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UniProtKB - Q6XD76 (ASCL4_HUMAN)

Entry version 133 (25 May 2022)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Achaete-scute homolog 4

Gene

ASCL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could be a transcriptional regulator involved in skin development.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6XD76

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6XD76

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Achaete-scute homolog 4
Short name:
ASH-4
Short name:
hASH4
Alternative name(s):
Achaete-scute-like protein 4
Class A basic helix-loop-helix protein 44
Short name:
bHLHa44
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASCL4
Synonyms:BHLHA44, HASH4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24311, ASCL4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609155, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6XD76

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000187855

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000187855

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134869300

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6XD76, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ASCL4

Domain mapping of disease mutations (DMDM)

More...DMDMi		74749505

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003172971 – 172Achaete-scute homolog 4Add BLAST172

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6XD76

PeptideAtlas

More...PeptideAtlasi		Q6XD76

PRoteomics IDEntifications database

More...PRIDEi		Q6XD76

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67795

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skin. 7-fold higher expression in fetal skin than in adult skin. Weak expression also detected in fetal lung, aorta and brain, and in adult stomach, kidney, ovary and breast.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000187855, Expressed in tonsil and 12 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000187855, Not detected

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q6XD76
With#Exp.IntAct
ACTA1 [P68133]3EBI-10254793,EBI-367510
APBB2 - isoform 2 [Q92870-2]3EBI-10254793,EBI-21535880
ATP1A3 [P13637]3EBI-10254793,EBI-948169
CASP6 [P55212]3EBI-10254793,EBI-718729
CCK [P06307]3EBI-10254793,EBI-6624398
CHAT - isoform R [P28329-3]3EBI-10254793,EBI-25837549
CYCS [P99999]3EBI-10254793,EBI-446479
DMWD [G5E9A7]3EBI-10254793,EBI-10976677
DNAJB6 [O75190]3EBI-10254793,EBI-1053164
DR1 [Q01658]3EBI-10254793,EBI-750300
ESR1 [P03372]3EBI-10254793,EBI-78473
FGFR3 [P22607]3EBI-10254793,EBI-348399
FHL3 [Q13643]3EBI-10254793,EBI-741101
FOS [P01100]3EBI-10254793,EBI-852851
GRB2 [P62993]3EBI-10254793,EBI-401755
GRIA1 [P42261]3EBI-10254793,EBI-6980805
GRN [P28799]3EBI-10254793,EBI-747754
GTF2B [Q00403]3EBI-10254793,EBI-389564
GTF3C3 [Q9Y5Q9]3EBI-10254793,EBI-1054873
HSPB1 [P04792]3EBI-10254793,EBI-352682
HTT [P42858]6EBI-10254793,EBI-466029
ID2 [Q02363]3EBI-10254793,EBI-713450
KIF1B - isoform 2 [O60333-2]3EBI-10254793,EBI-10975473
LAMP2 - isoform LAMP-2B [P13473-2]3EBI-10254793,EBI-21591415
MBD3 - isoform 2 [O95983-2]3EBI-10254793,EBI-11978579
OPTN [Q96CV9]3EBI-10254793,EBI-748974
PDZD4 [Q17RL8]3EBI-10254793,EBI-10239064
PECAM1 [P16284]3EBI-10254793,EBI-716404
PEX26 [Q7Z412]3EBI-10254793,EBI-752057
PLD1 [Q13393]3EBI-10254793,EBI-2827556
PRPS1 [P60891]3EBI-10254793,EBI-749195
RAB11A [P62491]3EBI-10254793,EBI-745098
RAN [P62826]3EBI-10254793,EBI-286642
RNF11 [Q9Y3C5]3EBI-10254793,EBI-396669
SPRED1 [Q7Z699]3EBI-10254793,EBI-5235340
SRC [P12931]3EBI-10254793,EBI-621482
TCF12 [Q99081]3EBI-10254793,EBI-722877
TCF12 - isoform 3 [Q99081-3]3EBI-10254793,EBI-11952764
TCF4 [P15884]3EBI-10254793,EBI-533224
TCF4 - isoform SEF2-1D [P15884-3]3EBI-10254793,EBI-13636688
TSC1 [Q86WV8]3EBI-10254793,EBI-12806590
UBQLN1 [Q9UMX0]3EBI-10254793,EBI-741480
VIM [P08670]3EBI-10254793,EBI-353844
VWF - isoform 2 [P04275-2]3EBI-10254793,EBI-25896548
WFS1 [O76024]3EBI-10254793,EBI-720609
Q9Y6493EBI-10254793,EBI-25900580

