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Entry version 116 (13 Feb 2019)
Sequence version 3 (03 May 2011)
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Protein

Mucin-6

Gene

MUC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • extracellular matrix structural constituent Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5621480 Dectin-2 family
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-977068 Termination of O-glycan biosynthesis

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I08.952

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mucin-6
Short name:
MUC-6
Alternative name(s):
Gastric mucin-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MUC6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000184956.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7517 MUC6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
158374 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6W4X9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4588

Open Targets

More...
OpenTargetsi
ENSG00000184956

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MUC6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
332278200

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025949623 – 2439Mucin-6Add BLAST2417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi? ↔ 2437By similarity
Disulfide bondi67 ↔ 75By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi486N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi659N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi975N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1179N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2349 ↔ 2396By similarity
Disulfide bondi2363 ↔ 2410By similarity
Disulfide bondi2372 ↔ 2430By similarity
Disulfide bondi2376 ↔ 2432By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6W4X9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6W4X9

PeptideAtlas

More...
PeptideAtlasi
Q6W4X9

PRoteomics IDEntifications database

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PRIDEi
Q6W4X9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67744

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1521

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6W4X9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6W4X9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.5 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factors.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184956 Expressed in 153 organ(s), highest expression level in body of stomach

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6W4X9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6W4X9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002165

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Multimer; disulfide-linked.1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000406861

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q6W4X9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6W4X9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 246VWFD 1PROSITE-ProRule annotationAdd BLAST203
Domaini302 – 357TILAdd BLAST56
Domaini396 – 608VWFD 2PROSITE-ProRule annotationAdd BLAST213
Domaini867 – 1075VWFD 3PROSITE-ProRule annotationAdd BLAST209
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1561 – 17381; truncatedAdd BLAST178
Repeati1785 – 19532Add BLAST169
Domaini2349 – 2438CTCKPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1607 – 1953Approximate repeatsAdd BLAST347

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1241 – 1664Pro-richAdd BLAST424
Compositional biasi1246 – 2344Thr-richAdd BLAST1099
Compositional biasi2069 – 2275Ser-richAdd BLAST207

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1216 Eukaryota
ENOG410XNSK LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161708

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG081998

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6W4X9

KEGG Orthology (KO)

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KOi
K22023

Identification of Orthologs from Complete Genome Data

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OMAi
THAQMAT

Database of Orthologous Groups

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OrthoDBi
12226at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6W4X9

TreeFam database of animal gene trees

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TreeFami
TF300299

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006207 Cys_knot_C
IPR030124 MUC6
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D

