UniProtKB - Q6W5P4 (NPSR1_HUMAN)
Protein
Neuropeptide S receptor
Gene
NPSR1
Organism
Homo sapiens (Human)
Status
Functioni
G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca2+ stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.3 Publications
Miscellaneous
Only isoforms with 7 transmembrane topology (isoform 1, isoform 3 and isoform 4) are transported into the plasma membrane in transfected cells, while the truncated ones retain intracellular compartments.1 Publication
GO - Molecular functioni
- neuropeptide receptor activity Source: UniProtKB
- vasopressin receptor activity Source: InterPro
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: Reactome
- negative regulation of inflammatory response to antigenic stimulus Source: Reactome
- neuropeptide signaling pathway Source: UniProtKB
- positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q6W5P4 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Protein family/group databases
TCDBi | 9.A.14.10.5, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Neuropeptide S receptorAlternative name(s): G-protein coupled receptor 154 G-protein coupled receptor PGR14 G-protein coupled receptor for asthma susceptibility |
Gene namesi | Name:NPSR1 Synonyms:GPR154, GPRA, PGR14 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23631, NPSR1 |
MIMi | 608595, gene |
neXtProti | NX_Q6W5P4 |
VEuPathDBi | HostDB:ENSG00000187258.13 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein Curated
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Curated
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Curated
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- cytoplasm Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 52 | ExtracellularSequence analysisAdd BLAST | 52 | |
Transmembranei | 53 – 73 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 74 – 82 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 83 – 103 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 104 – 123 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 124 – 144 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 145 – 164 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 165 – 185 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 186 – 212 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 213 – 233 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 234 – 275 | CytoplasmicSequence analysisAdd BLAST | 42 | |
Transmembranei | 276 – 296 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 297 – 312 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 313 – 333 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 334 – 371 | CytoplasmicSequence analysisAdd BLAST | 38 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
Asthma-related traits 2 (ASRT2)3 Publications
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionAsthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.
Related information in OMIMKeywords - Diseasei
AsthmaOrganism-specific databases
DisGeNETi | 387129 |
MalaCardsi | NPSR1 |
MIMi | 608584, phenotype |
OpenTargetsi | ENSG00000187258 |
PharmGKBi | PA134951416 |
Miscellaneous databases
Pharosi | Q6W5P4, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5162 |
DrugBanki | DB01159, Halothane |
GuidetoPHARMACOLOGYi | 302 |
Genetic variation databases
BioMutai | NPSR1 |
DMDMi | 74758626 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069639 | 1 – 371 | Neuropeptide S receptorAdd BLAST | 371 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 121 ↔ 197 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q6W5P4 |
PaxDbi | Q6W5P4 |
PeptideAtlasi | Q6W5P4 |
PRIDEi | Q6W5P4 |
ProteomicsDBi | 67745 [Q6W5P4-1] 67746 [Q6W5P4-2] 67747 [Q6W5P4-3] 67748 [Q6W5P4-4] 67749 [Q6W5P4-5] 67750 [Q6W5P4-6] 67751 [Q6W5P4-7] 67752 [Q6W5P4-8] 67753 [Q6W5P4-9] |
PTM databases
GlyGeni | Q6W5P4, 1 site |
iPTMneti | Q6W5P4 |
PhosphoSitePlusi | Q6W5P4 |
Expressioni
Tissue specificityi
Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level) (PubMed:15947423). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients.2 Publications
Gene expression databases
Bgeei | ENSG00000187258, Expressed in intestine and 25 other tissues |
ExpressionAtlasi | Q6W5P4, baseline and differential |
Organism-specific databases
HPAi | ENSG00000187258, Tissue enhanced (brain, retina, stomach) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 132263, 16 interactors |
IntActi | Q6W5P4, 16 interactors |
MINTi | Q6W5P4 |
STRINGi | 9606.ENSP00000370950 |
Chemistry databases
BindingDBi | Q6W5P4 |
Miscellaneous databases
RNActi | Q6W5P4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3184, Eukaryota KOG3656, Eukaryota |
GeneTreei | ENSGT00940000155094 |
HOGENOMi | CLU_2385563_0_0_1 |
InParanoidi | Q6W5P4 |
OMAi | WIPYMTV |
OrthoDBi | 1034048at2759 |
PhylomeDBi | Q6W5P4 |
TreeFami | TF106499 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR027294, NPS_rcpt IPR001817, Vasoprsn_rcpt |
PANTHERi | PTHR24244:SF2, PTHR24244:SF2, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00896, VASOPRESSINR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (9)i Sequence
Sequence statusi: Complete.
