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Entry version 122 (02 Jun 2021)
Sequence version 2 (29 Mar 2005)
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Protein

Sclerostin domain-containing protein 1

Gene

SOSTDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity).

Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6X4U4

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q6X4U4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sclerostin domain-containing protein 1
Alternative name(s):
Ectodermal BMP inhibitor
Short name:
Ectodin
Uterine sensitization-associated gene 1 protein
Short name:
USAG-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SOSTDC1
Synonyms:USAG1
ORF Names:CDA019
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21748, SOSTDC1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609675, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6X4U4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000171243.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25928

Open Targets

More...
OpenTargetsi
ENSG00000171243

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134937603

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6X4U4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SOSTDC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62287504

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 231 PublicationAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003318024 – 206Sclerostin domain-containing protein 1Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi75 ↔ 133PROSITE-ProRule annotation
Disulfide bondi89 ↔ 147PROSITE-ProRule annotation
Disulfide bondi100 ↔ 163PROSITE-ProRule annotation
Disulfide bondi104 ↔ 165PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6X4U4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6X4U4

PeptideAtlas

More...
PeptideAtlasi
Q6X4U4

PRoteomics IDEntifications database

More...
PRIDEi
Q6X4U4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
2091
67782 [Q6X4U4-1]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2944, 6 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6X4U4, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6X4U4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6X4U4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in kidney and weakly in lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171243, Expressed in pigmented layer of retina and 173 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6X4U4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6X4U4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000171243, Tissue enhanced (brain, retina, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BMP2, BMP4, BMP6 and BMP7 with high affinity.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117428, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000304930

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6X4U4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6X4U4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini75 – 170CTCKPROSITE-ProRule annotationAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni174 – 206DisorderedSequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi189 – 206Basic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sclerostin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QV5G, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014900

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_087969_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6X4U4

Identification of Orthologs from Complete Genome Data

More...
OMAi
ENWHETE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6X4U4

TreeFam database of animal gene trees

More...
TreeFami
TF353019

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006207, Cys_knot_C
IPR029034, Cystine-knot_cytokine
IPR008835, Sclerostin/SOSTDC1

The PANTHER Classification System

More...
PANTHERi
PTHR14903, PTHR14903, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05463, Sclerostin, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01225, CTCK_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6X4U4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPPAIHFYL LPLACILMKS CLAFKNDATE ILYSHVVKPV PAHPSSNSTL
60 70 80 90 100
NQARNGGRHF SNTGLDRNTR VQVGCRELRS TKYISDGQCT SISPLKELVC
110 120 130 140 150
AGECLPLPVL PNWIGGGYGT KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG
160 170 180 190 200
STRTYKITVV TACKCKRYTR QHNESSHNFE SMSPAKPVQH HRERKRASKS

SKHSMS
Length:206
Mass (Da):23,307
Last modified:March 29, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FB3CC41E4B53834
GO
Isoform 2 (identifier: Q6X4U4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-69: NT → NRTESLTRQNYFWLFPGAFLRQLQEA

Show »
Length:230
Mass (Da):26,260
Checksum:iBFF4B250E7D07775
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8 – 14FYLLPLA → LSLIPLL in AAQ83296 (Ref. 3) Curated7
Sequence conflicti20S → N in AAQ83296 (Ref. 3) Curated1
Sequence conflicti41P → S in AAQ83296 (Ref. 3) Curated1
Sequence conflicti62N → S in AAQ83296 (Ref. 3) Curated1
Sequence conflicti69T → S in AAQ83296 (Ref. 3) Curated1
Sequence conflicti106P → L in CAB43243 (PubMed:17974005).Curated1
Sequence conflicti127S → G in AAQ83296 (Ref. 3) Curated1
Sequence conflicti182M → V in AAQ83296 (Ref. 3) Curated1
Sequence conflicti188V → A in AAQ83296 (Ref. 3) Curated1
Sequence conflicti205M → L in AAQ83296 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053682189Q → H. Corresponds to variant dbSNP:rs34016012Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05424068 – 69NT → NRTESLTRQNYFWLFPGAFL RQLQEA in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB059270 mRNA Translation: BAC20331.1
AF361494 mRNA Translation: AAL57219.1
AY255634 mRNA Translation: AAQ83296.1
AK093408 mRNA Translation: BAG52710.1
AC005014 Genomic DNA No translation available.
AC079155 Genomic DNA Translation: AAQ96855.1
BC008484 mRNA Translation: AAH08484.1
AL050024 mRNA Translation: CAB43243.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5360.1 [Q6X4U4-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T08710