The PANTHER Classification System

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PANTHERi
PTHR11339:SF264 PTHR11339:SF264, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742 C8, 3 hits
PF01826 TIL, 2 hits
PF00094 VWD, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832 C8, 3 hits
SM00041 CT, 1 hit
SM00215 VWC_out, 2 hits
SM00216 VWD, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57567 SSF57567, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01225 CTCK_2, 1 hit
PS51233 VWFD, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q6W4X9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQRWLLLSC CGALLSAGLA NTSYTSPGLQ RLKDSPQTAP DKGQCSTWGA
60 70 80 90 100
GHFSTFDHHV YDFSGTCNYI FAATCKDAFP TFSVQLRRGP DGSISRIIVE
110 120 130 140 150
LGASVVTVSE AIISVKDIGV ISLPYTSNGL QITPFGQSVR LVAKQLELEL
160 170 180 190 200
EVVWGPDSHL MVLVERKYMG QMCGLCGNFD GKVTNEFVSE EGKFLEPHKF
210 220 230 240 250
AALQKLDDPG EICTFQDIPS THVRQAQHAR ICTQLLTLVA PECSVSKEPF
260 270 280 290 300
VLSCQADVAA APQPGPQNSS CATLSEYSRQ CSMVGQPVRR WRSPGLCSVG
310 320 330 340 350
QCPANQVYQE CGSACVKTCS NPQHSCSSSC TFGCFCPEGT VLNDLSNNHT
360 370 380 390 400
CVPVTQCPCV LHGAMYAPGE VTIAACQTCR CTLGRWVCTE RPCPGHCSLE
410 420 430 440 450
GGSFVTTFDA RPYRFHGTCT YILLQSPQLP EDGALMAVYD KSGVSHSETS
460 470 480 490 500
LVAVVYLSRQ DKIVISQDEV VTNNGEAKWL PYKTRNITVF RQTSTHLQMA
510 520 530 540 550
TSFGLELVVQ LRPIFQAYVT VGPQFRGQTR GLCGNFNGDT TDDFTTSMGI
560 570 580 590 600
AEGTASLFVD SWRAGNCPAA LERETDPCSM SQLNKVCAET HCSMLLRTGT
610 620 630 640 650
VFERCHATVN PAPFYKRCVY QACNYEETFP HICAALGDYV HACSLRGVLL
660 670 680 690 700
WGWRSSVDNC TIPCTGNTTF SYNSQACERT CLSLSDRATE CHHSAVPVDG
710 720 730 740 750
CNCPDGTYLN QKGECVRKAQ CPCILEGYKF ILAEQSTVIN GITCHCINGR
760 770 780 790 800
LSCPQRPQMF LASCQAPKTF KSCSQSSENK FGAACAPTCQ MLATGVACVP
810 820 830 840 850
TKCEPGCVCA EGLYENADGQ CVPPEECPCE FSGVSYPGGA ELHTDCRTCS
860 870 880 890 900
CSRGRWACQQ GTHCPSTCTL YGEGHVITFD GQRFVFDGNC EYILATDVCG
910 920 930 940 950
VNDSQPTFKI LTENVICGNS GVTCSRAIKI FLGGLSVVLA DRNYTVTGEE
960 970 980 990 1000
PHVQLGVTPG ALSLVVDISI PGRYNLTLIW NRHMTILIRI ARASQDPLCG
1010 1020 1030 1040 1050
LCGNFNGNMK DDFETRSRYV ASSELELVNS WKESPLCGDV SFVTDPCSLN
1060 1070 1080 1090 1100
AFRRSWAERK CSVINSQTFA TCHSKVYHLP YYEACVRDAC GCDSGGDCEC
1110 1120 1130 1140 1150
LCDAVAAYAQ ACLDKGVCVD WRTPAFCPIY CGFYNTHTQD GHGEYQYTQE
1160 1170 1180 1190 1200
ANCTWHYQPC LCPSQPQSVP GSNIEGCYNC SQDEYFDHEE GVCVPCMPPT
1210 1220 1230 1240 1250
TPQPPTTPQL PTTGSRPTQV WPMTGTSTTI GLLSSTGPSP SSNHTPASPT
1260 1270 1280 1290 1300
QTPLLPATLT SSKPTASSGE PPRPTTAVTP QATSGLPPTA TLRSTATKPT
1310 1320 1330 1340 1350
VTQATTRATA STASPATTST AQSTTRTTMT LPTPATSGTS PTLPKSTNQE
1360 1370 1380 1390 1400
LPGTTATQTT GPRPTPASTT GPTTPQPGQP TRPTATETTQ TRTTTEYTTP
1410 1420 1430 1440 1450
QTPHTTHSPP TAGSPVPSTG PVTATSFHAT TTYPTPSHPE TTLPTHVPPF
1460 1470 1480 1490 1500
STSLVTPSTH TVITPTHAQM ATSASNHSAP TGTIPPPTTL KATGSTHTAP
1510 1520 1530 1540 1550
PITPTTSGTS QAHSSFSTNK TPTSLHSHTS STHHPEVTPT STTTITPNPT
1560 1570 1580 1590 1600
STRTRTPVAH TNSATSSRPP PPFTTHSPPT GSSPFSSTGP MTATSFKTTT
1610 1620 1630 1640 1650
TYPTPSHPQT TLPTHVPPFS TSLVTPSTHT VITPTHAQMA TSASIHSMPT
1660 1670 1680 1690 1700
GTIPPPTTLK ATGSTHTAPT MTLTTSGTSQ ALSSLNTAKT STSLHSHTSS
1710 1720 1730 1740 1750
THHAEATSTS TTNITPNPTS TGTPPMTVTT SGTSQSRSSF STAKTSTSLH
1760 1770 1780 1790 1800
SHTSSTHHPE VTSTSTTSIT PNHTSTGTRT PVAHTTSATS SRLPTPFTTH
1810 1820 1830 1840 1850
SPPTGTTPIS STGPVTATSF QTTTTYPTPS HPHTTLPTHV PSFSTSLVTP
1860 1870 1880 1890 1900
STHTVIIPTH TQMATSASIH SMPTGTIPPP TTIKATGSTH TAPPMTPTTS
1910 1920 1930 1940 1950
GTSQSPSSFS TAKTSTSLPY HTSSTHHPEV TPTSTTNITP KHTSTGTRTP
1960 1970 1980 1990 2000
VAHTTSASSS RLPTPFTTHS PPTGSSPFSS TGPMTATSFQ TTTTYPTPSH
2010 2020 2030 2040 2050
PQTTLPTHVP PFSTSLVTPS THTVIITTHT QMATSASIHS TPTGTVPPPT
2060 2070 2080 2090 2100
TLKATGSTHT APPMTVTTSG TSQTHSSFST ATASSSFISS SSWLPQNSSS
2110 2120 2130 2140 2150
RPPSSPITTQ LPHLSSATTP VSTTNQLSSS FSPSPSAPST VSSYVPSSHS
2160 2170 2180 2190 2200
SPQTSSPSVG TSSSFVSAPV HSTTLSSGSH SSLSTHPTTA SVSASPLFPS
2210 2220 2230 2240 2250
SPAASTTIRA TLPHTISSPF TLSALLPIST VTVSPTPSSH LASSTIAFPS
2260 2270 2280 2290 2300
TPRTTASTHT APAFSSQSTT SRSTSLTTRV PTSGFVSLTS GVTGIPTSPV
2310 2320 2330 2340 2350
TNLTTRHPGP TLSPTTRFLT SSLTAHGSTP ASAPVSSLGT PTPTSPGVCS
2360 2370 2380 2390 2400
