Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 141 (17 Jun 2020)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Immunoglobulin superfamily member 10

Gene

IGSF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Osteogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin superfamily member 10
Short name:
IgSF10
Alternative name(s):
Calvaria mechanical force protein 608
Short name:
CMF608
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGSF10
Synonyms:CMF608
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000152580.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26384 IGSF10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617351 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6WRI0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mutations in IGSF10 may be a cause of self-limited delayed puberty. This common condition is defined as the absence of testicular enlargement in boys or breast development in girls at an age that is 2-2.5 standard deviations later than the population mean. Self-limited delayed puberty segregates within families, with the majority of families displaying an autosomal dominant pattern of inheritance.1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000152580

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134900760

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6WRI0 Tdark

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00114 Pyridoxal phosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IGSF10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749492

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028681729 – 2623Immunoglobulin superfamily member 10Add BLAST2595

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi497 ↔ 551PROSITE-ProRule annotation
Disulfide bondi595 ↔ 645PROSITE-ProRule annotation
Glycosylationi627N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi774N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi999N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1670 ↔ 1723PROSITE-ProRule annotation
Disulfide bondi1767 ↔ 1820PROSITE-ProRule annotation
Disulfide bondi1864 ↔ 1917PROSITE-ProRule annotation
Glycosylationi1899N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1962N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1963 ↔ 2016PROSITE-ProRule annotation
Disulfide bondi2060 ↔ 2119PROSITE-ProRule annotation
Glycosylationi2101N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2163 ↔ 2213PROSITE-ProRule annotation
Disulfide bondi2261 ↔ 2313PROSITE-ProRule annotation
Disulfide bondi2359 ↔ 2411PROSITE-ProRule annotation
Disulfide bondi2454 ↔ 2506PROSITE-ProRule annotation
Disulfide bondi2550 ↔ 2605PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2603PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6WRI0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6WRI0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6WRI0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6WRI0

PeptideAtlas

More...
PeptideAtlasi
Q6WRI0

PRoteomics IDEntifications database

More...
PRIDEi
Q6WRI0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67774 [Q6WRI0-1]
67775 [Q6WRI0-2]
67776 [Q6WRI0-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q6WRI0

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6WRI0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6WRI0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152580 Expressed in layer of synovial tissue and 179 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6WRI0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6WRI0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000152580 Tissue enhanced (ovary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
130074, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q6WRI0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000282466

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6WRI0 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 56LRRNTAdd BLAST28
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati58 – 79LRR 1Add BLAST22
Repeati82 – 103LRR 2Add BLAST22
Repeati106 – 127LRR 3Add BLAST22
Repeati130 – 151LRR 4Add BLAST22
Repeati154 – 175LRR 5Add BLAST22
Repeati186 – 207LRR 6Add BLAST22
Domaini219 – 281LRRCTAdd BLAST63
Domaini461 – 567Ig-like C2-type 1Add BLAST107
Domaini571 – 661Ig-like C2-type 2Add BLAST91
Domaini1648 – 1739Ig-like C2-type 3Add BLAST92
Domaini1745 – 1836Ig-like C2-type 4Add BLAST92
Domaini1841 – 1933Ig-like C2-type 5Add BLAST93
Domaini1941 – 2034Ig-like C2-type 6Add BLAST94
Domaini2037 – 2135Ig-like C2-type 7Add BLAST99
Domaini2141 – 2229Ig-like C2-type 8Add BLAST89
Domaini2234 – 2331Ig-like C2-type 9Add BLAST98
Domaini2337 – 2427Ig-like C2-type 10Add BLAST91
Domaini2432 – 2518Ig-like C2-type 11Add BLAST87
Domaini2528 – 2623Ig-like C2-type 12Add BLAST96

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
ENOG410YEVU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158290

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000580_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6WRI0

Identification of Orthologs from Complete Genome Data

More...
OMAi
DHKQHFK

Database of Orthologous Groups

More...
OrthoDBi
8971at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6WRI0

