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Protein

BTB/POZ domain-containing protein KCTD12

Gene

Kctd12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein homooligomerization Source: InterPro
  • regulation of G protein-coupled receptor signaling pathway Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD12
Alternative name(s):
Pfetin
Predominantly fetal expressed T1 domain
Gene namesi
Name:Kctd12
Synonyms:Pfet1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2145823 Kctd12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001912962 – 327BTB/POZ domain-containing protein KCTD12Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei119PhosphotyrosineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei187PhosphoserineBy similarity1
Modified residuei198PhosphothreonineCombined sources1
Modified residuei202PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6WVG3
MaxQBiQ6WVG3
PeptideAtlasiQ6WVG3
PRIDEiQ6WVG3

PTM databases

iPTMnetiQ6WVG3
PhosphoSitePlusiQ6WVG3
SwissPalmiQ6WVG3

Expressioni

Tissue specificityi

Expressed in the brain, mainly in the hippocampus and cerebellum.1 Publication

Interactioni

Subunit structurei

Interacts as a tetramer with GABRB1 and GABRB2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi232062, 2 interactors
CORUMiQ6WVG3
IntActiQ6WVG3, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6WVG3
SMRiQ6WVG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG052218
InParanoidiQ6WVG3
KOiK21918
PhylomeDBiQ6WVG3

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6WVG3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALADSARGL PNGGGGGGGS GSSSSSAEPP LFPDIVELNV GGQVYVTRRC
60 70 80 90 100
TVVSVPDSLL WRMFTQQQPQ ELARDSKGRF FLDRDGFFFR YILDYLRDLQ
110 120 130 140 150
LVLPDYFPER SRLQREAEYF ELPELVRRLG APQQPGPGPP PPHSRRGVHK
160 170 180 190 200
EGSLGDELLP LGYAEPEPQE GASAGAPSPT LELASRSPSG GAAGPLLTPS
210 220 230 240 250
QSLDGSRRSG YITIGYRGSY TIGRDAQADA KFRRVARITV CGKTSLAKEV
260 270 280 290 300
FGDTLNESRD PDRPPERYTS RYYLKFNFLE QAFDKLSESG FHMVACSSTG
310 320
TCAFASSTDQ SEDKIWTSYT EYVFCRE
Length:327
Mass (Da):35,892
Last modified:July 5, 2004 - v1
Checksum:i0C84A1AB0CDFEAF5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J2B2A0A0R4J2B2_MOUSE
BTB/POZ domain-containing protein K...
Kctd12
327Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7A → T in BAE43079 (PubMed:16141072).Curated1
Sequence conflicti88F → L in BAE43079 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY267461 Genomic DNA Translation: AAP92150.1
AK172581 mRNA Translation: BAE43079.1
CCDSiCCDS70611.1
RefSeqiNP_808383.3, NM_177715.4
UniGeneiMm.246466

Genome annotation databases

GeneIDi239217
KEGGimmu:239217
UCSCiuc007uwe.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY267461 Genomic DNA Translation: AAP92150.1
AK172581 mRNA Translation: BAE43079.1
CCDSiCCDS70611.1
RefSeqiNP_808383.3, NM_177715.4
UniGeneiMm.246466

3D structure databases

ProteinModelPortaliQ6WVG3
SMRiQ6WVG3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232062, 2 interactors
CORUMiQ6WVG3
IntActiQ6WVG3, 2 interactors

PTM databases

iPTMnetiQ6WVG3
PhosphoSitePlusiQ6WVG3
SwissPalmiQ6WVG3

Proteomic databases

EPDiQ6WVG3
MaxQBiQ6WVG3
PeptideAtlasiQ6WVG3
PRIDEiQ6WVG3

Protocols and materials databases

DNASUi239217
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi239217
KEGGimmu:239217
UCSCiuc007uwe.1 mouse

Organism-specific databases

CTDi115207
MGIiMGI:2145823 Kctd12

Phylogenomic databases

HOVERGENiHBG052218
InParanoidiQ6WVG3
KOiK21918
PhylomeDBiQ6WVG3

Miscellaneous databases

ChiTaRSiKctd12 mouse
PROiPR:Q6WVG3
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCD12_MOUSE
AccessioniPrimary (citable) accession number: Q6WVG3
Secondary accession number(s): Q3T9E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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