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UniProtKB - Q6X1B6 (Q6X1B6_9MONO)

Entry version 98 (19 Jan 2022)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Avian orthoavulavirus 1
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.

ARBA annotation

RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both activities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseARBA annotation, MethyltransferaseUniRule annotationARBA annotation, Multifunctional enzymeARBA annotation, Nucleotidyltransferase, RNA-directed RNA polymeraseUniRule annotation, Transferase
Biological processmRNA cappingUniRule annotationARBA annotation, mRNA processing, Viral RNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding, S-adenosyl-L-methionineUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase LUniRule annotation
Short name:
Protein LUniRule annotation
Alternative name(s):
Large structural proteinUniRule annotation
ReplicaseUniRule annotation
TranscriptaseUniRule annotation
Including the following 5 domains:
RNA-directed RNA polymeraseUniRule annotation (EC:2.7.7.48UniRule annotation)
GTP phosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)
GDP polyribonucleotidyltransferaseUniRule annotation (EC:2.7.7.88UniRule annotation)
Alternative name(s):
PRNTaseUniRule annotation
mRNA (nucleoside-2'-O-)-methyltransferaseUniRule annotation (EC:2.1.1.-UniRule annotation)
Short name:
N1-2'-O-MTaseUniRule annotation
mRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
Short name:
G-N7-MTaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAvian orthoavulavirus 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri2560319 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Negarnaviricota › Haploviricotina › Monjiviricetes › Mononegavirales › Paramyxoviridae › Avulavirinae › Orthoavulavirus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host cytoplasmUniRule annotationARBA annotation, VirionUniRule annotationARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini634 – 818RdRp catalyticInterPro annotationAdd BLAST185
Domaini1745 – 1958Mononegavirus-type SAM-dependent 2'-O-MTaseInterPro annotationAdd BLAST214

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili257 – 277Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the paramyxovirus L protein family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024352, L_methyltrans_paramyxo
IPR039736, L_poly_C
IPR026890, Mononeg_mRNAcap
IPR014023, Mononeg_RNA_pol_cat
IPR025786, Mononega_L_MeTrfase
IPR016269, RNA-dir_pol_paramyxovirus