TreeFam database of animal gene trees

More...
TreeFami
TF326318

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 12 hits
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 6 hits
PF13855 LRR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 12 hits
SM00408 IGc2, 12 hits
SM00406 IGv, 7 hits
SM00369 LRR_TYP, 6 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6WRI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVKGRGITC LLVSFAVICL VATPGGKACP RRCACYMPTE VHCTFRYLTS
60 70 80 90 100
IPDSIPPNVE RINLGYNSLV RLMETDFSGL TKLELLMLHS NGIHTIPDKT
110 120 130 140 150
FSDLQALQVL KMSYNKVRKL QKDTFYGLRS LTRLHMDHNN IEFINPEVFY
160 170 180 190 200
GLNFLRLVHL EGNQLTKLHP DTFVSLSYLQ IFKISFIKFL YLSDNFLTSL
210 220 230 240 250
PQEMVSYMPD LDSLYLHGNP WTCDCHLKWL SDWIQEKPDV IKCKKDRSPS
260 270 280 290 300
SAQQCPLCMN PRTSKGKPLA MVSAAAFQCA KPTIDSSLKS KSLTILEDSS
310 320 330 340 350
SAFISPQGFM APFGSLTLNM TDQSGNEANM VCSIQKPSRT SPIAFTEEND
360 370 380 390 400
YIVLNTSFST FLVCNIDYGH IQPVWQILAL YSDSPLILER SHLLSETPQL
410 420 430 440 450
YYKYKQVAPK PEDIFTNIEA DLRADPSWLM QDQISLQLNR TATTFSTLQI
460 470 480 490 500
QYSSDAQITL PRAEMRPVKH KWTMISRDNN TKLEHTVLVG GTVGLNCPGQ
510 520 530 540 550
GDPTPHVDWL LADGSKVRAP YVSEDGRILI DKSGKLELQM ADSFDTGVYH
560 570 580 590 600
CISSNYDDAD ILTYRITVVE PLVEAYQENG IHHTVFIGET LDLPCHSTGI
610 620 630 640 650
PDASISWVIP GNNVLYQSSR DKKVLNNGTL RILQVTPKDQ GYYRCVAANP
660 670 680 690 700
SGVDFLIFQV SVKMKGQRPL EHDGETEGSG LDESNPIAHL KEPPGAQLRT
710 720 730 740 750
SALMEAEVGK HTSSTSKRHN YRELTLQRRG DSTHRRFREN RRHFPPSARR
760 770 780 790 800
IDPQHWAALL EKAKKNAMPD KRENTTVSPP PVVTQLPNIP GEEDDSSGML
810 820 830 840 850
ALHEEFMVPA TKALNLPART VTADSRTISD SPMTNINYGT EFSPVVNSQI
860 870 880 890 900
LPPEEPTDFK LSTAIKTTAM SKNINPTMSS QIQGTTNQHS STVFPLLLGA
910 920 930 940 950
TEFQDSDQMG RGREHFQSRP PITVRTMIKD VNVKMLSSTT NKLLLESVNT
960 970 980 990 1000
TNSHQTSVRE VSEPRHNHFY SHTTQILSTS TFPSDPHTAA HSQFPIPRNS
1010 1020 1030 1040 1050
TVNIPLFRRF GRQRKIGGRG RIISPYRTPV LRRHRYSIFR STTRGSSEKS
1060 1070 1080 1090 1100
TTAFSATVLN VTCLSCLPRE RLTTATAALS FPSAAPITFP KADIARVPSE
1110 1120 1130 1140 1150
ESTTLVQNPL LLLENKPSVE KTTPTIKYFR TEISQVTPTG AVMTYAPTSI
1160 1170 1180 1190 1200
PMEKTHKVNA SYPRVSSTNE AKRDSVITSS LSGAITKPPM TIIAITRFSR
1210 1220 1230 1240 1250
RKIPWQQNFV NNHNPKGRLR NQHKVSLQKS TAVMLPKTSP ALPRDKVSPF
1260 1270 1280 1290 1300
HFTTLSTSVM QIPSNTLTTA HHTTTKTHNP GSLPTKKELP FPPLNPMLPS
