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Entry version 115 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Spectrin beta chain

Gene

Sptb

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin cappingUniRule annotationARBA annotation, Actin-bindingUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spectrin beta chainUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SptbImported
Synonyms:LOC314251Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

Rat genome database

More...
RGDi
1303243, Sptb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q6XDA0

PRoteomics IDEntifications database

More...
PRIDEi
Q6XDA0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6XDA0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6XDA0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000006911, Expressed in skeletal muscle tissue and 19 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q6XDA0, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 158Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini173 – 278Calponin-homology (CH)InterPro annotationAdd BLAST106

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 32DisorderedSequence analysisAdd BLAST32
Regioni2071 – 2117DisorderedSequence analysisAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili113 – 133Sequence analysisAdd BLAST21
Coiled coili457 – 498Sequence analysisAdd BLAST42
Coiled coili785 – 805Sequence analysisAdd BLAST21
Coiled coili997 – 1017Sequence analysisAdd BLAST21
Coiled coili1096 – 1116Sequence analysisAdd BLAST21
Coiled coili1418 – 1441Sequence analysisAdd BLAST24
Coiled coili1538 – 1565Sequence analysisAdd BLAST28
Coiled coili1977 – 2001Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 16PolarSequence analysisAdd BLAST16
Compositional biasi2071 – 2091PolyampholyteSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the spectrin family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000146_1_0_1

