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Protein

One cut domain family member 2

Gene

Onecut2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-20 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi325 – 411CUTPROSITE-ProRule annotationAdd BLAST87
DNA bindingi427 – 486HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: MGI
  • cell fate commitment Source: MGI
  • cilium assembly Source: MGI
  • endocrine pancreas development Source: MGI
  • epithelial cell development Source: MGI
  • liver development Source: MGI
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • pancreas development Source: MGI
  • peripheral nervous system neuron development Source: MGI
  • positive regulation of cell migration Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of cell-matrix adhesion Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
One cut domain family member 2
Alternative name(s):
One cut homeobox 2
Transcription factor ONECUT-2
Short name:
OC-2
Gene namesi
Name:Onecut2
Synonyms:Oc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1891408 Onecut2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002024061 – 505One cut domain family member 2Add BLAST505

Proteomic databases

MaxQBiQ6XBJ3
PaxDbiQ6XBJ3
PRIDEiQ6XBJ3

PTM databases

PhosphoSitePlusiQ6XBJ3

Expressioni

Gene expression databases

BgeeiENSMUSG00000045991
CleanExiMM_ONECUT2
ExpressionAtlasiQ6XBJ3 baseline and differential
GenevisibleiQ6XBJ3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110798

Structurei

3D structure databases

ProteinModelPortaliQ6XBJ3
SMRiQ6XBJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 56Gly-richAdd BLAST27
Compositional biasi81 – 84Poly-Pro4
Compositional biasi93 – 100Poly-Ala8
Compositional biasi167 – 185His-richAdd BLAST19
Compositional biasi318 – 323Poly-Ser6

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2252 Eukaryota
ENOG410YWY4 LUCA
GeneTreeiENSGT00530000063019
HOGENOMiHOG000232114
HOVERGENiHBG005981
InParanoidiQ6XBJ3
OMAiNGMHHPG
OrthoDBiEOG091G0E7H
PhylomeDBiQ6XBJ3
TreeFamiTF318206

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR003350 CUT_dom
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376 CUT, 1 hit
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM01109 CUT, 1 hit
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS51042 CUT, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6XBJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAAYTAYRC LTKDLEGCAM NPELTMESLG TLHGPVGGGS GGGGGGGGGG
60 70 80 90 100
GGGGPGHEQE LLASPSPHHA GRGAAGSLRG PPPPTAHQEL GTAAAAAAAA
110 120 130 140 150
SRSAMVTSMA SILDGSDYRP ELSIPLHHAM SMSCDSSPPG MGMSNTYTTL
160 170 180 190 200
TPLQPLPPIS TVSDKFHHPH PHHHPHHHHH HHHHHQRLSG NVSGSFTLMR
210 220 230 240 250
DERGLPSMNN LYSPYKEMPS MSQSLSPLAA TPLGNGLGGL HNAQQSLPNY
260 270 280 290 300
GPPGHDKMLS PNFDAHHTAM LTRGEQHLSR GLGTPPAAMM SHLNGLHHPG
310 320 330 340 350
HTQSHGPVLA PSRERPPSSS SGSQVATSGQ LEEINTKEVA QRITAELKRY
360 370 380 390 400
SIPQAIFAQR VLCRSQGTLS DLLRNPKPWS KLKSGRETFR RMWKWLQEPE
410 420 430 440 450
FQRMSALRLA ACKRKEQEPN KDRNNSQKKS RLVFTDLQRR TLFAIFKENK
460 470 480 490 500
RPSKEMQITI SQQLGLELTT VSNFFMNARR RSLEKWQDDL GTGGSSSTSS

TCTKA
Length:505
Mass (Da):54,554
Last modified:April 20, 2010 - v2
Checksum:iEACECA422CDCB1A3
GO

Sequence cautioni

The sequence AAP69907 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151T → A in AAP69907 (PubMed:12971999).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY242995 mRNA Translation: AAP69907.1 Different initiation.
AC102106 Genomic DNA No translation available.
CCDSiCCDS29302.2
RefSeqiNP_919244.2, NM_194268.2
UniGeneiMm.234723

Genome annotation databases

EnsembliENSMUST00000115145; ENSMUSP00000110798; ENSMUSG00000045991
GeneIDi225631
KEGGimmu:225631
UCSCiuc008fef.1 mouse

Similar proteinsi

Entry informationi

Entry nameiONEC2_MOUSE
AccessioniPrimary (citable) accession number: Q6XBJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: April 20, 2010
Last modified: March 28, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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