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Entry version 154 (12 Aug 2020)
Sequence version 3 (26 Jun 2013)
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Protein

Rab11 family-interacting protein 1

Gene

RAB11FIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Rab GTPase binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6WKZ4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rab11 family-interacting protein 1
Short name:
Rab11-FIP1
Alternative name(s):
Rab-coupling protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAB11FIP1
Synonyms:RCP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000156675.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30265, RAB11FIP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608737, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6WKZ4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1254Y → F: Does not abolish the interaction with RAB11A, homooligomerization and subcellular location. Reduces the interaction with RAB4A. 1 Publication1
Mutagenesisi1255I → E: Abolishes the interaction with RAB11A and RAB4A, homooligomerization and subcellular location. 1 Publication1
Mutagenesisi1256D → N: Does not abolish the interaction with RAB11A, homooligomerization and subcellular location. Reduces the interaction with RAB4A. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
80223

Open Targets

More...
OpenTargetsi
ENSG00000156675

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134937501

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6WKZ4, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RAB11FIP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
519668675

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000973041 – 1283Rab11 family-interacting protein 1Add BLAST1283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei184PhosphoserineBy similarity1
Modified residuei202PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei300PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei341PhosphoserineBy similarity1
Modified residuei343PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei382PhosphoserineBy similarity1
Modified residuei435PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei529PhosphoserineCombined sources1
Modified residuei545PhosphoserineCombined sources1
Modified residuei758PhosphoserineCombined sources1
Modified residuei1135PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6WKZ4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6WKZ4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6WKZ4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6WKZ4

PeptideAtlas

More...
PeptideAtlasi
Q6WKZ4

PRoteomics IDEntifications database

More...
PRIDEi
Q6WKZ4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67762 [Q6WKZ4-4]
67763 [Q6WKZ4-1]
67764 [Q6WKZ4-2]
67765 [Q6WKZ4-3]
67766 [Q6WKZ4-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6WKZ4

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q6WKZ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6WKZ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156675, Expressed in amniotic fluid and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6WKZ4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6WKZ4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000156675, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer (isoform 2).

Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25. According to PubMed:15280022, RAB4A binding to RAB11FIP1 is of very low affinity in vitro and in vivo.

5 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123189, 38 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q6WKZ4

Protein interaction database and analysis system

More...
IntActi
Q6WKZ4, 24 interactors

Molecular INTeraction database

More...
MINTi
Q6WKZ4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000331342

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6WKZ4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11283
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6WKZ4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 126C2PROSITE-ProRule annotationAdd BLAST126
Domaini1211 – 1273FIP-RBDPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1219 – 1283Necessary for interaction with RAB4A and RAB11A, subcellular location and endosomal recyclingAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi209 – 218Poly-Lys10
Compositional biasi556 – 609Ser-richAdd BLAST54

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVT0, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159649

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015242_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6WKZ4

KEGG Orthology (KO)

More...
KOi
K12484

Identification of Orthologs from Complete Genome Data

More...
OMAi
EFGIHKP

Database of Orthologous Groups

More...
OrthoDBi
567750at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6WKZ4

TreeFam database of animal gene trees

More...
TreeFami
TF326172

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037245, FIP-RBD_C_sf
IPR037789, FIP_classI
IPR019018, Rab-bd_FIP-RBD

