFMVPLAI IASSHVAVSL QLHHRGRQRT GRFVRLVAAI
260 270 280 290 300
VVAFILCWGP YHIFSLLEAR AHSVTTLRQL ASRGLPFVTS LAFFNSVVNP
310 320 330 340 350
LLYVLTCPDM LHKLRRSLLT VLESVLVEDS DLSTGPGKRC RRRHRRRASS
360 370 380 390 400
TTTPASTLLL ADRFPQLRPA RLIGWMRRGS AELPRRVREQ SQEKQGSLSC

TLD
Length:403
Mass (Da):45,316
Last modified:July 5, 2004 - v1
Checksum:iA89A0125DCB29885
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228550 mRNA Translation: AAP57088.1
CH473953 Genomic DNA Translation: EDM12854.1
RefSeqiNP_001012070.1, NM_001012070.1
XP_006231102.1, XM_006231040.3
XP_008758453.1, XM_008760231.2
XP_017444751.1, XM_017589262.1
XP_017444752.1, XM_017589263.1
XP_017444753.1, XM_017589264.1
UniGeneiRn.198542

Genome annotation databases

EnsembliENSRNOT00000054808; ENSRNOP00000066082; ENSRNOG00000036631
GeneIDi309212
KEGGirno:309212
UCSCiRGD:1311986 rat

Similar proteinsi

Entry informationi

Entry nameiPD2R2_RAT
AccessioniPrimary (citable) accession number: Q6XKD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health