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Entry version 138 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
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Protein

RNA-binding motif, single-stranded-interacting protein 3

Gene

RBMS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds poly(A) and poly(U) oligoribonucleotides.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6XE24

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding motif, single-stranded-interacting protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBMS3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000144642.20

Human Gene Nomenclature Database

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HGNCi
HGNC:13427, RBMS3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605786, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6XE24

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27303

Open Targets

More...
OpenTargetsi
ENSG00000144642

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34276

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6XE24, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RBMS3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762382

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002749061 – 437RNA-binding motif, single-stranded-interacting protein 3Add BLAST437

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6XE24

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6XE24

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6XE24

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6XE24

PeptideAtlas

More...
PeptideAtlasi
Q6XE24

PRoteomics IDEntifications database

More...
PRIDEi
Q6XE24

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
33960
67796 [Q6XE24-1]
67797 [Q6XE24-2]
67798 [Q6XE24-3]
67799 [Q6XE24-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6XE24

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6XE24

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144642, Expressed in dorsal root ganglion and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6XE24, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6XE24, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000144642, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
118126, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q6XE24, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373277

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6XE24, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6XE24

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini61 – 134RRM 1PROSITE-ProRule annotationAdd BLAST74
Domaini140 – 225RRM 2PROSITE-ProRule annotationAdd BLAST86

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4733, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157131

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6XE24

Database of Orthologous Groups

More...
OrthoDBi
810893at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6XE24

TreeFam database of animal gene trees

More...
TreeFami
TF314644

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12475, RRM2_RBMS3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002343, Hud_Sxl_RNA
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR034406, RBMS3_RRM2
IPR000504, RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076, RRM_1, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00961, HUDSXLRNA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360, RRM, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6XE24-1) [UniParc]FASTAAdd to basket
Also known as: DD23-L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS
60 70 80 90 100
NNSSGEQLSK TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ
110 120 130 140 150
CKGYGFVDFD SPAAAQKAVA SLKANGVQAQ MAKQQEQDPT NLYISNLPIS
160 170 180 190 200
MDEQELENML KPFGHVISTR ILRDANGVSR GVGFARMEST EKCEVVIQHF
210 220 230 240 250
NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG RPWPREGEAG
260 270 280 290 300
MALTYDPTAA IQNGFYSSPY SIATNRMIPQ TSITPFIAAS PVSTYQVQST
310 320 330 340 350
SWMPHPPYVM QPTGAVITPT MDHPMSMQPA NMMGPLTQQM NHLSLGTTGT
360 370 380 390 400
IQSQDRIMIL HQLLCQYMTA AAPMQGTYIP QYTPVPPTAV SIEGVVADTS
410 420 430
PQTVAPSSQD TSGQQQQIAV DTSNEHAPAY SYQQSKP
Length:437
Mass (Da):47,840
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7EFC2ECFE24E323C
GO
Isoform 2 (identifier: Q6XE24-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-247: G → GEVLRGRTVPRQNR
     351-366: Missing.
     437-437: Missing.

Show »
Length:433
Mass (Da):47,384
Checksum:i77366F8B4C908862
GO
Isoform 3 (identifier: Q6XE24-3) [UniParc]FASTAAdd to basket
Also known as: DD23-S

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: Missing.
     297-313: Missing.

Show »
Length:419
Mass (Da):45,744
Checksum:iAEC2F5E15BDA4E4D
GO
Isoform 4 (identifier: Q6XE24-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-366: Missing.
     437-437: Missing.

Show »
Length:420
Mass (Da):45,822
Checksum:i2732762E9B9F9043
GO
Isoform 5 (identifier: Q6XE24-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-366: Missing.

Show »
Length:421
Mass (Da):45,919
Checksum:i19F732762E9B9F90
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JIJ9C9JIJ9_HUMAN
RNA-binding motif, single-stranded-...
RBMS3
436Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9B2C9J9B2_HUMAN
RNA-binding motif, single-stranded-...
RBMS3
264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUW5A0A1B0GUW5_HUMAN
RNA-binding motif, single-stranded-...
RBMS3
563Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTI7A0A1B0GTI7_HUMAN
RNA-binding motif, single-stranded-...
RBMS3
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC63910 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti93I → L in AAP75556 (Ref. 2) Curated1
Sequence conflicti165H → P in AAP75556 (Ref. 2) Curated1
Sequence conflicti418I → V in BAF85478 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02292726Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_022928247G → GEVLRGRTVPRQNR in isoform 2. 1 Publication1
Alternative sequenceiVSP_022929297 – 313Missing in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_022930351 – 366Missing in isoform 2, isoform 4 and isoform 5. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_022931437Missing in isoform 2 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF023259 mRNA Translation: AAC63910.1 Frameshift.
AY236871 mRNA Translation: AAP75555.1
AY236872 mRNA Translation: AAP75556.1
AK292789 mRNA Translation: BAF85478.1
AC012262 Genomic DNA No translation available.
AC021068 Genomic DNA No translation available.
AC092795 Genomic DNA No translation available.
AC092796 Genomic DNA No translation available.
AC097633 Genomic DNA No translation available.
AC098650 Genomic DNA No translation available.
AC099048 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64405.1
BC117315 mRNA Translation: AAI17316.1
BC143521 mRNA Translation: AAI43522.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33724.1 [Q6XE24-1]
CCDS33725.1 [Q6XE24-3]
CCDS33726.1 [Q6XE24-4]
CCDS54557.1 [Q6XE24-2]
CCDS54558.1 [Q6XE24-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001003792.1, NM_001003792.2 [Q6XE24-3]
NP_001003793.1, NM_001003793.2 [Q6XE24-1]
NP_001171182.1, NM_001177711.1 [Q6XE24-5]
NP_001171183.1, NM_001177712.1 [Q6XE24-2]
NP_055298.2, NM_014483.3 [Q6XE24-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000273139; ENSP00000273139; ENSG00000144642 [Q6XE24-4]
ENST00000383766; ENSP00000373276; ENSG00000144642 [Q6XE24-3]
ENST00000383767; ENSP00000373277; ENSG00000144642 [Q6XE24-1]
ENST00000452462; ENSP00000397926; ENSG00000144642 [Q6XE24-5]
ENST00000456853; ENSP00000400519; ENSG00000144642 [Q6XE24-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27303