The PANTHER Classification System

More...
PANTHERi
PTHR15746, PTHR15746, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF09457, RBD-FIP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF144270, SSF144270, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS51511, FIP_RBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6WKZ4-4) [UniParc]FASTAAdd to basket
Also known as: Rab11-FIP 1B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLMVSAGRG LGAVWSPTHV QVTVLQARGL RAKGPGGTSD AYAVIQVGKE
60 70 80 90 100
KYATSVSERS LGAPVWREEA TFELPSLLSS GPAAAATLQL TVLHRALLGL
110 120 130 140 150
DKFLGRAEVD LRDLHRDQGR RKTQWYKLKS KPGKKDKERG EIEVDIQFMR
160 170 180 190 200
NNMTASMFDL SMKDKSRNPF GKLKDKIKGK NKDSGSDTAS AIIPSTTPSV
210 220 230 240 250
DSDDESVVKD KKKKSKIKTL LSKSNLQKTP LSQSMSVLPT SKPEKVLLRP
260 270 280 290 300
GDFQSQWDED DNEDESSSAS DVMSHKRTAS TDLKQLNQVN FTLPKKEGLS
310 320 330 340 350
FLGGLRSKND VLSRSNVCIN GNHVYLEQPE AKGEIKDSSP SSSPSPKGFR
360 370 380 390 400
KKHLFSSTEN LAAGSWKEPA EGGGLSSDRQ LSESSTKDSL KSMTLPSYRP
410 420 430 440 450
APLVSGDLRE NMAPANSEAT KEAKESKKPE SRRSSLLSLM TGKKDVAKGS
460 470 480 490 500
EGENPLTVPG REKEGMLMGV KPGEDASGPA EDLVRRSEKD TAAVVSRQGS
510 520 530 540 550
SLNLFEDVQI TEPEAEPESK SEPRPPISSP RAPQTRAVKP RLEVSPEAQP
560 570 580 590 600
TARLPSPTDS PSSLPPLPSS SGQASVPSEL GHGADTQSSE SPSVFSSLSS
610 620 630 640 650
PIAAPISTST PIESWPLVDR GQAKSEGPPL LPKAELQTES LTPVPNSGSS
660 670 680 690 700
ALGSLFKQPS FPANKGTEDS LMGRTRETGT EKNTSSLELE ESLPEQPETG
710 720 730 740 750
RQEEELPRFP CKKQDYSPSS GEAQEVPFAL SLSSDGAVSP VGELAAGGDR
760 770 780 790 800
DLESQAGSLV ESKARDAAEE VAPPLPMGAS VPSIDSMMRK LEEMGLNLRK
810 820 830 840 850
DQKKTKKRVS FSEQLFTEEA VAGAALLVEG HSSCPQELNP AWSVAGNASD
860 870 880 890 900
GEPPESPHAE DSERESVTTP GPATCGAPAS PADHLLLPSQ EESFSEVPMS
910 920 930 940 950
EASSAKDTPL FRMEGEDALV TQYQSKASDH EGLLSDPLSD LQLVSDFKSP
960 970 980 990 1000
IMADLNLSLP SIPEVASDDE RIDQVEDDGD QVEDDGETAK SSTLDIGALS
1010 1020 1030 1040 1050
LGLVVPCPER GKGPSGEADR LVLGEGLCDF RLQAPQASVT APSEQTTEFG
1060 1070 1080 1090 1100
IHKPHLGKSS SLDKQLPGPS GGEEEKPMGN GSPSPPPGTS LDNPVPSPSP
1110 1120 1130 1140 1150
SEIFPVTHSF PSSAHSDTHH TSTAESQKKA TAEGSAGRVE NFGKRKPLLQ
1160 1170 1180 1190 1200
AWVSPSETHP VSAQPGAGTG SAKHRLHPVK PMNAMATKVA NCSLGTATII
1210 1220 1230 1240 1250
SENLNNEVMM KKYSPSDPAF AYAQLTHDEL IQLVLKQKET ISKKEFQVRE
1260 1270 1280
LEDYIDNLLV RVMEETPNIL RIPTQVGKKA GKM
Length:1,283
Mass (Da):137,167
Last modified:June 26, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19DF0C848435780B
GO
Isoform 2 (identifier: Q6WKZ4-3) [UniParc]FASTAAdd to basket
Also known as: Rab11-FIP 1C

The sequence of this isoform differs from the canonical sequence as follows:
     541-1174: Missing.

Show »
Length:649
Mass (Da):70,983
Checksum:iC291028B31112E01
GO
Isoform 3 (identifier: Q6WKZ4-1) [UniParc]FASTAAdd to basket
Also known as: Rab11-FIP 1A

The sequence of this isoform differs from the canonical sequence as follows:
     1-671: Missing.