1310 1320 1330 1340 1350
IISKDSSTKS IISTQTAIPA TTPTFPASVI TYETQTERSR AQTIQREQEP
1360 1370 1380 1390 1400
QKKNRTDPNI SPDQSSGFTT PTAMTPPVLT TAETSVKPSV SAFTHSPPEN
1410 1420 1430 1440 1450
TTGISSTISF HSRTLNLTDV IEELAQASTQ TLKSTIASET TLSSKSHQST
1460 1470 1480 1490 1500
TTRKAIIRHS TIPPFLSSSA TLMPVPISPP FTQRAVTDNV ATPISGLMTN
1510 1520 1530 1540 1550
TVVKLHESSR HNAKPQQLVA EVATSPKVHP NAKFTIGTTH FIYSNLLHST
1560 1570 1580 1590 1600
PMPALTTVKS QNSKLTPSPW AENQFWHKPY SEIAEKGKKP EVSMLATTGL
1610 1620 1630 1640 1650
SEATTLVSDW DGQKNTKKSD FDKKPVQEAT TSKLLPFDSL SRYIFEKPRI
1660 1670 1680 1690 1700
VGGKAASFTI PANSDAFLPC EAVGNPLPTI HWTRVPSGLD LSKRKQNSRV
1710 1720 1730 1740 1750
QVLPNGTLSI QRVEIQDRGQ YLCSASNLFG TDHLHVTLSV VSYPPRILER
1760 1770 1780 1790 1800
RTKEITVHSG STVELKCRAE GRPSPTVTWI LANQTVVSES SQGSRQAVVT
1810 1820 1830 1840 1850
VDGTLVLHNL SIYDRGFYKC VASNPGGQDS LLVKIQVIAA PPVILEQRRQ
1860 1870 1880 1890 1900
VIVGTWGESL KLPCTAKGTP QPSVYWVLSD GTEVKPLQFT NSKLFLFSNG
1910 1920 1930 1940 1950
TLYIRNLASS DRGTYECIAT SSTGSERRVV MLTMEERVTS PRIEAASQKR
1960 1970 1980 1990 2000
TEVNFGDKLL LNCSATGEPK PQIMWRLPSK AVVDQQHRVG SWIHVYPNGS
2010 2020 2030 2040 2050
LFIGSVTEKD SGVYLCVARN KMGDDLILMH VSLRLKPAKI DHKQYFRKQV
2060 2070 2080 2090 2100
LHGKDFQVDC KASGSPVPEI SWSLPDGTMI NNAMQADDSG HRTRRYTLFN
2110 2120 2130 2140 2150
NGTLYFNKVG VAEEGDYTCY AQNTLGKDEM KVHLTVITAA PRIRQSNKTN
2160 2170 2180 2190 2200
KRIKAGDTAV LDCEVTGDPK PKIFWLLPSN DMISFSIDRY TFHANGSLTI
2210 2220 2230 2240 2250
NKVKLLDSGE YVCVARNPSG DDTKMYKLDV VSKPPLINGL YTNRTVIKAT
2260 2270 2280 2290 2300
AVRHSKKHFD CRAEGTPSPE VMWIMPDNIF LTAPYYGSRI TVHKNGTLEI
2310 2320 2330 2340 2350
RNVRLSDSAD FICVARNEGG ESVLVVQLEV LEMLRRPTFR NPFNEKIVAQ
2360 2370 2380 2390 2400
LGKSTALNCS VDGNPPPEII WILPNGTRFS NGPQSYQYLI ASNGSFIISK
2410 2420 2430 2440 2450
TTREDAGKYR CAARNKVGYI EKLVILEIGQ KPVILTYAPG TVKGISGESL
2460 2470 2480 2490 2500
SLHCVSDGIP KPNIKWTMPS GYVVDRPQIN GKYILHDNGT LVIKEATAYD
2510 2520 2530 2540 2550
RGNYICKAQN SVGHTLITVP VMIVAYPPRI TNRPPRSIVT RTGAAFQLHC
2560 2570 2580 2590 2600
VALGVPKPEI TWEMPDHSLL STASKERTHG SEQLHLQGTL VIQNPQTSDS
2610 2620
GIYKCTAKNP LGSDYAATYI QVI
Length:2,623
Mass (Da):290,838
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCBE7139B0DF16CF8
GO
Isoform 2 (identifier: Q6WRI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1973: Missing.
     1974-1987: MWRLPSKAVVDQQH → MVESVRLENQPCDL

