UniProtKB - Q6W4T3 (ANGR_VIBA7)
Protein
Anguibactin system regulator
Gene
angR
Organism
Vibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum)
Status
Functioni
Bifunctional protein that plays an essential role in virulence. Plays a role in both production of the siderophore anguibactin and regulation of iron transport genes.2 Publications
Caution
Lacks the conserved Ser at position 1000 required for covalent attachment of 4-phosphopantetheine.Curated
: anguibactin biosynthesis Pathwayi
This protein is involved in the pathway anguibactin biosynthesis, which is part of Siderophore biosynthesis.1 PublicationView all proteins of this organism that are known to be involved in the pathway anguibactin biosynthesis and in Siderophore biosynthesis.
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- ligase activity Source: UniProtKB-KW
GO - Biological processi
- ion transport Source: UniProtKB-KW
- iron ion homeostasis Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, DNA-binding, Ligase |
Biological process | Ion transport, Iron transport, Transcription, Transcription regulation, Transport |
Ligand | Iron |
Enzyme and pathway databases
BioCyci | MetaCyc:MONOMER-20471 |
UniPathwayi | UPA00016 |
Names & Taxonomyi
Protein namesi | Recommended name: Anguibactin system regulator |
Gene namesi | Name:angR |
Encoded oni | Plasmid pJM1 |
Organismi | Vibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum) |
Taxonomic identifieri | 882102 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › |
Proteomesi |
|
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 151 | V → D: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication | 1 | |
Mutagenesisi | 267 | H → L: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication | 1 | |
Mutagenesisi | 267 | H → N: Increases anguibactin production. Does not affect ability to grow under iron-limited conditions. No change in virulence. 1 Publication | 1 | |
Mutagenesisi | 267 | H → Q: Decreases anguibactin production, decreases ability to grow under iron-limited conditions and decreases virulence. 1 Publication | 1 | |
Mutagenesisi | 303 | Q → P: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication | 1 | |
Mutagenesisi | 609 | K → F or G: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication | 1 | |
Mutagenesisi | 852 | V → K: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication | 1 | |
Mutagenesisi | 859 | I → P: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication | 1 | |
Mutagenesisi | 888 | T → P: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication | 1 | |
Mutagenesisi | 889 | L → P: Does not produce anguibactin, impairs ability to grow under iron-limited conditions and decreases virulence. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000417119 | 1 – 1048 | Anguibactin system regulatorAdd BLAST | 1048 |
Expressioni
Inductioni
AngR transcription is regulated by iron.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 965 – 1039 | CarrierPROSITE-ProRule annotationAdd BLAST | 75 |
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Phylogenomic databases
eggNOGi | COG1020, Bacteria |
OMAi | DYWSIDK |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.30.559.10, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR010071, AA_adenyl_domain IPR036736, ACP-like_sf IPR025110, AMP-bd_C IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf IPR023213, CAT-like_dom_sf IPR001242, Condensatn IPR009081, PP-bd_ACP |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit PF00668, Condensation, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit |
TIGRFAMsi | TIGR01733, AA-adenyl-dom, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit PS50075, CARRIER, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6W4T3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNQNEHPFAF PETKLPLTSN QNWQLSTQRQ RTEKKSITNF TYQEFDYENI
60 70 80 90 100
SRDTLERCLT TIIKHHPIFG AKLSDDFYLH FPSKTHIETF AVNDLSNALK
110 120 130 140 150
QDIDKQLADT RSAVTKSRSQ AIISIMFSIL PKNIIRLHVR FNSVVVDNPS
160 170 180 190 200
VTLFFEQLTQ LLSGSPLSFL NQEQTISAYN HKVNNELLSV DLESARWNEY
210 220 230 240 250
ILTLPSSANL PTICEPEKLD ETDITRRCIT LSQRKWQQLV TVSKKHNVTP
260 270 280 290 300
EITLASIFST VLSLWGHQKY LMMRFDITKI NDYTGIIGQF TEPLLVGMSG
310 320 330 340 350
FEQSFLSLVK NNQKKFEEAY HYDVKVPVFQ CVNKLSNISD SHRYPANITF
360 370 380 390 400
SSELLNTNHS KKAVWGCRQS ANTWLSLHAV IEQEQLVLQW DSQDAIFPKD
410 420 430 440 450
MIKDMLHSYT DLLDLLSQKD VNWAQPLPTL LPKHQESIRN KINQQGDLEL
460 470 480 490 500
TKELLHQRFF KNVESTPNAL AIIHGQESLD YITLASYAKS CAGALTEAGV
510 520 530 540 550
KSGDRVAVTM NKGIGQIVAV LGILYAGAIY VPVSLDQPQE RRESIYQGAG
560 570 580 590 600
INVILINESD SKNSPSNDLF FFLDWQTAIK SEPMRSPQDV APSQPAYIIY
610 620 630 640 650
TSGSTGTPKG VVISHQGALN TCIAINRRYQ IGKNDRVLAL SALHFDLSVY
660 670 680 690 700
DIFGLLSAGG TIVLVSELER RDPIAWCQAI EEHNVTMWNS VPALFDMLLT
710 720 730 740 750
YATCFNSIAP SKLRLTMLSG DWIGLDLPQR YRNYRVDGQF IAMGGATEAS
760 770 780 790 800
IWSNVFDVEK VPMEWRSIPY GYPLPRQQYR VVDDLGRDCP DWVAGELWIG
810 820 830 840 850
GDGIALGYFD DELKTQAQFL HIDGHAWYRT GDMGCYWPDG TLEFLGRRDK
860 870 880 890 900
QVKVGGYRIE LGEIEVALNN IPGVQRAVAI AVGNKDKTLA AFIVMDSEQA
910 920 930 940 950
PIVTAPLDAE EVQLLLNKQL PNYMVPKRII FLETFPLTAN GKVDHKALTR
960 970 980 990 1000
MTNREKKTSQ SINKPIITAS EDRVAKIWND VLGPTELYKS SDFFLSGGDA
1010 1020 1030 1040
YNAIEVVKRC HKAGYLIKLS MLYRYSTIEA FAIIMDRCRL APQEEAEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34504 Genomic DNA Translation: AAA79860.1 AY312585 Genomic DNA Translation: AAR12528.1 |
PIRi | JQ0416, YGVCAR |
RefSeqi | NP_943553.1, NC_005250.1 WP_011154639.1, NC_005250.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34504 Genomic DNA Translation: AAA79860.1 AY312585 Genomic DNA Translation: AAR12528.1 |
PIRi | JQ0416, YGVCAR |
RefSeqi | NP_943553.1, NC_005250.1 WP_011154639.1, NC_005250.1 |
3D structure databases
SMRi | Q6W4T3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 55601.VANGNB10_67p038 |
Phylogenomic databases
eggNOGi | COG1020, Bacteria |
OMAi | DYWSIDK |
Enzyme and pathway databases
UniPathwayi | UPA00016 |
BioCyci | MetaCyc:MONOMER-20471 |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.30.559.10, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR010071, AA_adenyl_domain IPR036736, ACP-like_sf IPR025110, AMP-bd_C IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf IPR023213, CAT-like_dom_sf IPR001242, Condensatn IPR009081, PP-bd_ACP |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit PF00668, Condensation, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit |
TIGRFAMsi | TIGR01733, AA-adenyl-dom, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit PS50075, CARRIER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANGR_VIBA7 | |
Accessioni | Q6W4T3Primary (citable) accession number: Q6W4T3 Secondary accession number(s): P19828 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2012 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 10, 2021 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
PlasmidDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families