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Protein

Ran-binding protein 10

Gene

Ranbp10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (PubMed:18347012). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (PubMed:19801445).By similarityCurated2 Publications

GO - Molecular functioni

  • beta-tubulin binding Source: MGI
  • Ran GTPase binding Source: MGI
  • Ran guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

  • microtubule cytoskeleton organization Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-binding protein 10
Short name:
RanBP10
Gene namesi
Name:Ranbp10
Synonyms:Kiaa1464
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1921584 Ranbp10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mutant mice are viable and show no conspicuous phenotype. They have normal platelet counts and only slightly reduced proplatelet formation. Resting platelets tend to have a more spherical shape. Many platelets exhibit disorders in microtubule filament numbers and localization. The animals show a markedly prolonged bleeding time. Granule release is also reduced.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi301L → I: Complete loss RAN-GEF activity. Partial loss of RAN-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003052382 – 620Ran-binding protein 10Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei361PhosphoserineBy similarity1
Modified residuei362PhosphotyrosineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei367PhosphoserineCombined sources1
Modified residuei369PhosphoserineCombined sources1
Modified residuei422PhosphoserineBy similarity1
Modified residuei451PhosphoserineCombined sources1
Modified residuei453PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6VN19
MaxQBiQ6VN19
PaxDbiQ6VN19
PRIDEiQ6VN19

PTM databases

iPTMnetiQ6VN19
PhosphoSitePlusiQ6VN19
SwissPalmiQ6VN19

Expressioni

Tissue specificityi

Expressed at highest levels in spleen and liver. Expressed in megakaryocytes and platelets (at protein level).1 Publication

Gene expression databases

CleanExiMM_RANBP10

Interactioni

Subunit structurei

May form homodimers. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with RAN and RANBP9. Interacts with the HGF receptor MET. Interacts with AR (By similarity). Interacts with TUBB1 (PubMed:18347012). Interacts with YPEL5 (By similarity). May interact with TUBB5 (PubMed:18347012). Interacts with DDX4 (PubMed:27622290).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216672, 3 interactors
IntActiQ6VN19, 1 interactor
STRINGi10090.ENSMUSP00000040045

Structurei

Secondary structure

1620
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6VN19
SMRiQ6VN19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 222B30.2/SPRYPROSITE-ProRule annotationAdd BLAST188
Domaini253 – 285LisHPROSITE-ProRule annotationAdd BLAST33
Domaini291 – 348CTLHPROSITE-ProRule annotationAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi346 – 453Ser-richAdd BLAST108

Domaini

The SPRY domain mediates the interaction with MET.By similarity

Sequence similaritiesi

Belongs to the RANBP9/10 family.Curated

Phylogenomic databases

eggNOGiKOG1477 Eukaryota
ENOG410XPCC LUCA
HOGENOMiHOG000008133
HOVERGENiHBG053444
InParanoidiQ6VN19
TreeFamiTF331658