VREQQEEITF KGCMANVTVT RCEGACISAA SFNIITQQVD ARCSCCRPLH
2410 2420 2430
SYEQQLELPC PDPSTPGRRL VLTLQVFSHC VCSSVACGD
Length:2,439
Mass (Da):257,051
Last modified:May 3, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A1A7E6A7C30F895
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JN42A0A0G2JN42_HUMAN
Mucin-6
MUC6
2,439Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNJ8A0A0G2JNJ8_HUMAN
Mucin-6
MUC6
2,439Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJC5E9PJC5_HUMAN
Mucin-6
MUC6
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDA7H0YDA7_HUMAN
Mucin-6
MUC6
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEZ6H0YEZ6_HUMAN
Mucin-6
MUC6
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK092533 differs from that shown. Reason: Erroneous termination at position 2357. Translated as Glu.Curated
The sequence BAC04860 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81T → S in AAQ82434 (PubMed:15081123).Curated1
Sequence conflicti231I → G in AAQ82434 (PubMed:15081123).Curated1
Sequence conflicti271C → Y in AAQ82434 (PubMed:15081123).Curated1
Sequence conflicti289 – 291RRW → AL in AAQ82434 (PubMed:15081123).Curated3
Sequence conflicti322 – 323PQ → SE in AAQ82434 (PubMed:15081123).Curated2
Sequence conflicti341V → D in AAQ82434 (PubMed:15081123).Curated1
Sequence conflicti569A → D in AAQ82434 (PubMed:15081123).Curated1
Sequence conflicti614F → I in AAQ82434 (PubMed:15081123).Curated1
Sequence conflicti619V → M in AAQ82434 (PubMed:15081123).Curated1
Sequence conflicti757P → L in AAQ82434 (PubMed:15081123).Curated1
Sequence conflicti818D → Y in AAQ82434 (PubMed:15081123).Curated1
Sequence conflicti903D → Y in AAQ82434 (PubMed:15081123).Curated1
Sequence conflicti1472T → S in AAQ82434 (PubMed:15081123).Curated1
Sequence conflicti1544T → S in AAQ82434 (PubMed:15081123).Curated1
Sequence conflicti1558V → M in AAQ82434 (PubMed:15081123).Curated1
Sequence conflicti1806 – 1807TT → SS in AAA35866 (PubMed:7680650).Curated2
Sequence conflicti1815V → M in AAA35866 (PubMed:7680650).Curated1
Sequence conflicti1833H → E in AAA35866 (PubMed:7680650).Curated1
Sequence conflicti1842S → P in AAA35866 (PubMed:7680650).Curated1
Sequence conflicti1857I → T in AAA35866 (PubMed:7680650).Curated1
Sequence conflicti1861T → A in AAA35866 (PubMed:7680650).Curated1
Sequence conflicti1872M → T in AAA35866 (PubMed:7680650).Curated1
Sequence conflicti1880 – 1885PTTIKA → LTTLMN in AAA35866 (PubMed:7680650).Curated6
Sequence conflicti1895M → V in AAA35866 (PubMed:7680650).Curated1
Sequence conflicti1905 – 1906SP → AA in AAA35866 (PubMed:7680650).Curated2
Sequence conflicti1919 – 1920PY → HS in AAA35866 (PubMed:7680650).Curated2
Sequence conflicti1934S → A in AAA35866 (PubMed:7680650).Curated1
Sequence conflicti1937 – 1951NITPK…TRTPV → KITTNPTSIGSSTPM in AAA35866 (PubMed:7680650).CuratedAdd BLAST15
Sequence conflicti1940P → F in BAC04860 (Ref. 6) Curated1
Sequence conflicti1958S → T in AAA35866 (PubMed:7680650).Curated1
Sequence conflicti1963P → T in AAA35866 (PubMed:7680650).Curated1
Sequence conflicti1972P → S in AAA35866 (PubMed:7680650).Curated1
Sequence conflicti2091S → SSWS in AAC51370 (PubMed:9195947).Curated1
Sequence conflicti2129S → F in BAC04860 (Ref. 6) Curated1
Sequence conflicti2190 – 2192ASV → GSG in AAC51370 (PubMed:9195947).Curated3
Sequence conflicti2272R → G in AAC51370 (PubMed:9195947).Curated1
Sequence conflicti2318F → S in AAC51370 (PubMed:9195947).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The number of repeats is highly polymorphic and varies among different alleles. These repeats are very similar but not identical.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0595421578P → S. Corresponds to variant dbSNP:rs10736904Ensembl.1
Natural variantiVAR_0614881794P → T1 PublicationCorresponds to variant dbSNP:rs35549382Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC139749 Genomic DNA No translation available.
AY312160 mRNA Translation: AAQ82434.1
AY458429 mRNA Translation: AAS13634.1
AY500284 Genomic DNA Translation: AAS76674.1
L07517 mRNA Translation: AAA35866.2
AK092533 mRNA No translation available.
AK096772 mRNA Translation: BAC04860.1 Different initiation.
U97698 mRNA Translation: AAC51370.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44513.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A46629

