UniProtKB - Q6W6X5 (Q6W6X5_ACTSC)
Protein
Phosphoenolpyruvate carboxykinase (ATP)
Gene
pckA
Organism
Actinobacillus succinogenes
Status
Functioni
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.UniRule annotation
Catalytic activityi
- EC:4.1.1.49UniRule annotationARBA annotation
Cofactori
Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation
: gluconeogenesis Pathwayi
This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotationARBA annotationView all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 64 | SubstrateUniRule annotation | 1 | |
Binding sitei | 205 | SubstrateUniRule annotation | 1 | |
Metal bindingi | 211 | ManganeseUniRule annotation | 1 | |
Binding sitei | 211 | ATPUniRule annotation | 1 | |
Binding sitei | 211 | SubstrateUniRule annotation | 1 | |
Metal bindingi | 230 | Manganese; via tele nitrogenUniRule annotation | 1 | |
Binding sitei | 230 | ATPUniRule annotation | 1 | |
Metal bindingi | 267 | ManganeseUniRule annotation | 1 | |
Binding sitei | 295 | ATPUniRule annotation | 1 | |
Binding sitei | 331 | ATPUniRule annotation | 1 | |
Binding sitei | 331 | SubstrateUniRule annotation | 1 | |
Binding sitei | 453 | ATPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 246 – 254 | ATPUniRule annotation | 9 | |
Nucleotide bindingi | 447 – 448 | ATPUniRule annotation | 2 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- kinase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- phosphoenolpyruvate carboxykinase (ATP) activity Source: UniProtKB-UniRule
GO - Biological processi
- gluconeogenesis Source: UniProtKB-UniRule
Keywordsi
Molecular function | DecarboxylaseUniRule annotationARBA annotation, KinaseImported, Lyase, Transferase |
Biological process | GluconeogenesisUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported |
Enzyme and pathway databases
BRENDAi | 4.1.1.49, 8032 |
UniPathwayi | UPA00138 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphoenolpyruvate carboxykinase (ATP)UniRule annotationARBA annotation (EC:4.1.1.49UniRule annotationARBA annotation)Short name: PCKUniRule annotation Short name: PEP carboxykinaseUniRule annotation Short name: PEPCKUniRule annotation |
Gene namesi | Name:pckAUniRule annotation |
Organismi | Actinobacillus succinogenesImported |
Taxonomic identifieri | 67854 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus |
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationInteractioni
Subunit structurei
Monomer.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Family and domain databases
CDDi | cd00484, PEPCK_ATP, 1 hit |
Gene3Di | 3.40.449.10, 1 hit 3.90.228.20, 1 hit |
HAMAPi | MF_00453, PEPCK_ATP, 1 hit |
InterProi | View protein in InterPro IPR001272, PEP_carboxykinase_ATP IPR013035, PEP_carboxykinase_C IPR008210, PEP_carboxykinase_N IPR015994, PEPCK_ATP_CS |
PANTHERi | PTHR30031, PTHR30031, 1 hit |
Pfami | View protein in Pfam PF01293, PEPCK_ATP, 1 hit |
PIRSFi | PIRSF006294, PEP_crbxkin, 1 hit |
SUPFAMi | SSF68923, SSF68923, 1 hit |
TIGRFAMsi | TIGR00224, pckA, 1 hit |
PROSITEi | View protein in PROSITE PS00532, PEPCK_ATP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6W6X5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTDLNKLVKE LNDLGLTDVK EIVYNPSYEQ LFEEETKPGL EGFDKGTLTT
60 70 80 90 100
LGAVAVDTGI FTGRSPKDKY IVCDETTKDT VWWNSEAAKN DNKPMTQETW
110 120 130 140 150
KSLRELVAKQ LSGKRLFVVE GYCGASEKHR IGVRMVTEVA WQAHFVKNMF
160 170 180 190 200
IRPTDEELKN FKADFTVLNG AKCTNPNWKE QGLNSENFVA FNITEGIQLI
210 220 230 240 250
GGTWYGGEMK KGMFSMMNYF LPLKGVASMH CSANVGKDGD VAIFFGLSGT
260 270 280 290 300
GKTTLSTDPK RQLIGDDEHG WDESGVFNFE GGCYAKTINL SQENEPDIYG
310 320 330 340 350
AIRRDALLEN VVVRADGSVD FDDGSKTENT RVSYPIYHID NIVRPVSKAG
360 370 380 390 400
HATKVIFLTA DAFGVLPPVS KLTPEQTEYY FLSGFTAKLA GTERGVTEPT
410 420 430 440 450
PTFSACFGAA FLSLHPIQYA DVLVERMKAS GAEAYLVNTG WNGTGKRISI
460 470 480 490 500
KDTRGIIDAI LDGSIEKAEM GELPIFNLAI PKALPGVDPA ILDPRDTYAD
510 520 530
KAQWQVKAED LANRFVKNFV KYTANPEAAK LVGAGPKA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY308832 Genomic DNA Translation: AAQ76084.1 EU253567 Genomic DNA Translation: ABX39017.1 |
RefSeqi | WP_011978877.1, NZ_NHRD01000001.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY308832 Genomic DNA Translation: AAQ76084.1 EU253567 Genomic DNA Translation: ABX39017.1 |
RefSeqi | WP_011978877.1, NZ_NHRD01000001.1 |
3D structure databases
SMRi | Q6W6X5 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00138 |
BRENDAi | 4.1.1.49, 8032 |
Family and domain databases
CDDi | cd00484, PEPCK_ATP, 1 hit |
Gene3Di | 3.40.449.10, 1 hit 3.90.228.20, 1 hit |
HAMAPi | MF_00453, PEPCK_ATP, 1 hit |
InterProi | View protein in InterPro IPR001272, PEP_carboxykinase_ATP IPR013035, PEP_carboxykinase_C IPR008210, PEP_carboxykinase_N IPR015994, PEPCK_ATP_CS |
PANTHERi | PTHR30031, PTHR30031, 1 hit |
Pfami | View protein in Pfam PF01293, PEPCK_ATP, 1 hit |
PIRSFi | PIRSF006294, PEP_crbxkin, 1 hit |
SUPFAMi | SSF68923, SSF68923, 1 hit |
TIGRFAMsi | TIGR00224, pckA, 1 hit |
PROSITEi | View protein in PROSITE PS00532, PEPCK_ATP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6W6X5_ACTSC | |
Accessioni | Q6W6X5Primary (citable) accession number: Q6W6X5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | October 7, 2020 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |