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Protein

Protein zyg-11 homolog A

Gene

ZYG11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein zyg-11 homolog A
Gene namesi
Name:ZYG11A
Synonyms:ZYG11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000203995.9
HGNCiHGNC:32058 ZYG11A
neXtProtiNX_Q6WRX3

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi440590
OpenTargetsiENSG00000203995
PharmGKBiPA142670467

Polymorphism and mutation databases

BioMutaiZYG11A
DMDMi317373488

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050851 – 759Protein zyg-11 homolog AAdd BLAST759

Proteomic databases

MaxQBiQ6WRX3
PaxDbiQ6WRX3
PeptideAtlasiQ6WRX3
PRIDEiQ6WRX3
ProteomicsDBi67777
67778 [Q6WRX3-2]

PTM databases

iPTMnetiQ6WRX3
PhosphoSitePlusiQ6WRX3

Expressioni

Gene expression databases

BgeeiENSG00000203995 Expressed in 35 organ(s), highest expression level in female gonad
CleanExiHS_ZYG11A
GenevisibleiQ6WRX3 HS

Organism-specific databases

HPAiHPA030378
HPA030379

Interactioni

Protein-protein interaction databases

BioGridi136714, 6 interactors
STRINGi9606.ENSP00000360583

Structurei

3D structure databases

ProteinModelPortaliQ6WRX3
SMRiQ6WRX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati204 – 227LRR 1Add BLAST24
Repeati235 – 260LRR 2Add BLAST26
Repeati490 – 513LRR 3Add BLAST24

Sequence similaritiesi

Belongs to the zyg-11 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG3665 Eukaryota
ENOG410XPSX LUCA
GeneTreeiENSGT00530000063187
HOGENOMiHOG000004816
HOVERGENiHBG108780
InParanoidiQ6WRX3
KOiK10350
OMAiDDFRMHF
OrthoDBiEOG091G031E
PhylomeDBiQ6WRX3
TreeFamiTF313007

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032675 LRR_dom_sf
SUPFAMiSSF48371 SSF48371, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6WRX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVHFLHPGHT PRNIVPPDAQ KDALGCCVVQ EEASPYTLVN ICLNVLIANL
60 70 80 90 100
EKLCSERPDG TLCLPEHWSF PQEVAERFLR VMTWQGKLTD RTASIFRGNQ
110 120 130 140 150
MKLKLVNIQK AKISTAAFIK AFCRHKLIEL NATAVHADLP VPDIISGLCS
160 170 180 190 200
NRWIQQNLQC LLLDSTSIPQ NSRLLFFSQL TGLRILSVFN VCFHTEDLAN
210 220 230 240 250
VSQLPRLESL DISNTLVTDI SALLTCKDRL KSLTMHYLKC LAMTKSQILA
260 270 280 290 300
VIRELKCLLH LDISDHRQLK SDLAFHLLQQ KDILPNVVSL DISGGNCITD
310 320 330 340 350
EAVELFIRLR PAMQFVGLLA TDAGSSDFFT TKQGLRVAGG ASMSQISEAL
360 370 380 390 400
SRYRNRSCFV KEALHRLFTE TFSMEVTMPA ILKLVAIGMR NHPLDLRVQF
410 420 430 440 450
TASACALNLT RQGLAKGMPV RLLSEVTCLL FKALKNFPHY QQLQKNCLLS
460 470 480 490 500
LTNSRILVDV PFDRFDAAKF VMRWLCKHEN PKMQTMAVSV TSILALQLSP
510 520 530 540 550
EQTAQLEELF MAVKELLAIV KQKTTENLDD VTFLFTLKAL WNLTDGSPAA
560 570 580 590 600
CKHFIENQGL QIFIQVLETF SESAIQSKVL GLLNNIAEVR ELSSKLVTED
610 620 630 640 650
VLKHINSLLC SREMEVSYFA AGIIAHLTSD RQLWISRDFQ RRTLLQDLHA
660 670 680 690 700
TIQNWPSSSC KMTALVTYRS FKTFFPLLGN FSQPEVQLWA LWAMYHVCSK
710 720 730 740 750
NPSKYCKMLV EEEGLQLLCD IQEHSEATPK AQQIAASILD DFRMHFMNYQ

RPTLCQMPF
Length:759
Mass (Da):85,808
Last modified:January 11, 2011 - v3
Checksum:iA7E681631070BFE0
GO
Isoform 2 (identifier: Q6WRX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-342: Missing.

