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Entry version 141 (18 Sep 2019)
Sequence version 1 (05 Jul 2004)
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Protein

WD repeat and FYVE domain-containing protein 3

Gene

Wdfy3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures) (By similarity). Important for normal brain development (PubMed:25198012, PubMed:27648578). Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (PubMed:27648578). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (By similarity). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (PubMed:27330028). After cytokinetic abscission, involved in midbody remnant degradation. In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (By similarity).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri3436 – 3496FYVE-typePROSITE-ProRule annotationAdd BLAST61

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processAutophagy
LigandLipid-binding, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat and FYVE domain-containing protein 3
Alternative name(s):
Beach domain, WD repeat and FYVE domain-containing protein 1
Short name:
BWF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Wdfy3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1096875 Wdfy3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Homozygous mice are born at close to the expected Mendelian ratios, but die perinatally (PubMed:25198012, PubMed:27648578). Newborn animals exhibit striking abnormalities in the forebrain, midbrain and hindbrain, including visibly smaller brains and gross enlargement of the lateral ventricles. There is an apparent loss and disorganization of interhemispheric axonal tracts throughout the brain (PubMed:25198012, PubMed:27648578).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002426941 – 3508WD repeat and FYVE domain-containing protein 3Add BLAST3508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1942PhosphoserineCombined sources1
Modified residuei2277PhosphoserineBy similarity1
Modified residuei2474PhosphoserineCombined sources1
Modified residuei3317PhosphoserineCombined sources1
Modified residuei3321PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6VNB8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6VNB8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6VNB8

PeptideAtlas

More...
PeptideAtlasi
Q6VNB8

PRoteomics IDEntifications database

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PRIDEi
Q6VNB8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6VNB8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6VNB8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6VNB8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with high levels in the brain (at protein level) (PubMed:15342963, PubMed:15292400, PubMed:27648578). In the brain, expressed by both neuronal and non-neuronal cells (PubMed:27648578). Expressed in bones, in the periosteum, cartilage, growth plate, trabeculae of the primary spongiosa, and scattered hematopoietic cells within the medullary cavity. Tends to be expressed at lower levels in the hypertrophic zone compared to trabeculae. Expressed in osteoblasts, osteoclasts and bone-marrow derived macrophages (PubMed:27330028).4 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in the developing central nervous system already at 11.5 dpc (PubMed:27648578). At 13.5 dpc, strong expression in the proliferative zones surrounding the lateral ventricle and weaker expression throughout the developing forebrain. At 14.5 dpc, highest expression within the proliferative regions surrounding the ventricles. Specifically expressed in the leptomeninges, cortical intermediate zone, choroid plexus and in radial glia cells within the ventricular zone (VZ). Within the VZ, expression is observed in a subset of cells actively undergoing mitosis. The expression persists through all phases of cell division, but decreases during telophase. Expression is often maintained in radial units, where it is the highest in progenitors closest to the ventricle, then gradually diminishes as distance from the ventricular surface increases (PubMed:15342963, PubMed:25198012). Expression levels in the brain decrease after birth (at protein level) (PubMed:15342963).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000043940 Expressed in 277 organ(s), highest expression level in retina

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6VNB8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6VNB8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Directly interacts with ATG5 and associates with the ATG12-ATG5-ATG16L complex.

Interacts with p62/SQSTM1. Directly interacts with GABARAP, GABARAPL1 and GABARAPL2; the interaction with GABARAP is required for WDFY3 recruitment to MAP1LC3B-positive p62/SQSTM1 bodies. Weakly interacts with MAP1LC3C; this interaction is direct. Does not interact with MAP1LC3A, nor MAP1LC3B (By similarity).

Interacts with TRAF6 (PubMed:27330028).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
215181, 3 interactors

Protein interaction database and analysis system

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IntActi
Q6VNB8, 3 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000052607

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2513 – 2638BEACH-type PHPROSITE-ProRule annotationAdd BLAST126
Domaini2665 – 2958BEACHPROSITE-ProRule annotationAdd BLAST294
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati3059 – 3097WD 1Add BLAST39
Repeati3107 – 3146WD 2Add BLAST40
Repeati3149 – 3188WD 3Add BLAST40
Repeati3192 – 3236WD 4Add BLAST45
Repeati3390 – 3429WD 5Add BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2284 – 2963Sufficient for translocalization to p62 bodies/ALISBy similarityAdd BLAST680
Regioni2568 – 3508Interaction with SQSTM1By similarityAdd BLAST941
Regioni2963 – 3508Interaction with ATG5By similarityAdd BLAST546

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi3326 – 3331LIR6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi472 – 475Poly-Ser4
Compositional biasi2498 – 2501Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LIR (LC3-interacting region) motif mediates the interaction with MAP1LC3C and other ATG8 family members.By similarity
The FYVE domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns3P).By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3436 – 3496FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1786 Eukaryota
KOG1788 Eukaryota
ENOG410XNQC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155680

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000017170

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6VNB8

KEGG Orthology (KO)

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KOi
K22262

Identification of Orthologs from Complete Genome Data

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OMAi
IVEGQWH

Database of Orthologous Groups

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OrthoDBi
101142at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6VNB8

TreeFam database of animal gene trees

More...
TreeFami
TF313658

Family and domain databases

Conserved Domains Database

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CDDi
cd06071 Beach, 1 hit
cd01201 PH_BEACH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1540.10, 1 hit
2.130.10.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR000409 BEACH_dom
IPR036372 BEACH_dom_sf
IPR013320 ConA-like_dom_sf
IPR023362 PH-BEACH_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

