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Entry version 142 (18 Sep 2019)
Sequence version 3 (25 Nov 2008)
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Protein

Myosin phosphatase Rho-interacting protein

Gene

MPRIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6802952 Signaling by BRAF and RAF fusions

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q6WCQ1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin phosphatase Rho-interacting protein
Short name:
M-RIP
Alternative name(s):
Rho-interacting protein 3
Short name:
RIP3
p116Rip
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MPRIP
Synonyms:KIAA0864, MRIP, RHOIP3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30321 MPRIP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612935 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6WCQ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23164

Open Targets

More...
OpenTargetsi
ENSG00000133030

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162396092

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MPRIP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274136

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCurated
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002239302 – 1025Myosin phosphatase Rho-interacting proteinAdd BLAST1024

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei192PhosphoserineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei218PhosphoserineBy similarity1
Modified residuei220PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Modified residuei292PhosphoserineCombined sources1
Modified residuei295PhosphothreonineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei348PhosphothreonineCombined sources1
Modified residuei362PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei619PhosphoserineCombined sources1
Modified residuei646PhosphothreonineCombined sources1
Modified residuei663PhosphoserineCombined sources1
Modified residuei800PhosphoserineCombined sources1
Modified residuei891PhosphoserineCombined sources1
Modified residuei977PhosphoserineCombined sources1
Modified residuei993PhosphoserineCombined sources1
Modified residuei1014PhosphoserineBy similarity1
Modified residuei1016PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6WCQ1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6WCQ1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6WCQ1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6WCQ1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6WCQ1

PeptideAtlas

More...
PeptideAtlasi
Q6WCQ1

PRoteomics IDEntifications database

More...
PRIDEi
Q6WCQ1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67759 [Q6WCQ1-1]
67760 [Q6WCQ1-2]
67761 [Q6WCQ1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6WCQ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6WCQ1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6WCQ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133030 Expressed in 236 organ(s), highest expression level in left coronary artery

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6WCQ1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6WCQ1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022901

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds F-actin through its N-terminus.

Interacts with MYZAP (By similarity). Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116776, 92 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q6WCQ1

Protein interaction database and analysis system

More...
IntActi
Q6WCQ1, 72 interactors

Molecular INTeraction database

More...
MINTi
Q6WCQ1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379156

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6WCQ1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 150PH 1PROSITE-ProRule annotationAdd BLAST108
Domaini387 – 483PH 2PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 383Interaction with F-actinBy similarityAdd BLAST382
Regioni546 – 824Interaction with RHOA1 PublicationAdd BLAST279
Regioni824 – 879Interaction with PPP1R12AAdd BLAST56

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili673 – 977Sequence analysisAdd BLAST305

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi179 – 252Ser-richAdd BLAST74

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4807 Eukaryota
ENOG410ZA8F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155286

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6WCQ1

Database of Orthologous Groups

More...
OrthoDBi
428862at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6WCQ1

