UniProtKB - Q6XE24 (RBMS3_HUMAN)
Protein
RNA-binding motif, single-stranded-interacting protein 3
Gene
RBMS3
Organism
Homo sapiens (Human)
Status
Functioni
Binds poly(A) and poly(U) oligoribonucleotides.1 Publication
GO - Molecular functioni
- mRNA 3'-UTR AU-rich region binding Source: UniProtKB
- mRNA 3'-UTR binding Source: GO_Central
- poly(A) binding Source: UniProtKB
- poly(U) RNA binding Source: UniProtKB
- RNA binding Source: GO_Central
GO - Biological processi
- defense response to tumor cell Source: UniProtKB
- negative regulation of canonical Wnt signaling pathway Source: UniProtKB
- negative regulation of gene expression Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q6XE24 |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding motif, single-stranded-interacting protein 3 |
Gene namesi | Name:RBMS3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13427, RBMS3 |
MIMi | 605786, gene |
neXtProti | NX_Q6XE24 |
VEuPathDBi | HostDB:ENSG00000144642.20 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
- ribonucleoprotein complex Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 27303 |
OpenTargetsi | ENSG00000144642 |
PharmGKBi | PA34276 |
Miscellaneous databases
Pharosi | Q6XE24, Tbio |
Genetic variation databases
BioMutai | RBMS3 |
DMDMi | 74762382 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274906 | 1 – 437 | RNA-binding motif, single-stranded-interacting protein 3Add BLAST | 437 |
Proteomic databases
jPOSTi | Q6XE24 |
MassIVEi | Q6XE24 |
MaxQBi | Q6XE24 |
PaxDbi | Q6XE24 |
PeptideAtlasi | Q6XE24 |
PRIDEi | Q6XE24 |
ProteomicsDBi | 33960 67796 [Q6XE24-1] 67797 [Q6XE24-2] 67798 [Q6XE24-3] 67799 [Q6XE24-4] |
PTM databases
iPTMneti | Q6XE24 |
PhosphoSitePlusi | Q6XE24 |
Expressioni
Tissue specificityi
Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000144642, Expressed in dorsal root ganglion and 229 other tissues |
ExpressionAtlasi | Q6XE24, baseline and differential |
Genevisiblei | Q6XE24, HS |
Organism-specific databases
HPAi | ENSG00000144642, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 118126, 13 interactors |
IntActi | Q6XE24, 5 interactors |
STRINGi | 9606.ENSP00000373277 |
Miscellaneous databases
RNActi | Q6XE24, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 134 | RRM 1PROSITE-ProRule annotationAdd BLAST | 74 | |
Domaini | 140 – 225 | RRM 2PROSITE-ProRule annotationAdd BLAST | 86 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4733, Eukaryota |
GeneTreei | ENSGT00940000157131 |
InParanoidi | Q6XE24 |
OMAi | HYLQTKX |
OrthoDBi | 810893at2759 |
PhylomeDBi | Q6XE24 |
TreeFami | TF314644 |
Family and domain databases
CDDi | cd12475, RRM2_RBMS3, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR002343, Hud_Sxl_RNA IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR034406, RBMS3_RRM2 IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
PRINTSi | PR00961, HUDSXLRNA |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6XE24-1) [UniParc]FASTAAdd to basket
Also known as: DD23-L
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS
60 70 80 90 100
NNSSGEQLSK TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ
110 120 130 140 150
CKGYGFVDFD SPAAAQKAVA SLKANGVQAQ MAKQQEQDPT NLYISNLPIS
160 170 180 190 200
MDEQELENML KPFGHVISTR ILRDANGVSR GVGFARMEST EKCEVVIQHF