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Pfami
View protein in Pfam
PF02138 Beach, 1 hit
PF01363 FYVE, 1 hit
PF14844 PH_BEACH, 1 hit
PF00400 WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01026 Beach, 1 hit
SM00064 FYVE, 1 hit
SM00320 WD40, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 1 hit
SSF49899 SSF49899, 1 hit
SSF50978 SSF50978, 1 hit
SSF57903 SSF57903, 1 hit
SSF81837 SSF81837, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50197 BEACH, 1 hit
PS51783 PH_BEACH, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
PS50178 ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6VNB8-1) [UniParc]FASTAAdd to basket
Also known as: a1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNMVKRIMGR PRQEECSPQD NALGLMHLRR LFTELCHPPR HMTQKEQEEK
60 70 80 90 100
LYMMLPVFNR VFGNAPPNTM TEKFSDLLQF TTQVSRLMVT EIRRRASNKS
110 120 130 140 150
TEAASRAIVQ FLEINQSEEA SRGWMLLTTI NLLASSGQKT VDCMTTMSVP
160 170 180 190 200
STLVKCLYLF FDLPHVPEAG GGAQNELPLA ERRGLLQKAF VQILVKLCSF
210 220 230 240 250
VSPAEELAQK DDLQLLFSAI TSWCPPYNLP WRKSAGEVLM TISRHGLSVN
260 270 280 290 300
VVKYIHEKEC LSTCVQNMQQ SDDLSPLEIV EMFAGLSCFL KDSSDVSQTL
310 320 330 340 350
LDDFRIWQGY NFLCDLLLRL EQGKEAECRD ALKDLVSLVT SLTTYGVSEL
360 370 380 390 400
KPAGVTTGAP FLLPGFAVPQ PAGKGHSVRN IQAFAVLQNA FLKAKTNFLA
410 420 430 440 450
QIILDAITNI YMADNANYFI LESQHTLSQF AEKISKLPEV QNKYFEMLEF
460 470 480 490 500
VVFSLNYIPC KELISVSILL KSSSSYHCSI IAMKTLLKFT RHDYIFKDVF
510 520 530 540 550
REVGLLEVMV NLLHKYAALL KDPAQALNEQ GDSRNNSSVE DQKHLALLVM
560 570 580 590 600
EALTVLLQGS NTNAGIFREF GGARCAHNIV KYPQCRQHAL MTIQQLVLSP
610 620 630 640 650
NGEDDMGTLL GLMHSAPPTE LQLKTDILRA LLSVLRESHR SRTVFRKVGG
660 670 680 690 700
FVYITSLLVA MERSLSSPPK NGWEKVSQSQ VLELLHTVFC TLTAALRYEP
710 720 730 740 750
ANSHFFKTEI QYEKLADAVR FLGCFSDLRK ISAVNVFPSN TQPFQRLLEE
760 770 780 790 800
GAVSVDSVSP TLRHCSKLFI YLYKVATDSF DSHAEQIPPC LTSESSLPSP
810 820 830 840 850
WGTPALSRKR HAFHCVSTPP VYPAKNVTDL KLQVTSSPLQ SSDAVIIHPG
860 870 880 890 900
AMLAMLDLLA SVGSVTQPEH ALDLQLAVAN ILQSLVHTER NQQVMCEAGL
910 920 930 940 950
HARLLQRCGA ALADEDHSLH PPLQRMFERL ASQALEPMVL REFLRLASPL
960 970 980 990 1000
NCGAWDKKLL KQYRVHKPSS LSFEPEMRSS VITSLEGLGS DNVFSSHEDN
1010 1020 1030 1040 1050
HYRISKSLVK SAEGSTVPLT RVKCLVSMTT PHDIRLHGSS VTPAFVEFDT
1060 1070 1080 1090 1100
SLEGFGCLFL PSLAPHNAPT NNTVTTGLTD GAVVSGMGSG ERFFPPPSGL
1110 1120 1130 1140 1150
SYSCWFCIEH FSSPPNNHPV RLLTVVRRAN SSEQHYVCLA IVLSAKDRSL
1160 1170 1180 1190 1200
IVSTKEELLQ NYVDDFSEES SFYEILPCCA RFRCGELVVE GQWHHLALLM
1210 1220 1230 1240 1250
SRGMLKNSTA ALYLDGQLVS TVKLHYVHST PGGSGSANPP VLSTVYAYVG
1260 1270 1280 1290 1300
TPPAQRQIAS LVWRLGPTHF LEEVLPPSSV TTIYELGPNY VGSFQAVCVP
1310 1320 1330 1340 1350
CKDAKSEGVT PSPVSLVAEE KVSFGLYALS VSSLTVARIR KVYNKLDSKA
1360 1370 1380 1390 1400
IAKQLGISSH ENATPVKLVH NAAGHLNGPA RTIGAALIGY LGVRTFVPKP
1410 1420 1430 1440 1450
VATTLQYIGG AAAILGLVAM ASDVEGLYAA VKALVCVVKS NPLASKEMER
1460 1470 1480 1490 1500
IKGYQLLAML LKKKRSLLNS HILHLTFSLV GTVDSGHETS IIPNSTAFQD
1510 1520 1530 1540 1550
LLCDFEVWLH APYELHLSLF EHFIELLTES SEASKNAKLM REFQLIPKLL
1560 1570 1580 1590 1600
