UniProtKB - Q6WN34 (CRDL2_HUMAN)
Chordin-like protein 2
CHRDL2
Functioni
May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity).
Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.
By similarity2 PublicationsCaution
GO - Biological processi
- cartilage development Source: UniProtKB-KW
- cell differentiation Source: UniProtKB-KW
- ossification Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Chondrogenesis, Differentiation, Osteogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q6WN34 |
SignaLinki | Q6WN34 |
Names & Taxonomyi
Protein namesi | Recommended name: Chordin-like protein 2Alternative name(s): Breast tumor novel factor 1 Short name: BNF-1 Chordin-related protein 2 |
Gene namesi | Name:CHRDL2 Synonyms:BNF1, CHL2 ORF Names:UNQ765/PRO1557 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24168, CHRDL2 |
MIMi | 613127, gene |
neXtProti | NX_Q6WN34 |
VEuPathDBi | HostDB:ENSG00000054938 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- Secreted Curated
Cytoplasm and Cytosol
- Cytoplasm Curated
Cytoplasm and Cytosol
- Cytoplasm Curated
Cytoplasm and Cytosol
- Cytoplasm Curated
Extracellular region or secreted
- extracellular space Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 25884 |
OpenTargetsi | ENSG00000054938 |
PharmGKBi | PA134883081 |
Miscellaneous databases
Pharosi | Q6WN34, Tbio |
Genetic variation databases
BioMutai | CHRDL2 |
DMDMi | 62900089 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | 1 PublicationAdd BLAST | 25 | |
ChainiPRO_0000005371 | 26 – 429 | Chordin-like protein 2Add BLAST | 404 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 114 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 182 | Phosphoserine; by FAM20C1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q6WN34 |
MassIVEi | Q6WN34 |
PeptideAtlasi | Q6WN34 |
PRIDEi | Q6WN34 |
ProteomicsDBi | 67768 [Q6WN34-1] 67769 [Q6WN34-2] 67770 [Q6WN34-3] 67771 [Q6WN34-4] 67772 [Q6WN34-5] |
PTM databases
GlyConnecti | 2935, 23 N-Linked glycans (1 site) |
GlyGeni | Q6WN34, 2 sites, 24 N-linked glycans (1 site), 1 O-linked glycan (1 site) |
iPTMneti | Q6WN34 |
PhosphoSitePlusi | Q6WN34 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000054938, Expressed in ectocervix and 131 other tissues |
ExpressionAtlasi | Q6WN34, baseline and differential |
Genevisiblei | Q6WN34, HS |
Organism-specific databases
HPAi | ENSG00000054938, Tissue enhanced (endometrium, gallbladder, lymphoid tissue, smooth muscle) |
Interactioni
Subunit structurei
Interacts with GDF5 (By similarity). May interact with BMP2, BMP4, BMP5, BMP6, BMP7 and INHBA.
By similarity2 PublicationsBinary interactionsi
Isoform 2 [Q6WN34-2]
Protein-protein interaction databases
BioGRIDi | 117395, 114 interactors |
CORUMi | Q6WN34 |
IntActi | Q6WN34, 15 interactors |
STRINGi | 9606.ENSP00000263671 |
Miscellaneous databases
RNActi | Q6WN34, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 96 | VWFC 1PROSITE-ProRule annotationAdd BLAST | 66 | |
Domaini | 109 – 175 | VWFC 2PROSITE-ProRule annotationAdd BLAST | 67 | |
Domaini | 250 – 315 | VWFC 3PROSITE-ProRule annotationAdd BLAST | 66 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 182 – 224 | DisorderedSequence analysisAdd BLAST | 43 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
GeneTreei | ENSGT00940000161241 |
HOGENOMi | CLU_048288_1_1_1 |
InParanoidi | Q6WN34 |
OMAi | TNEGHWN |
OrthoDBi | 454087at2759 |
PhylomeDBi | Q6WN34 |
TreeFami | TF106451 |
Family and domain databases
InterProi | View protein in InterPro IPR030117, Chordin-like_2 IPR045717, CHRDL1/2 IPR045716, CHRDL_1/2_C IPR001007, VWF_dom |
PANTHERi | PTHR46303, PTHR46303, 1 hit PTHR46303:SF3, PTHR46303:SF3, 1 hit |
