Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 157 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

BCL-6 corepressor

Gene

BCOR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q6W2J9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BCL-6 corepressor
Short name:
BCoR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCOR
Synonyms:KIAA1575
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000183337.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20893 BCOR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300485 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6W2J9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microphthalmia, syndromic, 2 (MCOPS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length). Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02092185P → L in MCOPS2. 1 PublicationCorresponds to variant dbSNP:rs121434618EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi507S → A: Abolishes interaction with BCL6 and inhibits BCL6 corepression activity; when associated with A-509 and A-511. 1 Publication1
Mutagenesisi508S → A: Diminishes interaction with BCL6. 1 Publication1
Mutagenesisi509W → A: Abolishes interaction with BCL6 and inhibits BCL6 corepression activity; when associated with A-507 and A-511. 1 Publication1
Mutagenesisi511V → A: Abolishes interaction with BCL6 and inhibits BCL6 corepression activity; when associated with A-507 and A-509. 1 Publication1
Mutagenesisi1706L → D or R: Slightly inhibits interaction with PCGF1. 1 Publication1

Keywords - Diseasei

Disease mutation, Microphthalmia

Organism-specific databases

DisGeNET

More...
DisGeNETi
54880

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
BCOR

MalaCards human disease database

More...
MalaCardsi
BCOR
MIMi300166 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000183337

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
520 Acute promyelocytic leukemia
457246 Clear cell sarcoma of kidney
568 Microphthalmia, Lenz type
2712 Oculofaciocardiodental syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134921737

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6W2J9 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BCOR

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669781 – 1755BCL-6 corepressorAdd BLAST1755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei336PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei367PhosphoserineCombined sources1
Modified residuei392N6-acetyllysineCombined sources1
Modified residuei423PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki786Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki872Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1127PhosphoserineBy similarity1
Modified residuei1139PhosphoserineCombined sources1
Cross-linki1256Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1290PhosphoserineCombined sources1
Modified residuei1345PhosphoserineBy similarity1
Modified residuei1410PhosphoserineCombined sources1
Cross-linki1413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6W2J9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6W2J9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6W2J9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6W2J9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6W2J9

PeptideAtlas

More...
PeptideAtlasi
Q6W2J9

PRoteomics IDEntifications database

More...
PRIDEi
Q6W2J9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67737 [Q6W2J9-1]
67738 [Q6W2J9-2]
67739 [Q6W2J9-3]
67740 [Q6W2J9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6W2J9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6W2J9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183337 Expressed in 205 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6W2J9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6W2J9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056308
HPA073591

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BCL6; the interaction is direct (PubMed:10898795). Forms ternary complexes with BCL6 and SMRT/NCOR2 on selected target genes promoters; potently repress expression (PubMed:23911289, PubMed:18280243). Can interact with HDAC1, HDAC3 and HDAC5 (PubMed:10898795).

Interacts with PCGF1; the interaction is direct (PubMed:16943429, PubMed:23523425, PubMed:26687479).

Interacts with KDM2B.

Component of an approximately 800 kDa repressive BCOR complex at least composed of BCOR, RYBP, PCGF1, RING1, RNF2/RING2, KDM2B and SKP1 (PubMed:16943429).

Interacts with CPNE4 (via VWFA domain) (By similarity). Isoform 1 may interact with MLLT3/AF9 (By similarity).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120228, 155 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q6W2J9

Database of interacting proteins

More...
DIPi
DIP-50009N

Protein interaction database and analysis system

More...
IntActi
Q6W2J9, 83 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367705

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6W2J9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11755
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6W2J9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q6W2J9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1462 – 1495ANK 1Add BLAST34
Repeati1496 – 1525ANK 2Add BLAST30
Repeati1529 – 1558ANK 3Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni498 – 514Interaction with BCL6Add BLAST17
Regioni1634 – 1748Necessary and sufficient for interaction with PCGF1Add BLAST115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi634 – 711Pro-richAdd BLAST78
Compositional biasi1625 – 1631Poly-Asp7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BCOR family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHDH Eukaryota
ENOG410YT00 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153737

