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Protein

Putative cancer susceptibility gene HEPN1 protein

Gene

HEPN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Product of a dubious CDS prediction. Encoded by the 3'-UTR of HEPACAM.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cancer susceptibility gene HEPN1 protein
Gene namesi
Name:HEPN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000221932.6
HGNCiHGNC:34400 HEPN1
MIMi611641 gene
neXtProtiNX_Q6WQI6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi641654
OpenTargetsiENSG00000221932
PharmGKBiPA162390850

Polymorphism and mutation databases

BioMutaiHEPN1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003171061 – 88Putative cancer susceptibility gene HEPN1 proteinAdd BLAST88

Proteomic databases

PaxDbiQ6WQI6
PRIDEiQ6WQI6
ProteomicsDBi67773

Expressioni

Tissue specificityi

Expressed in liver. Expression is either down-regulated or lost in hepatocellular carcinomas (HCC).1 Publication

Gene expression databases

BgeeiENSG00000221932 Expressed in 72 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_HEPN1

Organism-specific databases

HPAiHPA043768
HPA063054

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386143

Structurei

3D structure databases

ProteinModelPortaliQ6WQI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IUU6 Eukaryota
ENOG4110PUM LUCA
GeneTreeiENSGT00510000055197
HOGENOMiHOG000112888
InParanoidiQ6WQI6
OMAiWHGHVLA
OrthoDBiEOG091G16DZ
PhylomeDBiQ6WQI6

Sequencei

Sequence statusi: Complete.

Q6WQI6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNWGLGIAP WVDGESELEF RRLGMQGPLE ALRRREWNTQ RASFSFSFLI
60 70 80
ALSPHTVDYC HSYELFNRRW HGHVLATQRP SLFILMLV
Length:88
Mass (Da):10,305
Last modified:February 5, 2008 - v2
Checksum:i86B4FBE3F21C6EE0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05102737W → R1 PublicationCorresponds to variant dbSNP:rs3802904Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY275431 mRNA Translation: AAQ19120.1
BC037810 mRNA No translation available.
CCDSiCCDS41729.1
RefSeqiNP_001032647.2, NM_001037558.2
UniGeneiHs.159863

Genome annotation databases

EnsembliENST00000408930; ENSP00000386143; ENSG00000221932
GeneIDi641654
KEGGihsa:641654
UCSCiuc001qbj.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY275431 mRNA Translation: AAQ19120.1
BC037810 mRNA No translation available.
CCDSiCCDS41729.1
RefSeqiNP_001032647.2, NM_001037558.2
UniGeneiHs.159863

3D structure databases

ProteinModelPortaliQ6WQI6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386143

Polymorphism and mutation databases

BioMutaiHEPN1

Proteomic databases

PaxDbiQ6WQI6
PRIDEiQ6WQI6
ProteomicsDBi67773

Protocols and materials databases

DNASUi641654
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408930; ENSP00000386143; ENSG00000221932
GeneIDi641654
KEGGihsa:641654
UCSCiuc001qbj.2 human

Organism-specific databases

CTDi641654
DisGeNETi641654
EuPathDBiHostDB:ENSG00000221932.6
GeneCardsiHEPN1
HGNCiHGNC:34400 HEPN1
HPAiHPA043768
HPA063054
MIMi611641 gene
neXtProtiNX_Q6WQI6
OpenTargetsiENSG00000221932
PharmGKBiPA162390850
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUU6 Eukaryota
ENOG4110PUM LUCA
GeneTreeiENSGT00510000055197
HOGENOMiHOG000112888
InParanoidiQ6WQI6
OMAiWHGHVLA
OrthoDBiEOG091G16DZ
PhylomeDBiQ6WQI6

Miscellaneous databases

GenomeRNAii641654
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000221932 Expressed in 72 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_HEPN1

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiHEPN1_HUMAN
AccessioniPrimary (citable) accession number: Q6WQI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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