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6XDA0

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR016343, Spectrin_bsu
IPR002017, Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 17 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002297, Spectrin_beta_subunit, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6XDA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSATEFENV GNQPPYSRIN ARWDAPDDEL DNDSSSARLF ERSRIKALAD
60 70 80 90 100
EREVVQKKTF TKWVNSHLAR VSCRISDLYK DLRDGRMLIK LLEVLSGEML
110 120 130 140 150
PRPTKGKMRI HCLENVDKAL QFLKEQRVHL ENMGSHDIVD GNHRLVLGLI
160 170 180 190 200
WTIILRFQIQ DIVVQTQEGR ETRSAKDALL LWCQMKTAGY PQVNVTNFTS
210 220 230 240 250
SWKDGLAFNA LIHKHRPDLI DFDKLKDSNA RHNLEHAFDV AERQLGIIPL
260 270 280 290 300
LDPEDVFTEN PDEKSIITYV VAFYHYFSKM KVLAVEGKRV GKVIDHAIET
310 320 330 340 350
EKMIEKYSGL ASDLLTWIEQ TISVLNSRKF ANSLSGVQQQ LQAFSTYRTV
360 370 380 390 400
EKPPKFQEKG NLEVLLFTIQ SRMRANNQKV YTPHDGKLVS DINRAWESLE
410 420 430 440 450
EAEYQRELAL RSELIRQEKL EQLARRFDRK AAMRETWLNE NQRLVTQDNF
460 470 480 490 500
GYDLAAVEAA KKKHEAIETD TAAYEERVKA LEDLAQELEK ENYHDQKRIS
510 520 530 540 550
ARKNNILRLW SYLQELLRSR RQRLEATLAL QKLFQDMLHS IDWMDEIKAH
560 570 580 590 600
ILSAEFGKHL LEVEDLLQKH KLMEADIAIQ GDKVKTITAA TLQFTEGKGY
610 620 630 640 650
QPCDPQVIQD RVSHLEQCFS ELSNMAAGRK AQLEQSKRLW KFFWEMDEAE
660 670 680 690 700
SWIKEKEQIY SSLDYGKDLT SVLILQRKHK AFEDELRGLD AHLKQIFQEA
710 720 730 740 750
EDMVAQKQFG HPQIETRVKE VSAQWDHLKE LAAFRKKDLQ DAENFFQFQG
760 770 780 790 800
DADDLKAWLQ DAHRLLSGED VGQDEGATRA LGKKHKEFLE ELEESRGVME
810 820 830 840 850
HLENQAQGFP EEFRDSPDVT NRLQALRKLY QQVMAQAELR GHKLQEALDL
860 870 880 890 900
YTVFGESDAC ELWMTEKGKW LDQMDIPNTL EDLEVVQHRF DILDQEMKTL
910 920 930 940 950
MAQIDGVNLA ANNLVESGHP RSGEVKQYQD RLNKRWQAFQ AVVSEQREAV
960 970 980 990 1000
DSALRVNNYC VDCEETSKWI VDKTKVVEST KDLGQDLAGV IAIQRKLSGL
1010 1020 1030 1040 1050
ERDVLAIRDR VSALERESQY LMESHPDQKE DIGQRQADVE KMWKGLQDAL
1060 1070 1080 1090 1100
QGQELSLGEA SKLQAFLQDL DDFKAWLSMA QKAVASEDMP ESLPEAEQLL
1110 1120 1130 1140 1150
QQHAAIKEEI DAHKDDYHRV KASGEKVIEG QTDPDYQLLG QRLEGLDTDW
1160 1170 1180 1190 1200
DALWRMWESR GNTLTQCLGF QEFQKDAKQA EAILSNQEYT LAHLEPPDSL
1210 1220 1230 1240 1250
AAAEAGIRKF EDFLVSMENN RDKVLSPVDS GNMLVSEGNL YSNKIKEKVQ
1260 1270 1280 1290 1300
LIEDRHMKNN EKAQEVTALL KDNLELQNFL QNCKELTLWI NDKLLTSPDI
1310 1320 1330 1340 1350
SYDEARNLHN KWMKHQAFMA ELASHQGWLE NIVAEGRQLM AEKPQFTDVV
1360 1370 1380 1390 1400
SERLEALHKL WDELQTTTKA KTEQLSAARS SDLRLQTHAD LSKWISAMED
1410 1420 1430 1440 1450
QLRSDDLGKD LTTVNRMLVK LKRVEEQVNL RKEELEELFA EAPPLGAEAG
1460 1470 1480 1490 1500
DTDMSIEKRF LDLLEPLGRR KKQLELSKAK LQISRDLEDE TLWVEERLPL
1510 1520 1530 1540 1550
AQSADYGTNL QTVQLFMKKN QTLQNEILGH APRVEDVLHR GQELVKAAEI
1560 1570 1580 1590 1600
DCQDIEERLG HLQSSWDTLR EAAAGRLQRL REAHEAQQYY LDAGEAEAWI
1610 1620 1630 1640 1650
SEQELYVFSD EPPKDEEGAI VMLKRHLRQQ RTVEEYGRNI KQLAGRAQSL
1660 1670 1680 1690 1700
LSAGHPEGEQ IIRLQGQVDK QYAGLKDMAE ERRRKLENMY HLFQLKREAD
1710 1720 1730 1740 1750
DLEQWITEKE MVASSQEMGQ DFDHVTMLRD KFRDFARETG AIGQERVDNV
1760 1770 1780 1790 1800
NSIIERLIDA GHSEAATIAE WKDGLNDMWA DLLELIDTRM QLLAASYDLH
1810 1820 1830 1840 1850
RYFYTGTEIL GLIDEKHREL PEDVGLDAST AESFHRVHTA FERELHLLGV
1860 1870 1880 1890 1900
QVQQFQDVAT RLQTAYAGEK ADAIQSKEQE VSAAWQALLD ACAGRRAQLV
1910 1920 1930 1940 1950
DTADKFRFFS MVRDLLSWME SIIRQIETQE RPRDVSSVEL LLKYHQGIKA
1960 1970 1980 1990 2000
EINTRAKNFS TCLELGESLL QRQHQASDEI REKLQQVISR RQEMNDKWEA
2010 2020 2030 2040 2050
RSDRLHMLLE VCQFSRDASV AEAWLIAQEP YLASRDFGHT VDSVEKLIKR
2060 2070 2080 2090 2100
HEAFEKSTAS WAERFAALEK PTTLELKERQ TPDRPTEEPG PQEEEGETAG
2110 2120 2130
EAPQVHHAAT ERTSPVSFMS RLSSSWESLL PEPAHPF
Length:2,137
Mass (Da):246,329
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EC476DF6970D878
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY238343 mRNA Translation: AAQ02379.1

NCBI Reference Sequences

More...
RefSeqi
NP_997687.1, NM_212522.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
314251

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:314251

UCSC genome browser

More...
UCSCi
RGD:1303243, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238343 mRNA Translation: AAQ02379.1
RefSeqiNP_997687.1, NM_212522.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ6XDA0, 1 interactor

PTM databases

iPTMnetiQ6XDA0
PhosphoSitePlusiQ6XDA0

Proteomic databases

PeptideAtlasiQ6XDA0
PRIDEiQ6XDA0

Genome annotation databases

GeneIDi314251
KEGGirno:314251
UCSCiRGD:1303243, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6710
RGDi1303243, Sptb

Phylogenomic databases

HOGENOMiCLU_000146_1_0_1
PhylomeDBiQ6XDA0

Gene expression databases

BgeeiENSRNOG00000006911, Expressed in skeletal muscle tissue and 19 other tissues

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR016343, Spectrin_bsu
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 17 hits
PIRSFiPIRSF002297, Spectrin_beta_subunit, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 17 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6XDA0_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XDA0
Secondary accession number(s): F1MAL3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: December 2, 2020
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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