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27303

UCSC genome browser

More...
UCSCi
uc003cek.4, human [Q6XE24-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023259 mRNA Translation: AAC63910.1 Frameshift.
AY236871 mRNA Translation: AAP75555.1
AY236872 mRNA Translation: AAP75556.1
AK292789 mRNA Translation: BAF85478.1
AC012262 Genomic DNA No translation available.
AC021068 Genomic DNA No translation available.
AC092795 Genomic DNA No translation available.
AC092796 Genomic DNA No translation available.
AC097633 Genomic DNA No translation available.
AC098650 Genomic DNA No translation available.
AC099048 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64405.1
BC117315 mRNA Translation: AAI17316.1
BC143521 mRNA Translation: AAI43522.1
CCDSiCCDS33724.1 [Q6XE24-1]
CCDS33725.1 [Q6XE24-3]
CCDS33726.1 [Q6XE24-4]
CCDS54557.1 [Q6XE24-2]
CCDS54558.1 [Q6XE24-5]
RefSeqiNP_001003792.1, NM_001003792.2 [Q6XE24-3]
NP_001003793.1, NM_001003793.2 [Q6XE24-1]
NP_001171182.1, NM_001177711.1 [Q6XE24-5]
NP_001171183.1, NM_001177712.1 [Q6XE24-2]
NP_055298.2, NM_014483.3 [Q6XE24-4]

3D structure databases

SMRiQ6XE24
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118126, 11 interactors
IntActiQ6XE24, 5 interactors
STRINGi9606.ENSP00000373277

PTM databases

iPTMnetiQ6XE24
PhosphoSitePlusiQ6XE24

Polymorphism and mutation databases

BioMutaiRBMS3
DMDMi74762382

Proteomic databases

jPOSTiQ6XE24
MassIVEiQ6XE24
MaxQBiQ6XE24
PaxDbiQ6XE24
PeptideAtlasiQ6XE24
PRIDEiQ6XE24
ProteomicsDBi33960
67796 [Q6XE24-1]
67797 [Q6XE24-2]
67798 [Q6XE24-3]
67799 [Q6XE24-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
11544, 166 antibodies

Genome annotation databases

EnsembliENST00000273139; ENSP00000273139; ENSG00000144642 [Q6XE24-4]
ENST00000383766; ENSP00000373276; ENSG00000144642 [Q6XE24-3]
ENST00000383767; ENSP00000373277; ENSG00000144642 [Q6XE24-1]
ENST00000452462; ENSP00000397926; ENSG00000144642 [Q6XE24-5]
ENST00000456853; ENSP00000400519; ENSG00000144642 [Q6XE24-2]
GeneIDi27303
KEGGihsa:27303
UCSCiuc003cek.4, human [Q6XE24-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27303
DisGeNETi27303
EuPathDBiHostDB:ENSG00000144642.20

GeneCards: human genes, protein and diseases

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GeneCardsi
RBMS3
HGNCiHGNC:13427, RBMS3
HPAiENSG00000144642, Low tissue specificity
MIMi605786, gene
neXtProtiNX_Q6XE24
OpenTargetsiENSG00000144642
PharmGKBiPA34276

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4733, Eukaryota
GeneTreeiENSGT00940000157131
InParanoidiQ6XE24
OrthoDBi810893at2759
PhylomeDBiQ6XE24
TreeFamiTF314644

Enzyme and pathway databases

PathwayCommonsiQ6XE24

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
27303, 2 hits in 839 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RBMS3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27303
PharosiQ6XE24, Tbio

Protein Ontology

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PROi
PR:Q6XE24
RNActiQ6XE24, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000144642, Expressed in dorsal root ganglion and 229 other tissues
ExpressionAtlasiQ6XE24, baseline and differential
GenevisibleiQ6XE24, HS

Family and domain databases

CDDicd12475, RRM2_RBMS3, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR002343, Hud_Sxl_RNA
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR034406, RBMS3_RRM2
IPR000504, RRM_dom
PfamiView protein in Pfam
PF00076, RRM_1, 2 hits
PRINTSiPR00961, HUDSXLRNA
SMARTiView protein in SMART
SM00360, RRM, 2 hits
SUPFAMiSSF54928, SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBMS3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XE24
Secondary accession number(s): A8K9S4
, B7ZL17, G5E9J9, O75876, Q17RI0, Q6XE23
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: December 2, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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