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125737, 17 interactors

Protein interaction database and analysis system

More...IntActi		Q6XD76, 47 interactors

Molecular INTeraction database

More...MINTi		Q6XD76

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000345420

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6XD76, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q6XD76

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6XD76

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini72 – 124bHLHPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni144 – 172DisorderedSequence analysisAdd BLAST29

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4029, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162902

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_095919_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6XD76

Identification of Orthologs from Complete Genome Data

More...OMAi		RLDAACW

Database of Orthologous Groups

More...OrthoDBi		1545499at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6XD76

TreeFam database of animal gene trees

More...TreeFami		TF322889

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
IPR015660, MASH1/Ascl1a-like

The PANTHER Classification System

More...PANTHERi		PTHR13935, PTHR13935, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00010, HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00353, HLH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47459, SSF47459, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50888, BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6XD76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METRKPAERL ALPYSLRTAP LGVPGTLPGL PRRDPLRVAL RLDAACWEWA 
        60         70         80         90        100
RSGCARGWQY LPVPLDSAFE PAFLRKRNER ERQRVRCVNE GYARLRDHLP 
       110        120        130        140        150
RELADKRLSK VETLRAAIDY IKHLQELLER QAWGLEGAAG AVPQRRAECN 
       160        170 
SDGESKASSA PSPSSEPEEG GS
Length:172
Mass (Da):19,253
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94686681C4E64FB1
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence DAA01055 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY238895 mRNA Translation: AAP69222.1
AC007622 Genomic DNA No translation available.
BC128211 mRNA Translation: AAI28212.1
BC128212 mRNA Translation: AAI28213.1
BK000275 mRNA Translation: DAA01055.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31894.2

NCBI Reference Sequences

More...RefSeqi		NP_982260.2, NM_203436.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000342331.5; ENSP00000345420.5; ENSG00000187855.6

Database of genes from NCBI RefSeq genomes

More...GeneIDi		121549

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:121549

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000342331.5; ENSP00000345420.5; NM_203436.3; NP_982260.3

UCSC genome browser

More...UCSCi		uc001tmr.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238895 mRNA Translation: AAP69222.1
AC007622 Genomic DNA No translation available.
BC128211 mRNA Translation: AAI28212.1
BC128212 mRNA Translation: AAI28213.1
BK000275 mRNA Translation: DAA01055.1 Different initiation.
CCDSiCCDS31894.2
RefSeqiNP_982260.2, NM_203436.2

3D structure databases

AlphaFoldDBiQ6XD76
SMRiQ6XD76
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125737, 17 interactors
IntActiQ6XD76, 47 interactors
MINTiQ6XD76
STRINGi9606.ENSP00000345420

Genetic variation databases

BioMutaiASCL4
DMDMi74749505

Proteomic databases

PaxDbiQ6XD76
PeptideAtlasiQ6XD76
PRIDEiQ6XD76
ProteomicsDBi67795

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30729, 34 antibodies from 17 providers

The DNASU plasmid repository

More...DNASUi		121549

Genome annotation databases

EnsembliENST00000342331.5; ENSP00000345420.5; ENSG00000187855.6
GeneIDi121549
KEGGihsa:121549
MANE-SelectiENST00000342331.5; ENSP00000345420.5; NM_203436.3; NP_982260.3
UCSCiuc001tmr.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		121549

GeneCards: human genes, protein and diseases

More...GeneCardsi		ASCL4
HGNCiHGNC:24311, ASCL4
HPAiENSG00000187855, Not detected
MIMi609155, gene
neXtProtiNX_Q6XD76
OpenTargetsiENSG00000187855
PharmGKBiPA134869300
VEuPathDBiHostDB:ENSG00000187855

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4029, Eukaryota
GeneTreeiENSGT00940000162902
HOGENOMiCLU_095919_1_0_1
InParanoidiQ6XD76
OMAiRLDAACW
OrthoDBi1545499at2759
PhylomeDBiQ6XD76
TreeFamiTF322889

Enzyme and pathway databases

PathwayCommonsiQ6XD76
SignaLinkiQ6XD76

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		121549, 15 hits in 1088 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		121549
PharosiQ6XD76, Tdark

Protein Ontology

More...PROi		PR:Q6XD76
RNActiQ6XD76, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000187855, Expressed in tonsil and 12 other tissues

Family and domain databases

Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
IPR015660, MASH1/Ascl1a-like
PANTHERiPTHR13935, PTHR13935, 1 hit
PfamiView protein in Pfam
PF00010, HLH, 1 hit
SMARTiView protein in SMART
SM00353, HLH, 1 hit
SUPFAMiSSF47459, SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASCL4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6XD76
Secondary accession number(s): Q7RTS2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: May 25, 2022
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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