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Entry version 98 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Probable serine/threonine-protein kinase roco11

Gene

roco11

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1216ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1313Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi392 – 399GTPPROSITE-ProRule annotation8
Nucleotide bindingi448 – 452GTPPROSITE-ProRule annotation5
Nucleotide bindingi507 – 510GTPPROSITE-ProRule annotation4
Nucleotide bindingi1191 – 1199ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • sorocarp stalk morphogenesis Source: dictyBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, GTP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable serine/threonine-protein kinase roco11 (EC:2.7.11.1)
Alternative name(s):
Ras of complex proteins and C-terminal of roc 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:roco11
ORF Names:DDB_G0268636
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0268636 roco11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003588971 – 1487Probable serine/threonine-protein kinase roco11Add BLAST1487

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6XHA5

PRoteomics IDEntifications database

More...
PRIDEi
Q6XHA5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0191297

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6XHA5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati295 – 316LRR 1Add BLAST22
Repeati318 – 340LRR 2Add BLAST23
Repeati341 – 362LRR 3Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini379 – 564RocPROSITE-ProRule annotationAdd BLAST186
Domaini1185 – 1452Protein kinasePROSITE-ProRule annotationAdd BLAST268

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni379 – 564Small GTPase-likeAdd BLAST186

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi83 – 100Poly-GlnAdd BLAST18
Compositional biasi119 – 124Poly-His6
Compositional biasi125 – 139Poly-GlnAdd BLAST15
Compositional biasi412 – 415Poly-Ser4
Compositional biasi595 – 620Asn-richAdd BLAST26
Compositional biasi630 – 641Poly-ThrAdd BLAST12
Compositional biasi897 – 926Ser-richAdd BLAST30
Compositional biasi925 – 931Poly-Thr7
Compositional biasi954 – 1006Poly-AsnAdd BLAST53

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0192 Eukaryota
COG1100 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6XHA5