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6W2J9

KEGG Orthology (KO)

More...
KOi
K23215

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPGHTRK

Database of Orthologous Groups

More...
OrthoDBi
85469at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6W2J9

TreeFam database of animal gene trees

More...
TreeFami
TF333317

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
3.10.260.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR031628 BCOR
IPR032365 PUFD
IPR038227 PUFD_som_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF15808 BCOR, 1 hit
PF16553 PUFD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6W2J9-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSATPLYGN VHSWMNSERV RMCGASEDRK ILVNDGDASK ARLELREENP
60 70 80 90 100
LNHNVVDAST AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SSLCGLGSEK
110 120 130 140 150
GREAATSTLG GLGFSSERNP EMQFKPNTPE TVEASAVSGK PPNGFSAIYK
160 170 180 190 200
TPPGIQKSAV ATAEALGLDR PASDKQSPLN INGASYLRLP WVNPYMEGAT
210 220 230 240 250
PAIYPFLDSP NKYSLNMYKA LLPQQSYSLA QPLYSPVCTN GERFLYLPPP
260 270 280 290 300
HYVGPHIPSS LASPMRLSTP SASPAIPPLV HCADKSLPWK MGVSPGNPVD
310 320 330 340 350
SHAYPHIQNS KQPRVPSAKA VTSGLPGDTA LLLPPSPRPS PRVHLPTQPA
360 370 380 390 400
ADTYSEFHKH YARISTSPSV ALSKPYMTVS SEFPAARLSN GKYPKAPEGG
410 420 430 440 450
EGAQPVPGHA RKTAVQDRKD GSSPPLLEKQ TVTKDVTDKP LDLSSKVVDV
460 470 480 490 500
DASKADHMKK MAPTVLVHSR AGSGLVLSGS EIPKETLSPP GNGCAIYRSE
510 520 530 540 550
IISTAPSSWV VPGPSPNEEN NGKSMSLKNK ALDWAIPQQR SSSCPRMGGT
560 570 580 590 600
DAVITNVSGS VSSAGRPASA SPAPNANADG TKTSRSSVET TPSVIQHVGQ
610 620 630 640 650
PPATPAKHSS STSSKGAKAS NPEPSFKANE NGLPPSSIFL SPNEAFRSPP
660 670 680 690 700
IPYPRSYLPY PAPEGIAVSP LSLHGKGPVY PHPVLLPNGS LFPGHLAPKP
710 720 730 740 750
GLPYGLPTGR PEFVTYQDAL GLGMVHPMLI PHTPIEITKE EKPERRSRSH
760 770 780 790 800
ERARYEDPTL RNRFSEILET SSTKLHPDVP TDKNLKPNPN WNQGKTVVKS
810 820 830 840 850
DKLVYVDLLR EEPDAKTDTN VSKPSFAAES VGQSAEPPKP SVEPALQQHR
860 870 880 890 900
DFIALREELG RISDFHETYT FKQPVFTVSK DSVLAGTNKE NLGLPVSTPF
910 920 930 940 950
LEPPLGSDGP AVTFGKTQED PKPFCVGSAP PSVDVTPTYT KDGADEAESN
960 970 980 990 1000
DGKVLKPKPS KLAKRIANSA GYVGDRFKCV TTELYADSSQ LSREQRALQM
1010 1020 1030 1040 1050
EGLQEDSILC LPAAYCERAM MRFSELEMKE REGGHPATKD SEMCKFSPAD
1060 1070 1080 1090 1100
WERLKGNQDK KPKSVTLEEA IAEQNESERC EYSVGNKHRD PFEAPEDKDL
1110 1120 1130 1140 1150
PVEKYFVERQ PVSEPPADQV ASDMPHSPTL RVDRKRKVSG DSSHTETTAE
1160 1170 1180 1190 1200
EVPEDPLLKA KRRRVSKDDW PEREMTNSSS NHLEDPHYSE LTNLKVCIEL
1210 1220 1230 1240 1250
TGLHPKKQRH LLHLRERWEQ QVSAADGKPG RQSRKEVTQA TQPEAIPQGT
1260 1270 1280 1290 1300
NITEEKPGRK RAEAKGNRSW SEESLKPSDN EQGLPVFSGS PPMKSLSSTS
1310 1320 1330 1340 1350
AGGKKQAQPS CAPASRPPAK QQKIKENQKT DVLCADEEED CQAASLLQKY
1360 1370 1380 1390 1400
TDNSEKPSGK RLCKTKHLIP QESRRGLPLT GEYYVENADG KVTVRRFRKR
1410 1420 1430 1440 1450
PEPSSDYDLS PAKQEPKPFD RLQQLLPASQ STQLPCSSSP QETTQSRPMP
1460 1470 1480 1490 1500
PEARRLIVNK NAGETLLQRA ARLGYEEVVL YCLENKICDV NHRDNAGYCA
1510 1520 1530 1540 1550
LHEACARGWL NIVRHLLEYG ADVNCSAQDG TRPLHDAVEN DHLEIVRLLL
1560 1570 1580 1590 1600
SYGADPTLAT YSGRTIMKMT HSELMEKFLT DYLNDLQGRN DDDASGTWDF
1610 1620 1630 1640 1650
YGSSVCEPDD ESGYDVLANP PGPEDQDDDD DAYSDVFEFE FSETPLLPCY
1660 1670 1680 1690 1700
NIQVSVAQGP RNWLLLSDVL KKLKMSSRIF RCNFPNVEIV TIAEAEFYRQ
1710 1720 1730 1740 1750
VSASLLFSCS KDLEAFNPES KELLDLVEFT NEIQTLLGSS VEWLHPSDLA