This entry describes 9 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q6W5P4-1) [UniParc]FASTAAdd to basket
Also known as: Isoform A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPANFTEGSF DSSGTGQTLD SSPVACTETV TFTEVVEGKE WGSFYYSFKT
60 70 80 90 100
EQLITLWVLF VFTIVGNSVV LFSTWRRKKK SRMTFFVTQL AITDSFTGLV
110 120 130 140 150
NILTDINWRF TGDFTAPDLV CRVVRYLQVV LLYASTYVLV SLSIDRYHAI
160 170 180 190 200
VYPMKFLQGE KQARVLIVIA WSLSFLFSIP TLIIFGKRTL SNGEVQCWAL
210 220 230 240 250
WPDDSYWTPY MTIVAFLVYF IPLTIISIMY GIVIRTIWIK SKTYETVISN
260 270 280 290 300
CSDGKLCSSY NRGLISKAKI KAIKYSIIII LAFICCWSPY FLFDILDNFN
310 320 330 340 350
LLPDTQERFY ASVIIQNLPA LNSAINPLIY CVFSSSISFP CREQRSQDSR
360 370
MTFRERTERH EMQILSKPEF I
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023757 | 107 | N → I Increases cell surface expression and NPS-dependent calcium mobilization; does not affect affinity for NPS.. 5 PublicationsCorresponds to variant dbSNP:rs324981EnsemblClinVar. | 1 | |
Natural variantiVAR_025103 | 122 | R → Q1 PublicationCorresponds to variant dbSNP:rs35436513Ensembl. | 1 | |
Natural variantiVAR_025104 | 143 | S → G1 PublicationCorresponds to variant dbSNP:rs325465EnsemblClinVar. | 1 | |
Natural variantiVAR_025105 | 197 | C → F1 PublicationCorresponds to variant dbSNP:rs34705969Ensembl. | 1 | |
Natural variantiVAR_025106 | 212 | T → I1 PublicationCorresponds to variant dbSNP:rs35537374Ensembl. | 1 | |
Natural variantiVAR_023758 | 241 | S → R1 PublicationCorresponds to variant dbSNP:rs727162Ensembl. | 1 | |
Natural variantiVAR_025107 | 315 | I → T1 PublicationCorresponds to variant dbSNP:rs10270766Ensembl. | 1 | |
Natural variantiVAR_023759 | 344 | Q → R1 PublicationCorresponds to variant dbSNP:rs6972158Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016078 | 93 – 103 | Missing in isoform 5. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_016079 | 94 – 159 | Missing in isoform 2. 1 PublicationAdd BLAST | 66 | |
Alternative sequenceiVSP_016080 | 94 – 158 | DSFTG…MKFLQ → GCAALRLYLRPGVPQHRQIP CHRLPHEVPSRRKASQGPHC DRLEPVFSVLHSHPDHIWEE DTVQR in isoform 6. 1 PublicationAdd BLAST | 65 | |
Alternative sequenceiVSP_016081 | 94 | D → V in isoform 9. 1 Publication | 1 | |
Alternative sequenceiVSP_016082 | 95 – 371 | Missing in isoform 9. 1 PublicationAdd BLAST | 277 | |
Alternative sequenceiVSP_016083 | 129 – 136 | VVLLYAST → KSKPGSSL in isoform 7. 1 Publication | 8 | |
Alternative sequenceiVSP_016084 | 130 – 143 | VLLYA…LVSLS → MVMKLFHIQKMNME in isoform 8. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_016085 | 137 – 371 | Missing in isoform 7. 1 PublicationAdd BLAST | 235 | |
Alternative sequenceiVSP_016086 | 144 – 371 | Missing in isoform 8. 1 PublicationAdd BLAST | 228 | |
Alternative sequenceiVSP_016087 | 159 – 371 | Missing in isoform 6. 1 PublicationAdd BLAST | 213 | |
Alternative sequenceiVSP_016088 | 343 – 371 | EQRSQ…KPEFI → ANSSVYLLACDVSVLWALVL TSEKESCESWRRKGAKITGF QNDVPGEN in isoform 3. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_016089 | 343 – 371 | EQRSQ…KPEFI → VIRLRQLQEAALMLCPQREN WKGTWPGVPSWALPR in isoform 4 and isoform 5. 3 PublicationsAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY310326 mRNA Translation: AAQ76966.1 AY310327 mRNA Translation: AAQ76967.1 AY310328 mRNA Translation: AAQ76968.1 AY310329 mRNA Translation: AAQ76969.1 AY310330 mRNA Translation: AAQ76970.1 AY310331 mRNA Translation: AAQ76971.1 AY310332 mRNA Translation: AAQ76972.1 AY956446 mRNA Translation: AAX63744.1 AY956447 mRNA Translation: AAX63745.1 AY956448 mRNA Translation: AAX63746.1 AK172847 mRNA Translation: BAD18811.1 DQ272236 Genomic DNA Translation: ABB72550.1 CH471073 Genomic DNA Translation: EAW94036.1 BC132693 mRNA Translation: AAI32694.1 BC132695 mRNA Translation: AAI32696.1 |