NCBI Reference Sequences

More...
RefSeqi
NP_056279.1, NM_015464.2 [Q6X4U4-1]
XP_016867432.1, XM_017011943.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307068; ENSP00000304930; ENSG00000171243 [Q6X4U4-1]
ENST00000396652; ENSP00000379889; ENSG00000171243 [Q6X4U4-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25928

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25928

UCSC genome browser

More...
UCSCi
uc003stg.4, human [Q6X4U4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB059270 mRNA Translation: BAC20331.1
AF361494 mRNA Translation: AAL57219.1
AY255634 mRNA Translation: AAQ83296.1
AK093408 mRNA Translation: BAG52710.1
AC005014 Genomic DNA No translation available.
AC079155 Genomic DNA Translation: AAQ96855.1
BC008484 mRNA Translation: AAH08484.1
AL050024 mRNA Translation: CAB43243.2
CCDSiCCDS5360.1 [Q6X4U4-1]
PIRiT08710
RefSeqiNP_056279.1, NM_015464.2 [Q6X4U4-1]
XP_016867432.1, XM_017011943.1

3D structure databases

SMRiQ6X4U4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117428, 3 interactors
STRINGi9606.ENSP00000304930

PTM databases

GlyConnecti2944, 6 N-Linked glycans (1 site)
GlyGeniQ6X4U4, 2 sites
iPTMnetiQ6X4U4
PhosphoSitePlusiQ6X4U4

Genetic variation databases

BioMutaiSOSTDC1
DMDMi62287504

Proteomic databases

MassIVEiQ6X4U4
PaxDbiQ6X4U4
PeptideAtlasiQ6X4U4
PRIDEiQ6X4U4
ProteomicsDBi2091
67782 [Q6X4U4-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
56432, 153 antibodies

The DNASU plasmid repository

More...
DNASUi
25928

Genome annotation databases

EnsembliENST00000307068; ENSP00000304930; ENSG00000171243 [Q6X4U4-1]
ENST00000396652; ENSP00000379889; ENSG00000171243 [Q6X4U4-2]
GeneIDi25928
KEGGihsa:25928
UCSCiuc003stg.4, human [Q6X4U4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25928
DisGeNETi25928

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SOSTDC1
HGNCiHGNC:21748, SOSTDC1
HPAiENSG00000171243, Tissue enhanced (brain, retina, stomach)
MIMi609675, gene
neXtProtiNX_Q6X4U4
OpenTargetsiENSG00000171243
PharmGKBiPA134937603
VEuPathDBiHostDB:ENSG00000171243.7

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QV5G, Eukaryota
GeneTreeiENSGT00390000014900
HOGENOMiCLU_087969_0_0_1
InParanoidiQ6X4U4
OMAiENWHETE
PhylomeDBiQ6X4U4
TreeFamiTF353019

Enzyme and pathway databases

PathwayCommonsiQ6X4U4
SIGNORiQ6X4U4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
25928, 7 hits in 985 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SOSTDC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25928
PharosiQ6X4U4, Tbio

Protein Ontology

More...
PROi
PR:Q6X4U4
RNActiQ6X4U4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
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Gene expression databases

BgeeiENSG00000171243, Expressed in pigmented layer of retina and 173 other tissues
ExpressionAtlasiQ6X4U4, baseline and differential
GenevisibleiQ6X4U4, HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207, Cys_knot_C
IPR029034, Cystine-knot_cytokine
IPR008835, Sclerostin/SOSTDC1
PANTHERiPTHR14903, PTHR14903, 1 hit
PfamiView protein in Pfam
PF05463, Sclerostin, 1 hit
PROSITEiView protein in PROSITE
PS01225, CTCK_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSOSD1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6X4U4
Secondary accession number(s): A8MUA6, Q96HJ7, Q9Y3U3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: June 2, 2021
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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