SDNYW
Length:1,755
Mass (Da):192,189
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA80CFCD5618EE717
GO
Isoform 2 (identifier: Q6W2J9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1168-1201: Missing.

Show »
Length:1,721
Mass (Da):188,202
Checksum:iF22343D545DB67AB
GO
Isoform 3 (identifier: Q6W2J9-3) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1000-1004: MEGLQ → VSPPT
     1005-1755: Missing.

Show »
Length:1,004
Mass (Da):107,404
Checksum:i126BD762958CB9F4
GO
Isoform 4 (identifier: Q6W2J9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1000-1017: Missing.
     1168-1201: Missing.

Show »
Length:1,703
Mass (Da):186,235
Checksum:i7433FBCE7238261F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYY2H7BYY2_HUMAN
BCL-6 corepressor
BCOR
1,287Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ37H7BZ37_HUMAN
BCL-6 corepressor
BCOR
332Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2V9H7C2V9_HUMAN
BCL-6 corepressor
BCOR
594Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A1A564A1A564_HUMAN
BCL-6 corepressor
BCOR
411Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C231H7C231_HUMAN
BCL-6 corepressor
BCOR
1,208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JHP3C9JHP3_HUMAN
BCL-6 corepressor
BCOR
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGX7A0A5F9ZGX7_HUMAN
BCL-6 corepressor
BCOR
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH63536 differs from that shown. Contaminating sequence. Presence of complementary strand sequence in the clone.Curated
The sequence BAA91061 differs from that shown. Intron retention.Curated
The sequence BAB13401 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB85037 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti406V → A in BAB85037 (PubMed:14702039).Curated1
Sequence conflicti596Q → L in BAB85037 (PubMed:14702039).Curated1
Sequence conflicti1459N → S in BAA91061 (PubMed:14702039).Curated1
Sequence conflicti1577K → R in BAA91061 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02092185P → L in MCOPS2. 1 PublicationCorresponds to variant dbSNP:rs121434618EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0125551000 – 1017Missing in isoform 4. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_0125541000 – 1004MEGLQ → VSPPT in isoform 3. 2 Publications5
Alternative sequenceiVSP_0125561005 – 1755Missing in isoform 3. 2 PublicationsAdd BLAST751
Alternative sequenceiVSP_0125571168 – 1201Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF317391 mRNA Translation: AAG41429.1
AF317392 mRNA Translation: AAG41430.1
AY316592 mRNA Translation: AAR08265.1
AB046795 mRNA Translation: BAB13401.2 Different initiation.
CH471141 Genomic DNA Translation: EAW59425.1
CH471141 Genomic DNA Translation: EAW59427.1
CH471141 Genomic DNA Translation: EAW59428.1
CH471141 Genomic DNA Translation: EAW59430.1
BC009675 mRNA Translation: AAH09675.2
BC063536 mRNA Translation: AAH63536.1 Sequence problems.