Show »
Length:612
Mass (Da):65,217
Checksum:i310263344F395FD4
GO
Isoform 4 (identifier: Q6WKZ4-2) [UniParc]FASTAAdd to basket
Also known as: Rab11-FIP 1H, No Rab11-binding protein 2

The sequence of this isoform differs from the canonical sequence as follows:
     1-148: Missing.
     541-1174: Missing.
     1212-1221: KYSPSDPAFA → VCPLRSWCVR
     1222-1283: Missing.

Show »
Length:439
Mass (Da):47,704
Checksum:i9A54EC6C78C3C3F3
GO
Isoform 5 (identifier: Q6WKZ4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-142: RDQGRRKTQWYKLKSKPGKKDKERGEI → SSLGKSFFKTLKKRAWAIFLRLCLKKN
     143-1283: Missing.

Show »
Length:142
Mass (Da):15,304
Checksum:i6C070166F8160FDF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EX40E7EX40_HUMAN
Rab11 family-interacting protein 1
RAB11FIP1
501Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti330 – 332EAK → QPT in AAM09571 (PubMed:11786538).Curated3
Sequence conflicti353H → T in AAM09571 (PubMed:11786538).Curated1
Sequence conflicti377S → T in AAM09571 (PubMed:11786538).Curated1
Sequence conflicti380 – 381QL → DV in AAM09571 (PubMed:11786538).Curated2
Sequence conflicti397S → T in AAM09571 (PubMed:11786538).Curated1
Sequence conflicti404V → I in AAM09571 (PubMed:11786538).Curated1
Sequence conflicti411N → K in AAM09571 (PubMed:11786538).Curated1
Sequence conflicti455P → L in AAM09571 (PubMed:11786538).Curated1
Sequence conflicti482D → G in AAQ18788 (PubMed:16920206).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069365622Q → K2 PublicationsCorresponds to variant dbSNP:rs7341564Ensembl.1
Natural variantiVAR_059714651A → V1 PublicationCorresponds to variant dbSNP:rs12541651Ensembl.1
Natural variantiVAR_056977768A → V. Corresponds to variant dbSNP:rs16887092Ensembl.1
Natural variantiVAR_0224471185M → T3 PublicationsCorresponds to variant dbSNP:rs7817179Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0137261 – 671Missing in isoform 3. 2 PublicationsAdd BLAST671
Alternative sequenceiVSP_0137271 – 148Missing in isoform 4. 1 PublicationAdd BLAST148
Alternative sequenceiVSP_013728116 – 142RDQGR…ERGEI → SSLGKSFFKTLKKRAWAIFL RLCLKKN in isoform 5. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_013729143 – 1283Missing in isoform 5. 1 PublicationAdd BLAST1141
Alternative sequenceiVSP_013730541 – 1174Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST634
Alternative sequenceiVSP_0137311212 – 1221KYSPSDPAFA → VCPLRSWCVR in isoform 4. 1 Publication10
Alternative sequenceiVSP_0137321222 – 1283Missing in isoform 4. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF368294 mRNA Translation: AAM09571.1
DQ236342 mRNA Translation: ABB43161.1
AY280966 mRNA Translation: AAQ18784.1
AY280968 mRNA Translation: AAQ18786.1
AY280970 mRNA Translation: AAQ18788.1
AK026275 mRNA Translation: BAB15424.1
AK122583 mRNA Translation: BAC56924.1
AK291781 mRNA Translation: BAF84470.1
AC130304 Genomic DNA No translation available.
BC077720 mRNA Translation: AAH77720.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34881.1 [Q6WKZ4-3]
CCDS34882.1 [Q6WKZ4-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001002814.2, NM_001002814.2 [Q6WKZ4-4]
NP_079427.4, NM_025151.4 [Q6WKZ4-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000287263; ENSP00000287263; ENSG00000156675 [Q6WKZ4-3]
ENST00000330843; ENSP00000331342; ENSG00000156675 [Q6WKZ4-4]
ENST00000524118; ENSP00000430680; ENSG00000156675 [Q6WKZ4-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80223