TreeFam database of animal gene trees

More...
TreeFami
TF329258

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13275 PH_M-RIP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039597 M-RIP_PH
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q6WCQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAAKENPCR KFQANIFNKS KCQNCFKPRE SHLLNDEDLT QAKPIYGGWL
60 70 80 90 100
LLAPDGTDFD NPVHRSRKWQ RRFFILYEHG LLRYALDEMP TTLPQGTINM
110 120 130 140 150
NQCTDVVDGE GRTGQKFSLC ILTPEKEHFI RAETKEIVSG WLEMLMVYPR
160 170 180 190 200
TNKQNQKKKR KVEPPTPQEP GPAKVAVTSS SSSSSSSSSI PSAEKVPTTK
210 220 230 240 250
STLWQEEMRT KDQPDGSSLS PAQSPSQSQP PAASSLREPG LESKEEESAM
260 270 280 290 300
SSDRMDCGRK VRVESGYFSL EKTKQDLKAE EQQLPPPLSP PSPSTPNHRR
310 320 330 340 350
SQVIEKFEAL DIEKAEHMET NAVGPSPSSD TRQGRSEKRA FPRKRDFTNE
360 370 380 390 400
APPAPLPDAS ASPLSPHRRA KSLDRRSTEP SVTPDLLNFK KGWLTKQYED
410 420 430 440 450
GQWKKHWFVL ADQSLRYYRD SVAEEAADLD GEIDLSACYD VTEYPVQRNY
460 470 480 490 500
GFQIHTKEGE FTLSAMTSGI RRNWIQTIMK HVHPTTAPDV TSSLPEEKNK
510 520 530 540 550
SSCSFETCPR PTEKQEAELG EPDPEQKRSR ARERRREGRS KTFDWAEFRP
560 570 580 590 600
IQQALAQERV GGVGPADTHE PLRPEAEPGE LERERARRRE ERRKRFGMLD
610 620 630 640 650
ATDGPGTEDA ALRMEVDRSP GLPMSDLKTH NVHVEIEQRW HQVETTPLRE
660 670 680 690 700
EKQVPIAPVH LSSEDGGDRL STHELTSLLE KELEQSQKEA SDLLEQNRLL
710 720 730 740 750
QDQLRVALGR EQSAREGYVL QATCERGFAA MEETHQKKIE DLQRQHQREL
760 770 780 790 800
EKLREEKDRL LAEETAATIS AIEAMKNAHR EEMERELEKS QRSQISSVNS
810 820 830 840 850
DVEALRRQYL EELQSVQREL EVLSEQYSQK CLENAHLAQA LEAERQALRQ
860 870 880 890 900
CQRENQELNA HNQELNNRLA AEITRLRTLL TGDGGGEATG SPLAQGKDAY
910 920 930 940 950
ELEVLLRVKE SEIQYLKQEI SSLKDELQTA LRDKKYASDK YKDIYTELSI
960 970 980 990 1000
AKAKADCDIS RLKEQLKAAT EALGEKSPDS ATVSGYDIMK SKSNPDFLKK
1010 1020
DRSCVTRQLR NIRSKSVIEQ VSWDT
Length:1,025
Mass (Da):116,533
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B7A30CDB3685E4E
GO
Isoform 21 Publication (identifier: Q6WCQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1017-1025: VIEQVSWDT → LKEGLTVQERLKLFESRDLKKD

Show »
Length:1,038
Mass (Da):118,103
Checksum:iEE674842C8133516
GO
Isoform 3Curated (identifier: Q6WCQ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-383: Missing.
     1017-1025: VIEQVSWDT → LKEGLTVQERLKLFESRDLKKD

Show »
Length:1,000
Mass (Da):114,049
Checksum:iFCFDB3210A73EEF9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KSW8J3KSW8_HUMAN
Myosin phosphatase Rho-interacting ...
MPRIP
844Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y2S9H0Y2S9_HUMAN
Myosin phosphatase Rho-interacting ...
MPRIP
1,794Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7E2H0Y7E2_HUMAN
Myosin phosphatase Rho-interacting ...
MPRIP
1,091Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3G6H7C3G6_HUMAN
Myosin phosphatase Rho-interacting ...
MPRIP
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRL2J3QRL2_HUMAN
Myosin phosphatase Rho-interacting ...
MPRIP
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BZV2A0A494BZV2_HUMAN
Myosin phosphatase Rho-interacting ...
MPRIP
2,425Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPU9A0A1W2PPU9_HUMAN
Myosin phosphatase Rho-interacting ...
MPRIP
294Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL39K7EL39_HUMAN
Myosin phosphatase Rho-interacting ...
MPRIP
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSK7J3KSK7_HUMAN
Myosin phosphatase Rho-interacting ...
MPRIP
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MZF8A8MZF8_HUMAN
Myosin phosphatase Rho-interacting ...
MPRIP
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31S → P in AAQ63176 (PubMed:14506264).Curated1
Sequence conflicti184S → R in BAD89507 (PubMed:15545284).Curated1
Sequence conflicti188 – 189Missing in BAD89507 (PubMed:15545284).Curated2
Sequence conflicti188 – 189Missing in AAH09982 (PubMed:15489334).Curated2
Sequence conflicti189Missing in AAQ63176 (PubMed:14506264).Curated1
Sequence conflicti189Missing in BAC78198 (Ref. 3) Curated1
Sequence conflicti189Missing in CAD39169 (PubMed:17974005).Curated1
Sequence conflicti235S → F in BAD89507 (PubMed:15545284).Curated1
Sequence conflicti352P → S in BAD89507 (PubMed:15545284).Curated1
Sequence conflicti528R → T in AAQ63176 (PubMed:14506264).Curated1
Sequence conflicti550P → L in BAC78198 (Ref. 3) Curated1
Sequence conflicti550P → L in CAD39169 (PubMed:17974005).Curated1
Sequence conflicti578P → S in AAQ63176 (PubMed:14506264).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051203327P → Q2 PublicationsCorresponds to variant dbSNP:rs3744137Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_051947346 – 383Missing in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_0519481017 – 1025VIEQVSWDT → LKEGLTVQERLKLFESRDLK KD in isoform 2 and isoform 3. 3 Publications9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY296247 mRNA Translation: AAQ63176.1
AB189741 mRNA Translation: BAD89507.1
AB098507 mRNA Translation: BAC78198.1
AC079111 Genomic DNA No translation available.
AC055811 Genomic DNA No translation available.
AL834513 mRNA Translation: CAD39169.1
BC009982 mRNA Translation: AAH09982.2
BC075847 mRNA Translation: AAH75847.1
BC105987 mRNA Translation: AAI05988.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32578.1 [Q6WCQ1-1]
CCDS42268.1 [Q6WCQ1-2]

