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UniProtKB - Q6WB93 (L_HMPVC)

Entry version 79 (07 Oct 2020)
Sequence version 1 (05 Jul 2004)
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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Human metapneumovirus (strain CAN97-83) (HMPV)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N7-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Multifunctional enzyme, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processmRNA capping, mRNA processing, Viral RNA replication
LigandATP-binding, Nucleotide-binding, S-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Including the following 4 domains:
RNA-directed RNA polymerase (EC:2.7.7.48)
mRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.56)
mRNA guanylyltransferase (EC:2.7.7.-)
GDP polyribonucleotidyltransferase (EC:2.7.7.88)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman metapneumovirus (strain CAN97-83) (HMPV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri694067 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Negarnaviricota › Haploviricotina › Monjiviricetes › Mononegavirales › Pneumoviridae › Metapneumovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001398 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Host cytoplasm, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003948101 – 2005RNA-directed RNA polymerase LAdd BLAST2005

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q6WB93

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with protein P.

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q6WB93, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6WB93

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini628 – 811RdRp catalyticPROSITE-ProRule annotationAdd BLAST184
Domaini1662 – 1852Mononegavirus-type SAM-dependent 2'-O-MTasePROSITE-ProRule annotationAdd BLAST191

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the paramyxovirus L protein family.Curated

