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Protein

Sclerostin domain-containing protein 1

Gene

SOSTDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.By similarity1 Publication

GO - Molecular functioni

  • BMP binding Source: UniProtKB
  • BMP receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

SIGNORiQ6X4U4

Names & Taxonomyi

Protein namesi
Recommended name:
Sclerostin domain-containing protein 1
Alternative name(s):
Ectodermal BMP inhibitor
Short name:
Ectodin
Uterine sensitization-associated gene 1 protein
Short name:
USAG-1
Gene namesi
Name:SOSTDC1
Synonyms:USAG1
ORF Names:CDA019
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000171243.7
HGNCiHGNC:21748 SOSTDC1
MIMi609675 gene
neXtProtiNX_Q6X4U4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi25928
OpenTargetsiENSG00000171243
PharmGKBiPA134937603

Polymorphism and mutation databases

BioMutaiSOSTDC1
DMDMi62287504

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000003318024 – 206Sclerostin domain-containing protein 1Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi75 ↔ 133PROSITE-ProRule annotation
Disulfide bondi89 ↔ 147PROSITE-ProRule annotation
Disulfide bondi100 ↔ 163PROSITE-ProRule annotation
Disulfide bondi104 ↔ 165PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6X4U4
PeptideAtlasiQ6X4U4
PRIDEiQ6X4U4
ProteomicsDBi67782

PTM databases

iPTMnetiQ6X4U4
PhosphoSitePlusiQ6X4U4

Expressioni

Tissue specificityi

Highly expressed in kidney and weakly in lung.1 Publication

Gene expression databases

BgeeiENSG00000171243 Expressed in 155 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SOSTDC1
ExpressionAtlasiQ6X4U4 baseline and differential
GenevisibleiQ6X4U4 HS

Interactioni

Subunit structurei

Interacts with BMP2, BMP4, BMP6 and BMP7 with high affinity.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117428, 3 interactors
STRINGi9606.ENSP00000304930

Structurei

3D structure databases

ProteinModelPortaliQ6X4U4
SMRiQ6X4U4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 170CTCKPROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Belongs to the sclerostin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIVA Eukaryota
ENOG410YEMP LUCA
GeneTreeiENSGT00390000014900
HOGENOMiHOG000252934
HOVERGENiHBG003729
InParanoidiQ6X4U4
OMAiAKPAQHH
OrthoDBiEOG091G13DX
PhylomeDBiQ6X4U4
TreeFamiTF353019

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR008835 Sclerostin/SOSTDC1
PANTHERiPTHR14903 PTHR14903, 1 hit
PfamiView protein in Pfam
PF05463 Sclerostin, 1 hit
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6X4U4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPPAIHFYL LPLACILMKS CLAFKNDATE ILYSHVVKPV PAHPSSNSTL
60 70 80 90 100
NQARNGGRHF SNTGLDRNTR VQVGCRELRS TKYISDGQCT SISPLKELVC
110 120 130 140 150
AGECLPLPVL PNWIGGGYGT KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG
160 170 180 190 200
STRTYKITVV TACKCKRYTR QHNESSHNFE SMSPAKPVQH HRERKRASKS

SKHSMS
Length:206
Mass (Da):23,307
Last modified:March 29, 2005 - v2
Checksum:i9FB3CC41E4B53834
GO
Isoform 2 (identifier: Q6X4U4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-69: NT → NRTESLTRQNYFWLFPGAFLRQLQEA