210 220 230 240 250
NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG RPWPREGEAG
260 270 280 290 300
MALTYDPTAA IQNGFYSSPY SIATNRMIPQ TSITPFIAAS PVSTYQVQST
310 320 330 340 350
SWMPHPPYVM QPTGAVITPT MDHPMSMQPA NMMGPLTQQM NHLSLGTTGT
360 370 380 390 400
IQSQDRIMIL HQLLCQYMTA AAPMQGTYIP QYTPVPPTAV SIEGVVADTS
410 420 430
PQTVAPSSQD TSGQQQQIAV DTSNEHAPAY SYQQSKP
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JIJ9 | C9JIJ9_HUMAN | RNA-binding motif, single-stranded-... | RBMS3 | 436 | Annotation score: | ||
C9J9B2 | C9J9B2_HUMAN | RNA-binding motif, single-stranded-... | RBMS3 | 264 | Annotation score: | ||
A0A1B0GUW5 | A0A1B0GUW5_HUMAN | RNA-binding motif, single-stranded-... | RBMS3 | 563 | Annotation score: | ||
A0A1B0GTI7 | A0A1B0GTI7_HUMAN | RNA-binding motif, single-stranded-... | RBMS3 | 50 | Annotation score: |
Sequence cautioni
The sequence AAC63910 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 93 | I → L in AAP75556 (Ref. 2) Curated | 1 | |
Sequence conflicti | 165 | H → P in AAP75556 (Ref. 2) Curated | 1 | |
Sequence conflicti | 418 | I → V in BAF85478 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022927 | 26 | Missing in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_022928 | 247 | G → GEVLRGRTVPRQNR in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_022929 | 297 – 313 | Missing in isoform 3. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_022930 | 351 – 366 | Missing in isoform 2, isoform 4 and isoform 5. 3 PublicationsAdd BLAST | 16 | |
Alternative sequenceiVSP_022931 | 437 | Missing in isoform 2 and isoform 4. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF023259 mRNA Translation: AAC63910.1 Frameshift. AY236871 mRNA Translation: AAP75555.1 AY236872 mRNA Translation: AAP75556.1 AK292789 mRNA Translation: BAF85478.1 AC012262 Genomic DNA No translation available. AC021068 Genomic DNA No translation available. AC092795 Genomic DNA No translation available. AC092796 Genomic DNA No translation available. AC097633 Genomic DNA No translation available. AC098650 Genomic DNA No translation available. AC099048 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64405.1 BC117315 mRNA Translation: AAI17316.1 BC143521 mRNA Translation: AAI43522.1 |
CCDSi | CCDS33724.1 [Q6XE24-1] CCDS33725.1 [Q6XE24-3] CCDS33726.1 [Q6XE24-4] CCDS54557.1 [Q6XE24-2] CCDS54558.1 [Q6XE24-5] |
RefSeqi | NP_001003792.1, NM_001003792.2 [Q6XE24-3] NP_001003793.1, NM_001003793.2 [Q6XE24-1] NP_001171182.1, NM_001177711.1 [Q6XE24-5] NP_001171183.1, NM_001177712.1 [Q6XE24-2] NP_055298.2, NM_014483.3 [Q6XE24-4] |
Genome annotation databases
Ensembli | ENST00000273139; ENSP00000273139; ENSG00000144642 [Q6XE24-4] ENST00000383766; ENSP00000373276; ENSG00000144642 [Q6XE24-3] ENST00000383767; ENSP00000373277; ENSG00000144642 [Q6XE24-1] ENST00000452462; ENSP00000397926; ENSG00000144642 [Q6XE24-5] ENST00000456853; ENSP00000400519; ENSG00000144642 [Q6XE24-2] |
GeneIDi | 27303 |
KEGGi | hsa:27303 |
