UniProtKB - Q6W5C0 (CXCL3_MOUSE)
Protein
C-X-C motif chemokine 3
Gene
Cxcl3
Organism
Mus musculus (Mouse)
Status
Functioni
Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion.By similarity1 Publication
GO - Molecular functioni
- chemokine activity Source: UniProtKB
- CXCR chemokine receptor binding Source: GO_Central
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: GO_Central
- cellular response to lipopolysaccharide Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- inflammatory response Source: MGI
- neutrophil chemotaxis Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: MGI
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis, Inflammatory response |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events R-MMU-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C motif chemokine 3Alternative name(s): Dendritic cell inflammatory protein 11 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3037818, Cxcl3 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | By similarityAdd BLAST | 31 | |
ChainiPRO_5000091636 | 32 – 100 | C-X-C motif chemokine 3By similarityAdd BLAST | 69 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 36 ↔ 62 | By similarity | ||
Disulfide bondi | 38 ↔ 78 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
MaxQBi | Q6W5C0 |
PaxDbi | Q6W5C0 |
PRIDEi | Q6W5C0 |
ProteomicsDBi | 279220 |
PTM databases
iPTMneti | Q6W5C0 |
PhosphoSitePlusi | Q6W5C0 |
Expressioni
Inductioni
By lipopolysaccharide.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000029379, Expressed in camera-type eye and 74 other tissues |
Genevisiblei | Q6W5C0, MM |
Interactioni
GO - Molecular functioni
- chemokine activity Source: UniProtKB
- CXCR chemokine receptor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000031326 |
Miscellaneous databases
RNActi | Q6W5C0, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine alpha (chemokine CxC) family.Sequence analysis
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S7MM, Eukaryota |
GeneTreei | ENSGT00940000155233 |
HOGENOMi | CLU_143902_3_1_1 |
InParanoidi | Q6W5C0 |
OMAi | RIHPKNI |
OrthoDBi | 1617719at2759 |
PhylomeDBi | Q6W5C0 |
TreeFami | TF333433 |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6W5C0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPPTCRLLS AALVLLLLLA TNHQATGAVV ASELRCQCLN TLPRVDFETI
60 70 80 90 100
QSLTVTPPGP HCTQTEVIAT LKDGQEVCLN PQGPRLQIII KKILKSGKSS
Sequence cautioni
The sequence BAE25738 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY311403 mRNA Translation: AAQ86936.1 AY311404 Genomic DNA Translation: AAQ86937.1 AK144158 mRNA Translation: BAE25738.1 Frameshift. AK150314 mRNA Translation: BAE29460.1 AK154334 mRNA Translation: BAE32520.1 CH466617 Genomic DNA Translation: EDL05303.1 BC117014 mRNA Translation: AAI17015.1 BC117016 mRNA Translation: AAI17017.1 |
CCDSi | CCDS19417.1 |
RefSeqi | NP_976065.1, NM_203320.3 |
Genome annotation databases
Ensembli | ENSMUST00000031326; ENSMUSP00000031326; ENSMUSG00000029379 |
GeneIDi | 330122 |
KEGGi | mmu:330122 |
UCSCi | uc008ybj.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY311403 mRNA Translation: AAQ86936.1 AY311404 Genomic DNA Translation: AAQ86937.1 AK144158 mRNA Translation: BAE25738.1 Frameshift. AK150314 mRNA Translation: BAE29460.1 AK154334 mRNA Translation: BAE32520.1 CH466617 Genomic DNA Translation: EDL05303.1 BC117014 mRNA Translation: AAI17015.1 BC117016 mRNA Translation: AAI17017.1 |
CCDSi | CCDS19417.1 |
RefSeqi | NP_976065.1, NM_203320.3 |
3D structure databases
SMRi | Q6W5C0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000031326 |
PTM databases
iPTMneti | Q6W5C0 |
PhosphoSitePlusi | Q6W5C0 |
Proteomic databases
MaxQBi | Q6W5C0 |
PaxDbi | Q6W5C0 |
PRIDEi | Q6W5C0 |
ProteomicsDBi | 279220 |
Genome annotation databases
Ensembli | ENSMUST00000031326; ENSMUSP00000031326; ENSMUSG00000029379 |
GeneIDi | 330122 |
KEGGi | mmu:330122 |
UCSCi | uc008ybj.2, mouse |
Organism-specific databases
CTDi | 2921 |
MGIi | MGI:3037818, Cxcl3 |
Phylogenomic databases
eggNOGi | ENOG502S7MM, Eukaryota |
GeneTreei | ENSGT00940000155233 |
HOGENOMi | CLU_143902_3_1_1 |
InParanoidi | Q6W5C0 |
OMAi | RIHPKNI |
OrthoDBi | 1617719at2759 |
PhylomeDBi | Q6W5C0 |
TreeFami | TF333433 |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 330122, 0 hits in 52 CRISPR screens |
PROi | PR:Q6W5C0 |
RNActi | Q6W5C0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029379, Expressed in camera-type eye and 74 other tissues |
Genevisiblei | Q6W5C0, MM |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXCL3_MOUSE | |
Accessioni | Q6W5C0Primary (citable) accession number: Q6W5C0 Secondary accession number(s): Q3UNK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 20, 2009 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families