LTLRDMSLSQ PTIAAISNVL SFLLQGFPNS NDLLRFGQFI SSTLPTFAVC
1610 1620 1630 1640 1650
EKFVVMEINN EEKPDPGAEE EFGGLVSANL ILLRNRLLDI LLKLVYTSKE
1660 1670 1680 1690 1700
KTNINLQACE ELVRTLGFDW IMMFMEEHLH PTTVTAAMRI LVVLLSNQSI
1710 1720 1730 1740 1750
LIKFKEGLSG GGWLEQTDSV LTNKIGTVLG FNVGRSAGGR STVREINRDA
1760 1770 1780 1790 1800
CHFPGFLVLQ SFLPKHTNVP ALYFLLMALF LQQPVSELPE NLQVSVPVTS
1810 1820 1830 1840 1850
SRCKQGCQFD LDSIWTFIFG VPASSGTVVS SIHNVCTESA FLLLGMLRSM
1860 1870 1880 1890 1900
LNSPWQSEEE GSWLREYPVT LMQFFRYLYH NVPDLASMWL SPDFLCALAA
1910 1920 1930 1940 1950
TVFPFNIRPY SEMVTDLDDE VGSPAEEFKA FAADTGMNRS QSEYCNVGTK
1960 1970 1980 1990 2000
TYLTNHPAKK FVFDFMRVLI IDNLCLTPAS KQTPLIDLLL EASPERSTRT
2010 2020 2030 2040 2050
QQKEFQTHVL DSVMDHLLAA DVLLGEDASL PITSGGSYQV LVNNVFYFTQ
2060 2070 2080 2090 2100
RVVDKLWQGM FNKESKLLID FIIQLIAQSK RRSQGLSLDA VYHCLNRTIL
2110 2120 2130 2140 2150
YQFSRAHKTV PQQVALLDSL RVLTVNRNLI LGPGNHDQEF ISCLAHCLIN
2160 2170 2180 2190 2200
LHAGSVEGFG LEAEARMTTW HIMIPSDIEP DGGYSQDISE GRQLLIKAVN
2210 2220 2230 2240 2250
RVWTELIHSK KQVLEELFKV SLPVNDRGHV DIALARPLIE EAGLKCWQNH
2260 2270 2280 2290 2300
LAHEKKCISR GEALVPTTQS KLSRVSSGFG LSKLTGSRRN RKESGLHKHS
2310 2320 2330 2340 2350
PSPQEISQWM FTHIAVVRDL VDTQYKEYQE RQQNALKYVT EEWCQIECEL
2360 2370 2380 2390 2400
LRERGLWGPP IGSHLDKWML EMTEGPCRMR KKMVRNDMFY NHYPYVPETE
2410 2420 2430 2440 2450
QEASVGKPAR YRRAISYDSK EYYLRLASGN PAIVQDAIVE SSEGEATQQE
2460 2470 2480 2490 2500
PEHGEDTIAK VKGLVKPPLK RSRSAPDGGD EETQEQLQDQ IAESGSIEEE
2510 2520 2530 2540 2550
EKTDNATLLR LLEEGEKIQH MYRCARVQGL DTSEGLLLFG KEHFYVIDGF
2560 2570 2580 2590 2600
TMTATREIRD IETLPPNMHE PIIPRGARQG PSQLKRTCSI FAYEDIKEVH
2610 2620 2630 2640 2650
KRRYLLQPIA VEVFSGDGRN YLLAFQKGIR NKVYQRFLAV VPSLTDSSES
2660 2670 2680 2690 2700
VSGQRPNTSV EQGSGLLSTL VGEKSVTQRW ERGEISNFQY LMHLNTLAGR
2710 2720 2730 2740 2750
SYNDLMQYPV FPWILSDYDS EEVDLTNPKT FRNLAKPMGA QTDERLAQYK
2760 2770 2780 2790 2800
KRYKDWEDPN GETPAYHYGT HYSSAMIVAS YLVRMEPFTQ IFLRLQGGHF
2810 2820 2830 2840 2850
DLADRMFHSV REAWYSASKH NMADVKELIP EFFYLPEFLF NSNNFDLGCK
2860 2870 2880 2890 2900
QNGTKLGDVI LPPWAKGDPR EFIRVHREAL ECDYVSAHLH EWIDLIFGYK
2910 2920 2930 2940 2950
QQGPAAVEAV NVFHHLFYEG QVDIYNINDP LKETATIGFI NNFGQIPKQL
2960 2970 2980 2990 3000
FKKPHPPKRV RSRLNGDNIG ISVPPGATSD KIFFHHLDNL RPSLTPVKEL
3010 3020 3030 3040 3050
KEPVGQIVCT DKGILAVEQN KVLIPPAWNK TFAWGYADLS CRLGTYESDK
3060 3070 3080 3090 3100
AVTVYECLSE WGQILCAVCP NPKLVITGGT STVVCVWEMG TSKEKAKPLT
3110 3120 3130 3140 3150
LKQALLGHTD TVTCATASLA YHIIVSGSRD RTCIIWDLNK LSFLTQLRGH
3160 3170 3180 3190 3200
RAPVSALCIN ELTGDIVSCA GTYIHVWSIN GNPIVSVNTF TGRSQQIVCC
3210 3220 3230 3240 3250
CMSEMNEWDT QNVIVTGHSD GVVRFWRMEF LQVPETPAPE PVEDLEMQEG
3260 3270 3280 3290 3300
CPEAQIGQQA QDDDSSDSET EEPSVSQDPK DTSSQPSSTS HRPRAASCRA
3310 3320 3330 3340 3350
TATWCTDSGS DDSRRWSDQL SLDEKDGFIF VNYSEGQTRA HLQGPLAHPH
3360 3370 3380 3390 3400
PNPIEARSYS RLKPGYRWER QLVFRSKLTM HTAFDRKDNT HPAEVTALGV
3410 3420 3430 3440 3450
SKDHSRILVG DSRGRVFSWS VSDQPGRSAA DHWVKDEGGD SCSGCSVRFS
3460 3470 3480 3490 3500
LTERRHHCRN CGQLFCQKCS RFQSEIKRLK ISSPVRVCQN CYYSLQHERG

