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Protein

Sclerostin domain-containing protein 1

Gene

SOSTDC1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can activate or inhibit Wnt signaling in a context-dependent manner. Activates the canonical Wnt pathway whereby acts through Disheveled proteins and beta-catenin. Antagonises Wnt signaling through the canonical pathways presumably by blocking accessibility of certain WNTs to their receptors. Induces posterior neural markers via components of the canonical Wnt pathway.1 Publication

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Sclerostin domain-containing protein 1
Alternative name(s):
Wnt-signaling modulator
Gene namesi
Name:SOSTDC1
Synonyms:WISE
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003318423 – 206Sclerostin domain-containing protein 1Add BLAST184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi75 ↔ 133PROSITE-ProRule annotation
Disulfide bondi89 ↔ 147PROSITE-ProRule annotation
Disulfide bondi100 ↔ 163PROSITE-ProRule annotation
Disulfide bondi104 ↔ 165PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6VYA3
PRIDEiQ6VYA3

Expressioni

Developmental stagei

Expression was first detected broadly at stage 9, and then localised in the posterior surface ectoderm overlying the presomitic mesoderm by stage 10-11 embryo.1 Publication

Gene expression databases

BgeeiENSGALG00000010797 Expressed in 5 organ(s), highest expression level in female gonad

Interactioni

Subunit structurei

Interacts with LRP6.1 Publication

Protein-protein interaction databases

ELMiQ6VYA3
STRINGi9031.ENSGALP00000017538

Structurei

3D structure databases

SMRiQ6VYA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 170CTCKPROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Belongs to the sclerostin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIVA Eukaryota
ENOG410YEMP LUCA
GeneTreeiENSGT00390000014900
HOGENOMiHOG000252934
HOVERGENiHBG003729
InParanoidiQ6VYA3
OMAiNCLAFKN
OrthoDBiEOG091G13DX
PhylomeDBiQ6VYA3
TreeFamiTF353019

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR008835 Sclerostin/SOSTDC1
PANTHERiPTHR14903 PTHR14903, 1 hit
PfamiView protein in Pfam
PF05463 Sclerostin, 1 hit
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6VYA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLSAIHFYG LLLACTFTRS YSAFKNDATE ILYSHVVKPA PASPSSNSTL
60 70 80 90 100
NQARNGGRHY AGTGSDRNNR VQVGCRELRS TKYISDGQCT SINPLKELVC
110 120 130 140 150
AGECLPLPLL PNWIGGGYGT KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG
160 170 180 190 200
SIRTYKITVV TACKCKRYTR QHNESSHNFE GTSQAKPVQH HKERKRASKS

SKHSTS
Length:206
Mass (Da):23,144
Last modified:July 5, 2004 - v1
Checksum:i75F438854599CEAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY319926 mRNA Translation: AAQ57626.1
RefSeqiNP_989704.1, NM_204373.1
XP_015136747.1, XM_015281261.1
UniGeneiGga.9261

Genome annotation databases

EnsembliENSGALT00000080778; ENSGALP00000044773; ENSGALG00000036836
GeneIDi378800
KEGGigga:378800

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY319926 mRNA Translation: AAQ57626.1
RefSeqiNP_989704.1, NM_204373.1
XP_015136747.1, XM_015281261.1
UniGeneiGga.9261

3D structure databases

SMRiQ6VYA3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiQ6VYA3
STRINGi9031.ENSGALP00000017538

Proteomic databases

PaxDbiQ6VYA3
PRIDEiQ6VYA3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000080778; ENSGALP00000044773; ENSGALG00000036836
GeneIDi378800
KEGGigga:378800

Organism-specific databases

CTDi25928

Phylogenomic databases

eggNOGiENOG410IIVA Eukaryota
ENOG410YEMP LUCA
GeneTreeiENSGT00390000014900
HOGENOMiHOG000252934
HOVERGENiHBG003729
InParanoidiQ6VYA3
OMAiNCLAFKN
OrthoDBiEOG091G13DX
PhylomeDBiQ6VYA3
TreeFamiTF353019

Miscellaneous databases

PROiPR:Q6VYA3

Gene expression databases

BgeeiENSGALG00000010797 Expressed in 5 organ(s), highest expression level in female gonad

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR008835 Sclerostin/SOSTDC1
PANTHERiPTHR14903 PTHR14903, 1 hit
PfamiView protein in Pfam
PF05463 Sclerostin, 1 hit
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOSD1_CHICK
AccessioniPrimary (citable) accession number: Q6VYA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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