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Entry version 79 (07 Oct 2020)
Sequence version 1 (05 Jul 2004)
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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Human metapneumovirus (strain CAN97-83) (HMPV)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N7-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Multifunctional enzyme, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processmRNA capping, mRNA processing, Viral RNA replication
LigandATP-binding, Nucleotide-binding, S-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Including the following 4 domains:
RNA-directed RNA polymerase (EC:2.7.7.48)
mRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.56)
mRNA guanylyltransferase (EC:2.7.7.-)
GDP polyribonucleotidyltransferase (EC:2.7.7.88)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman metapneumovirus (strain CAN97-83) (HMPV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri694067 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeNegarnaviricotaHaploviricotinaMonjiviricetesMononegaviralesPneumoviridaeMetapneumovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001398 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003948101 – 2005RNA-directed RNA polymerase LAdd BLAST2005

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6WB93

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with protein P.

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q6WB93, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6WB93

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini628 – 811RdRp catalyticPROSITE-ProRule annotationAdd BLAST184
Domaini1662 – 1852Mononegavirus-type SAM-dependent 2'-O-MTasePROSITE-ProRule annotationAdd BLAST191

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the paramyxovirus L protein family.Curated

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039736, L_poly_C
IPR026890, Mononeg_mRNAcap
IPR014023, Mononeg_RNA_pol_cat
IPR025786, Mononega_L_MeTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14318, Mononeg_mRNAcap, 1 hit
PF00946, Mononeg_RNA_pol, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04198, paramyx_RNAcap, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50526, RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590, SAM_MT_MNV_L, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6WB93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPLNESTVN VYLPDSYLKG VISFSETNAI GSCLLKRPYL KNDNTAKVAI
60 70 80 90 100
ENPVIEHVRL KNAVNSKMKI SDYKVVEPVN MQHEIMKNVH SCELTLLKQF
110 120 130 140 150
LTRSKNISTL KLNMICDWLQ LKSTSDDTSI LSFIDVEFIP SWVSNWFSNW
160 170 180 190 200
YNLNKLILEF RREEVIRTGS ILCRSLGKLV FIVSSYGCIV KSNKSKRVSF
210 220 230 240 250
FTYNQLLTWK DVMLSRFNAN FCIWVSNSLN ENQEGLGLRS NLQGMLTNKL
260 270 280 290 300
YETVDYMLSL CCNEGFSLVK EFEGFIMSEI LRITEHAQFS TRFRNTLLNG
310 320 330 340 350
LTDQLTKLKN KNRLRVHSTV LENNDYPMYE VVLKLLGDTL RCIKLLINKN
360 370 380 390 400
LENAAELYYI FRIFGHPMVD ERDAMDAVKL NNEITKILRL ESLTELRGAF
410 420 430 440 450
ILRIIKGFVD NNKRWPKIKN LKVLSKRWTM YFKAKNYPSQ LELSEQDFLE
460 470 480 490 500
LAAIQFEQEF SVPEKTNLEM VLNDKAISPP KRLIWSVYPK NYLPETIKNR
510 520 530 540 550
YLEETFNASD SLKTRRVLEY YLKDNKFDQK ELKSYVVRQE YLNDKEHIVS
560 570 580 590 600
LTGKERELSV GRMFAMQPGK QRQIQILAEK LLADNIVPFF PETLTKYGDL
610 620 630 640 650
DLQRIMEIKS ELSSIKTRRN DSYNNYIARA SIVTDLSKFN QAFRYETTAI
660 670 680 690 700
CADVADELHG TQSLFCWLHL IVPMTTMICA YRHAPPETKG EYDIDKIEEQ