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80223

UCSC genome browser

More...
UCSCi
uc003xkm.3, human [Q6WKZ4-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368294 mRNA Translation: AAM09571.1
DQ236342 mRNA Translation: ABB43161.1
AY280966 mRNA Translation: AAQ18784.1
AY280968 mRNA Translation: AAQ18786.1
AY280970 mRNA Translation: AAQ18788.1
AK026275 mRNA Translation: BAB15424.1
AK122583 mRNA Translation: BAC56924.1
AK291781 mRNA Translation: BAF84470.1
AC130304 Genomic DNA No translation available.
BC077720 mRNA Translation: AAH77720.1
CCDSiCCDS34881.1 [Q6WKZ4-3]
CCDS34882.1 [Q6WKZ4-4]
RefSeqiNP_001002814.2, NM_001002814.2 [Q6WKZ4-4]
NP_079427.4, NM_025151.4 [Q6WKZ4-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D0GX-ray2.50C1216-1283[»]
SMRiQ6WKZ4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123189, 38 interactors
CORUMiQ6WKZ4
IntActiQ6WKZ4, 24 interactors
MINTiQ6WKZ4
STRINGi9606.ENSP00000331342

PTM databases

iPTMnetiQ6WKZ4
MetOSiteiQ6WKZ4
PhosphoSitePlusiQ6WKZ4

Polymorphism and mutation databases

BioMutaiRAB11FIP1
DMDMi519668675

Proteomic databases

EPDiQ6WKZ4
jPOSTiQ6WKZ4
MassIVEiQ6WKZ4
PaxDbiQ6WKZ4
PeptideAtlasiQ6WKZ4
PRIDEiQ6WKZ4
ProteomicsDBi67762 [Q6WKZ4-4]
67763 [Q6WKZ4-1]
67764 [Q6WKZ4-2]
67765 [Q6WKZ4-3]
67766 [Q6WKZ4-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4467, 196 antibodies

Genome annotation databases

EnsembliENST00000287263; ENSP00000287263; ENSG00000156675 [Q6WKZ4-3]
ENST00000330843; ENSP00000331342; ENSG00000156675 [Q6WKZ4-4]
ENST00000524118; ENSP00000430680; ENSG00000156675 [Q6WKZ4-2]
GeneIDi80223
KEGGihsa:80223
UCSCiuc003xkm.3, human [Q6WKZ4-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80223
DisGeNETi80223
EuPathDBiHostDB:ENSG00000156675.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RAB11FIP1
HGNCiHGNC:30265, RAB11FIP1
HPAiENSG00000156675, Tissue enhanced (intestine)
MIMi608737, gene
neXtProtiNX_Q6WKZ4
OpenTargetsiENSG00000156675
PharmGKBiPA134937501

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QVT0, Eukaryota
GeneTreeiENSGT00940000159649
HOGENOMiCLU_015242_0_0_1
InParanoidiQ6WKZ4
KOiK12484
OMAiEFGIHKP
OrthoDBi567750at2759
PhylomeDBiQ6WKZ4
TreeFamiTF326172

Enzyme and pathway databases

PathwayCommonsiQ6WKZ4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
80223, 5 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RAB11FIP1, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RAB11FIP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80223
PharosiQ6WKZ4, Tbio

Protein Ontology

More...
PROi
PR:Q6WKZ4
RNActiQ6WKZ4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156675, Expressed in amniotic fluid and 233 other tissues
ExpressionAtlasiQ6WKZ4, baseline and differential
GenevisibleiQ6WKZ4, HS

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037245, FIP-RBD_C_sf
IPR037789, FIP_classI
IPR019018, Rab-bd_FIP-RBD
PANTHERiPTHR15746, PTHR15746, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF09457, RBD-FIP, 1 hit
SMARTiView protein in SMART
SM00239, C2, 1 hit
SUPFAMiSSF144270, SSF144270, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS51511, FIP_RBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRFIP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6WKZ4
Secondary accession number(s): J3KNP0
, Q307T1, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 26, 2013
Last modified: August 12, 2020
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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