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UniProtKB - Q6WN34 (CRDL2_HUMAN)

Entry version 137 (25 May 2022)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Chordin-like protein 2

Gene

CHRDL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity).

Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.

By similarity2 Publications

Caution

According to PubMed:14660436, interacts with BMP2, BMP4, BMP5, BMP6, BMP7 but not INHBA. According to PubMed:15094188, interacts with INHBA but not BMP2, BMP4 and BMP6.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processChondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6WN34

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6WN34

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chordin-like protein 2
Alternative name(s):
Breast tumor novel factor 1
Short name:
BNF-1
Chordin-related protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHRDL2
Synonyms:BNF1, CHL2
ORF Names:UNQ765/PRO1557
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24168, CHRDL2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613127, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6WN34

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000054938

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		25884

Open Targets

More...OpenTargetsi		ENSG00000054938

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134883081

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6WN34, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CHRDL2

Domain mapping of disease mutations (DMDM)

More...DMDMi		62900089

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 251 PublicationAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000537126 – 429Chordin-like protein 2Add BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi114N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei182Phosphoserine; by FAM20C1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6WN34

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6WN34

PeptideAtlas

More...PeptideAtlasi		Q6WN34

PRoteomics IDEntifications database

More...PRIDEi		Q6WN34

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67768 [Q6WN34-1]
67769 [Q6WN34-2]
67770 [Q6WN34-3]
67771 [Q6WN34-4]
67772 [Q6WN34-5]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2935, 23 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6WN34, 2 sites, 24 N-linked glycans (1 site), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6WN34

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6WN34

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in breast tumors but also in lung and colon tumors.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000054938, Expressed in ectocervix and 131 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6WN34, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6WN34, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000054938, Tissue enhanced (endometrium, gallbladder, lymphoid tissue, smooth muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GDF5 (By similarity). May interact with BMP2, BMP4, BMP5, BMP6, BMP7 and INHBA.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117395, 114 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q6WN34

Protein interaction database and analysis system

More...IntActi		Q6WN34, 15 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263671

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6WN34, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q6WN34

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6WN34

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 96VWFC 1PROSITE-ProRule annotationAdd BLAST66
Domaini109 – 175VWFC 2PROSITE-ProRule annotationAdd BLAST67
Domaini250 – 315VWFC 3PROSITE-ProRule annotationAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni182 – 224DisorderedSequence analysisAdd BLAST43

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161241

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_048288_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6WN34

Identification of Orthologs from Complete Genome Data

More...OMAi		TNEGHWN

Database of Orthologous Groups

More...OrthoDBi		454087at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6WN34

TreeFam database of animal gene trees

More...TreeFami		TF106451

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030117, Chordin-like_2
IPR045717, CHRDL1/2
IPR045716, CHRDL_1/2_C
IPR001007, VWF_dom

The PANTHER Classification System

More...PANTHERi		PTHR46303, PTHR46303, 1 hit
PTHR46303:SF3, PTHR46303:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF19548, CHRDL_1_2_C, 1 hit
PF00093, VWC, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00214, VWC, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01208, VWFC_1, 3 hits
PS50184, VWFC_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Five additional mRNAs also exist. Differential expression of isoforms was observed during myoblast and osteoblast differentiation and maturation.

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6WN34-1) [UniParc]FASTAAdd to basket
Also known as: I

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPEVRVLSS LLGLALLWFP LDSHARARPD MFCLFHGKRY SPGESWHPYL 
        60         70         80         90        100
EPQGLMYCLR CTCSEGAHVS CYRLHCPPVH CPQPVTEPQQ CCPKCVEPHT 
       110        120        130        140        150
PSGLRAPPKS CQHNGTMYQH GEIFSAHELF PSRLPNQCVL CSCTEGQIYC 
       160        170        180        190        200
GLTTCPEPGC PAPLPLPDSC CQACKDEASE QSDEEDSVQS LHGVRHPQDP 
       210        220        230        240        250
CSSDAGRKRG PGTPAPTGLS APLSFIPRHF RPKGAGSTTV KIVLKEKHKK 
       260        270        280        290        300
ACVHGGKTYS HGEVWHPAFR AFGPLPCILC TCEDGRQDCQ RVTCPTEYPC 
       310        320        330        340        350
RHPEKVAGKC CKICPEDKAD PGHSEISSTR CPKAPGRVLV HTSVSPSPDN 
       360        370        380        390        400
LRRFALEHEA SDLVEIYLWK LVKGIFHLTQ IKKVRKQDFQ KEAQHFRLLA 
       410        420 
GPHEGHWNVF LAQTLELKVT ASPDKVTKT
Length:429
Mass (Da):47,495
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8111F26B2EF96A4
GO
Isoform 2 (identifier: Q6WN34-2) [UniParc]FASTAAdd to basket
Also known as: II

The sequence of this isoform differs from the canonical sequence as follows:
     374-426: GIFHLTQIKK...LKVTASPDKV → DEETEAQRGE...GQSRQSDQDI

Show »
Length:451
Mass (Da):49,675
Checksum:iCFBF0BFA7D58CFE3
GO
Isoform 3 (identifier: Q6WN34-3) [UniParc]FASTAAdd to basket
Also known as: VII

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     21-28: LDSHARAR → MALVGLPG
     66-162: GAHVSCYRLH...TTCPEPGCPA → NLTLPLDSGP...KRTVCSRSMG
     163-429: Missing.