UCSCi | uc003cek.4, human [Q6XE24-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF023259 mRNA Translation: AAC63910.1 Frameshift. AY236871 mRNA Translation: AAP75555.1 AY236872 mRNA Translation: AAP75556.1 AK292789 mRNA Translation: BAF85478.1 AC012262 Genomic DNA No translation available. AC021068 Genomic DNA No translation available. AC092795 Genomic DNA No translation available. AC092796 Genomic DNA No translation available. AC097633 Genomic DNA No translation available. AC098650 Genomic DNA No translation available. AC099048 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64405.1 BC117315 mRNA Translation: AAI17316.1 BC143521 mRNA Translation: AAI43522.1 |
CCDSi | CCDS33724.1 [Q6XE24-1] CCDS33725.1 [Q6XE24-3] CCDS33726.1 [Q6XE24-4] CCDS54557.1 [Q6XE24-2] CCDS54558.1 [Q6XE24-5] |
RefSeqi | NP_001003792.1, NM_001003792.2 [Q6XE24-3] NP_001003793.1, NM_001003793.2 [Q6XE24-1] NP_001171182.1, NM_001177711.1 [Q6XE24-5] NP_001171183.1, NM_001177712.1 [Q6XE24-2] NP_055298.2, NM_014483.3 [Q6XE24-4] |
3D structure databases
SMRi | Q6XE24 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118126, 13 interactors |
IntActi | Q6XE24, 5 interactors |
STRINGi | 9606.ENSP00000373277 |
PTM databases
iPTMneti | Q6XE24 |
PhosphoSitePlusi | Q6XE24 |
Genetic variation databases
BioMutai | RBMS3 |
DMDMi | 74762382 |
Proteomic databases
jPOSTi | Q6XE24 |
MassIVEi | Q6XE24 |
MaxQBi | Q6XE24 |
PaxDbi | Q6XE24 |
PeptideAtlasi | Q6XE24 |
PRIDEi | Q6XE24 |
ProteomicsDBi | 33960 67796 [Q6XE24-1] 67797 [Q6XE24-2] 67798 [Q6XE24-3] 67799 [Q6XE24-4] |
Protocols and materials databases
Antibodypediai | 11544, 175 antibodies |
Genome annotation databases
Ensembli | ENST00000273139; ENSP00000273139; ENSG00000144642 [Q6XE24-4] ENST00000383766; ENSP00000373276; ENSG00000144642 [Q6XE24-3] ENST00000383767; ENSP00000373277; ENSG00000144642 [Q6XE24-1] ENST00000452462; ENSP00000397926; ENSG00000144642 [Q6XE24-5] ENST00000456853; ENSP00000400519; ENSG00000144642 [Q6XE24-2] |
GeneIDi | 27303 |
KEGGi | hsa:27303 |
UCSCi | uc003cek.4, human [Q6XE24-1] |
Organism-specific databases
CTDi | 27303 |
DisGeNETi | 27303 |
GeneCardsi | RBMS3 |
HGNCi | HGNC:13427, RBMS3 |
HPAi | ENSG00000144642, Low tissue specificity |
MIMi | 605786, gene |
neXtProti | NX_Q6XE24 |
OpenTargetsi | ENSG00000144642 |
PharmGKBi | PA34276 |
VEuPathDBi | HostDB:ENSG00000144642.20 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4733, Eukaryota |
GeneTreei | ENSGT00940000157131 |
InParanoidi | Q6XE24 |
OMAi | HYLQTKX |
OrthoDBi | 810893at2759 |
PhylomeDBi | Q6XE24 |
TreeFami | TF314644 |
Enzyme and pathway databases
PathwayCommonsi | Q6XE24 |
Miscellaneous databases
BioGRID-ORCSi | 27303, 2 hits in 983 CRISPR screens |
ChiTaRSi | RBMS3, human |
GenomeRNAii | 27303 |
Pharosi | Q6XE24, Tbio |
PROi | PR:Q6XE24 |
RNActi | Q6XE24, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144642, Expressed in dorsal root ganglion and 229 other tissues |
ExpressionAtlasi | Q6XE24, baseline and differential |
Genevisiblei | Q6XE24, HS |
Family and domain databases
CDDi | cd12475, RRM2_RBMS3, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR002343, Hud_Sxl_RNA IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR034406, RBMS3_RRM2 IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
PRINTSi | PR00961, HUDSXLRNA |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBMS3_HUMAN | |
Accessioni | Q6XE24Primary (citable) accession number: Q6XE24 Secondary accession number(s): A8K9S4 Q6XE23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot