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Entry version 80 (29 Sep 2021)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Nonribosomal peptide synthetase

Gene

vioA

Organism
Streptomyces vinaceus
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nonribosomal peptide synthetaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vioAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces vinaceusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1960 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei578O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1642O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini543 – 618CarrierInterPro annotationAdd BLAST76
Domaini1607 – 1682CarrierInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1678 – 1699DisorderedSequence analysisAdd BLAST22

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 2 hits
3.30.559.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 2 hits
PF13193, AMP-binding_C, 2 hits
PF00668, Condensation, 2 hits
PF00550, PP-binding, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 2 hits
PS00012, PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6WZB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEARDDAHHL LALTASNAAA SNGPGGRDAT LHELVGAQAA ATPGATAVVH
60 70 80 90 100
DDGLLTYAEL DERSTRLAHR LRALGVRAET PVGVMLERDP ELVVALLGVL
110 120 130 140 150
KAGGAFVPVD PTYPAARIRH MLDDSGARAV LLRQELRDRL PEDLRDGTGQ
160 170 180 190 200
VAVVPVGAES GAGTSTRRPV TPVEQEPRPE RLAYIVYTSG STGLPKGVMV
210 220 230 240 250
EHRGIVSYLL GMLEHFPMGP RDRMLQVTSL SFDVSVYEIF LPLLTGGATV
260 270 280 290 300
LPRSGSHTDA AYLSGLIAEH GVTSFHMVPS LLRTFVDGLD PRQCAGLRRI
310 320 330 340 350
FVSGEALDTT LVVDVHDRLP CDVVNLYGAT EVSVDSTWWT APRDLPDAPV
360 370 380 390 400
LVGRPMAGAT AYVLDDEMRR LAPNEVGEVY LGGASVTRGY HGRAALTAQR
410 420 430 440 450
FLPDPYGPPG SRLYRTGDLG RVEDNGELRL LGRIDHQVKL HGRRIEPGEI
460 470 480 490 500
EAAMTAHPHV SLAAAVPAGA GAGATLTGFF TGAEADAEEL RGFLAQRLPA
510 520 530 540 550
ALVPSRLVAL DTLPLSPNGK IDRNALADIA ARQDLAAVPP APEHTDPVLR
560 570 580 590 600
AVLDATADVL GGTPVAPHEN FFDKGGNSLH ATRLVAKLRS ALDTAIGVRT
610 620 630 640 650
VFEHQTPAQL ADALRVTLDD APDSGARGTA EGELSAAQHR MWLLAQISET
660 670 680 690 700
PAEYAITLAL HLAGALDTEA LGWAVDAVVR RHDSLRSCFP DRDGTPVRAE
710 720 730 740 750
VPAEALRLIH APPEPGGDPD EVVRRVVAEE TAGLDLVAGP LFRPVLVPLG
760 770 780 790 800
AEEYLLVIVL HHIVADGWST EVLLEDIAAH YRARTGGEAV PGRPVVSYRR
810 820 830 840 850
YVDIERRNER DGVTDRDLEY FTTELHGIPE EVTLPLDRPR PAQRTGRGAT
860 870 880 890 900
LRPAFGPRGA DAVRRLAAAH RTTPFVVLLA GLSTLVHRAG GHEDVVIGSA
910 920 930 940 950
VAGRFDAELD DLVGLCLNSV ALRWPVGPTT AFATVVERAE RSLLDAMDHS
960 970 980 990 1000
AVPFARVVEK LGVRRDARRT PVFQVIALYD DFPDSPDLPG LSVRALETDD
1010 1020 1030 1040 1050
GTAQCDVLFT FRPPTDDGMS LGIEFSTDVY DHTTVLCWAE QLETLLTAAA
1060 1070 1080 1090 1100
DAPGTEVARL PLLSGSALDA LLTLGAGPVR PLPDDLTLTG LLARQVALAP