Show »
Length:142
Mass (Da):15,136
Checksum:i66564AA513E1D2E7
GO
Isoform 4 (identifier: Q6WN34-4) [UniParc]FASTAAdd to basket
Also known as: VIII

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     21-28: LDSHARAR → MALVGLPG
     145-162: EGQIYCGLTTCPEPGCPA → MRQVSNRMKRTVCSRSMG
     163-429: Missing.

Show »
Length:142
Mass (Da):15,922
Checksum:i577245066155CBC1
GO
Isoform 5 (identifier: Q6WN34-5) [UniParc]FASTAAdd to basket
Also known as: IX

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     21-28: LDSHARAR → MALVGLPG
     66-113: GAHVSCYRLH...LRAPPKSCQH → NLTLPLDSGP...PTSVSSAAAQ
     114-429: Missing.

Show »
Length:93
Mass (Da):9,846
Checksum:i9DFEC54E7C1EF6CE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6WN33Q6WN33_HUMAN
Chordin-like protein 2
CHRDL2 CHL2
308Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MQ10A8MQ10_HUMAN
Chordin-like protein 2
CHRDL2
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCU0H0YCU0_HUMAN
Chordin-like protein 2
CHRDL2
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDT1H0YDT1_HUMAN
Chordin-like protein 2
CHRDL2
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti187S → R in AX140199 (PubMed:15094188).Curated1
Sequence conflicti231R → I in AX140199 (PubMed:15094188).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055651335P → L. Corresponds to variant dbSNP:rs35903991Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0135121 – 20Missing in isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_01351321 – 28LDSHARAR → MALVGLPG in isoform 3, isoform 4 and isoform 5. 1 Publication8
Alternative sequenceiVSP_01351466 – 162GAHVS…PGCPA → NLTLPLDSGPHQSPASTTGP CTNTERSSVPMSCSPPACPT SVSSAAAQRARSTAASQPAP NQAAQHPSRCQTPAAKPAKM RQVSNRMKRTVCSRSMG in isoform 3. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_01351566 – 113GAHVS…KSCQH → NLTLPLDSGPHQSPASTTGP CTNTERSSVPMSCSPPACPT SVSSAAAQ in isoform 5. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_013516114 – 429Missing in isoform 5. 1 PublicationAdd BLAST316
Alternative sequenceiVSP_013517145 – 162EGQIY…PGCPA → MRQVSNRMKRTVCSRSMG in isoform 4. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_013518163 – 429Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST267
Alternative sequenceiVSP_013519374 – 426GIFHL…SPDKV → DEETEAQRGEVPGPRPHSQN LPLDSDQESQEARLPERGTA LPTARWPPRRSLERLPSPDP GAEGHGQSRQSDQDI in isoform 2. 3 PublicationsAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY163868 mRNA Translation: AAO31809.1
AY279090 mRNA Translation: AAQ19179.1
AY279092 mRNA Translation: AAQ19181.1
AY279093 mRNA Translation: AAQ19182.1
AY279094 mRNA Translation: AAQ19183.1
AX140199 mRNA No translation available.
AY358522 mRNA Translation: AAQ88886.1
BC142623 mRNA Translation: AAI42624.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS60893.1 [Q6WN34-1]
CCDS8234.1 [Q6WN34-2]

NCBI Reference Sequences

More...RefSeqi		NP_001265402.1, NM_001278473.2 [Q6WN34-1]
NP_001291319.1, NM_001304390.1
NP_001291320.1, NM_001304391.1
NP_001291344.1, NM_001304415.1
NP_001291345.1, NM_001304416.1
NP_001291346.1, NM_001304417.1
NP_056239.3, NM_015424.5 [Q6WN34-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263671.9; ENSP00000263671.5; ENSG00000054938.17 [Q6WN34-2]
ENST00000376332.8; ENSP00000365510.3; ENSG00000054938.17
ENST00000528471.1; ENSP00000434589.1; ENSG00000054938.17 [Q6WN34-5]
ENST00000534276.5; ENSP00000432055.1; ENSG00000054938.17 [Q6WN34-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25884

