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Protein

Achaete-scute homolog 4

Gene

ASCL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could be a transcriptional regulator involved in skin development.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Achaete-scute homolog 4
Short name:
ASH-4
Short name:
hASH4
Alternative name(s):
Achaete-scute-like protein 4
Class A basic helix-loop-helix protein 44
Short name:
bHLHa44
Gene namesi
Name:ASCL4
Synonyms:BHLHA44, HASH4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000187855.5
HGNCiHGNC:24311 ASCL4
MIMi609155 gene
neXtProtiNX_Q6XD76

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134869300

Polymorphism and mutation databases

DMDMi74749505

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172971 – 172Achaete-scute homolog 4Add BLAST172

Proteomic databases

PaxDbiQ6XD76
PeptideAtlasiQ6XD76
PRIDEiQ6XD76
ProteomicsDBi67795

Expressioni

Tissue specificityi

Expressed in skin. 7-fold higher expression in fetal skin than in adult skin. Weak expression also detected in fetal lung, aorta and brain, and in adult stomach, kidney, ovary and breast.1 Publication

Gene expression databases

BgeeiENSG00000187855
CleanExiHS_ASCL4

Organism-specific databases

HPAiHPA036116

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125737, 3 interactors
IntActiQ6XD76, 8 interactors
MINTiQ6XD76
STRINGi9606.ENSP00000345420

Structurei

3D structure databases

ProteinModelPortaliQ6XD76
SMRiQ6XD76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 124bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
HOGENOMiHOG000034089
InParanoidiQ6XD76
KOiK09067
OMAiAIGYIKH
OrthoDBiEOG091G0OGL
PhylomeDBiQ6XD76
TreeFamiTF322889

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR015660 MASH1/Ascl1a-like
PANTHERiPTHR13935 PTHR13935, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q6XD76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METRKPAERL ALPYSLRTAP LGVPGTLPGL PRRDPLRVAL RLDAACWEWA
60 70 80 90 100
RSGCARGWQY LPVPLDSAFE PAFLRKRNER ERQRVRCVNE GYARLRDHLP
110 120 130 140 150
RELADKRLSK VETLRAAIDY IKHLQELLER QAWGLEGAAG AVPQRRAECN
160 170
SDGESKASSA PSPSSEPEEG GS
Length:172
Mass (Da):19,253
Last modified:July 5, 2004 - v1
Checksum:i94686681C4E64FB1
GO

Sequence cautioni

The sequence DAA01055 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238895 mRNA Translation: AAP69222.1
AC007622 Genomic DNA No translation available.
BC128211 mRNA Translation: AAI28212.1
BC128212 mRNA Translation: AAI28213.1
BK000275 mRNA Translation: DAA01055.1 Different initiation.
RefSeqiNP_982260.2, NM_203436.2
UniGeneiHs.149910

Genome annotation databases

EnsembliENST00000342331; ENSP00000345420; ENSG00000187855
GeneIDi121549
KEGGihsa:121549
UCSCiuc001tmr.3 human

Similar proteinsi

Entry informationi

Entry nameiASCL4_HUMAN
AccessioniPrimary (citable) accession number: Q6XD76
Secondary accession number(s): Q7RTS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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