ASCL4

Functionⁱ

Could be a transcriptional regulator involved in skin development.1 Publication

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro
RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription by RNA polymerase II Source: GO_Central
skin development
Source: UniProtKB
Non-traceable author statementⁱ
- 15475265
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Achaete-scute homolog 4 Short name: ASH-4 Short name: hASH4 Alternative name(s): Achaete-scute-like protein 4 Class A basic helix-loop-helix protein 44 Short name: bHLHa44
Gene namesⁱ	Name:ASCL4 Synonyms:BHLHA44, HASH4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000187855.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24311 ASCL4
MIMⁱ	609155 gene
neXtProtⁱ	NX_Q6XD76

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA134869300

PharmGKBⁱ

PA134869300

Polymorphism and mutation databases

DMDMⁱ	74749505

DMDMⁱ

74749505

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000317297	1 – 172	Achaete-scute homolog 4Add BLAST		172

Proteomic databases

PaxDbⁱ	Q6XD76
PeptideAtlas More...PeptideAtlasⁱ	Q6XD76
PRIDEⁱ	Q6XD76
ProteomicsDBⁱ	67795

Expressionⁱ

Tissue specificityⁱ

Expressed in skin. 7-fold higher expression in fetal skin than in adult skin. Weak expression also detected in fetal lung, aorta and brain, and in adult stomach, kidney, ovary and breast.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000187855
CleanExⁱ	HS_ASCL4

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036116

HPAⁱ

HPA036116

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TCF12	Q99081	3	EBI-10254793,EBI-722877
TCF4	P15884	3	EBI-10254793,EBI-533224

Show more details

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	125737, 3 interactors
IntActⁱ	Q6XD76, 8 interactors
Molecular INTeraction database More...MINTⁱ	Q6XD76
STRINGⁱ	9606.ENSP00000345420

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6XD76
SMRⁱ	Q6XD76
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	72 – 124	bHLHPROSITE-ProRule annotationAdd BLAST		53

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
HOGENOMⁱ	HOG000034089
InParanoidⁱ	Q6XD76
KEGG Orthology (KO) More...KOⁱ	K09067
OMAⁱ	AIGYIKH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OGL
PhylomeDBⁱ	Q6XD76
TreeFamⁱ	TF322889

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR015660 MASH1/Ascl1a-like
PANTHERⁱ	PTHR13935 PTHR13935, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6XD76-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
METRKPAERL ALPYSLRTAP LGVPGTLPGL PRRDPLRVAL RLDAACWEWA 
        60         70         80         90        100
RSGCARGWQY LPVPLDSAFE PAFLRKRNER ERQRVRCVNE GYARLRDHLP 
       110        120        130        140        150
RELADKRLSK VETLRAAIDY IKHLQELLER QAWGLEGAAG AVPQRRAECN 
       160        170 
SDGESKASSA PSPSSEPEEG GS

Length:172

Mass (Da):19,253

Last modified:July 5, 2004 - v1

Checksum:ⁱ94686681C4E64FB1

GO

Sequence cautionⁱ

The sequence DAA01055 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY238895 mRNA Translation: AAP69222.1 AC007622 Genomic DNA No translation available. BC128211 mRNA Translation: AAI28212.1 BC128212 mRNA Translation: AAI28213.1 BK000275 mRNA Translation: DAA01055.1 Different initiation.
NCBI Reference Sequences More...RefSeqⁱ	NP_982260.2, NM_203436.2
UniGeneⁱ	Hs.149910

Genome annotation databases

Ensemblⁱ	ENST00000342331; ENSP00000345420; ENSG00000187855
GeneIDⁱ	121549
KEGGⁱ	hsa:121549
UCSC genome browser More...UCSCⁱ	uc001tmr.3 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q6XD76	UPI00001973FA		HUMAN		173
ASCL4 isoform 1		PANTR		173
Uncharacterized protein		MACMU		173
Achaete-scute family bHLH transcription factor 4		GORGO		173
Uncharacterized protein		MACFA		173
+11

Protein	Similar proteins		Species	Score	Length
Q6XD76	UPI00001973FA		HUMAN		173
ASCL4 isoform 1		PANTR		173
UPI0002746CE6		PANPA		173
Achaete-scute family bHLH transcription factor 4		GORGO		173
UPI0005F57D4C		MANLE		173
+52

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY238895 mRNA Translation: AAP69222.1 AC007622 Genomic DNA No translation available. BC128211 mRNA Translation: AAI28212.1 BC128212 mRNA Translation: AAI28213.1 BK000275 mRNA Translation: DAA01055.1 Different initiation.
NCBI Reference Sequences More...RefSeqⁱ	NP_982260.2, NM_203436.2
UniGeneⁱ	Hs.149910

3D structure databases

ProteinModelPortalⁱ	Q6XD76
SMRⁱ	Q6XD76
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125737, 3 interactors
IntActⁱ	Q6XD76, 8 interactors
Molecular INTeraction database More...MINTⁱ	Q6XD76
STRINGⁱ	9606.ENSP00000345420

Polymorphism and mutation databases

DMDMⁱ	74749505

DMDMⁱ

74749505

Proteomic databases

PaxDbⁱ	Q6XD76
PeptideAtlas More...PeptideAtlasⁱ	Q6XD76
PRIDEⁱ	Q6XD76
ProteomicsDBⁱ	67795

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000342331; ENSP00000345420; ENSG00000187855
GeneIDⁱ	121549
KEGGⁱ	hsa:121549
UCSC genome browser More...UCSCⁱ	uc001tmr.3 human

Organism-specific databases

CTDⁱ	121549
EuPathDBⁱ	HostDB:ENSG00000187855.5
GeneCardsⁱ	ASCL4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24311 ASCL4
Human Protein Atlas More...HPAⁱ	HPA036116
MIMⁱ	609155 gene
neXtProtⁱ	NX_Q6XD76
PharmGKBⁱ	PA134869300
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
HOGENOMⁱ	HOG000034089
InParanoidⁱ	Q6XD76
KEGG Orthology (KO) More...KOⁱ	K09067
OMAⁱ	AIGYIKH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OGL
PhylomeDBⁱ	Q6XD76
TreeFamⁱ	TF322889

Miscellaneous databases

GenomeRNAiⁱ	121549
Protein Ontology More...PROⁱ	PR:Q6XD76
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000187855
CleanExⁱ	HS_ASCL4

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR015660 MASH1/Ascl1a-like
PANTHERⁱ	PTHR13935 PTHR13935, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ASCL4_HUMAN
Accessionⁱ	Q6XD76Primary (citable) accession number: Q6XD76 Secondary accession number(s): Q7RTS2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
	Last sequence update:	July 5, 2004
	Last modified:	June 20, 2018
	This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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Supporting data

UniProtKB - Q6XD76 (ASCL4_HUMAN)

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Achaete-scute homolog 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