Pfami | View protein in Pfam PF19548, CHRDL_1_2_C, 1 hit PF00093, VWC, 3 hits |
SMARTi | View protein in SMART SM00214, VWC, 3 hits |
PROSITEi | View protein in PROSITE PS01208, VWFC_1, 3 hits PS50184, VWFC_2, 3 hits |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVPEVRVLSS LLGLALLWFP LDSHARARPD MFCLFHGKRY SPGESWHPYL
60 70 80 90 100
EPQGLMYCLR CTCSEGAHVS CYRLHCPPVH CPQPVTEPQQ CCPKCVEPHT
110 120 130 140 150
PSGLRAPPKS CQHNGTMYQH GEIFSAHELF PSRLPNQCVL CSCTEGQIYC
160 170 180 190 200
GLTTCPEPGC PAPLPLPDSC CQACKDEASE QSDEEDSVQS LHGVRHPQDP
210 220 230 240 250
CSSDAGRKRG PGTPAPTGLS APLSFIPRHF RPKGAGSTTV KIVLKEKHKK
260 270 280 290 300
ACVHGGKTYS HGEVWHPAFR AFGPLPCILC TCEDGRQDCQ RVTCPTEYPC
310 320 330 340 350
RHPEKVAGKC CKICPEDKAD PGHSEISSTR CPKAPGRVLV HTSVSPSPDN
360 370 380 390 400
LRRFALEHEA SDLVEIYLWK LVKGIFHLTQ IKKVRKQDFQ KEAQHFRLLA
410 420
GPHEGHWNVF LAQTLELKVT ASPDKVTKT
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6WN33 | Q6WN33_HUMAN | Chordin-like protein 2 | CHRDL2 CHL2 | 308 | Annotation score: | ||
A8MQ10 | A8MQ10_HUMAN | Chordin-like protein 2 | CHRDL2 | 142 | Annotation score: | ||
H0YCU0 | H0YCU0_HUMAN | Chordin-like protein 2 | CHRDL2 | 91 | Annotation score: | ||
H0YDT1 | H0YDT1_HUMAN | Chordin-like protein 2 | CHRDL2 | 177 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 187 | S → R in AX140199 (PubMed:15094188).Curated | 1 | |
Sequence conflicti | 231 | R → I in AX140199 (PubMed:15094188).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055651 | 335 | P → L. Corresponds to variant dbSNP:rs35903991Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013512 | 1 – 20 | Missing in isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_013513 | 21 – 28 | LDSHARAR → MALVGLPG in isoform 3, isoform 4 and isoform 5. 1 Publication | 8 | |
Alternative sequenceiVSP_013514 | 66 – 162 | GAHVS…PGCPA → NLTLPLDSGPHQSPASTTGP CTNTERSSVPMSCSPPACPT SVSSAAAQRARSTAASQPAP NQAAQHPSRCQTPAAKPAKM RQVSNRMKRTVCSRSMG in isoform 3. 1 PublicationAdd BLAST | 97 | |
Alternative sequenceiVSP_013515 | 66 – 113 | GAHVS…KSCQH → NLTLPLDSGPHQSPASTTGP CTNTERSSVPMSCSPPACPT SVSSAAAQ in isoform 5. 1 PublicationAdd BLAST | 48 | |
Alternative sequenceiVSP_013516 | 114 – 429 | Missing in isoform 5. 1 PublicationAdd BLAST | 316 | |
Alternative sequenceiVSP_013517 | 145 – 162 | EGQIY…PGCPA → MRQVSNRMKRTVCSRSMG in isoform 4. 1 PublicationAdd BLAST | 18 | |
Alternative sequenceiVSP_013518 | 163 – 429 | Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST | 267 | |
Alternative sequenceiVSP_013519 | 374 – 426 | GIFHL…SPDKV → DEETEAQRGEVPGPRPHSQN LPLDSDQESQEARLPERGTA LPTARWPPRRSLERLPSPDP GAEGHGQSRQSDQDI in isoform 2. 3 PublicationsAdd BLAST | 53 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY163868 mRNA Translation: AAO31809.1 AY279090 mRNA Translation: AAQ19179.1 AY279092 mRNA Translation: AAQ19181.1 AY279093 mRNA Translation: AAQ19182.1 AY279094 mRNA Translation: AAQ19183.1 AX140199 mRNA No translation available. AY358522 mRNA Translation: AAQ88886.1 BC142623 mRNA Translation: AAI42624.1 |
CCDSi | CCDS60893.1 [Q6WN34-1] CCDS8234.1 [Q6WN34-2] |
RefSeqi | NP_001265402.1, NM_001278473.2 [Q6WN34-1] NP_001291319.1, NM_001304390.1 NP_001291320.1, NM_001304391.1 NP_001291344.1, NM_001304415.1 NP_001291345.1, NM_001304416.1 NP_001291346.1, NM_001304417.1 NP_056239.3, NM_015424.5 [Q6WN34-2] |
Genome annotation databases
Ensembli | ENST00000263671.9; ENSP00000263671.5; ENSG00000054938.17 [Q6WN34-2] ENST00000376332.8; ENSP00000365510.3; ENSG00000054938.17 ENST00000528471.1; ENSP00000434589.1; ENSG00000054938.17 [Q6WN34-5] ENST00000534276.5; ENSP00000432055.1; ENSG00000054938.17 [Q6WN34-4] |
GeneIDi | 25884 |
KEGGi | hsa:25884 |
MANE-Selecti | ENST00000376332.8; ENSP00000365510.3; NM_001278473.3; NP_001265402.1 |
