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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Avian avulavirus 1
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both activities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotation, Multifunctional enzymeSAAS annotation, Nucleotidyltransferase, RNA-directed RNA polymeraseUniRule annotationSAAS annotation, Transferase
Biological processmRNA cappingUniRule annotationSAAS annotation, mRNA processing, Viral RNA replicationUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding, S-adenosyl-L-methionineUniRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase LUniRule annotation
Short name:
Protein LUniRule annotation
Alternative name(s):
Large structural proteinUniRule annotation
ReplicaseUniRule annotation
TranscriptaseUniRule annotation
Including the following 4 domains:
RNA-directed RNA polymeraseUniRule annotation (EC:2.7.7.48UniRule annotation)
mRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.56UniRule annotation)
GDP polyribonucleotidyltransferaseUniRule annotation (EC:2.7.7.88UniRule annotation)
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2UniRule annotation (EC:2.1.1.296UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAvian avulavirus 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11176 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeAvulavirus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasmUniRule annotationSAAS annotation, VirionUniRule annotationSAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini634 – 818RdRp catalyticInterPro annotationAdd BLAST185
Domaini1745 – 1958Mononegavirus-type SAM-dependent 2'-O-MTaseInterPro annotationAdd BLAST214

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili257 – 277Sequence analysisAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the paramyxovirus L protein family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024352 L_methyltrans_paramyxo
IPR039736 L_poly_C
IPR026890 Mononeg_mRNAcap
IPR014023 Mononeg_RNA_pol_cat
IPR025786 Mononega_L_MeTrfase
IPR016269 RNA-dir_pol_paramyxovirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12803 G-7-MTase, 1 hit
PF14318 Mononeg_mRNAcap, 1 hit
PF00946 Mononeg_RNA_pol, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000830 RNA_pol_ParamyxoV, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04198 paramyx_RNAcap, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50526 RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590 SAM_MT_MNV_L, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6X1B6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSGPERAE HQIILPESHL SSPLVKHKLL YYWKLTGLPL PDECDFDHLI
60 70 80 90 100
VSRQWKKILE SAAPDTERMI KLGRAVHQTL NHNSKITGVL HPRCLEKLAS
110 120 130 140 150
IEVPDSTNKF RKIEKKIQIH NTRYGELFTR LCTNVEKKLL GSSWSNNVSR
160 170 180 190 200
SEEFNSIRTD PAFWFHSKWS KAKFGWAHFK QVPRHLIVAA RTRSAVTKFV
210 220 230 240 250
TLTHKLGQVF GTPELVMGNH TNENKSPCLT QELVLMYADM MEGRDMVNII
260 270 280 290 300
SSTATHLRSL SEKIDDILRL VDALAKDLGN QVYDVVALME GFAYGAVQLL
310 320 330 340 350
EPSGTFAGDF FAFNLQELKD TLIELLPNDV AELVTHAIAT VFSGLEQNQA
360 370 380 390 400
AEMLCLLRLW GHPLLESRIA AKAVRSQMCA PKMIDFDMIL QVLSFFKGTI
410 420 430 440 450
INGYRKKNSG VWPHVKMDTI YGKVIGQLHA DSAEISHDVM LREYKSLSAL
460 470 480 490 500
EFEPCIEYDP VTNLSMFLKD KAIAHPRDNW LASFRRNLLS EDQKRHIKEA
510 520 530 540 550
TSTNRLLIEF LESNDFDPYK EMEYLTTLEY LRDDNVAVSY SLKEKEVKVN
560 570 580 590 600
GRIFAKLTKK LRNCQVMAEG ILADQIAPFF QGNGVIQDSI SLTKSMLAMS
610 620 630 640 650
QLSFNSNKKR ITDCKERVSS NRNHDPKSKN RRRVATFITT DLQKYCLNWR
660 670 680 690 700
YQTVKLFAHA INQLMGLPHF FEWIHLRLMD TTMFVGDPFN PPSDPTDCDL
710 720 730 740 750
SRVPNDDIYI VSARGGIEGL CQKLWTMISI AAIQLAAARS HCRVACMVQG
760 770 780 790 800
DNQVIAVTRE VRSDDSPEMV WTQWLQASDN FFKEMIHVNH LNGHNLKDRE
810 820 830 840 850
TIRSDTFFLY SKRIFKDGAI LSQVLKNSSK LVLISGDLSE NTVMSCANIA
860 870 880 890 900
STIARLCENG LPKDFCYYLN YIMSCVQTYF DSEFSITHSS QPDSNQSWFE
910 920 930 940 950
DISFVHSYVL TPAQLGGLSN LQYSRLYTRN IGDPGTTAFA EVKRLEAVGL
960 970 980 990 1000
LSPSIMTNIL TRPPGNGDWA SLCNDPYSFN FETVASPNIV LKKHTQKVLF
1010 1020 1030 1040 1050
ETCSNPLLSG VHTEDNEAEE KALVEFLLNQ EVVHPRVAHA IMESSSVGRR
1060 1070 1080 1090 1100
KQIQGLVDTT NTVINIALTR RPLGIKRLMR IINYSSMHAM LFTDDVFLSN
1110 1120 1130 1140 1150
RPNHPLVSSN MCSLTLADYA RNRSWSPLTG GRKILGVSNP DTIEPVEGEI
1160 1170 1180 1190 1200
LSVSGGCKKC DSGDEQFTWF HLPSNIQLTD DTSKNPPMRV PYLGSKTQER
1210 1220 1230 1240 1250
RAASLAKIAH MSPHVKAALR ASSVLIWAYG DNEVNWTAAL KIARSRCNIS
1260 1270 1280 1290 1300
SEYLRLLSPL PTAGNLQHRL DDGITQMTFT PASLYRVSPY IHISNDSQRL
1310 1320 1330 1340 1350
FTEEGIKEGN VVYQQIMLLG LSLIESLFPM TTTKTYDEIT LHLHSKFSCC
1360 1370 1380 1390 1400
IREAPVAVPF ELLGLAPELR AVTSNKFMYD PSPVSERDFA RLDLAIFKSY
1410 1420 1430 1440 1450
ELNLESYPTI ELMNILSISS GKLIGQSVVS YDEDTSIKND AIIVYDNTRN
1460 1470 1480 1490 1500
WISEAQNSDV VRLFEYAALE VLLDCSYQLY YLRVRGLNNI VLYMSDLYKN
1510 1520 1530 1540 1550
MPGILLSNIA ATISHPIIHS RLNAVGLVNH DGSHQLADTD FIEMSAKLLV
1560 1570 1580 1590 1600
SCTRRVVSGL YAGNKYDLLF PSVLDDNLSE KMLQLISRLC CLYTVLFATT
1610 1620 1630 1640 1650
REIPKIRGLS AEEKCSVLTE YLLSDAVKPL LRSEQVSCIM SPNIITFPAN
1660 1670 1680 1690 1700
LYYMSRKSLN LIREREDRDA ILALLFPQEP LLEFRPVQDI GVRVKDPFTR
1710 1720 1730 1740 1750
QPAALLQELD LSAPARYDAF TLNEVRSEHT LPNPEEDYLV RYLFRGIGTA
1760 1770 1780 1790 1800
SSSWYKASHL LSVPEVRCAR YGNSLYLAEG SGAIMSLLEL HVPHETIYYN
1810 1820 1830 1840 1850
TLFSNEMNPP QRHFGPTPTQ FLNSVVYRNL QAEVPCKDGF IQEFRPLWRE
1860 1870 1880 1890 1900
NAEESDLTSD KAVGYITSAV PYRSVSLLHC DIEIPPGSNQ SLLDQLAINL
1910 1920 1930 1940 1950
SLIAMHSVRE GGVVIIKVLY AMGYYFHLLM NLFTPCSTKG YILSNGYACR
1960 1970 1980 1990 2000
GDMECYLIFV MGYLGGPTFV HEVVRMAKTL VQRHGTLLSK SDEITLTRLF
2010 2020 2030 2040 2050
TSQQHRVTDI LSSPLPRLMK FLRENIDAAL IEAGGQPVRP FCAESLVSTL
2060 2070 2080 2090 2100
TDMTQMTQII ASHIDTVIRS VIYMEAEGDL ADTVFLFTPY NLSTDGKKRT
2110 2120 2130 2140 2150
SLKQCTRQIL EVTILGLRVK DLNKVGDVIG LVLRGMVSLE DLIPLRTYLR
2160 2170 2180 2190 2200
RSTCPKYLKA VLGITKLKEM FTDTSLLYLT LAQQKFYMKT IGNAAKGYYS

NCDS
Length:2,204
Mass (Da):248,782
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B518A87D05FA088
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY262106 mRNA Translation: AAP86958.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262106 mRNA Translation: AAP86958.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR024352 L_methyltrans_paramyxo
IPR039736 L_poly_C
IPR026890 Mononeg_mRNAcap
IPR014023 Mononeg_RNA_pol_cat
IPR025786 Mononega_L_MeTrfase
IPR016269 RNA-dir_pol_paramyxovirus
PfamiView protein in Pfam
PF12803 G-7-MTase, 1 hit
PF14318 Mononeg_mRNAcap, 1 hit
PF00946 Mononeg_RNA_pol, 1 hit
PIRSFiPIRSF000830 RNA_pol_ParamyxoV, 1 hit
TIGRFAMsiTIGR04198 paramyx_RNAcap, 1 hit
PROSITEiView protein in PROSITE
PS50526 RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590 SAM_MT_MNV_L, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6X1B6_9MONO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6X1B6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: December 5, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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