AEDGPRNC
Length:3,508
Mass (Da):392,338
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9718CB1AABCB3B8E
GO
Isoform 2 (identifier: Q6VNB8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     782-809: Missing.
     942-3508: Missing.

Show »
Length:913
Mass (Da):102,219
Checksum:iCA4F642584736900
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UYW1G3UYW1_MOUSE
WD repeat and FYVE domain-containin...
Wdfy3
3,526Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RLV7A0A1D5RLV7_MOUSE
WD repeat and FYVE domain-containin...
Wdfy3
3,512Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UY81G3UY81_MOUSE
WD repeat and FYVE domain-containin...
Wdfy3
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC32952 differs from that shown. Reason: Frameshift at position 34.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019477782 – 809Missing in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_019478942 – 3508Missing in isoform 2. 1 PublicationAdd BLAST2567

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY336569 mRNA Translation: AAQ84516.1
AK047077 mRNA Translation: BAC32952.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19473.1 [Q6VNB8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_766470.2, NM_172882.3 [Q6VNB8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000053177; ENSMUSP00000052607; ENSMUSG00000043940 [Q6VNB8-1]
ENSMUST00000174698; ENSMUSP00000134541; ENSMUSG00000043940 [Q6VNB8-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
72145

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:72145

UCSC genome browser

More...
UCSCi
uc008yis.2 mouse [Q6VNB8-1]
uc008yit.1 mouse [Q6VNB8-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336569 mRNA Translation: AAQ84516.1
AK047077 mRNA Translation: BAC32952.1 Frameshift.
CCDSiCCDS19473.1 [Q6VNB8-1]
RefSeqiNP_766470.2, NM_172882.3 [Q6VNB8-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi215181, 3 interactors
IntActiQ6VNB8, 3 interactors
STRINGi10090.ENSMUSP00000052607

PTM databases

iPTMnetiQ6VNB8
PhosphoSitePlusiQ6VNB8
SwissPalmiQ6VNB8

Proteomic databases

EPDiQ6VNB8
jPOSTiQ6VNB8
PaxDbiQ6VNB8
PeptideAtlasiQ6VNB8
PRIDEiQ6VNB8

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
72145
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053177; ENSMUSP00000052607; ENSMUSG00000043940 [Q6VNB8-1]
ENSMUST00000174698; ENSMUSP00000134541; ENSMUSG00000043940 [Q6VNB8-2]
GeneIDi72145
KEGGimmu:72145
UCSCiuc008yis.2 mouse [Q6VNB8-1]
uc008yit.1 mouse [Q6VNB8-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23001
MGIiMGI:1096875 Wdfy3

Phylogenomic databases

eggNOGiKOG1786 Eukaryota
KOG1788 Eukaryota
ENOG410XNQC LUCA
GeneTreeiENSGT00940000155680
HOGENOMiHOG000017170
InParanoidiQ6VNB8
KOiK22262
OMAiIVEGQWH
OrthoDBi101142at2759
PhylomeDBiQ6VNB8
TreeFamiTF313658

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Wdfy3 mouse

Protein Ontology

More...
PROi
PR:Q6VNB8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000043940 Expressed in 277 organ(s), highest expression level in retina
ExpressionAtlasiQ6VNB8 baseline and differential
GenevisibleiQ6VNB8 MM

Family and domain databases

CDDicd06071 Beach, 1 hit
cd01201 PH_BEACH, 1 hit
Gene3Di1.10.1540.10, 1 hit
2.130.10.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000409 BEACH_dom
IPR036372 BEACH_dom_sf
IPR013320 ConA-like_dom_sf
IPR023362 PH-BEACH_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF02138 Beach, 1 hit
PF01363 FYVE, 1 hit
PF14844 PH_BEACH, 1 hit
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM01026 Beach, 1 hit
SM00064 FYVE, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49899 SSF49899, 1 hit
SSF50978 SSF50978, 1 hit
SSF57903 SSF57903, 1 hit
SSF81837 SSF81837, 1 hit
PROSITEiView protein in PROSITE
PS50197 BEACH, 1 hit
PS51783 PH_BEACH, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
PS50178 ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDFY3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6VNB8
Secondary accession number(s): Q8C8H7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: September 18, 2019
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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