UCSCi | uc001ovh.5, human [Q6WN34-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY163868 mRNA Translation: AAO31809.1 AY279090 mRNA Translation: AAQ19179.1 AY279092 mRNA Translation: AAQ19181.1 AY279093 mRNA Translation: AAQ19182.1 AY279094 mRNA Translation: AAQ19183.1 AX140199 mRNA No translation available. AY358522 mRNA Translation: AAQ88886.1 BC142623 mRNA Translation: AAI42624.1 |
CCDSi | CCDS60893.1 [Q6WN34-1] CCDS8234.1 [Q6WN34-2] |
RefSeqi | NP_001265402.1, NM_001278473.2 [Q6WN34-1] NP_001291319.1, NM_001304390.1 NP_001291320.1, NM_001304391.1 NP_001291344.1, NM_001304415.1 NP_001291345.1, NM_001304416.1 NP_001291346.1, NM_001304417.1 NP_056239.3, NM_015424.5 [Q6WN34-2] |
3D structure databases
AlphaFoldDBi | Q6WN34 |
SMRi | Q6WN34 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117395, 114 interactors |
CORUMi | Q6WN34 |
IntActi | Q6WN34, 15 interactors |
STRINGi | 9606.ENSP00000263671 |
PTM databases
GlyConnecti | 2935, 23 N-Linked glycans (1 site) |
GlyGeni | Q6WN34, 2 sites, 24 N-linked glycans (1 site), 1 O-linked glycan (1 site) |
iPTMneti | Q6WN34 |
PhosphoSitePlusi | Q6WN34 |
Genetic variation databases
BioMutai | CHRDL2 |
DMDMi | 62900089 |
Proteomic databases
jPOSTi | Q6WN34 |
MassIVEi | Q6WN34 |
PeptideAtlasi | Q6WN34 |
PRIDEi | Q6WN34 |
ProteomicsDBi | 67768 [Q6WN34-1] 67769 [Q6WN34-2] 67770 [Q6WN34-3] 67771 [Q6WN34-4] 67772 [Q6WN34-5] |
Protocols and materials databases
Antibodypediai | 17275, 152 antibodies from 22 providers |
DNASUi | 25884 |
Genome annotation databases
Ensembli | ENST00000263671.9; ENSP00000263671.5; ENSG00000054938.17 [Q6WN34-2] ENST00000376332.8; ENSP00000365510.3; ENSG00000054938.17 ENST00000528471.1; ENSP00000434589.1; ENSG00000054938.17 [Q6WN34-5] ENST00000534276.5; ENSP00000432055.1; ENSG00000054938.17 [Q6WN34-4] |
GeneIDi | 25884 |
KEGGi | hsa:25884 |
MANE-Selecti | ENST00000376332.8; ENSP00000365510.3; NM_001278473.3; NP_001265402.1 |
UCSCi | uc001ovh.5, human [Q6WN34-1] |
Organism-specific databases
CTDi | 25884 |
DisGeNETi | 25884 |
GeneCardsi | CHRDL2 |
HGNCi | HGNC:24168, CHRDL2 |
HPAi | ENSG00000054938, Tissue enhanced (endometrium, gallbladder, lymphoid tissue, smooth muscle) |
MIMi | 613127, gene |
neXtProti | NX_Q6WN34 |
OpenTargetsi | ENSG00000054938 |
PharmGKBi | PA134883081 |
VEuPathDBi | HostDB:ENSG00000054938 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161241 |
HOGENOMi | CLU_048288_1_1_1 |
InParanoidi | Q6WN34 |
OMAi | TNEGHWN |
OrthoDBi | 454087at2759 |
PhylomeDBi | Q6WN34 |
TreeFami | TF106451 |
Enzyme and pathway databases
PathwayCommonsi | Q6WN34 |
SignaLinki | Q6WN34 |
Miscellaneous databases
BioGRID-ORCSi | 25884, 16 hits in 1071 CRISPR screens |
ChiTaRSi | CHRDL2, human |
GenomeRNAii | 25884 |
Pharosi | Q6WN34, Tbio |
PROi | PR:Q6WN34 |
RNActi | Q6WN34, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000054938, Expressed in ectocervix and 131 other tissues |
ExpressionAtlasi | Q6WN34, baseline and differential |
Genevisiblei | Q6WN34, HS |
Family and domain databases
InterProi | View protein in InterPro IPR030117, Chordin-like_2 IPR045717, CHRDL1/2 IPR045716, CHRDL_1/2_C IPR001007, VWF_dom |
PANTHERi | PTHR46303, PTHR46303, 1 hit PTHR46303:SF3, PTHR46303:SF3, 1 hit |
Pfami | View protein in Pfam PF19548, CHRDL_1_2_C, 1 hit PF00093, VWC, 3 hits |
SMARTi | View protein in SMART SM00214, VWC, 3 hits |
PROSITEi | View protein in PROSITE PS01208, VWFC_1, 3 hits PS50184, VWFC_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CRDL2_HUMAN | |
Accessioni | Q6WN34Primary (citable) accession number: Q6WN34 Secondary accession number(s): A5PKU9 Q7Z5J3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot