UniProtKB - Q6VUC0 (AP2E_HUMAN)
Transcription factor AP-2-epsilon
TFAP2E
Functioni
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity).
By similarityGO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- identical protein binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- anatomical structure development Source: GO_Central
- regulation of cell population proliferation Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q6VUC0 |
Reactomei | R-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor AP-2-epsilonShort name: AP2-epsilon Alternative name(s): Activating enhancer-binding protein 2-epsilon |
Gene namesi | Name:TFAP2EImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30774, TFAP2E |
MIMi | 614428, gene |
neXtProti | NX_Q6VUC0 |
VEuPathDBi | HostDB:ENSG00000116819 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 339488 |
OpenTargetsi | ENSG00000116819 |
PharmGKBi | PA134992283 |
Miscellaneous databases
Pharosi | Q6VUC0, Tbio |
Genetic variation databases
BioMutai | TFAP2E |
DMDMi | 74749476 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000309516 | 1 – 442 | Transcription factor AP-2-epsilonAdd BLAST | 442 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 246 | Phosphoserine; by PKABy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6VUC0 |
jPOSTi | Q6VUC0 |
MassIVEi | Q6VUC0 |
MaxQBi | Q6VUC0 |
PaxDbi | Q6VUC0 |
PeptideAtlasi | Q6VUC0 |
PRIDEi | Q6VUC0 |
ProteomicsDBi | 67731 |
PTM databases
iPTMneti | Q6VUC0 |
PhosphoSitePlusi | Q6VUC0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000116819, Expressed in cerebellar hemisphere and 128 other tissues |
Genevisiblei | Q6VUC0, HS |
Organism-specific databases
HPAi | ENSG00000116819, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
IntActi | Q6VUC0, 1 interactor |
STRINGi | 9606.ENSP00000362332 |
Miscellaneous databases
RNActi | Q6VUC0, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q6VUC0 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 287 – 417 | H-S-H (helix-span-helix), dimerizationSequence analysisAdd BLAST | 131 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 54 – 59 | PPxY motifSequence analysis | 6 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3811, Eukaryota |
GeneTreei | ENSGT00950000182848 |
HOGENOMi | CLU_035175_4_1_1 |
InParanoidi | Q6VUC0 |
OMAi | QEAGYPH |
OrthoDBi | 641707at2759 |
PhylomeDBi | Q6VUC0 |
TreeFami | TF313718 |
Family and domain databases
InterProi | View protein in InterPro IPR004979, TF_AP2 IPR013854, TF_AP2_C |
PANTHERi | PTHR10812, PTHR10812, 1 hit |
Pfami | View protein in Pfam PF03299, TF_AP-2, 1 hit |
PRINTSi | PR01748, AP2TNSCPFCT |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MLVHTYSAME RPDGLGAAAG GARLSSLPQA AYGPAPPLCH TPAATAAAEF
60 70 80 90 100
QPPYFPPPYP QPPLPYGQAP DAAAAFPHLA GDPYGGLAPL AQPQPPQAAW
110 120 130 140 150
AAPRAAARAH EEPPGLLAPP ARALGLDPRR DYATAVPRLL HGLADGAHGL
160 170 180 190 200
ADAPLGLPGL AAAPGLEDLQ AMDEPGMSLL DQSVIKKVPI PSKASSLSAL
210 220 230 240 250
SLAKDSLVGG ITNPGEVFCS VPGRLSLLSS TSKYKVTVGE VQRRLSPPEC
260 270 280 290 300
LNASLLGGVL RRAKSKNGGR CLRERLEKIG LNLPAGRRKA ANVTLLTSLV
310 320 330 340 350
EGEAVHLARD FGYVCETEFP AKAAAEYLCR QHADPGELHS RKSMLLAAKQ
360 370 380 390 400
ICKEFADLMA QDRSPLGNSR PALILEPGVQ SCLTHFSLIT HGFGGPAICA