NCBI Reference Sequences

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RefSeqi
NP_055949.2, NM_015134.3 [Q6WCQ1-2]
NP_958431.2, NM_201274.3 [Q6WCQ1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000341712; ENSP00000342379; ENSG00000133030 [Q6WCQ1-1]
ENST00000395811; ENSP00000379156; ENSG00000133030 [Q6WCQ1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23164

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23164

UCSC genome browser

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UCSCi
uc002gqu.3 human [Q6WCQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY296247 mRNA Translation: AAQ63176.1
AB189741 mRNA Translation: BAD89507.1
AB098507 mRNA Translation: BAC78198.1
AC079111 Genomic DNA No translation available.
AC055811 Genomic DNA No translation available.
AL834513 mRNA Translation: CAD39169.1
BC009982 mRNA Translation: AAH09982.2
BC075847 mRNA Translation: AAH75847.1
BC105987 mRNA Translation: AAI05988.1
CCDSiCCDS32578.1 [Q6WCQ1-1]
CCDS42268.1 [Q6WCQ1-2]
RefSeqiNP_055949.2, NM_015134.3 [Q6WCQ1-2]
NP_958431.2, NM_201274.3 [Q6WCQ1-1]

3D structure databases

SMRiQ6WCQ1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116776, 92 interactors
CORUMiQ6WCQ1
IntActiQ6WCQ1, 72 interactors
MINTiQ6WCQ1
STRINGi9606.ENSP00000379156

PTM databases

iPTMnetiQ6WCQ1
PhosphoSitePlusiQ6WCQ1
SwissPalmiQ6WCQ1

Polymorphism and mutation databases

BioMutaiMPRIP
DMDMi215274136

Proteomic databases

EPDiQ6WCQ1
jPOSTiQ6WCQ1
MassIVEiQ6WCQ1
MaxQBiQ6WCQ1
PaxDbiQ6WCQ1
PeptideAtlasiQ6WCQ1
PRIDEiQ6WCQ1
ProteomicsDBi67759 [Q6WCQ1-1]
67760 [Q6WCQ1-2]
67761 [Q6WCQ1-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341712; ENSP00000342379; ENSG00000133030 [Q6WCQ1-1]
ENST00000395811; ENSP00000379156; ENSG00000133030 [Q6WCQ1-2]
GeneIDi23164
KEGGihsa:23164
UCSCiuc002gqu.3 human [Q6WCQ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23164
DisGeNETi23164

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MPRIP
HGNCiHGNC:30321 MPRIP
HPAiHPA022901
MIMi612935 gene
neXtProtiNX_Q6WCQ1
OpenTargetsiENSG00000133030
PharmGKBiPA162396092

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4807 Eukaryota
ENOG410ZA8F LUCA
GeneTreeiENSGT00940000155286
InParanoidiQ6WCQ1
OrthoDBi428862at2759
PhylomeDBiQ6WCQ1
TreeFamiTF329258

Enzyme and pathway databases

ReactomeiR-HSA-6802952 Signaling by BRAF and RAF fusions
SIGNORiQ6WCQ1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MPRIP human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
M-RIP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23164

Pharos

More...
Pharosi
Q6WCQ1

Protein Ontology

More...
PROi
PR:Q6WCQ1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000133030 Expressed in 236 organ(s), highest expression level in left coronary artery
ExpressionAtlasiQ6WCQ1 baseline and differential
GenevisibleiQ6WCQ1 HS

Family and domain databases

CDDicd13275 PH_M-RIP, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR039597 M-RIP_PH
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 2 hits
SMARTiView protein in SMART
SM00233 PH, 2 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPRIP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6WCQ1
Secondary accession number(s): Q3KQZ5
, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 25, 2008
Last modified: September 18, 2019
This is version 142 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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