Show »
Length:650
Mass (Da):72,091
Checksum:i8DA678726D7AF644
GO
Isoform 3 (identifier: Q6WRI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2021: Missing.

Show »
Length:602
Mass (Da):66,741
Checksum:i6BA060C56FBE460B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4M2H7C4M2_HUMAN
Immunoglobulin superfamily member 1...
IGSF10
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05429 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2243N → S in AAH31063 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032179124T → I. Corresponds to variant dbSNP:rs35953658Ensembl.1
Natural variantiVAR_032180150Y → D. Corresponds to variant dbSNP:rs7619322Ensembl.1
Natural variantiVAR_078550156R → L Probable disease-associated variant found in autosomal dominant self-limited delayed puberty; the mutant protein is not secreted. 1 PublicationCorresponds to variant dbSNP:rs138756085Ensembl.1
Natural variantiVAR_078551161E → K Probable disease-associated variant found in autosomal dominant self-limited delayed puberty; the mutant protein is not secreted. 1 PublicationCorresponds to variant dbSNP:rs114161831Ensembl.1
Natural variantiVAR_032181571P → S. Corresponds to variant dbSNP:rs17204557Ensembl.1
Natural variantiVAR_061313795D → N. Corresponds to variant dbSNP:rs58583961Ensembl.1
Natural variantiVAR_0321821199S → A. Corresponds to variant dbSNP:rs16863403Ensembl.1
Natural variantiVAR_0321831370T → I. Corresponds to variant dbSNP:rs34933248Ensembl.1
Natural variantiVAR_0321841875Y → H. Corresponds to variant dbSNP:rs12487205Ensembl.1
Natural variantiVAR_0785522264E → G Found in autosomal dominant self-limited delayed puberty; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1204847665Ensembl.1
Natural variantiVAR_0321852476R → W. Corresponds to variant dbSNP:rs3732775Ensembl.1
Natural variantiVAR_0321862579H → Y. Corresponds to variant dbSNP:rs7624011Ensembl.1
Natural variantiVAR_0785532614D → N Found in autosomal dominant self-limited delayed puberty; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs112889898Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0251941 – 2021Missing in isoform 3. 1 PublicationAdd BLAST2021
Alternative sequenceiVSP_0251951 – 1973Missing in isoform 2. 1 PublicationAdd BLAST1973
Alternative sequenceiVSP_0251961974 – 1987MWRLP…VDQQH → MVESVRLENQPCDL in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY273815 mRNA Translation: AAQ16156.1
AK093069 mRNA Translation: BAC04042.1
AK098838 mRNA Translation: BAC05429.1 Different initiation.
BC031063 mRNA Translation: AAH31063.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3160.1 [Q6WRI0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001171616.1, NM_001178145.1 [Q6WRI0-2]
NP_001171617.1, NM_001178146.1 [Q6WRI0-3]
NP_849144.2, NM_178822.4 [Q6WRI0-1]
XP_011511011.1, XM_011512709.2 [Q6WRI0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282466; ENSP00000282466; ENSG00000152580 [Q6WRI0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
285313

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:285313

UCSC genome browser

More...
UCSCi
uc011bod.3 human [Q6WRI0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273815 mRNA Translation: AAQ16156.1
AK093069 mRNA Translation: BAC04042.1
AK098838 mRNA Translation: BAC05429.1 Different initiation.
BC031063 mRNA Translation: AAH31063.1
CCDSiCCDS3160.1 [Q6WRI0-1]
RefSeqiNP_001171616.1, NM_001178145.1 [Q6WRI0-2]
NP_001171617.1, NM_001178146.1 [Q6WRI0-3]
NP_849144.2, NM_178822.4 [Q6WRI0-1]
XP_011511011.1, XM_011512709.2 [Q6WRI0-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi130074, 4 interactors
IntActiQ6WRI0, 1 interactor
STRINGi9606.ENSP00000282466

Chemistry databases

DrugBankiDB00114 Pyridoxal phosphate

PTM databases

CarbonylDBiQ6WRI0
iPTMnetiQ6WRI0
PhosphoSitePlusiQ6WRI0

Polymorphism and mutation databases

BioMutaiIGSF10
DMDMi74749492

Proteomic databases

EPDiQ6WRI0
jPOSTiQ6WRI0
MassIVEiQ6WRI0
PaxDbiQ6WRI0
PeptideAtlasiQ6WRI0
PRIDEiQ6WRI0
ProteomicsDBi67774 [Q6WRI0-1]
67775 [Q6WRI0-2]
67776 [Q6WRI0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2541 61 antibodies

Genome annotation databases

EnsembliENST00000282466; ENSP00000282466; ENSG00000152580 [Q6WRI0-1]
GeneIDi285313
KEGGihsa:285313
UCSCiuc011bod.3 human [Q6WRI0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
285313
EuPathDBiHostDB:ENSG00000152580.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IGSF10
HGNCiHGNC:26384 IGSF10
HPAiENSG00000152580 Tissue enhanced (ovary)
MIMi617351 gene
neXtProtiNX_Q6WRI0
OpenTargetsiENSG00000152580
PharmGKBiPA134900760

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
ENOG410YEVU LUCA
GeneTreeiENSGT00940000158290
HOGENOMiCLU_000580_0_0_1
InParanoidiQ6WRI0
OMAiDHKQHFK
OrthoDBi8971at2759
PhylomeDBiQ6WRI0
TreeFamiTF326318

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
285313 0 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IGSF10 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
285313
PharosiQ6WRI0 Tdark

Protein Ontology

More...
PROi
PR:Q6WRI0
RNActiQ6WRI0 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152580 Expressed in layer of synovial tissue and 179 other tissues
ExpressionAtlasiQ6WRI0 baseline and differential
GenevisibleiQ6WRI0 HS

Family and domain databases

Gene3Di2.60.40.10, 12 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF07679 I-set, 6 hits
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00409 IG, 12 hits
SM00408 IGc2, 12 hits
SM00406 IGv, 7 hits
SM00369 LRR_TYP, 6 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SUPFAMiSSF48726 SSF48726, 12 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGS10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6WRI0
Secondary accession number(s): Q86YJ9, Q8N772, Q8NA84
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: June 17, 2020
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again