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UniProtKB - Q6W4T3 (ANGR_VIBA7)

Entry version 74 (10 Feb 2021)
Sequence version 1 (10 May 2005)
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Protein

Anguibactin system regulator

Gene

angR

Organism
Vibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional protein that plays an essential role in virulence. Plays a role in both production of the siderophore anguibactin and regulation of iron transport genes.2 Publications

Caution

Lacks the conserved Ser at position 1000 required for covalent attachment of 4-phosphopantetheine.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: anguibactin biosynthesis

This protein is involved in the pathway anguibactin biosynthesis, which is part of Siderophore biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in the pathway anguibactin biosynthesis and in Siderophore biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Ligase
Biological processIon transport, Iron transport, Transcription, Transcription regulation, Transport
LigandIron

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:MONOMER-20471

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00016

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anguibactin system regulator
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:angR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid pJM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri882102 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006800 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Plasmid pJM1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi151V → D: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication1
Mutagenesisi267H → L: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication1
Mutagenesisi267H → N: Increases anguibactin production. Does not affect ability to grow under iron-limited conditions. No change in virulence. 1 Publication1
Mutagenesisi267H → Q: Decreases anguibactin production, decreases ability to grow under iron-limited conditions and decreases virulence. 1 Publication1
Mutagenesisi303Q → P: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication1
Mutagenesisi609K → F or G: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication1
Mutagenesisi852V → K: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication1
Mutagenesisi859I → P: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication1
Mutagenesisi888T → P: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication1
Mutagenesisi889L → P: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004171191 – 1048Anguibactin system regulatorAdd BLAST1048

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

AngR transcription is regulated by iron.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		55601.VANGNB10_67p038

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6W4T3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini965 – 1039CarrierPROSITE-ProRule annotationAdd BLAST75

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1020, Bacteria

Identification of Orthologs from Complete Genome Data

More...OMAi		DYWSIDK

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1200.10, 1 hit
3.30.559.10, 1 hit
3.40.50.12780, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR009081, PP-bd_ACP

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00501, AMP-binding, 1 hit
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47336, SSF47336, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01733, AA-adenyl-dom, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00455, AMP_BINDING, 1 hit
PS50075, CARRIER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6W4T3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQNEHPFAF PETKLPLTSN QNWQLSTQRQ RTEKKSITNF TYQEFDYENI 
        60         70         80         90        100
SRDTLERCLT TIIKHHPIFG AKLSDDFYLH FPSKTHIETF AVNDLSNALK 
       110        120        130        140        150
QDIDKQLADT RSAVTKSRSQ AIISIMFSIL PKNIIRLHVR FNSVVVDNPS 
       160        170        180        190        200
VTLFFEQLTQ LLSGSPLSFL NQEQTISAYN HKVNNELLSV DLESARWNEY 
       210        220        230        240        250
ILTLPSSANL PTICEPEKLD ETDITRRCIT LSQRKWQQLV TVSKKHNVTP 
       260        270        280        290        300
EITLASIFST VLSLWGHQKY LMMRFDITKI NDYTGIIGQF TEPLLVGMSG 
       310        320        330        340        350
FEQSFLSLVK NNQKKFEEAY HYDVKVPVFQ CVNKLSNISD SHRYPANITF 
       360        370        380        390        400
SSELLNTNHS KKAVWGCRQS ANTWLSLHAV IEQEQLVLQW DSQDAIFPKD 
       410        420        430        440        450
MIKDMLHSYT DLLDLLSQKD VNWAQPLPTL LPKHQESIRN KINQQGDLEL 
       460        470        480        490        500
TKELLHQRFF KNVESTPNAL AIIHGQESLD YITLASYAKS CAGALTEAGV 
       510        520        530        540        550
KSGDRVAVTM NKGIGQIVAV LGILYAGAIY VPVSLDQPQE RRESIYQGAG 
       560        570        580        590        600
INVILINESD SKNSPSNDLF FFLDWQTAIK SEPMRSPQDV APSQPAYIIY 
       610        620        630        640        650
TSGSTGTPKG VVISHQGALN TCIAINRRYQ IGKNDRVLAL SALHFDLSVY 
       660        670        680        690        700
DIFGLLSAGG TIVLVSELER RDPIAWCQAI EEHNVTMWNS VPALFDMLLT 
       710        720        730        740        750
YATCFNSIAP SKLRLTMLSG DWIGLDLPQR YRNYRVDGQF IAMGGATEAS 
       760        770        780        790        800
IWSNVFDVEK VPMEWRSIPY GYPLPRQQYR VVDDLGRDCP DWVAGELWIG 
       810        820        830        840        850
GDGIALGYFD DELKTQAQFL HIDGHAWYRT GDMGCYWPDG TLEFLGRRDK 
       860        870        880        890        900
QVKVGGYRIE LGEIEVALNN IPGVQRAVAI AVGNKDKTLA AFIVMDSEQA 
       910        920        930        940        950
PIVTAPLDAE EVQLLLNKQL PNYMVPKRII FLETFPLTAN GKVDHKALTR 
       960        970        980        990       1000
MTNREKKTSQ SINKPIITAS EDRVAKIWND VLGPTELYKS SDFFLSGGDA 
      1010       1020       1030       1040 
YNAIEVVKRC HKAGYLIKLS MLYRYSTIEA FAIIMDRCRL APQEEAEL
Length:1,048
Mass (Da):118,421
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53CF4B81D25A3CC4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M34504 Genomic DNA Translation: AAA79860.1
AY312585 Genomic DNA Translation: AAR12528.1

Protein sequence database of the Protein Information Resource

More...PIRi		JQ0416, YGVCAR

NCBI Reference Sequences

More...RefSeqi		NP_943553.1, NC_005250.1
WP_011154639.1, NC_005250.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34504 Genomic DNA Translation: AAA79860.1
AY312585 Genomic DNA Translation: AAR12528.1
PIRiJQ0416, YGVCAR
RefSeqiNP_943553.1, NC_005250.1
WP_011154639.1, NC_005250.1

3D structure databases

SMRiQ6W4T3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi55601.VANGNB10_67p038

Phylogenomic databases

eggNOGiCOG1020, Bacteria
OMAiDYWSIDK

Enzyme and pathway databases

UniPathwayiUPA00016
BioCyciMetaCyc:MONOMER-20471

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.30.559.10, 1 hit
3.40.50.12780, 1 hit
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR009081, PP-bd_ACP
PfamiView protein in Pfam
PF00501, AMP-binding, 1 hit
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 1 hit
SUPFAMiSSF47336, SSF47336, 1 hit
TIGRFAMsiTIGR01733, AA-adenyl-dom, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 1 hit
PS50075, CARRIER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANGR_VIBA7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6W4T3
Secondary accession number(s): P19828
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: May 10, 2005
Last modified: February 10, 2021
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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