NCBI Reference Sequences

More...
RefSeqi
NP_005952.2, NM_005961.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.528432

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000421673; ENSP00000406861; ENSG00000184956
ENST00000636545; ENSP00000490759; ENSG00000283350

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4588

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4588

UCSC genome browser

More...
UCSCi
uc001lsw.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Mucin database
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139749 Genomic DNA No translation available.
AY312160 mRNA Translation: AAQ82434.1
AY458429 mRNA Translation: AAS13634.1
AY500284 Genomic DNA Translation: AAS76674.1
L07517 mRNA Translation: AAA35866.2
AK092533 mRNA No translation available.
AK096772 mRNA Translation: BAC04860.1 Different initiation.
U97698 mRNA Translation: AAC51370.1
CCDSiCCDS44513.1
PIRiA46629
RefSeqiNP_005952.2, NM_005961.2
UniGeneiHs.528432

3D structure databases

ProteinModelPortaliQ6W4X9
SMRiQ6W4X9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000406861

Protein family/group databases

MEROPSiI08.952

PTM databases

GlyConnecti1521
iPTMnetiQ6W4X9
PhosphoSitePlusiQ6W4X9

Polymorphism and mutation databases

BioMutaiMUC6
DMDMi332278200

Proteomic databases

jPOSTiQ6W4X9
PaxDbiQ6W4X9
PeptideAtlasiQ6W4X9
PRIDEiQ6W4X9
ProteomicsDBi67744

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421673; ENSP00000406861; ENSG00000184956
ENST00000636545; ENSP00000490759; ENSG00000283350
GeneIDi4588
KEGGihsa:4588
UCSCiuc001lsw.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4588
DisGeNETi4588
EuPathDBiHostDB:ENSG00000184956.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MUC6

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0023085
HGNCiHGNC:7517 MUC6
HPAiCAB002165
MIMi158374 gene
neXtProtiNX_Q6W4X9
OpenTargetsiENSG00000184956

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1216 Eukaryota
ENOG410XNSK LUCA
GeneTreeiENSGT00940000161708
HOVERGENiHBG081998
InParanoidiQ6W4X9
KOiK22023
OMAiTHAQMAT
OrthoDBi12226at2759
PhylomeDBiQ6W4X9
TreeFamiTF300299

Enzyme and pathway databases

ReactomeiR-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5621480 Dectin-2 family
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-977068 Termination of O-glycan biosynthesis

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MUC6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4588

Protein Ontology

More...
PROi
PR:Q6W4X9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184956 Expressed in 153 organ(s), highest expression level in body of stomach
ExpressionAtlasiQ6W4X9 baseline and differential
GenevisibleiQ6W4X9 HS

Family and domain databases

InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR030124 MUC6
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
PANTHERiPTHR11339:SF264 PTHR11339:SF264, 3 hits
PfamiView protein in Pfam
PF08742 C8, 3 hits
PF01826 TIL, 2 hits
PF00094 VWD, 3 hits
SMARTiView protein in SMART
SM00832 C8, 3 hits
SM00041 CT, 1 hit
SM00215 VWC_out, 2 hits
SM00216 VWD, 3 hits
SUPFAMiSSF57567 SSF57567, 3 hits
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit
PS51233 VWFD, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUC6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6W4X9
Secondary accession number(s): O15329
, Q14394, Q2TUQ5, Q4L207, Q8N8I1, Q8NAK1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 3, 2011
Last modified: February 13, 2019
This is version 116 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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