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UniProtKB - Q6XDA0 (Q6XDA0_RAT)

Entry version 115 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Spectrin beta chain

Gene

Sptb

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin cappingUniRule annotationARBA annotation, Actin-bindingUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spectrin beta chainUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SptbImported
Synonyms:LOC314251Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus

Organism-specific databases

Rat genome database

More...RGDi		1303243, Sptb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		Q6XDA0

PRoteomics IDEntifications database

More...PRIDEi		Q6XDA0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6XDA0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6XDA0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000006911, Expressed in skeletal muscle tissue and 19 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q6XDA0, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 158Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini173 – 278Calponin-homology (CH)InterPro annotationAdd BLAST106

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 32DisorderedSequence analysisAdd BLAST32
Regioni2071 – 2117DisorderedSequence analysisAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili113 – 133Sequence analysisAdd BLAST21
Coiled coili457 – 498Sequence analysisAdd BLAST42
Coiled coili785 – 805Sequence analysisAdd BLAST21
Coiled coili997 – 1017Sequence analysisAdd BLAST21
Coiled coili1096 – 1116Sequence analysisAdd BLAST21
Coiled coili1418 – 1441Sequence analysisAdd BLAST24
Coiled coili1538 – 1565Sequence analysisAdd BLAST28
Coiled coili1977 – 2001Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 16PolarSequence analysisAdd BLAST16
Compositional biasi2071 – 2091PolyampholyteSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the spectrin family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000146_1_0_1

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6XDA0

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR016343, Spectrin_bsu
IPR002017, Spectrin_repeat