BC114220 mRNA Translation: AAI14221.1
AK000292 mRNA Translation: BAA91061.1 Sequence problems.
AK074286 mRNA Translation: BAB85037.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14250.1 [Q6W2J9-2]
CCDS48092.1 [Q6W2J9-4]
CCDS48093.1 [Q6W2J9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001116855.1, NM_001123383.1 [Q6W2J9-2]
NP_001116856.1, NM_001123384.1 [Q6W2J9-4]
NP_001116857.1, NM_001123385.1 [Q6W2J9-1]
NP_060215.4, NM_017745.5 [Q6W2J9-2]
XP_005272673.1, XM_005272616.1 [Q6W2J9-1]
XP_005272675.1, XM_005272618.3 [Q6W2J9-1]
XP_005272677.1, XM_005272620.3 [Q6W2J9-4]
XP_006724599.1, XM_006724536.3 [Q6W2J9-1]
XP_011542231.1, XM_011543929.2 [Q6W2J9-1]
XP_011542232.1, XM_011543930.1 [Q6W2J9-1]
XP_011542233.1, XM_011543931.2 [Q6W2J9-1]
XP_016885104.1, XM_017029615.1 [Q6W2J9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000342274; ENSP00000345923; ENSG00000183337 [Q6W2J9-2]
ENST00000378444; ENSP00000367705; ENSG00000183337 [Q6W2J9-1]
ENST00000378455; ENSP00000367716; ENSG00000183337 [Q6W2J9-4]
ENST00000397354; ENSP00000380512; ENSG00000183337 [Q6W2J9-2]
ENST00000673391; ENSP00000500446; ENSG00000183337 [Q6W2J9-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54880

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54880

UCSC genome browser

More...
UCSCi
uc004dem.5 human [Q6W2J9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317391 mRNA Translation: AAG41429.1
AF317392 mRNA Translation: AAG41430.1
AY316592 mRNA Translation: AAR08265.1
AB046795 mRNA Translation: BAB13401.2 Different initiation.
CH471141 Genomic DNA Translation: EAW59425.1
CH471141 Genomic DNA Translation: EAW59427.1
CH471141 Genomic DNA Translation: EAW59428.1
CH471141 Genomic DNA Translation: EAW59430.1
BC009675 mRNA Translation: AAH09675.2
BC063536 mRNA Translation: AAH63536.1 Sequence problems.
BC114220 mRNA Translation: AAI14221.1
AK000292 mRNA Translation: BAA91061.1 Sequence problems.
AK074286 mRNA Translation: BAB85037.1 Frameshift.
CCDSiCCDS14250.1 [Q6W2J9-2]
CCDS48092.1 [Q6W2J9-4]
CCDS48093.1 [Q6W2J9-1]
RefSeqiNP_001116855.1, NM_001123383.1 [Q6W2J9-2]
NP_001116856.1, NM_001123384.1 [Q6W2J9-4]
NP_001116857.1, NM_001123385.1 [Q6W2J9-1]
NP_060215.4, NM_017745.5 [Q6W2J9-2]
XP_005272673.1, XM_005272616.1 [Q6W2J9-1]
XP_005272675.1, XM_005272618.3 [Q6W2J9-1]
XP_005272677.1, XM_005272620.3 [Q6W2J9-4]
XP_006724599.1, XM_006724536.3 [Q6W2J9-1]
XP_011542231.1, XM_011543929.2 [Q6W2J9-1]
XP_011542232.1, XM_011543930.1 [Q6W2J9-1]
XP_011542233.1, XM_011543931.2 [Q6W2J9-1]
XP_016885104.1, XM_017029615.1 [Q6W2J9-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N1LNMR-A1634-1748[»]
3BIMX-ray2.60I/J/K/L/M/N/O/P498-514[»]
4HPLX-ray2.00A1634-1748[»]
6B7GNMR-B1176-1207[»]
SMRiQ6W2J9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120228, 155 interactors
CORUMiQ6W2J9
DIPiDIP-50009N
IntActiQ6W2J9, 83 interactors
STRINGi9606.ENSP00000367705