410 420 430 440
ALTAFQNYLL ESLKGLDKMF LSSVGSGHGE TKASEKDAKH RK
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY326454 mRNA Translation: AAQ91614.1 AL157951, AC004865 Genomic DNA Translation: CAI23520.1 CH471059 Genomic DNA Translation: EAX07409.1 Sequence problems. BC041175 mRNA Translation: AAH41175.1 Different initiation. |
CCDSi | CCDS393.2 |
RefSeqi | NP_848643.2, NM_178548.3 |
Genome annotation databases
Ensembli | ENST00000373235.4; ENSP00000362332.3; ENSG00000116819.9 |
GeneIDi | 339488 |
KEGGi | hsa:339488 |
MANE-Selecti | ENST00000373235.4; ENSP00000362332.3; NM_178548.4; NP_848643.2 |
UCSCi | uc010ohy.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Activating protein 2 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY326454 mRNA Translation: AAQ91614.1 AL157951, AC004865 Genomic DNA Translation: CAI23520.1 CH471059 Genomic DNA Translation: EAX07409.1 Sequence problems. BC041175 mRNA Translation: AAH41175.1 Different initiation. |
CCDSi | CCDS393.2 |
RefSeqi | NP_848643.2, NM_178548.3 |
3D structure databases
AlphaFoldDBi | Q6VUC0 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q6VUC0, 1 interactor |
STRINGi | 9606.ENSP00000362332 |
PTM databases
iPTMneti | Q6VUC0 |
PhosphoSitePlusi | Q6VUC0 |
Genetic variation databases
BioMutai | TFAP2E |
DMDMi | 74749476 |
Proteomic databases
EPDi | Q6VUC0 |
jPOSTi | Q6VUC0 |
MassIVEi | Q6VUC0 |
MaxQBi | Q6VUC0 |
PaxDbi | Q6VUC0 |
PeptideAtlasi | Q6VUC0 |
PRIDEi | Q6VUC0 |
ProteomicsDBi | 67731 |
Protocols and materials databases
Antibodypediai | 31581, 55 antibodies from 17 providers |
DNASUi | 339488 |
Genome annotation databases
Ensembli | ENST00000373235.4; ENSP00000362332.3; ENSG00000116819.9 |
GeneIDi | 339488 |
KEGGi | hsa:339488 |
MANE-Selecti | ENST00000373235.4; ENSP00000362332.3; NM_178548.4; NP_848643.2 |
UCSCi | uc010ohy.3, human |
Organism-specific databases
CTDi | 339488 |
DisGeNETi | 339488 |
GeneCardsi | TFAP2E |
HGNCi | HGNC:30774, TFAP2E |
HPAi | ENSG00000116819, Tissue enhanced (brain) |
MIMi | 614428, gene |
neXtProti | NX_Q6VUC0 |
OpenTargetsi | ENSG00000116819 |
PharmGKBi | PA134992283 |
VEuPathDBi | HostDB:ENSG00000116819 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3811, Eukaryota |
GeneTreei | ENSGT00950000182848 |
HOGENOMi | CLU_035175_4_1_1 |
InParanoidi | Q6VUC0 |
OMAi | QEAGYPH |
OrthoDBi | 641707at2759 |
PhylomeDBi | Q6VUC0 |
TreeFami | TF313718 |
Enzyme and pathway databases
PathwayCommonsi | Q6VUC0 |
Reactomei | R-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
Miscellaneous databases
BioGRID-ORCSi | 339488, 19 hits in 1087 CRISPR screens |
GenomeRNAii | 339488 |
Pharosi | Q6VUC0, Tbio |
PROi | PR:Q6VUC0 |
RNActi | Q6VUC0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116819, Expressed in cerebellar hemisphere and 128 other tissues |
Genevisiblei | Q6VUC0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004979, TF_AP2 IPR013854, TF_AP2_C |
PANTHERi | PTHR10812, PTHR10812, 1 hit |
Pfami | View protein in Pfam PF03299, TF_AP-2, 1 hit |
PRINTSi | PR01748, AP2TNSCPFCT |
MobiDBi | Search... |
Entry informationi
Entry namei | AP2E_HUMAN | |
Accessioni | Q6VUC0Primary (citable) accession number: Q6VUC0 Secondary accession number(s): Q8IW12 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families