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Entry version 104 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Beta-lactamase

Gene

bla OXA-48

Organism
Klebsiella pneumoniae
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei70Acyl-ester intermediateUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processAntibiotic resistanceUniRule annotation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.2.6 2814

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-lactamaseUniRule annotation (EC:3.5.2.6UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bla OXA-48Imported
Synonyms:blaOXA-48Imported
ORF Names:KPE71T_00045Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid pJEG011Imported
Plasmid pKP112Imported
Plasmid pKPoxa-48N1Imported
Plasmid pKPoxa-48N2Imported
Plasmid pKpn-E1.Nr7Imported
Plasmid pOXA-48Imported
Plasmid pOXA-48E1Imported
Plasmid unnamedImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiKlebsiella pneumoniaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri573 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1287604

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509859323 – 265Beta-lactamaseSequence analysisAdd BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei73N6-carboxylysineUniRule annotation1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 259TranspeptidaseInterPro annotationAdd BLAST212

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-D beta-lactamase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K18976

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR002137 Beta-lactam_class-D_AS
IPR001460 PCN-bd_Tpept

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00905 Transpeptidase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56601 SSF56601, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00337 BETA_LACTAMASE_D, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6XEC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVLALSAVF LVASIIGMPA VAKEWQENKS WNAHFTEHKS QGVVVLWNEN
60 70 80 90 100
KQQGFTNNLK RANQAFLPAS TFKIPNSLIA LDLGVVKDEH QVFKWDGQTR
110 120 130 140 150
DIATWNRDHN LITAMKYSVV PVYQEFARQI GEARMSKMLH AFDYGNEDIS
160 170 180 190 200
GNVDSFWLDG GIRISATEQI SFLRKLYHNK LHVSERSQRI VKQAMLTEAN
210 220 230 240 250
GDYIIRAKTG YSTRIEPKIG WWVGWVELDD NVWFFAMNMD MPTSDGLGLR
260
QAITKEVLKQ EKIIP
Length:265
Mass (Da):30,359
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4EB4F122BF58EA7F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY236073 Genomic DNA Translation: AAP70012.1
JN626286 Genomic DNA Translation: AEV46197.1
KC354801 Genomic DNA Translation: AGJ73905.1
KC757416 Genomic DNA Translation: AGL12970.1
KC757417 Genomic DNA Translation: AGL13044.1
KC335143 Genomic DNA Translation: AGW25497.1
KM406491 Genomic DNA Translation: AKA86737.1
KP659188 Genomic DNA Translation: AKJ18670.1
KT265173 Genomic DNA Translation: ALA50742.1
KT265174 Genomic DNA Translation: ALA50745.1
KT265175 Genomic DNA Translation: ALA50748.1
KT265176 Genomic DNA Translation: ALA50751.1
KT265177 Genomic DNA Translation: ALA50754.1
KT265178 Genomic DNA Translation: ALA50757.1
KT265179 Genomic DNA Translation: ALA50760.1
KT265180 Genomic DNA Translation: ALA50763.1
KT265181 Genomic DNA Translation: ALA50766.1
KT265182 Genomic DNA Translation: ALA50769.1
KT265183 Genomic DNA Translation: ALA50772.1
LN864819 Genomic DNA Translation: CRN12897.1

NCBI Reference Sequences

More...
RefSeqi
WP_015059991.1, NZ_VEVL01000089.1
YP_006958782.1, NC_019154.1
YP_007878504.1, NC_021078.1
YP_008090831.1, NC_021488.1
YP_008110831.1, NC_021502.1
YP_008888785.1, NC_023027.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
13913776
15334346
15842648
15842812
17860775
39638493

