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Protein

Transcription factor AP-2-epsilon

Gene

Tfap2e

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-MMU-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor AP-2-epsilon
Short name:
AP2-epsilon
Alternative name(s):
Activating enhancer-binding protein 2-epsilon
Gene namesi
Name:Tfap2e
Synonyms:Tcfap2e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2679630 Tfap2e

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003095171 – 442Transcription factor AP-2-epsilonAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei246Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6VUP9
PaxDbiQ6VUP9
PeptideAtlasiQ6VUP9
PRIDEiQ6VUP9

PTM databases

iPTMnetiQ6VUP9
PhosphoSitePlusiQ6VUP9

Expressioni

Tissue specificityi

Expressed most prominently in the mitral cell layer of the developing olfactory bulb and to a lesser extent in the granule cell layer. Also expressed in skin, articular cartilage, primary chondrocytes, and chondrosarcoma cell line SW1353.3 Publications

Gene expression databases

BgeeiENSMUSG00000042477 Expressed in 51 organ(s), highest expression level in primary oocyte
CleanExiMM_TCFAP2E
GenevisibleiQ6VUP9 MM

Interactioni

Subunit structurei

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi237142, 1 interactor
STRINGi10090.ENSMUSP00000035902

Structurei

3D structure databases

ProteinModelPortaliQ6VUP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni287 – 417H-S-H (helix-span-helix), dimerizationSequence analysisAdd BLAST131

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi54 – 59PPxY motifSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 122Gln/Pro-rich (transactivation domain)Sequence analysisAdd BLAST101

Sequence similaritiesi

Belongs to the AP-2 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3811 Eukaryota
ENOG410XR9E LUCA
GeneTreeiENSGT00550000074577
HOGENOMiHOG000231737
HOVERGENiHBG002455
InParanoidiQ6VUP9
KOiK09179
OMAiEYLCRQS
OrthoDBiEOG091G0PR6
PhylomeDBiQ6VUP9
TreeFamiTF313718

Family and domain databases

InterProiView protein in InterPro
IPR004979 TF_AP2
IPR013854 TF_AP2_C
PANTHERiPTHR10812 PTHR10812, 1 hit
PfamiView protein in Pfam
PF03299 TF_AP-2, 1 hit
PRINTSiPR01748 AP2TNSCPFCT

Sequencei

Sequence statusi: Complete.

Q6VUP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVHTYSAME RPDGLGAAAG GTRLSSLPQA AYGPAPPLCH TPAASATADY
60 70 80 90 100
HPPYFPPPYP QAPLPYGQGP DATAAFPHLA ADPYGGLAPL AQPQPPQAAW
110 120 130 140 150
AAPRAAARAH DEPPGLLAPP ARALGLDPRR DYAAAVPRLL HSLADGAHGL
160 170 180 190 200
ADAPLGLPGL AEPPGLEELQ AIDDPGMSLL DQSVIKKVPI PSKAGSLSTL
210 220 230 240 250
ALSKDSLVGG ISNPSEVFCS VPGRLSLLSS TSKYKVTVGE VQRRLSPPEC
260 270 280 290 300
LNASLLGGVL RRAKSKNGGR CLRERLEKIG LNLPAGRRKA ANVTLLTSLV
310 320 330 340 350
EGEAVHLARD FGYVCETEFP AKAAAEYLCR QHADPGELHS RKSMLLAAKQ
360 370 380 390 400
ICKEFADLMA QDRSPLGNSR PALILEPGVQ SCLTHFSLIT HGFGGPAICA
410 420 430 440
ALTAFQNYLL ESLKGLEKMF LSGAGGGHGE SKASEKDTKH RK
Length:442
Mass (Da):46,283
Last modified:November 13, 2007 - v2
Checksum:iF069B53A483F69CB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti269G → S in AAQ90059 (PubMed:14636996).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325902 mRNA Translation: AAQ90059.1
AL607129 Genomic DNA No translation available.
CCDSiCCDS18658.1
RefSeqiNP_945198.2, NM_198960.2
UniGeneiMm.331881

Genome annotation databases

EnsembliENSMUST00000048194; ENSMUSP00000035902; ENSMUSG00000042477
GeneIDi332937
KEGGimmu:332937
UCSCiuc008uts.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325902 mRNA Translation: AAQ90059.1
AL607129 Genomic DNA No translation available.
CCDSiCCDS18658.1
RefSeqiNP_945198.2, NM_198960.2
UniGeneiMm.331881

3D structure databases

ProteinModelPortaliQ6VUP9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237142, 1 interactor
STRINGi10090.ENSMUSP00000035902

PTM databases

iPTMnetiQ6VUP9
PhosphoSitePlusiQ6VUP9

Proteomic databases

MaxQBiQ6VUP9
PaxDbiQ6VUP9
PeptideAtlasiQ6VUP9
PRIDEiQ6VUP9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048194; ENSMUSP00000035902; ENSMUSG00000042477
GeneIDi332937
KEGGimmu:332937
UCSCiuc008uts.1 mouse

Organism-specific databases

CTDi339488
MGIiMGI:2679630 Tfap2e

Phylogenomic databases

eggNOGiKOG3811 Eukaryota
ENOG410XR9E LUCA
GeneTreeiENSGT00550000074577
HOGENOMiHOG000231737
HOVERGENiHBG002455
InParanoidiQ6VUP9
KOiK09179
OMAiEYLCRQS
OrthoDBiEOG091G0PR6
PhylomeDBiQ6VUP9
TreeFamiTF313718

Enzyme and pathway databases

ReactomeiR-MMU-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-MMU-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Miscellaneous databases

PROiPR:Q6VUP9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042477 Expressed in 51 organ(s), highest expression level in primary oocyte
CleanExiMM_TCFAP2E
GenevisibleiQ6VUP9 MM

Family and domain databases

InterProiView protein in InterPro
IPR004979 TF_AP2
IPR013854 TF_AP2_C
PANTHERiPTHR10812 PTHR10812, 1 hit
PfamiView protein in Pfam
PF03299 TF_AP-2, 1 hit
PRINTSiPR01748 AP2TNSCPFCT
ProtoNetiSearch...

Entry informationi

Entry nameiAP2E_MOUSE
AccessioniPrimary (citable) accession number: Q6VUP9
Secondary accession number(s): A2A883
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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