1110 1120 1130 1140 1150
QRTALTWREA TGTVATLSYA GFDERSSRVA HALREYGVGA NTPVALCLAR
1160 1170 1180 1190 1200
GADVLPAVYG VLKAGGGYVP IEPDNPPERI AGLVRDSGAR VLLTQRRQTA
1210 1220 1230 1240 1250
SLPKLPGVTV LVVDDHEALS RFPATVPKPV PRPQDLAYVI YTSGSTGRPK
1260 1270 1280 1290 1300
GVMVEHHSVV NYLTTLQEKF RLTSDDRLLL KSPLSFDVSV REVFWALSTG
1310 1320 1330 1340 1350
ATLVVAEAGR HADPDYLVEA IERERVTVVH FVPSMLHVLL ETLDGPGRCP
1360 1370 1380 1390 1400
TLRQVMTSGE TLPVQTARRC LELLGAELRN MYGPTETTVE MTDCEVRGRT
1410 1420 1430 1440 1450
DTERLPIGRP FPNTRVYVLD DELRLVPRGT VGELYVSGAP VARGYLGRPA
1460 1470 1480 1490 1500
LTADRFLPDP YGPPGSRMYR TGDLGRFTGE GLLDFQGRGD FQVQLRGHRI
1510 1520 1530 1540 1550
EPGEIETVLC EQPGVTAAVA VVRRPDSPEA AHLVAYAVRA EEPHGTDQAL
1560 1570 1580 1590 1600
RAKLAERLPH YMVPTAVVTM DALPLTVNGK LDRAALPDPW EARATGDSGS
1610 1620 1630 1640 1650
DGAAVPALNG RRELALAEIW RSLLSTDEVG PQDNFFSLGG HSLLVATLSA
1660 1670 1680 1690 1700
RVRAELGVRA PLTLFLRHPV LRDLAAALPE PDGGRAPRDD AGLRQRGTDR
1710 1720 1730 1740 1750
APLSAAQRRV WIDEQLWPGT AAYTVPEAFW LHGPLDEAAF EGALHDLMAR
1760 1770 1780 1790 1800
HEALRVRIVG GEDPWLAVDD PMAVRLSRAD MREDGETAVQ RLLEQAGRRV
1810 1820 1830 1840 1850
FALDGPLVEA TLARTDAEEW VFLLTAHHLV VDGWSFDILW RDLEILYRDR
1860 1870 1880 1890 1900
VAGGGISLPP PQLTFTDCTW WESERVAAGG NRPHLAFWRQ ELAGIAHGAG
1910 1920 1930 1940 1950
PADATDTDRS GSSRAVRLGG ELSDQLRLIA AELGVTPFVL TLTAFALAVT
1960 1970 1980 1990 2000
AEGSAEQVIG VEVAGRTDQR VADVVGLFIN HVPLRLRRRP GLTARQAVAA
2010 2020 2030 2040 2050
LDDAWRGVLE HSDVSFDTIV DGLGEQRGAG RGPGSDIAFS YLDARTPPRL
2060 2070 2080 2090 2100
DGIRVTPLEP VFNGTAKFGL LLEVFDTPDG LVGVFEHQLA RFGHGRMTRI
2110 2120
RNRWEALLLG LLADVDVPLD PQG
Length:2,123
Mass (Da):228,607
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i401B5F375F8ACAEC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY263398 Genomic DNA Translation: AAP92491.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ag:AAP92491

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY263398 Genomic DNA Translation: AAP92491.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

KEGGiag:AAP92491

Family and domain databases

Gene3Di1.10.1200.10, 2 hits
3.30.559.10, 2 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 2 hits
PF13193, AMP-binding_C, 2 hits
PF00668, Condensation, 2 hits
PF00550, PP-binding, 2 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 2 hits
SUPFAMiSSF47336, SSF47336, 2 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 2 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 2 hits
PS00012, PHOSPHOPANTETHEINE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6WZB2_STRVI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6WZB2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 29, 2021
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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