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ag:AAP70012

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|573.1347.peg.5526

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY236073 Genomic DNA Translation: AAP70012.1
JN626286 Genomic DNA Translation: AEV46197.1
KC354801 Genomic DNA Translation: AGJ73905.1
KC757416 Genomic DNA Translation: AGL12970.1
KC757417 Genomic DNA Translation: AGL13044.1
KC335143 Genomic DNA Translation: AGW25497.1
KM406491 Genomic DNA Translation: AKA86737.1
KP659188 Genomic DNA Translation: AKJ18670.1
KT265173 Genomic DNA Translation: ALA50742.1
KT265174 Genomic DNA Translation: ALA50745.1
KT265175 Genomic DNA Translation: ALA50748.1
KT265176 Genomic DNA Translation: ALA50751.1
KT265177 Genomic DNA Translation: ALA50754.1
KT265178 Genomic DNA Translation: ALA50757.1
KT265179 Genomic DNA Translation: ALA50760.1
KT265180 Genomic DNA Translation: ALA50763.1
KT265181 Genomic DNA Translation: ALA50766.1
KT265182 Genomic DNA Translation: ALA50769.1
KT265183 Genomic DNA Translation: ALA50772.1
LN864819 Genomic DNA Translation: CRN12897.1
RefSeqiWP_015059991.1, NZ_VEVL01000089.1
YP_006958782.1, NC_019154.1
YP_007878504.1, NC_021078.1
YP_008090831.1, NC_021488.1
YP_008110831.1, NC_021502.1
YP_008888785.1, NC_023027.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HBRX-ray1.90A/B/C/D1-265[»]
4S2JX-ray2.54A/B/C/D1-265[»]
4S2KX-ray2.10A/B/C/D1-265[»]
4S2NX-ray2.00A/B/C/D1-265[»]
4S2PX-ray1.70A/B1-265[»]
4WMCX-ray2.30A/B/C/D/E/F/G/H24-265[»]
5DTKX-ray1.60A/B/C/D1-265[»]
5DTSX-ray1.94A/B/C/D22-265[»]
5DTTX-ray2.10A/B/C/D22-265[»]
5DVAX-ray2.50A/B/C/D22-265[»]
5FAQX-ray1.96A/B25-265[»]
5FASX-ray1.74A/B24-265[»]
5FATX-ray2.09A/B23-265[»]
5HAPX-ray1.89A/B25-265[»]
5HAQX-ray2.14A/B25-265[»]
5OFTX-ray3.20A/B23-265[»]
5QA4X-ray1.95A/B/C/D23-265[»]
5QA5X-ray1.95A/B/C/D23-265[»]
5QA6X-ray1.95A/B/C/D23-265[»]
5QA7X-ray1.82A/B/C/D23-265[»]
5QA8X-ray2.50A/B/C/D23-265[»]
5QA9X-ray1.90A/B/C/D23-265[»]
5QAAX-ray1.95A/B/C/D23-265[»]
5QABX-ray2.15A/B/C/D23-265[»]
5QACX-ray2.00A/B/C/D23-265[»]
5QADX-ray1.75A/B/C/D23-265[»]
5QAEX-ray2.10A/B/C/D23-265[»]
5QAFX-ray2.15A/B/C/D23-265[»]
5QAGX-ray2.30A/B/C/D23-265[»]
5QAHX-ray1.95A/B/C/D23-265[»]
5QAIX-ray1.90A/B/C/D23-265[»]
5QAJX-ray2.00A/B/C/D23-265[»]
5QAKX-ray1.90A/B/C/D23-265[»]
5QALX-ray1.95A/B/C/D23-265[»]
5QAMX-ray1.87A/B/C/D23-265[»]
5QANX-ray2.30A/B/C/D23-265[»]
5QAOX-ray2.00A/B/C/D23-265[»]
5QAPX-ray1.79A/B/C/D23-265[»]
5QAQX-ray2.40A/B/C/D23-265[»]
5QARX-ray2.10A/B/C/D23-265[»]
5QASX-ray1.90A/B/C/D23-265[»]
5QATX-ray1.90A/B/C/D23-265[»]
5QAUX-ray1.75A/B/C/D23-265[»]
5QAVX-ray1.72A/B/C/D23-265[»]
5QAWX-ray2.20A/B/C/D23-265[»]
5QAXX-ray2.31A/B/C/D23-265[»]
5QAYX-ray1.70A/B/C/D23-265[»]
5QAZX-ray2.20A/B/C/D23-265[»]
5QB0X-ray1.95A/B/C/D23-265[»]
5QB1X-ray1.80A/B/C/D23-265[»]
5QB2X-ray1.75A/B/C/D23-265[»]
5QB3X-ray2.00A/B/C/D23-265[»]
5QB4X-ray1.95A/B/C/D23-265[»]
6GOAX-ray2.55A/B/C/D/E/F/G/H23-265[»]
6P96X-ray1.60A/B1-265[»]
6P97X-ray1.80A/B1-265[»]
6P98X-ray1.75A/B1-265[»]
6P99X-ray2.25A/B1-265[»]
6P9CX-ray1.90A/B1-265[»]
6Q5BX-ray2.22A/B/C/D1-265[»]
6Q5FX-ray2.50A/B/C/D1-265[»]
6RJ7X-ray1.73A/B23-265[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Chemistry databases

ChEMBLiCHEMBL1287604

Genome annotation databases

GeneIDi13913776
15334346
15842648
15842812
17860775
39638493
KEGGiag:AAP70012
PATRICifig|573.1347.peg.5526

Phylogenomic databases

KOiK18976

Enzyme and pathway databases

BRENDAi3.5.2.6 2814

Family and domain databases

InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR002137 Beta-lactam_class-D_AS
IPR001460 PCN-bd_Tpept
PfamiView protein in Pfam
PF00905 Transpeptidase, 1 hit
SUPFAMiSSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS00337 BETA_LACTAMASE_D, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6XEC0_KLEPN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XEC0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, PlasmidImported
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