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Protein

Zona pellucida-binding protein 2

Gene

ZPBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Is implicated in sperm-oocyte interaction during fertilization.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Zona pellucida-binding protein 2
Alternative name(s):
ZPBP-like protein
Gene namesi
Name:ZPBP2
Synonyms:ZPBPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000186075.12
HGNCiHGNC:20678 ZPBP2
MIMi608499 gene
neXtProtiNX_Q6X784

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi124626
OpenTargetsiENSG00000186075
PharmGKBiPA134894503

Polymorphism and mutation databases

BioMutaiZPBP2
DMDMi54036632

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004160121 – 338Zona pellucida-binding protein 2Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi221N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6X784
PeptideAtlasiQ6X784
PRIDEiQ6X784
ProteomicsDBi67790
67791 [Q6X784-2]

Expressioni

Tissue specificityi

Expressed specifically in testis.1 Publication

Gene expression databases

BgeeiENSG00000186075 Expressed in 30 organ(s), highest expression level in sperm
CleanExiHS_ZPBP2
ExpressionAtlasiQ6X784 baseline and differential
GenevisibleiQ6X784 HS

Organism-specific databases

HPAiHPA027997
HPA053070

Interactioni

Protein-protein interaction databases

BioGridi125879, 14 interactors
STRINGi9606.ENSP00000335384

Structurei

3D structure databases

ProteinModelPortaliQ6X784
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHHK Eukaryota
ENOG410YFNT LUCA
GeneTreeiENSGT00520000055647
HOGENOMiHOG000230972
HOVERGENiHBG079387
InParanoidiQ6X784
OMAiEPSYKCH
OrthoDBiEOG091G0C7V
PhylomeDBiQ6X784
TreeFamiTF335677

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR013783 Ig-like_fold
IPR010857 Sp38-bd
PANTHERiPTHR15443 PTHR15443, 1 hit
PfamiView protein in Pfam
PF07354 Sp38, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q6X784-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMRTCVLLSA VLWCLTGVQC PRFTLFNKKG FIYGKTGQPD KIYVELHQNS
60 70 80 90 100
PVLICMDFKL SKKEIVDPTY LWIGPNEKTL TGNNRINITE TGQLMVKDFL
110 120 130 140 150
EPLSGLYTCT LSYKTVKAET QEEKTVKKRY DFMVFAYREP DYSYQMAVRF
160 170 180 190 200
TTRSCIGRYN DVFFRVLKKI LDSLISDLSC HVIEPSYKCH SVEIPEHGLI
210 220 230 240 250
HELFIAFQVN PFAPGWKGAC NGSVDCEDTT NHNILQARDR IEDFFRSQAY
260 270 280 290 300
IFYHNFNKTL PAMHFVDHSL QVVRLDSCRP GFGKNERLHS NCASCCVVCS
310 320 330
PATFSPDVNV TCQTCVSVLT YGAKSCPQTS NKNQQYED
Length:338
Mass (Da):38,652
Last modified:July 5, 2004 - v1
Checksum:i5D5E271EAB9F3D47
GO
Isoform 2 (identifier: Q6X784-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-39: Missing.

Show »
Length:316
Mass (Da):36,140
Checksum:i63F2D847FA41CE16
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KRM0J3KRM0_HUMAN
Zona pellucida-binding protein 2
ZPBP2
265Annotation score:
J3KSF6J3KSF6_HUMAN
Zona pellucida-binding protein 2
ZPBP2
218Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05374768P → A. Corresponds to variant dbSNP:rs35591738Ensembl.1
Natural variantiVAR_06700369T → I1 PublicationCorresponds to variant dbSNP:rs189660050Ensembl.1
Natural variantiVAR_053748118A → T. Corresponds to variant dbSNP:rs35829084Ensembl.1
Natural variantiVAR_053749173S → I1 PublicationCorresponds to variant dbSNP:rs11557467Ensembl.1
Natural variantiVAR_053750335Q → E. Corresponds to variant dbSNP:rs35302660Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01168318 – 39Missing in isoform 2. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY251603 mRNA Translation: AAP83950.1
AY251604 mRNA Translation: AAP83951.1
AK292383 mRNA Translation: BAF85072.1
BC043152 mRNA Translation: AAH43152.3
CCDSiCCDS11352.1 [Q6X784-1]
CCDS11353.2 [Q6X784-2]
RefSeqiNP_942141.2, NM_198844.2 [Q6X784-2]
NP_955353.1, NM_199321.2 [Q6X784-1]
UniGeneiHs.367245

Genome annotation databases

EnsembliENST00000348931; ENSP00000335384; ENSG00000186075 [Q6X784-1]
ENST00000377940; ENSP00000367174; ENSG00000186075 [Q6X784-2]
GeneIDi124626
KEGGihsa:124626
UCSCiuc002hte.4 human [Q6X784-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY251603 mRNA Translation: AAP83950.1
AY251604 mRNA Translation: AAP83951.1
AK292383 mRNA Translation: BAF85072.1
BC043152 mRNA Translation: AAH43152.3
CCDSiCCDS11352.1 [Q6X784-1]
CCDS11353.2 [Q6X784-2]
RefSeqiNP_942141.2, NM_198844.2 [Q6X784-2]
NP_955353.1, NM_199321.2 [Q6X784-1]
UniGeneiHs.367245

3D structure databases

ProteinModelPortaliQ6X784
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125879, 14 interactors
STRINGi9606.ENSP00000335384

Polymorphism and mutation databases

BioMutaiZPBP2
DMDMi54036632

Proteomic databases

PaxDbiQ6X784
PeptideAtlasiQ6X784
PRIDEiQ6X784
ProteomicsDBi67790
67791 [Q6X784-2]

Protocols and materials databases

DNASUi124626
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348931; ENSP00000335384; ENSG00000186075 [Q6X784-1]
ENST00000377940; ENSP00000367174; ENSG00000186075 [Q6X784-2]
GeneIDi124626
KEGGihsa:124626
UCSCiuc002hte.4 human [Q6X784-1]

Organism-specific databases

CTDi124626
DisGeNETi124626
EuPathDBiHostDB:ENSG00000186075.12
GeneCardsiZPBP2
HGNCiHGNC:20678 ZPBP2
HPAiHPA027997
HPA053070
MIMi608499 gene
neXtProtiNX_Q6X784
OpenTargetsiENSG00000186075
PharmGKBiPA134894503
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHHK Eukaryota
ENOG410YFNT LUCA
GeneTreeiENSGT00520000055647
HOGENOMiHOG000230972
HOVERGENiHBG079387
InParanoidiQ6X784
OMAiEPSYKCH
OrthoDBiEOG091G0C7V
PhylomeDBiQ6X784
TreeFamiTF335677

Miscellaneous databases

GenomeRNAii124626
PROiPR:Q6X784
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186075 Expressed in 30 organ(s), highest expression level in sperm
CleanExiHS_ZPBP2
ExpressionAtlasiQ6X784 baseline and differential
GenevisibleiQ6X784 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR013783 Ig-like_fold
IPR010857 Sp38-bd
PANTHERiPTHR15443 PTHR15443, 1 hit
PfamiView protein in Pfam
PF07354 Sp38, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZPBP2_HUMAN
AccessioniPrimary (citable) accession number: Q6X784
Secondary accession number(s): A8K8L8, Q6X783, Q86XL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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