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25884

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000376332.8; ENSP00000365510.3; NM_001278473.3; NP_001265402.1

UCSC genome browser

More...UCSCi		uc001ovh.5, human [Q6WN34-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY163868 mRNA Translation: AAO31809.1
AY279090 mRNA Translation: AAQ19179.1
AY279092 mRNA Translation: AAQ19181.1
AY279093 mRNA Translation: AAQ19182.1
AY279094 mRNA Translation: AAQ19183.1
AX140199 mRNA No translation available.
AY358522 mRNA Translation: AAQ88886.1
BC142623 mRNA Translation: AAI42624.1
CCDSiCCDS60893.1 [Q6WN34-1]
CCDS8234.1 [Q6WN34-2]
RefSeqiNP_001265402.1, NM_001278473.2 [Q6WN34-1]
NP_001291319.1, NM_001304390.1
NP_001291320.1, NM_001304391.1
NP_001291344.1, NM_001304415.1
NP_001291345.1, NM_001304416.1
NP_001291346.1, NM_001304417.1
NP_056239.3, NM_015424.5 [Q6WN34-2]

3D structure databases

AlphaFoldDBiQ6WN34
SMRiQ6WN34
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117395, 114 interactors
CORUMiQ6WN34
IntActiQ6WN34, 15 interactors
STRINGi9606.ENSP00000263671

PTM databases

GlyConnecti2935, 23 N-Linked glycans (1 site)
GlyGeniQ6WN34, 2 sites, 24 N-linked glycans (1 site), 1 O-linked glycan (1 site)
iPTMnetiQ6WN34
PhosphoSitePlusiQ6WN34

Genetic variation databases

BioMutaiCHRDL2
DMDMi62900089

Proteomic databases

jPOSTiQ6WN34
MassIVEiQ6WN34
PeptideAtlasiQ6WN34
PRIDEiQ6WN34
ProteomicsDBi67768 [Q6WN34-1]
67769 [Q6WN34-2]
67770 [Q6WN34-3]
67771 [Q6WN34-4]
67772 [Q6WN34-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17275, 152 antibodies from 22 providers

The DNASU plasmid repository

More...DNASUi		25884

Genome annotation databases

EnsembliENST00000263671.9; ENSP00000263671.5; ENSG00000054938.17 [Q6WN34-2]
ENST00000376332.8; ENSP00000365510.3; ENSG00000054938.17
ENST00000528471.1; ENSP00000434589.1; ENSG00000054938.17 [Q6WN34-5]
ENST00000534276.5; ENSP00000432055.1; ENSG00000054938.17 [Q6WN34-4]
GeneIDi25884
KEGGihsa:25884
MANE-SelectiENST00000376332.8; ENSP00000365510.3; NM_001278473.3; NP_001265402.1
UCSCiuc001ovh.5, human [Q6WN34-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25884
DisGeNETi25884

GeneCards: human genes, protein and diseases

More...GeneCardsi		CHRDL2
HGNCiHGNC:24168, CHRDL2
HPAiENSG00000054938, Tissue enhanced (endometrium, gallbladder, lymphoid tissue, smooth muscle)
MIMi613127, gene
neXtProtiNX_Q6WN34
OpenTargetsiENSG00000054938
PharmGKBiPA134883081
VEuPathDBiHostDB:ENSG00000054938

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000161241
HOGENOMiCLU_048288_1_1_1
InParanoidiQ6WN34
OMAiTNEGHWN
OrthoDBi454087at2759
PhylomeDBiQ6WN34
TreeFamiTF106451

Enzyme and pathway databases

PathwayCommonsiQ6WN34
SignaLinkiQ6WN34

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		25884, 16 hits in 1071 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CHRDL2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25884
PharosiQ6WN34, Tbio

Protein Ontology

More...PROi		PR:Q6WN34
RNActiQ6WN34, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000054938, Expressed in ectocervix and 131 other tissues
ExpressionAtlasiQ6WN34, baseline and differential
GenevisibleiQ6WN34, HS

Family and domain databases

InterProiView protein in InterPro
IPR030117, Chordin-like_2
IPR045717, CHRDL1/2
IPR045716, CHRDL_1/2_C
IPR001007, VWF_dom
PANTHERiPTHR46303, PTHR46303, 1 hit
PTHR46303:SF3, PTHR46303:SF3, 1 hit
PfamiView protein in Pfam
PF19548, CHRDL_1_2_C, 1 hit
PF00093, VWC, 3 hits
SMARTiView protein in SMART
SM00214, VWC, 3 hits
PROSITEiView protein in PROSITE
PS01208, VWFC_1, 3 hits
PS50184, VWFC_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRDL2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6WN34
Secondary accession number(s): A5PKU9
, Q6WN30, Q6WN31, Q6WN32, Q7Z5J3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: May 25, 2022
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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