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12803, G-7-MTase, 1 hit
PF14318, Mononeg_mRNAcap, 1 hit
PF00946, Mononeg_RNA_pol, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000830, RNA_pol_ParamyxoV, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR04198, paramyx_RNAcap, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50526, RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590, SAM_MT_MNV_L, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6X1B6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSGPERAE HQIILPESHL SSPLVKHKLL YYWKLTGLPL PDECDFDHLI 
        60         70         80         90        100
VSRQWKKILE SAAPDTERMI KLGRAVHQTL NHNSKITGVL HPRCLEKLAS 
       110        120        130        140        150
IEVPDSTNKF RKIEKKIQIH NTRYGELFTR LCTNVEKKLL GSSWSNNVSR 
       160        170        180        190        200
SEEFNSIRTD PAFWFHSKWS KAKFGWAHFK QVPRHLIVAA RTRSAVTKFV 
       210        220        230        240        250
TLTHKLGQVF GTPELVMGNH TNENKSPCLT QELVLMYADM MEGRDMVNII 
       260        270        280        290        300
SSTATHLRSL SEKIDDILRL VDALAKDLGN QVYDVVALME GFAYGAVQLL 
       310        320        330        340        350
EPSGTFAGDF FAFNLQELKD TLIELLPNDV AELVTHAIAT VFSGLEQNQA 
       360        370        380        390        400
AEMLCLLRLW GHPLLESRIA AKAVRSQMCA PKMIDFDMIL QVLSFFKGTI 
       410        420        430        440        450
INGYRKKNSG VWPHVKMDTI YGKVIGQLHA DSAEISHDVM LREYKSLSAL 
       460        470        480        490        500
EFEPCIEYDP VTNLSMFLKD KAIAHPRDNW LASFRRNLLS EDQKRHIKEA 
       510        520        530        540        550
TSTNRLLIEF LESNDFDPYK EMEYLTTLEY LRDDNVAVSY SLKEKEVKVN 
       560        570        580        590        600
GRIFAKLTKK LRNCQVMAEG ILADQIAPFF QGNGVIQDSI SLTKSMLAMS 
       610        620        630        640        650
QLSFNSNKKR ITDCKERVSS NRNHDPKSKN RRRVATFITT DLQKYCLNWR 
       660        670        680        690        700
YQTVKLFAHA INQLMGLPHF FEWIHLRLMD TTMFVGDPFN PPSDPTDCDL 
       710        720        730        740        750
SRVPNDDIYI VSARGGIEGL CQKLWTMISI AAIQLAAARS HCRVACMVQG 
       760        770        780        790        800
DNQVIAVTRE VRSDDSPEMV WTQWLQASDN FFKEMIHVNH LNGHNLKDRE 
       810        820        830        840        850
TIRSDTFFLY SKRIFKDGAI LSQVLKNSSK LVLISGDLSE NTVMSCANIA 
       860        870        880        890        900
STIARLCENG LPKDFCYYLN YIMSCVQTYF DSEFSITHSS QPDSNQSWFE 
       910        920        930        940        950
DISFVHSYVL TPAQLGGLSN LQYSRLYTRN IGDPGTTAFA EVKRLEAVGL 
       960        970        980        990       1000
LSPSIMTNIL TRPPGNGDWA SLCNDPYSFN FETVASPNIV LKKHTQKVLF 
      1010       1020       1030       1040       1050
ETCSNPLLSG VHTEDNEAEE KALVEFLLNQ EVVHPRVAHA IMESSSVGRR 
      1060       1070       1080       1090       1100
KQIQGLVDTT NTVINIALTR RPLGIKRLMR IINYSSMHAM LFTDDVFLSN 
      1110       1120       1130       1140       1150
RPNHPLVSSN MCSLTLADYA RNRSWSPLTG GRKILGVSNP DTIEPVEGEI 
      1160       1170       1180       1190       1200
LSVSGGCKKC DSGDEQFTWF HLPSNIQLTD DTSKNPPMRV PYLGSKTQER 
      1210       1220       1230       1240       1250
RAASLAKIAH MSPHVKAALR ASSVLIWAYG DNEVNWTAAL KIARSRCNIS 
      1260       1270       1280       1290       1300
SEYLRLLSPL PTAGNLQHRL DDGITQMTFT PASLYRVSPY IHISNDSQRL 
      1310       1320       1330       1340       1350
FTEEGIKEGN VVYQQIMLLG LSLIESLFPM TTTKTYDEIT LHLHSKFSCC 
      1360       1370       1380       1390       1400
IREAPVAVPF ELLGLAPELR AVTSNKFMYD PSPVSERDFA RLDLAIFKSY 
      1410       1420       1430       1440       1450
ELNLESYPTI ELMNILSISS GKLIGQSVVS YDEDTSIKND AIIVYDNTRN 
      1460       1470       1480       1490       1500
WISEAQNSDV VRLFEYAALE VLLDCSYQLY YLRVRGLNNI VLYMSDLYKN 
      1510       1520       1530       1540       1550
MPGILLSNIA ATISHPIIHS RLNAVGLVNH DGSHQLADTD FIEMSAKLLV 
      1560       1570       1580       1590       1600
SCTRRVVSGL YAGNKYDLLF PSVLDDNLSE KMLQLISRLC CLYTVLFATT 
      1610       1620       1630       1640       1650
REIPKIRGLS AEEKCSVLTE YLLSDAVKPL LRSEQVSCIM SPNIITFPAN 
      1660       1670       1680       1690       1700
LYYMSRKSLN LIREREDRDA ILALLFPQEP LLEFRPVQDI GVRVKDPFTR 
      1710       1720       1730       1740       1750
QPAALLQELD LSAPARYDAF TLNEVRSEHT LPNPEEDYLV RYLFRGIGTA 
      1760       1770       1780       1790       1800
SSSWYKASHL LSVPEVRCAR YGNSLYLAEG SGAIMSLLEL HVPHETIYYN 
      1810       1820       1830       1840       1850
TLFSNEMNPP QRHFGPTPTQ FLNSVVYRNL QAEVPCKDGF IQEFRPLWRE 
      1860       1870       1880       1890       1900
NAEESDLTSD KAVGYITSAV PYRSVSLLHC DIEIPPGSNQ SLLDQLAINL 
      1910       1920       1930       1940       1950
SLIAMHSVRE GGVVIIKVLY AMGYYFHLLM NLFTPCSTKG YILSNGYACR 
      1960       1970       1980       1990       2000
GDMECYLIFV MGYLGGPTFV HEVVRMAKTL VQRHGTLLSK SDEITLTRLF 
      2010       2020       2030       2040       2050
TSQQHRVTDI LSSPLPRLMK FLRENIDAAL IEAGGQPVRP FCAESLVSTL 
      2060       2070       2080       2090       2100
TDMTQMTQII ASHIDTVIRS VIYMEAEGDL ADTVFLFTPY NLSTDGKKRT 
      2110       2120       2130       2140       2150
SLKQCTRQIL EVTILGLRVK DLNKVGDVIG LVLRGMVSLE DLIPLRTYLR 
      2160       2170       2180       2190       2200
RSTCPKYLKA VLGITKLKEM FTDTSLLYLT LAQQKFYMKT IGNAAKGYYS 

NCDS
Length:2,204
Mass (Da):248,782
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B518A87D05FA088
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY262106 mRNA Translation: AAP86958.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262106 mRNA Translation: AAP86958.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR024352, L_methyltrans_paramyxo
IPR039736, L_poly_C
IPR026890, Mononeg_mRNAcap
IPR014023, Mononeg_RNA_pol_cat
IPR025786, Mononega_L_MeTrfase
IPR016269, RNA-dir_pol_paramyxovirus
PfamiView protein in Pfam
PF12803, G-7-MTase, 1 hit
PF14318, Mononeg_mRNAcap, 1 hit
PF00946, Mononeg_RNA_pol, 1 hit
PIRSFiPIRSF000830, RNA_pol_ParamyxoV, 1 hit
TIGRFAMsiTIGR04198, paramyx_RNAcap, 1 hit
PROSITEiView protein in PROSITE
PS50526, RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590, SAM_MT_MNV_L, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6X1B6_9MONO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6X1B6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 19, 2022
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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