Show »
Length:417
Mass (Da):47,730
Checksum:i560288F7FE26F3AE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0282231 – 342Missing in isoform 2. 1 PublicationAdd BLAST342

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY271826 mRNA Translation: AAQ01753.1
AC099677 Genomic DNA No translation available.
CCDSiCCDS44148.1 [Q6WRX3-1]
CCDS76166.1 [Q6WRX3-2]
RefSeqiNP_001004339.2, NM_001004339.2 [Q6WRX3-1]
NP_001294860.1, NM_001307931.1 [Q6WRX3-2]
UniGeneiHs.658458

Genome annotation databases

EnsembliENST00000371528; ENSP00000360583; ENSG00000203995 [Q6WRX3-1]
ENST00000371532; ENSP00000360587; ENSG00000203995 [Q6WRX3-2]
ENST00000612017; ENSP00000482761; ENSG00000203995 [Q6WRX3-2]
GeneIDi440590
KEGGihsa:440590
UCSCiuc001cuk.3 human [Q6WRX3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY271826 mRNA Translation: AAQ01753.1
AC099677 Genomic DNA No translation available.
CCDSiCCDS44148.1 [Q6WRX3-1]
CCDS76166.1 [Q6WRX3-2]
RefSeqiNP_001004339.2, NM_001004339.2 [Q6WRX3-1]
NP_001294860.1, NM_001307931.1 [Q6WRX3-2]
UniGeneiHs.658458

3D structure databases

ProteinModelPortaliQ6WRX3
SMRiQ6WRX3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136714, 6 interactors
STRINGi9606.ENSP00000360583

PTM databases

iPTMnetiQ6WRX3
PhosphoSitePlusiQ6WRX3

Polymorphism and mutation databases

BioMutaiZYG11A
DMDMi317373488

Proteomic databases

MaxQBiQ6WRX3
PaxDbiQ6WRX3
PeptideAtlasiQ6WRX3
PRIDEiQ6WRX3
ProteomicsDBi67777
67778 [Q6WRX3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371528; ENSP00000360583; ENSG00000203995 [Q6WRX3-1]
ENST00000371532; ENSP00000360587; ENSG00000203995 [Q6WRX3-2]
ENST00000612017; ENSP00000482761; ENSG00000203995 [Q6WRX3-2]
GeneIDi440590
KEGGihsa:440590
UCSCiuc001cuk.3 human [Q6WRX3-1]

Organism-specific databases

CTDi440590
DisGeNETi440590
EuPathDBiHostDB:ENSG00000203995.9
GeneCardsiZYG11A
HGNCiHGNC:32058 ZYG11A
HPAiHPA030378
HPA030379
neXtProtiNX_Q6WRX3
OpenTargetsiENSG00000203995
PharmGKBiPA142670467
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3665 Eukaryota
ENOG410XPSX LUCA
GeneTreeiENSGT00530000063187
HOGENOMiHOG000004816
HOVERGENiHBG108780
InParanoidiQ6WRX3
KOiK10350
OMAiDDFRMHF
OrthoDBiEOG091G031E
PhylomeDBiQ6WRX3
TreeFamiTF313007

Miscellaneous databases

ChiTaRSiZYG11A human
GenomeRNAii440590
PROiPR:Q6WRX3

Gene expression databases

BgeeiENSG00000203995 Expressed in 35 organ(s), highest expression level in female gonad
CleanExiHS_ZYG11A
GenevisibleiQ6WRX3 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032675 LRR_dom_sf
SUPFAMiSSF48371 SSF48371, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZY11A_HUMAN
AccessioniPrimary (citable) accession number: Q6WRX3
Secondary accession number(s): A6NCK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 11, 2011
Last modified: September 12, 2018
This is version 103 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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