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UniProtKB - Q6VUC0 (AP2E_HUMAN)

Entry version 133 (25 May 2022)
Sequence version 1 (05 Jul 2004)
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Protein

Transcription factor AP-2-epsilon

Gene

TFAP2E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6VUC0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor AP-2-epsilon
Short name:
AP2-epsilon
Alternative name(s):
Activating enhancer-binding protein 2-epsilon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TFAP2EImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30774, TFAP2E

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614428, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6VUC0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000116819

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		339488

Open Targets

More...OpenTargetsi		ENSG00000116819

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134992283

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6VUC0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TFAP2E

Domain mapping of disease mutations (DMDM)

More...DMDMi		74749476

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003095161 – 442Transcription factor AP-2-epsilonAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei246Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6VUC0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6VUC0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6VUC0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6VUC0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6VUC0

PeptideAtlas

More...PeptideAtlasi		Q6VUC0

PRoteomics IDEntifications database

More...PRIDEi		Q6VUC0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67731

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6VUC0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6VUC0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa cell line.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116819, Expressed in cerebellar hemisphere and 128 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6VUC0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000116819, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q6VUC0, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362332

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6VUC0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q6VUC0

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni287 – 417H-S-H (helix-span-helix), dimerizationSequence analysisAdd BLAST131

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi54 – 59PPxY motifSequence analysis6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AP-2 family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3811, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182848

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_035175_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6VUC0

Identification of Orthologs from Complete Genome Data

More...OMAi		QEAGYPH

Database of Orthologous Groups

More...OrthoDBi		641707at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6VUC0

TreeFam database of animal gene trees

More...TreeFami		TF313718

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004979, TF_AP2
IPR013854, TF_AP2_C

The PANTHER Classification System

More...PANTHERi		PTHR10812, PTHR10812, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03299, TF_AP-2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01748, AP2TNSCPFCT

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6VUC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVHTYSAME RPDGLGAAAG GARLSSLPQA AYGPAPPLCH TPAATAAAEF 
        60         70         80         90        100
QPPYFPPPYP QPPLPYGQAP DAAAAFPHLA GDPYGGLAPL AQPQPPQAAW 
       110        120        130        140        150
AAPRAAARAH EEPPGLLAPP ARALGLDPRR DYATAVPRLL HGLADGAHGL 
       160        170        180        190        200
ADAPLGLPGL AAAPGLEDLQ AMDEPGMSLL DQSVIKKVPI PSKASSLSAL 
       210        220        230        240        250
SLAKDSLVGG ITNPGEVFCS VPGRLSLLSS TSKYKVTVGE VQRRLSPPEC 
       260        270        280        290        300
LNASLLGGVL RRAKSKNGGR CLRERLEKIG LNLPAGRRKA ANVTLLTSLV 
       310        320        330        340        350
EGEAVHLARD FGYVCETEFP AKAAAEYLCR QHADPGELHS RKSMLLAAKQ 
       360        370        380        390        400
ICKEFADLMA QDRSPLGNSR PALILEPGVQ SCLTHFSLIT HGFGGPAICA 
       410        420        430        440 
ALTAFQNYLL ESLKGLDKMF LSSVGSGHGE TKASEKDAKH RK
Length:442
Mass (Da):46,212
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i823209DA7C0EC527
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH41175 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAX07409 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY326454 mRNA Translation: AAQ91614.1
AL157951, AC004865 Genomic DNA Translation: CAI23520.1
CH471059 Genomic DNA Translation: EAX07409.1 Sequence problems.
BC041175 mRNA Translation: AAH41175.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS393.2

NCBI Reference Sequences

More...RefSeqi		NP_848643.2, NM_178548.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373235.4; ENSP00000362332.3; ENSG00000116819.9

Database of genes from NCBI RefSeq genomes

More...GeneIDi		339488

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:339488

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000373235.4; ENSP00000362332.3; NM_178548.4; NP_848643.2

UCSC genome browser

More...UCSCi		uc010ohy.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Activating protein 2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY326454 mRNA Translation: AAQ91614.1
AL157951, AC004865 Genomic DNA Translation: CAI23520.1
CH471059 Genomic DNA Translation: EAX07409.1 Sequence problems.
BC041175 mRNA Translation: AAH41175.1 Different initiation.
CCDSiCCDS393.2
RefSeqiNP_848643.2, NM_178548.3

3D structure databases

AlphaFoldDBiQ6VUC0
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

IntActiQ6VUC0, 1 interactor
STRINGi9606.ENSP00000362332

PTM databases

iPTMnetiQ6VUC0
PhosphoSitePlusiQ6VUC0

Genetic variation databases

BioMutaiTFAP2E
DMDMi74749476

Proteomic databases

EPDiQ6VUC0
jPOSTiQ6VUC0
MassIVEiQ6VUC0
MaxQBiQ6VUC0
PaxDbiQ6VUC0
PeptideAtlasiQ6VUC0
PRIDEiQ6VUC0
ProteomicsDBi67731

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31581, 55 antibodies from 17 providers

The DNASU plasmid repository

More...DNASUi		339488

Genome annotation databases

EnsembliENST00000373235.4; ENSP00000362332.3; ENSG00000116819.9
GeneIDi339488
KEGGihsa:339488
MANE-SelectiENST00000373235.4; ENSP00000362332.3; NM_178548.4; NP_848643.2
UCSCiuc010ohy.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		339488
DisGeNETi339488

GeneCards: human genes, protein and diseases

More...GeneCardsi		TFAP2E
HGNCiHGNC:30774, TFAP2E
HPAiENSG00000116819, Tissue enhanced (brain)
MIMi614428, gene
neXtProtiNX_Q6VUC0
OpenTargetsiENSG00000116819
PharmGKBiPA134992283
VEuPathDBiHostDB:ENSG00000116819

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3811, Eukaryota
GeneTreeiENSGT00950000182848
HOGENOMiCLU_035175_4_1_1
InParanoidiQ6VUC0
OMAiQEAGYPH
OrthoDBi641707at2759
PhylomeDBiQ6VUC0
TreeFamiTF313718

Enzyme and pathway databases

PathwayCommonsiQ6VUC0
ReactomeiR-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		339488, 19 hits in 1087 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		339488
PharosiQ6VUC0, Tbio

Protein Ontology

More...PROi		PR:Q6VUC0
RNActiQ6VUC0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000116819, Expressed in cerebellar hemisphere and 128 other tissues
GenevisibleiQ6VUC0, HS

Family and domain databases

InterProiView protein in InterPro
IPR004979, TF_AP2
IPR013854, TF_AP2_C
PANTHERiPTHR10812, PTHR10812, 1 hit
PfamiView protein in Pfam
PF03299, TF_AP-2, 1 hit
PRINTSiPR01748, AP2TNSCPFCT

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAP2E_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6VUC0
Secondary accession number(s): Q8IW12
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: May 25, 2022
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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