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 17 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002297, Spectrin_beta_subunit, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 17 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6XDA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSATEFENV GNQPPYSRIN ARWDAPDDEL DNDSSSARLF ERSRIKALAD 
        60         70         80         90        100
EREVVQKKTF TKWVNSHLAR VSCRISDLYK DLRDGRMLIK LLEVLSGEML 
       110        120        130        140        150
PRPTKGKMRI HCLENVDKAL QFLKEQRVHL ENMGSHDIVD GNHRLVLGLI 
       160        170        180        190        200
WTIILRFQIQ DIVVQTQEGR ETRSAKDALL LWCQMKTAGY PQVNVTNFTS 
       210        220        230        240        250
SWKDGLAFNA LIHKHRPDLI DFDKLKDSNA RHNLEHAFDV AERQLGIIPL 
       260        270        280        290        300
LDPEDVFTEN PDEKSIITYV VAFYHYFSKM KVLAVEGKRV GKVIDHAIET 
       310        320        330        340        350
EKMIEKYSGL ASDLLTWIEQ TISVLNSRKF ANSLSGVQQQ LQAFSTYRTV 
       360        370        380        390        400
EKPPKFQEKG NLEVLLFTIQ SRMRANNQKV YTPHDGKLVS DINRAWESLE 
       410        420        430        440        450
EAEYQRELAL RSELIRQEKL EQLARRFDRK AAMRETWLNE NQRLVTQDNF 
       460        470        480        490        500
GYDLAAVEAA KKKHEAIETD TAAYEERVKA LEDLAQELEK ENYHDQKRIS 
       510        520        530        540        550
ARKNNILRLW SYLQELLRSR RQRLEATLAL QKLFQDMLHS IDWMDEIKAH 
       560        570        580        590        600
ILSAEFGKHL LEVEDLLQKH KLMEADIAIQ GDKVKTITAA TLQFTEGKGY 
       610        620        630        640        650
QPCDPQVIQD RVSHLEQCFS ELSNMAAGRK AQLEQSKRLW KFFWEMDEAE 
       660        670        680        690        700
SWIKEKEQIY SSLDYGKDLT SVLILQRKHK AFEDELRGLD AHLKQIFQEA 
       710        720        730        740        750
EDMVAQKQFG HPQIETRVKE VSAQWDHLKE LAAFRKKDLQ DAENFFQFQG 
       760        770        780        790        800
DADDLKAWLQ DAHRLLSGED VGQDEGATRA LGKKHKEFLE ELEESRGVME 
       810        820        830        840        850
HLENQAQGFP EEFRDSPDVT NRLQALRKLY QQVMAQAELR GHKLQEALDL 
       860        870        880        890        900
YTVFGESDAC ELWMTEKGKW LDQMDIPNTL EDLEVVQHRF DILDQEMKTL 
       910        920        930        940        950
MAQIDGVNLA ANNLVESGHP RSGEVKQYQD RLNKRWQAFQ AVVSEQREAV 
       960        970        980        990       1000
DSALRVNNYC VDCEETSKWI VDKTKVVEST KDLGQDLAGV IAIQRKLSGL 
      1010       1020       1030       1040       1050
ERDVLAIRDR VSALERESQY LMESHPDQKE DIGQRQADVE KMWKGLQDAL 
      1060       1070       1080       1090       1100
QGQELSLGEA SKLQAFLQDL DDFKAWLSMA QKAVASEDMP ESLPEAEQLL 
      1110       1120       1130       1140       1150
QQHAAIKEEI DAHKDDYHRV KASGEKVIEG QTDPDYQLLG QRLEGLDTDW 
      1160       1170       1180       1190       1200
DALWRMWESR GNTLTQCLGF QEFQKDAKQA EAILSNQEYT LAHLEPPDSL 
      1210       1220       1230       1240       1250
AAAEAGIRKF EDFLVSMENN RDKVLSPVDS GNMLVSEGNL YSNKIKEKVQ 
      1260       1270       1280       1290       1300
LIEDRHMKNN EKAQEVTALL KDNLELQNFL QNCKELTLWI NDKLLTSPDI 
      1310       1320       1330       1340       1350
SYDEARNLHN KWMKHQAFMA ELASHQGWLE NIVAEGRQLM AEKPQFTDVV 
      1360       1370       1380       1390       1400
SERLEALHKL WDELQTTTKA KTEQLSAARS SDLRLQTHAD LSKWISAMED 
      1410       1420       1430       1440       1450
QLRSDDLGKD LTTVNRMLVK LKRVEEQVNL RKEELEELFA EAPPLGAEAG 
      1460       1470       1480       1490       1500
DTDMSIEKRF LDLLEPLGRR KKQLELSKAK LQISRDLEDE TLWVEERLPL 
      1510       1520       1530       1540       1550
AQSADYGTNL QTVQLFMKKN QTLQNEILGH APRVEDVLHR GQELVKAAEI 
      1560       1570       1580       1590       1600
DCQDIEERLG HLQSSWDTLR EAAAGRLQRL REAHEAQQYY LDAGEAEAWI 
      1610       1620       1630       1640       1650
SEQELYVFSD EPPKDEEGAI VMLKRHLRQQ RTVEEYGRNI KQLAGRAQSL 
      1660       1670       1680       1690       1700
LSAGHPEGEQ IIRLQGQVDK QYAGLKDMAE ERRRKLENMY HLFQLKREAD 
      1710       1720       1730       1740       1750
DLEQWITEKE MVASSQEMGQ DFDHVTMLRD KFRDFARETG AIGQERVDNV 
      1760       1770       1780       1790       1800
NSIIERLIDA GHSEAATIAE WKDGLNDMWA DLLELIDTRM QLLAASYDLH 
      1810       1820       1830       1840       1850
RYFYTGTEIL GLIDEKHREL PEDVGLDAST AESFHRVHTA FERELHLLGV 
      1860       1870       1880       1890       1900
QVQQFQDVAT RLQTAYAGEK ADAIQSKEQE VSAAWQALLD ACAGRRAQLV 
      1910       1920       1930       1940       1950
DTADKFRFFS MVRDLLSWME SIIRQIETQE RPRDVSSVEL LLKYHQGIKA 
      1960       1970       1980       1990       2000
EINTRAKNFS TCLELGESLL QRQHQASDEI REKLQQVISR RQEMNDKWEA 
      2010       2020       2030       2040       2050
RSDRLHMLLE VCQFSRDASV AEAWLIAQEP YLASRDFGHT VDSVEKLIKR 
      2060       2070       2080       2090       2100
HEAFEKSTAS WAERFAALEK PTTLELKERQ TPDRPTEEPG PQEEEGETAG 
      2110       2120       2130 
EAPQVHHAAT ERTSPVSFMS RLSSSWESLL PEPAHPF
Length:2,137
Mass (Da):246,329
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EC476DF6970D878
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY238343 mRNA Translation: AAQ02379.1

NCBI Reference Sequences

More...RefSeqi		NP_997687.1, NM_212522.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		314251

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:314251

UCSC genome browser

More...UCSCi		RGD:1303243, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238343 mRNA Translation: AAQ02379.1
RefSeqiNP_997687.1, NM_212522.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiQ6XDA0, 1 interactor

PTM databases

iPTMnetiQ6XDA0
PhosphoSitePlusiQ6XDA0

Proteomic databases

PeptideAtlasiQ6XDA0
PRIDEiQ6XDA0

Genome annotation databases

GeneIDi314251
KEGGirno:314251
UCSCiRGD:1303243, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6710
RGDi1303243, Sptb

Phylogenomic databases

HOGENOMiCLU_000146_1_0_1
PhylomeDBiQ6XDA0

Gene expression databases

BgeeiENSRNOG00000006911, Expressed in skeletal muscle tissue and 19 other tissues

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR016343, Spectrin_bsu
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 17 hits
PIRSFiPIRSF002297, Spectrin_beta_subunit, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 17 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6XDA0_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XDA0
Secondary accession number(s): F1MAL3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: December 2, 2020
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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