Family and domain databases

CDDicd12909 SPRY_RanBP9_10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR013144 CRA_dom
IPR024964 CTLH/CRA
IPR006595 CTLH_C
IPR006594 LisH
IPR003877 SPRY_dom
IPR035782 SPRY_RanBP9/10
PfamiView protein in Pfam
PF10607 CLTH, 1 hit
PF08513 LisH, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00757 CRA, 1 hit
SM00668 CTLH, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6VN19-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAATADPGA GNPQAGDSSG GDSGGGLPSP GEQELSRRLQ RLYPAVNQHE
60 70 80 90 100
TPLPRSWSPK DKYNYIGLSQ GNLRVHYKGH GKNHKDAASV RATHPIPAAC
110 120 130 140 150
GIYYFEVKIV SKGRDGYMGI GLSAQGVNMN RLPGWDKHSY GYHGDDGHSF
160 170 180 190 200
CSSGTGQPYG PTFTTGDVIG CCVNLINGTC FYTKNGHSLG IAFTDLPANL
210 220 230 240 250
YPTVGLQTPG EIVDANFGQQ PFLFDIEDYM REWRAKVQGT VHGFPISARL
260 270 280 290 300
GEWQAVLQNM VSSYLVHHGY CSTATAFARM TETPIQEEQA SIKNRQKIQK
310 320 330 340 350
LVLEGRVGEA IETTQRFYPG LLEHNPNLLF MLKCRQFVEM VNGTDSEVRS
360 370 380 390 400
LSSRSPKSQD SYPGSPSLSP RHGPSSSHIH NTGADSPSCS NGVASTKNKQ
410 420 430 440 450
NHSKYPAPSS SSSSSSSSSS SSPSSVNYSE SNSTDSTKSQ PHSSTSNQET
460 470 480 490 500
SDSEMEMEAE HYPNGVLESV STRIVNGAYK HDDLQTDESS MDDGHPRRQL
510 520 530 540 550
CGGNQAATER IILFGRELQA LSEQLGREYG KNLAHTEMLQ DAFSLLAYSD
560 570 580 590 600
PWSCPVGHQL DPIQREPVCA ALNSAILESQ NLPKQPPLML ALGQASECLR
610 620
LMARAGLGSC SFARVDDYLH
Length:620
Mass (Da):67,188
Last modified:October 19, 2011 - v2
Checksum:i6A22ADAECC7B57F5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0G4A0A0R4J0G4_MOUSE
Ran-binding protein 10
Ranbp10
648Annotation score:

Sequence cautioni

The sequence AAH24698 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAR01221 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY337314 mRNA Translation: AAR01221.1 Different initiation.
BC024698 mRNA Translation: AAH24698.1 Different initiation.
AK173177 mRNA Translation: BAD32455.1
AK087165 mRNA Translation: BAC39817.1
RefSeqiNP_665823.2, NM_145824.4
UniGeneiMm.4206

Genome annotation databases

GeneIDi74334
KEGGimmu:74334
UCSCiuc009nec.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY337314 mRNA Translation: AAR01221.1 Different initiation.
BC024698 mRNA Translation: AAH24698.1 Different initiation.
AK173177 mRNA Translation: BAD32455.1
AK087165 mRNA Translation: BAC39817.1
RefSeqiNP_665823.2, NM_145824.4
UniGeneiMm.4206

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JIAX-ray1.80A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P29-238[»]
ProteinModelPortaliQ6VN19
SMRiQ6VN19
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216672, 3 interactors
IntActiQ6VN19, 1 interactor
STRINGi10090.ENSMUSP00000040045

PTM databases

iPTMnetiQ6VN19
PhosphoSitePlusiQ6VN19
SwissPalmiQ6VN19

Proteomic databases

EPDiQ6VN19
MaxQBiQ6VN19
PaxDbiQ6VN19
PRIDEiQ6VN19

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi74334
KEGGimmu:74334
UCSCiuc009nec.1 mouse

Organism-specific databases

CTDi57610
MGIiMGI:1921584 Ranbp10
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1477 Eukaryota
ENOG410XPCC LUCA
HOGENOMiHOG000008133
HOVERGENiHBG053444
InParanoidiQ6VN19
TreeFamiTF331658

Miscellaneous databases

PROiPR:Q6VN19
SOURCEiSearch...

Gene expression databases

CleanExiMM_RANBP10

Family and domain databases

CDDicd12909 SPRY_RanBP9_10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR013144 CRA_dom
IPR024964 CTLH/CRA
IPR006595 CTLH_C
IPR006594 LisH
IPR003877 SPRY_dom
IPR035782 SPRY_RanBP9/10
PfamiView protein in Pfam
PF10607 CLTH, 1 hit
PF08513 LisH, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00757 CRA, 1 hit
SM00668 CTLH, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBP10_MOUSE
AccessioniPrimary (citable) accession number: Q6VN19
Secondary accession number(s): Q69ZJ1, Q8C328, Q8R1E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 19, 2011
Last modified: September 12, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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