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6XHA5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032171 COR
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR027417 P-loop_NTPase
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR020859 ROC_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR020635 Tyr_kinase_cat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16095 COR, 1 hit
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 3 hits
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS51424 ROC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6XHA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METSQIRNGF NKVEVDVVGP LKDLLVRVMK NINTPFKILN ETFKINYCDQ
60 70 80 90 100
QETKTKSSFY IQTLDANDKS SLELTKSAIK NIQMQQQQQQ QQQQQQQQQQ
110 120 130 140 150
HHDIFQFTQP SSSHNHSNHH HHHHQQQLQQ QQQQQLQQQM KTPKLLFFIV
160 170 180 190 200
MSVGVGKSYI KNIKEEAGTI PILEWFTNYI RSWEEVFKLT SNQVTSHIKR
210 220 230 240 250
QLLTKACTTG NINLLDEILL SGISKEQIKE TQTIGHGIIL KSLIVNNLDS
260 270 280 290 300
IVVSGSMSLL GAVIDNDNDK KGSSLILSKL NLNLFPKSII TACFNLAELD
310 320 330 340 350
LSYNNIKEIP KEICQLKHLK ILNMNNNQLD DLPLELANLT NLKYLAVQDN
360 370 380 390 400
PLNKFPHHII EQGTKRTLVF LKNIIEGKKS ETWNKVKLMF VGQEGVGKSS
410 420 430 440 450
LCKALMGSRR RSSSSFAAEL QKSGDTISTE GVKIQSIKGK KIDFYAWDFG
460 470 480 490 500
GQQVFYPTHQ FFLTNQALYL LVFKLTDPNF AERVNYWTLQ IKANSGLSVP
510 520 530 540 550
MIFLVGTHCD ACTPEQLSSA EQILKENFVK YSRIRQNAIS FVSCTNGTGI
560 570 580 590 600
KELKKILTNE AEKSNLIKSN IPGSYLILEQ RLTDRGANSS RILINQNNIN
610 620 630 640 650
QNNNNNNNNN NHNNCNNNEN CTTTAATAGT TTMTSTTTTT TNYSNENILN
660 670 680 690 700
TSSNSLIALF TRSNSNSNLS NNYQKPLVNQ KYIDYNDFER ECKLSHLAQE
710 720 730 740 750
EIQGATEFLH NMGIILHYDT PILRSLVVLD PQWLADVMSS LITFSHNWIK
760 770 780 790 800
NGILNHSELV SIWSGKYDQS IWPSLLKLLE KFEVSYELPN EFPSRSLIPS
810 820 830 840 850
LLPEEPIDRI QEIKEKLWIP LPEAIESKRV QIFGCQYNFD FMPLGFFPRL
860 870 880 890 900
LLRILLIKGI DIKTYWANGI LLDILTTEDI KIQKLNHKKH SILPNNSSST
910 920 930 940 950
SSSTSSSTSS STSSSSSSST SSSSTSTTTT TVQIQSSPFG NSTTIVNKLT
960 970 980 990 1000
NIDNNNNNNN NNNNNNNNNN NINNNNNNNN NNNNNNNNNN NNNNNNNNNN
1010 1020 1030 1040 1050
NNNNNNIKNI INNFENQNNL NNIITNNFGG KFEIIKKNDF ESPLSSKKPK
1060 1070 1080 1090 1100
HQVLVTFKNQ KSFESKDKDT YKLNVEIRSF NVSNNNDKDF LASLFFQQLL
1110 1120 1130 1140 1150
STIDTLLSGS YGGLKVTRLI PCIHCIEKDP HSEPHLFDIN SCISQLLLGK
1160 1170 1180 1190 1200
SQLVCGKDST TPVRIDYIAP DLSIKKIPIL LEDQVVCEEQ IGVGGFGLVH
1210 1220 1230 1240 1250
KGKLILQDKS LVVAIKSYIV GNSSASDIIR KFQEFHHEMY IMSSLNHLNI
1260 1270 1280 1290 1300
VKLFGSMQNP PRMVMEFAPH GDLYHFLEKK KNIKWSFKVR LMLDIAKGIE
1310 1320 1330 1340 1350
YLQNQNPPIV HRDLRSPNIF LFSLDENAPV CAKVADFGLS QQSLYSVSGL
1360 1370 1380 1390 1400
LGNFQWMAPE TIGAEESYTE KIDTYSFSMI LFTILTGECP FDEFTSFGKM
1410 1420 1430 1440 1450
EFIRKIREED LRPTIPSDCP PTISNLIELC WSGDPKKRPH FSYIVKELTN
1460 1470 1480
FYYNLNLSPI PEQKSINDKS PHPDLISNGV PKLQIAK
Length:1,487
Mass (Da):168,497
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB5CD8F6D89F408B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY232273 Genomic DNA Translation: AAO83656.1
AAFI02000004 Genomic DNA Translation: EAL72907.1

NCBI Reference Sequences

More...
RefSeqi
XP_647005.1, XM_641913.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL72907; EAL72907; DDB_G0268636

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8616698

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0268636

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY232273 Genomic DNA Translation: AAO83656.1
AAFI02000004 Genomic DNA Translation: EAL72907.1
RefSeqiXP_647005.1, XM_641913.1

3D structure databases

SMRiQ6XHA5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0191297

Proteomic databases

PaxDbiQ6XHA5
PRIDEiQ6XHA5

Genome annotation databases

EnsemblProtistsiEAL72907; EAL72907; DDB_G0268636
GeneIDi8616698
KEGGiddi:DDB_G0268636

Organism-specific databases

dictyBaseiDDB_G0268636 roco11

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG1100 LUCA
InParanoidiQ6XHA5
PhylomeDBiQ6XHA5

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6XHA5

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032171 COR
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR027417 P-loop_NTPase
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR020859 ROC_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF16095 COR, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS51424 ROC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiROC11_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XHA5
Secondary accession number(s): Q55EL5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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