PTM databases

iPTMnetiQ6W2J9
PhosphoSitePlusiQ6W2J9

Polymorphism and mutation databases

BioMutaiBCOR

Proteomic databases

EPDiQ6W2J9
jPOSTiQ6W2J9
MassIVEiQ6W2J9
MaxQBiQ6W2J9
PaxDbiQ6W2J9
PeptideAtlasiQ6W2J9
PRIDEiQ6W2J9
ProteomicsDBi67737 [Q6W2J9-1]
67738 [Q6W2J9-2]
67739 [Q6W2J9-3]
67740 [Q6W2J9-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54880

Genome annotation databases

EnsembliENST00000342274; ENSP00000345923; ENSG00000183337 [Q6W2J9-2]
ENST00000378444; ENSP00000367705; ENSG00000183337 [Q6W2J9-1]
ENST00000378455; ENSP00000367716; ENSG00000183337 [Q6W2J9-4]
ENST00000397354; ENSP00000380512; ENSG00000183337 [Q6W2J9-2]
ENST00000673391; ENSP00000500446; ENSG00000183337 [Q6W2J9-2]
GeneIDi54880
KEGGihsa:54880
UCSCiuc004dem.5 human [Q6W2J9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54880
DisGeNETi54880
EuPathDBiHostDB:ENSG00000183337.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BCOR
GeneReviewsiBCOR
HGNCiHGNC:20893 BCOR
HPAiHPA056308
HPA073591
MalaCardsiBCOR
MIMi300166 phenotype
300485 gene
neXtProtiNX_Q6W2J9
OpenTargetsiENSG00000183337
Orphaneti520 Acute promyelocytic leukemia
457246 Clear cell sarcoma of kidney
568 Microphthalmia, Lenz type
2712 Oculofaciocardiodental syndrome
PharmGKBiPA134921737

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHDH Eukaryota
ENOG410YT00 LUCA
GeneTreeiENSGT00940000153737
InParanoidiQ6W2J9
KOiK23215
OMAiVPGHTRK
OrthoDBi85469at2759
PhylomeDBiQ6W2J9
TreeFamiTF333317

Enzyme and pathway databases

SIGNORiQ6W2J9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BCOR human
EvolutionaryTraceiQ6W2J9

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BCOR

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54880
PharosiQ6W2J9 Tbio

Protein Ontology

More...
PROi
PR:Q6W2J9
RNActiQ6W2J9 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000183337 Expressed in 205 organ(s), highest expression level in forebrain
ExpressionAtlasiQ6W2J9 baseline and differential
GenevisibleiQ6W2J9 HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
3.10.260.40, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR031628 BCOR
IPR032365 PUFD
IPR038227 PUFD_som_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF15808 BCOR, 1 hit
PF16553 PUFD, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCOR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6W2J9
Secondary accession number(s): D3DWB3
, D3DWB4, Q29RF6, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again