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):26,260
Checksum:iBFF4B250E7D07775
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8 – 14FYLLPLA → LSLIPLL in AAQ83296 (Ref. 3) Curated7
Sequence conflicti20S → N in AAQ83296 (Ref. 3) Curated1
Sequence conflicti41P → S in AAQ83296 (Ref. 3) Curated1
Sequence conflicti62N → S in AAQ83296 (Ref. 3) Curated1
Sequence conflicti69T → S in AAQ83296 (Ref. 3) Curated1
Sequence conflicti106P → L in CAB43243 (PubMed:17974005).Curated1
Sequence conflicti127S → G in AAQ83296 (Ref. 3) Curated1
Sequence conflicti182M → V in AAQ83296 (Ref. 3) Curated1
Sequence conflicti188V → A in AAQ83296 (Ref. 3) Curated1
Sequence conflicti205M → L in AAQ83296 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053682189Q → H. Corresponds to variant dbSNP:rs34016012Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05424068 – 69NT → NRTESLTRQNYFWLFPGAFL RQLQEA in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB059270 mRNA Translation: BAC20331.1
AF361494 mRNA Translation: AAL57219.1
AY255634 mRNA Translation: AAQ83296.1
AK093408 mRNA Translation: BAG52710.1
AC005014 Genomic DNA No translation available.
AC079155 Genomic DNA Translation: AAQ96855.1
BC008484 mRNA Translation: AAH08484.1
AL050024 mRNA Translation: CAB43243.2
CCDSiCCDS5360.1 [Q6X4U4-1]
PIRiT08710
RefSeqiNP_056279.1, NM_015464.2 [Q6X4U4-1]
XP_016867432.1, XM_017011943.1
UniGeneiHs.648106

Genome annotation databases

EnsembliENST00000307068; ENSP00000304930; ENSG00000171243 [Q6X4U4-1]
ENST00000396652; ENSP00000379889; ENSG00000171243 [Q6X4U4-2]
GeneIDi25928
KEGGihsa:25928
UCSCiuc003stg.4 human [Q6X4U4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB059270 mRNA Translation: BAC20331.1
AF361494 mRNA Translation: AAL57219.1
AY255634 mRNA Translation: AAQ83296.1
AK093408 mRNA Translation: BAG52710.1
AC005014 Genomic DNA No translation available.
AC079155 Genomic DNA Translation: AAQ96855.1
BC008484 mRNA Translation: AAH08484.1
AL050024 mRNA Translation: CAB43243.2
CCDSiCCDS5360.1 [Q6X4U4-1]
PIRiT08710
RefSeqiNP_056279.1, NM_015464.2 [Q6X4U4-1]
XP_016867432.1, XM_017011943.1
UniGeneiHs.648106

3D structure databases

ProteinModelPortaliQ6X4U4
SMRiQ6X4U4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117428, 3 interactors
STRINGi9606.ENSP00000304930

PTM databases

iPTMnetiQ6X4U4
PhosphoSitePlusiQ6X4U4

Polymorphism and mutation databases

BioMutaiSOSTDC1
DMDMi62287504

Proteomic databases

PaxDbiQ6X4U4
PeptideAtlasiQ6X4U4
PRIDEiQ6X4U4
ProteomicsDBi67782

Protocols and materials databases

DNASUi25928
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307068; ENSP00000304930; ENSG00000171243 [Q6X4U4-1]
ENST00000396652; ENSP00000379889; ENSG00000171243 [Q6X4U4-2]
GeneIDi25928
KEGGihsa:25928
UCSCiuc003stg.4 human [Q6X4U4-1]

Organism-specific databases

CTDi25928
DisGeNETi25928
EuPathDBiHostDB:ENSG00000171243.7
GeneCardsiSOSTDC1
HGNCiHGNC:21748 SOSTDC1
MIMi609675 gene
neXtProtiNX_Q6X4U4
OpenTargetsiENSG00000171243
PharmGKBiPA134937603
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIVA Eukaryota
ENOG410YEMP LUCA
GeneTreeiENSGT00390000014900
HOGENOMiHOG000252934
HOVERGENiHBG003729
InParanoidiQ6X4U4
OMAiAKPAQHH
OrthoDBiEOG091G13DX
PhylomeDBiQ6X4U4
TreeFamiTF353019

Enzyme and pathway databases

SIGNORiQ6X4U4

Miscellaneous databases

ChiTaRSiSOSTDC1 human
GeneWikiiSOSTDC1
GenomeRNAii25928
PROiPR:Q6X4U4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171243 Expressed in 155 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SOSTDC1
ExpressionAtlasiQ6X4U4 baseline and differential
GenevisibleiQ6X4U4 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR008835 Sclerostin/SOSTDC1
PANTHERiPTHR14903 PTHR14903, 1 hit
PfamiView protein in Pfam
PF05463 Sclerostin, 1 hit
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOSD1_HUMAN
AccessioniPrimary (citable) accession number: Q6X4U4
Secondary accession number(s): A8MUA6, Q96HJ7, Q9Y3U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: October 10, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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