CCDSi | CCDS5443.1 [Q6W5P4-4] CCDS5444.1 [Q6W5P4-1] CCDS75579.1 [Q6W5P4-3] CCDS75580.1 [Q6W5P4-5] CCDS75581.1 [Q6W5P4-2] |
RefSeqi | NP_001287862.1, NM_001300933.1 [Q6W5P4-5] NP_001287863.1, NM_001300934.1 [Q6W5P4-2] NP_001287864.1, NM_001300935.1 [Q6W5P4-3] NP_997055.1, NM_207172.1 [Q6W5P4-1] NP_997056.1, NM_207173.1 [Q6W5P4-4] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY310326 mRNA Translation: AAQ76966.1 AY310327 mRNA Translation: AAQ76967.1 AY310328 mRNA Translation: AAQ76968.1 AY310329 mRNA Translation: AAQ76969.1 AY310330 mRNA Translation: AAQ76970.1 AY310331 mRNA Translation: AAQ76971.1 AY310332 mRNA Translation: AAQ76972.1 AY956446 mRNA Translation: AAX63744.1 AY956447 mRNA Translation: AAX63745.1 AY956448 mRNA Translation: AAX63746.1 AK172847 mRNA Translation: BAD18811.1 DQ272236 Genomic DNA Translation: ABB72550.1 CH471073 Genomic DNA Translation: EAW94036.1 BC132693 mRNA Translation: AAI32694.1 BC132695 mRNA Translation: AAI32696.1 |
CCDSi | CCDS5443.1 [Q6W5P4-4] CCDS5444.1 [Q6W5P4-1] CCDS75579.1 [Q6W5P4-3] CCDS75580.1 [Q6W5P4-5] CCDS75581.1 [Q6W5P4-2] |
RefSeqi | NP_001287862.1, NM_001300933.1 [Q6W5P4-5] NP_001287863.1, NM_001300934.1 [Q6W5P4-2] NP_001287864.1, NM_001300935.1 [Q6W5P4-3] NP_997055.1, NM_207172.1 [Q6W5P4-1] NP_997056.1, NM_207173.1 [Q6W5P4-4] |
3D structure databases
SMRi | Q6W5P4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 132263, 16 interactors |
IntActi | Q6W5P4, 16 interactors |
MINTi | Q6W5P4 |
STRINGi | 9606.ENSP00000370950 |
Chemistry databases
BindingDBi | Q6W5P4 |
ChEMBLi | CHEMBL5162 |
DrugBanki | DB01159, Halothane |
GuidetoPHARMACOLOGYi | 302 |
Protein family/group databases
TCDBi | 9.A.14.10.5, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | Q6W5P4, 1 site |
iPTMneti | Q6W5P4 |
PhosphoSitePlusi | Q6W5P4 |
Genetic variation databases
BioMutai | NPSR1 |
DMDMi | 74758626 |
Proteomic databases
EPDi | Q6W5P4 |
PaxDbi | Q6W5P4 |
PeptideAtlasi | Q6W5P4 |
PRIDEi | Q6W5P4 |
ProteomicsDBi | 67745 [Q6W5P4-1] 67746 [Q6W5P4-2] 67747 [Q6W5P4-3] 67748 [Q6W5P4-4] 67749 [Q6W5P4-5] 67750 [Q6W5P4-6] 67751 [Q6W5P4-7] 67752 [Q6W5P4-8] 67753 [Q6W5P4-9] |
Protocols and materials databases
Antibodypediai | 1941, 193 antibodies |
DNASUi | 387129 |
Genome annotation databases
Organism-specific databases
CTDi | 387129 |
DisGeNETi | 387129 |
GeneCardsi | NPSR1 |
HGNCi | HGNC:23631, NPSR1 |
HPAi | ENSG00000187258, Tissue enhanced (brain, retina, stomach) |
MalaCardsi | NPSR1 |
MIMi | 608584, phenotype 608595, gene |
neXtProti | NX_Q6W5P4 |
OpenTargetsi | ENSG00000187258 |
PharmGKBi | PA134951416 |
VEuPathDBi | HostDB:ENSG00000187258.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3184, Eukaryota KOG3656, Eukaryota |
GeneTreei | ENSGT00940000155094 |
HOGENOMi | CLU_2385563_0_0_1 |
InParanoidi | Q6W5P4 |
OMAi | WIPYMTV |
OrthoDBi | 1034048at2759 |
PhylomeDBi | Q6W5P4 |
TreeFami | TF106499 |
Enzyme and pathway databases
PathwayCommonsi | Q6W5P4 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Miscellaneous databases
BioGRID-ORCSi | 387129, 7 hits in 986 CRISPR screens |
ChiTaRSi | NPSR1, human |
GeneWikii | Neuropeptide_S_receptor |
GenomeRNAii | 387129 |
Pharosi | Q6W5P4, Tchem |
PROi | PR:Q6W5P4 |
RNActi | Q6W5P4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187258, Expressed in intestine and 25 other tissues |
ExpressionAtlasi | Q6W5P4, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR027294, NPS_rcpt IPR001817, Vasoprsn_rcpt |
PANTHERi | PTHR24244:SF2, PTHR24244:SF2, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00896, VASOPRESSINR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NPSR1_HUMAN | |
Accessioni | Q6W5P4Primary (citable) accession number: Q6W5P4 Secondary accession number(s): A2RTZ4 Q6ZMB8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families