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039736, L_poly_C
IPR026890, Mononeg_mRNAcap
IPR014023, Mononeg_RNA_pol_cat
IPR025786, Mononega_L_MeTrfase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14318, Mononeg_mRNAcap, 1 hit
PF00946, Mononeg_RNA_pol, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR04198, paramyx_RNAcap, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50526, RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590, SAM_MT_MNV_L, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6WB93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPLNESTVN VYLPDSYLKG VISFSETNAI GSCLLKRPYL KNDNTAKVAI 
        60         70         80         90        100
ENPVIEHVRL KNAVNSKMKI SDYKVVEPVN MQHEIMKNVH SCELTLLKQF 
       110        120        130        140        150
LTRSKNISTL KLNMICDWLQ LKSTSDDTSI LSFIDVEFIP SWVSNWFSNW 
       160        170        180        190        200
YNLNKLILEF RREEVIRTGS ILCRSLGKLV FIVSSYGCIV KSNKSKRVSF 
       210        220        230        240        250
FTYNQLLTWK DVMLSRFNAN FCIWVSNSLN ENQEGLGLRS NLQGMLTNKL 
       260        270        280        290        300
YETVDYMLSL CCNEGFSLVK EFEGFIMSEI LRITEHAQFS TRFRNTLLNG 
       310        320        330        340        350
LTDQLTKLKN KNRLRVHSTV LENNDYPMYE VVLKLLGDTL RCIKLLINKN 
       360        370        380        390        400
LENAAELYYI FRIFGHPMVD ERDAMDAVKL NNEITKILRL ESLTELRGAF 
       410        420        430        440        450
ILRIIKGFVD NNKRWPKIKN LKVLSKRWTM YFKAKNYPSQ LELSEQDFLE 
       460        470        480        490        500
LAAIQFEQEF SVPEKTNLEM VLNDKAISPP KRLIWSVYPK NYLPETIKNR 
       510        520        530        540        550
YLEETFNASD SLKTRRVLEY YLKDNKFDQK ELKSYVVRQE YLNDKEHIVS 
       560        570        580        590        600
LTGKERELSV GRMFAMQPGK QRQIQILAEK LLADNIVPFF PETLTKYGDL 
       610        620        630        640        650
DLQRIMEIKS ELSSIKTRRN DSYNNYIARA SIVTDLSKFN QAFRYETTAI 
       660        670        680        690        700
CADVADELHG TQSLFCWLHL IVPMTTMICA YRHAPPETKG EYDIDKIEEQ 
       710        720        730        740        750
SGLYRYHMGG IEGWCQKLWT MEAISLLDVV SVKTRCQMTS LLNGDNQSID 
       760        770        780        790        800
VSKPVKLSEG LDEVKADYRL AVKMLKEIRD AYRNIGHKLK EGETYISRDL 
       810        820        830        840        850
QFISKVIQSE GVMHPTPIKK VLRVGPWINT ILDDIKTSAE SIGSLCQELE 
       860        870        880        890        900
FRGESIIVSL ILRNFWLYNL YMHESKQHPL AGKQLFKQLN KTLTSVQRFF 
       910        920        930        940        950
EIKRENEVVD LWMNIPMQFG GGDPVVFYRS FYRRTPDFLT EAISHVDILL 
       960        970        980        990       1000
KISANIKNET KVSFFKALLS IEKNERATLT TLMRDPQAVG SERQAKVTSD 
      1010       1020       1030       1040       1050
INRTAVTSIL SLSPNQLFSD SAIHYSRNEE EVGIIAENIT PVYPHGLRVL 
      1060       1070       1080       1090       1100
YESLPFHKAE KVVNMISGTK SITNLLQRTS AINGEDIDRA VSMMLENLGL 
      1110       1120       1130       1140       1150
LSRILSVVVD SIEIPIKSNG RLICCQISRT LRETSWNNME IVGVTSPSIT 
      1160       1170       1180       1190       1200
TCMDVIYATS SHLKGIIIEK FSTDRTTRGQ RGPKSPWVGS STQEKKLVPV 
      1210       1220       1230       1240       1250
YNRQILSKQQ REQLEAIGKM RWVYKGTPGL RRLLNKICLG SLGISYKCVK 
      1260       1270       1280       1290       1300
PLLPRFMSVN FLHRLSVSSR PMEFPASVPA YRTTNYHFDT SPINQALSER 
      1310       1320       1330       1340       1350
FGNEDINLVF QNAISCGISI MSVVEQLTGR SPKQLVLIPQ LEEIDIMPPP 
      1360       1370       1380       1390       1400
VFQGKFNYKL VDKITSDQHI FSPDKIDMLT LGKMLMPTIK GQKTDQFLNK 
      1410       1420       1430       1440       1450
RENYFHGNNL IESLSAALAC HWCGILTEQC IENNIFKKDW GDGFISDHAF 
      1460       1470       1480       1490       1500
MDFKIFLCVF KTKLLCSWGS QGKNIKDEDI VDESIDKLLR IDNTFWRMFS 
      1510       1520       1530       1540       1550
KVMFEPKVKK RIMLYDVKFL SLVGYIGFKN WFIEQLRSAE LHEIPWIVNA 
      1560       1570       1580       1590       1600
EGDLVEIKSI KIYLQLIEQS LFLRITVLNY TDMAHALTRL IRKKLMCDNA 
      1610       1620       1630       1640       1650
LLTPISSPMV NLTQVIDPTT QLDYFPKITF ERLKNYDTSS NYAKGKLTRN 
      1660       1670       1680       1690       1700
YMILLPWQHV NRYNFVFSST GCKVSLKTCI GKLMKDLNPK VLYFIGEGAG 
      1710       1720       1730       1740       1750
NWMARTACEY PDIKFVYRSL KDDLDHHYPL EYQRVIGELS RIIDSGEGLS 
      1760       1770       1780       1790       1800
METTDATQKT HWDLIHRVSK DALLITLCDA EFKDRDDFFK MVILWRKHVL 
      1810       1820       1830       1840       1850
SCRICTTYGT DLYLFAKYHA KDCNVKLPFF VRSVATFIMQ GSKLSGSECY 
      1860       1870       1880       1890       1900
ILLTLGHHNS LPCHGEIQNS KMKIAVCNDF YAAKKLDNKS IEANCKSLLS 
      1910       1920       1930       1940       1950
GLRIPINKKE LDRQRRLLTL QSNHSSVATV GGSKIIESKW LTNKASTIID 
      1960       1970       1980       1990       2000
WLEHILNSPK GELNYDFFEA LENTYPNMIK LIDNLGNAEI KKLIKVTGYM 

LVSKK
Length:2,005
Mass (Da):230,760
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC87A1F997DBBBD2D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY297749 Genomic RNA Translation: AAQ67700.1

NCBI Reference Sequences

More...RefSeqi		YP_012613.1, NC_004148.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY297749 Genomic RNA Translation: AAQ67700.1
RefSeqiYP_012613.1, NC_004148.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UCJX-ray3.26A/B1600-2005[»]
6U5Oelectron microscopy3.70L1-2005[»]
SMRiQ6WB93
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ6WB93, 1 interactor

Proteomic databases

PRIDEiQ6WB93

Family and domain databases

InterProiView protein in InterPro
IPR039736, L_poly_C
IPR026890, Mononeg_mRNAcap
IPR014023, Mononeg_RNA_pol_cat
IPR025786, Mononega_L_MeTrfase
PfamiView protein in Pfam
PF14318, Mononeg_mRNAcap, 1 hit
PF00946, Mononeg_RNA_pol, 1 hit
TIGRFAMsiTIGR04198, paramyx_RNAcap, 1 hit
PROSITEiView protein in PROSITE
PS50526, RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590, SAM_MT_MNV_L, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_HMPVC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6WB93
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2004
Last modified: October 7, 2020
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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