710 720 730 740 750
SGLYRYHMGG IEGWCQKLWT MEAISLLDVV SVKTRCQMTS LLNGDNQSID
760 770 780 790 800
VSKPVKLSEG LDEVKADYRL AVKMLKEIRD AYRNIGHKLK EGETYISRDL
810 820 830 840 850
QFISKVIQSE GVMHPTPIKK VLRVGPWINT ILDDIKTSAE SIGSLCQELE
860 870 880 890 900
FRGESIIVSL ILRNFWLYNL YMHESKQHPL AGKQLFKQLN KTLTSVQRFF
910 920 930 940 950
EIKRENEVVD LWMNIPMQFG GGDPVVFYRS FYRRTPDFLT EAISHVDILL
960 970 980 990 1000
KISANIKNET KVSFFKALLS IEKNERATLT TLMRDPQAVG SERQAKVTSD
1010 1020 1030 1040 1050
INRTAVTSIL SLSPNQLFSD SAIHYSRNEE EVGIIAENIT PVYPHGLRVL
1060 1070 1080 1090 1100
YESLPFHKAE KVVNMISGTK SITNLLQRTS AINGEDIDRA VSMMLENLGL
1110 1120 1130 1140 1150
LSRILSVVVD SIEIPIKSNG RLICCQISRT LRETSWNNME IVGVTSPSIT
1160 1170 1180 1190 1200
TCMDVIYATS SHLKGIIIEK FSTDRTTRGQ RGPKSPWVGS STQEKKLVPV
1210 1220 1230 1240 1250
YNRQILSKQQ REQLEAIGKM RWVYKGTPGL RRLLNKICLG SLGISYKCVK
1260 1270 1280 1290 1300
PLLPRFMSVN FLHRLSVSSR PMEFPASVPA YRTTNYHFDT SPINQALSER
1310 1320 1330 1340 1350
FGNEDINLVF QNAISCGISI MSVVEQLTGR SPKQLVLIPQ LEEIDIMPPP
1360 1370 1380 1390 1400
VFQGKFNYKL VDKITSDQHI FSPDKIDMLT LGKMLMPTIK GQKTDQFLNK
1410 1420 1430 1440 1450
RENYFHGNNL IESLSAALAC HWCGILTEQC IENNIFKKDW GDGFISDHAF
1460 1470 1480 1490 1500
MDFKIFLCVF KTKLLCSWGS QGKNIKDEDI VDESIDKLLR IDNTFWRMFS
1510 1520 1530 1540 1550
KVMFEPKVKK RIMLYDVKFL SLVGYIGFKN WFIEQLRSAE LHEIPWIVNA
1560 1570 1580 1590 1600
EGDLVEIKSI KIYLQLIEQS LFLRITVLNY TDMAHALTRL IRKKLMCDNA
1610 1620 1630 1640 1650
LLTPISSPMV NLTQVIDPTT QLDYFPKITF ERLKNYDTSS NYAKGKLTRN
1660 1670 1680 1690 1700
YMILLPWQHV NRYNFVFSST GCKVSLKTCI GKLMKDLNPK VLYFIGEGAG
1710 1720 1730 1740 1750
NWMARTACEY PDIKFVYRSL KDDLDHHYPL EYQRVIGELS RIIDSGEGLS
1760 1770 1780 1790 1800
METTDATQKT HWDLIHRVSK DALLITLCDA EFKDRDDFFK MVILWRKHVL
1810 1820 1830 1840 1850
SCRICTTYGT DLYLFAKYHA KDCNVKLPFF VRSVATFIMQ GSKLSGSECY
1860 1870 1880 1890 1900
ILLTLGHHNS LPCHGEIQNS KMKIAVCNDF YAAKKLDNKS IEANCKSLLS
1910 1920 1930 1940 1950
GLRIPINKKE LDRQRRLLTL QSNHSSVATV GGSKIIESKW LTNKASTIID
1960 1970 1980 1990 2000
WLEHILNSPK GELNYDFFEA LENTYPNMIK LIDNLGNAEI KKLIKVTGYM

LVSKK
Length:2,005
Mass (Da):230,760
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC87A1F997DBBBD2D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY297749 Genomic RNA Translation: AAQ67700.1

NCBI Reference Sequences

More...
RefSeqi
YP_012613.1, NC_004148.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY297749 Genomic RNA Translation: AAQ67700.1
RefSeqiYP_012613.1, NC_004148.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UCJX-ray3.26A/B1600-2005[»]
6U5Oelectron microscopy3.70L1-2005[»]
SMRiQ6WB93
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ6WB93, 1 interactor

Proteomic databases

PRIDEiQ6WB93

Family and domain databases

InterProiView protein in InterPro
IPR039736, L_poly_C
IPR026890, Mononeg_mRNAcap
IPR014023, Mononeg_RNA_pol_cat
IPR025786, Mononega_L_MeTrfase
PfamiView protein in Pfam
PF14318, Mononeg_mRNAcap, 1 hit
PF00946, Mononeg_RNA_pol, 1 hit
TIGRFAMsiTIGR04198, paramyx_RNAcap, 1 hit
PROSITEiView protein in PROSITE
PS50526, RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590, SAM_MT_MNV_L, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_HMPVC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6WB93
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2004
Last modified: October 7, 2020
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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