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UniProtKB - Q6VMQ6 (MCAF1_HUMAN)

Entry version 157 (12 Aug 2020)
Sequence version 3 (11 Jan 2011)
Previous versions | rss
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Protein

Activating transcription factor 7-interacting protein 1

Gene

ATF7IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processHost-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6VMQ6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214841, PKMTs methylate histone lysines

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Activating transcription factor 7-interacting protein 1Curated
Alternative name(s):
ATF-interacting protein
Short name:
ATF-IP
ATF7-interacting protein
ATFa-associated modulator
Short name:
hAM
MBD1-containing chromatin-associated factor 1
P621
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATF7IPImported
Synonyms:MCAF, MCAF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000171681.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:20092, ATF7IP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613644, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6VMQ6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi968D → A: Abolishes the interaction with SUMO. 1 Publication1
Mutagenesisi969L → A: Abolishes the interaction with SUMO. 1 Publication1
Mutagenesisi1224L → R: Abolishes interaction with MBD1 and subsequent transcriptional repression. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		55729

Open Targets

More...OpenTargetsi		ENSG00000171681

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6VMQ6, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATF7IP

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373420

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002817801 – 1270Activating transcription factor 7-interacting protein 1Add BLAST1270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei57PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei118PhosphothreonineCombined sources1
Modified residuei445PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei474PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei479PhosphoserineBy similarity1
Modified residuei496PhosphoserineCombined sources1
Cross-linki558Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei559PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei899PhosphoserineCombined sources1
Cross-linki910Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki938Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6VMQ6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6VMQ6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6VMQ6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6VMQ6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6VMQ6

PeptideAtlas

More...PeptideAtlasi		Q6VMQ6

PRoteomics IDEntifications database

More...PRIDEi		Q6VMQ6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		24334
32440
67728 [Q6VMQ6-1]
67729 [Q6VMQ6-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6VMQ6, 3 sites, 1 O-linked glycan (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6VMQ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6VMQ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected at low levels in breast, lung and stomach; highly up-regulated in the corresponding cancerous tissues (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171681, Expressed in amniotic fluid and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6VMQ6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6VMQ6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000171681, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MBD1; the interaction is enhanced when MBD1 is sumoylated (PubMed:12665582, PubMed:16757475).

Interacts with SETDB1; the interaction protects SETDB1 from proteasomal degradation and is required to stimulate histone methyltransferase activity and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (PubMed:14536086, PubMed:15691849, PubMed:27732843).

Interacts with SUMO ubiquitin-like proteins (SUMO1, SUNO2 and SUMO3), with a preference for SUMO2 and SUMO3 (PubMed:16757475, PubMed:18842587).

Interacts with SP1, ATF7 and ZHX1 (PubMed:10976766, PubMed:12659632, PubMed:19106100).

Interacts with the general transcription machinery, including ERCC2, ERCC3, GTF2E1, GTF2E2 and POLR2A (PubMed:19106100).

9 Publications

(Microbial infection) Interacts with Epstein-Barr virus BRLF1/Rta protein, leading to the regulation of host genes in Epstein-Barr virus-infected cells.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120849, 43 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q6VMQ6

Protein interaction database and analysis system

More...IntActi		Q6VMQ6, 70 interactors

Molecular INTeraction database

More...MINTi		Q6VMQ6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000440440

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6VMQ6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6VMQ6

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q6VMQ6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1160 – 1270Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni562 – 817Interaction with SETDB1Add BLAST256
Regioni965 – 975Interaction with SUMO1 PublicationAdd BLAST11
Regioni1154 – 1270Interaction with MBD1Add BLAST117

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili617 – 665Sequence analysisAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi553 – 571Nuclear localization signalBy similarityAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi349 – 580Glu-richAdd BLAST232

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MCAF family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSM2, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063707

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009529_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6VMQ6

Identification of Orthologs from Complete Genome Data

More...OMAi		QVGIPFK

Database of Orthologous Groups

More...OrthoDBi		324622at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6VMQ6

TreeFam database of animal gene trees

More...TreeFami		TF329427

Family and domain databases

Database of protein disorder

More...DisProti		DP01277

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00216

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026085, ATF7-int
IPR031870, ATF7IP_BD
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold

The PANTHER Classification System

More...PANTHERi		PTHR23210, PTHR23210, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16788, ATF7IP_BD, 1 hit
PF16794, fn3_4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265, SSF49265, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6VMQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSLEEPQKK VFKARKTMRV SDRQQLEAVY KVKEELLKTD VKLLNGNHEN 
        60         70         80         90        100
GDLDPTSPLE NMDYIKDKEE VNGIEEICFD PEGSKAEWKE TPCILSVNVK 
       110        120        130        140        150
NKQDDDLNCE PLSPHNITPE PVSKLPAEPV SGDPAPGDLD AGDPASGVLA 
       160        170        180        190        200
SGDSTSGDPT SSEPSSSDAA SGDATSGDAP SGDVSPGDAT SGDATADDLS 
       210        220        230        240        250
SGDPTSSDPI PGEPVPVEPI SGDCAADDIA SSEITSVDLA SGAPASTDPA 
       260        270        280        290        300
SDDLASGDLS SSELASDDLA TGELASDELT SESTFDRTFE PKSVPVCEPV 
       310        320        330        340        350
PEIDNIEPSS NKDDDFLEKN GADEKLEQIQ SKDSLDEKNK ADNNIDANEE 
       360        370        380        390        400
TLETDDTTIC SDRPPENEKK VEEDIITELA LGEDAISSSM EIDQGEKNED 
       410        420        430        440        450
ETSADLVETI NENVIEDNKS ENILENTDSM ETDEIIPILE KLAPSEDELT 
       460        470        480        490        500
CFSKTSLLPI DETNPDLEEK MESSFGSPSK QESSESLPKE AFLVLSDEED 
       510        520        530        540        550
ISGEKDESEV ISQNETCSPA EVESNEKDNK PEEEEQVIHE DDERPSEKNE 
       560        570        580        590        600
FSRRKRSKSE DMDNVQSKRR RYMEEEYEAE FQVKITAKGD INQKLQKVIQ 
       610        620        630        640        650
WLLEEKLCAL QCAVFDKTLA ELKTRVEKIE CNKRHKTVLT ELQAKIARLT 
       660        670        680        690        700
KRFEAAKEDL KKRHEHPPNP PVSPGKTVND VNSNNNMSYR NAGTVRQMLE 
       710        720        730        740        750
SKRNVSESAP PSFQTPVNTV SSTNLVTPPA VVSSQPKLQT PVTSGSLTAT 
       760        770        780        790        800
SVLPAPNTAT VVATTQVPSG NPQPTISLQP LPVILHVPVA VSSQPQLLQS 
       810        820        830        840        850
HPGTLVTNQP SGNVEFISVQ SPPTVSGLTK NPVSLPSLPN PTKPNNVPSV 
       860        870        880        890        900
PSPSIQRNPT ASAAPLGTTL AVQAVPTAHS IVQATRTSLP TVGPSGLYSP 
       910        920        930        940        950
STNRGPIQMK IPISAFSTSS AAEQNSNTTP RIENQTNKTI DASVSKKAAD 
       960        970        980        990       1000
STSQCGKATG SDSSGVIDLT MDDEESGASQ DPKKLNHTPV STMSSSQPVS 
      1010       1020       1030       1040       1050
RPLQPIQPAP PLQPSGVPTS GPSQTTIHLL PTAPTTVNVT HRPVTQVTTR 
      1060       1070       1080       1090       1100
LPVPRAPANH QVVYTTLPAP PAQAPLRGTV MQAPAVRQVN PQNSVTVRVP 
      1110       1120       1130       1140       1150
QTTTYVVNNG LTLGSTGPQL TVHHRPPQVH TEPPRPVHPA PLPEAPQPQR 
      1160       1170       1180       1190       1200
LPPEAASTSL PQKPHLKLAR VQSQNGIVLS WSVLEVDRSC ATVDSYHLYA 
      1210       1220       1230       1240       1250
YHEEPSATVP SQWKKIGEVK ALPLPMACTL TQFVSGSKYY FAVRAKDIYG 
      1260       1270
RFGPFCDPQS TDVISSTQSS
Length:1,270
Mass (Da):136,394
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i96F6E4FBA1D79385
GO
Isoform 2 (identifier: Q6VMQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     520-520: Missing.
     1095-1106: VTVRVPQTTTYV → KRFFLYMAPRYM
     1107-1270: Missing.

Show »
Length:1,105
Mass (Da):118,654
Checksum:i4B84876A207DDC12
GO
Isoform 3 (identifier: Q6VMQ6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHQDQRFRM

Show »
Length:1,278
Mass (Da):137,493
Checksum:i3775C6DF7DC731BD
GO
Isoform 4 (identifier: Q6VMQ6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     520-520: Missing.

Show »
Length:1,269
Mass (Da):136,323
Checksum:i220BCFBC8E0AB7A7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MV73A8MV73_HUMAN
Activating transcription factor 7-i...
ATF7IP
515Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H502F5H502_HUMAN
Activating transcription factor 7-i...
ATF7IP
176Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZ10F5GZ10_HUMAN
Activating transcription factor 7-i...
ATF7IP
169Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1K9F5H1K9_HUMAN
Activating transcription factor 7-i...
ATF7IP
176Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H2H9F5H2H9_HUMAN
Activating transcription factor 7-i...
ATF7IP
168Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H2W9F5H2W9_HUMAN
Activating transcription factor 7-i...
ATF7IP
152Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H8I0F5H8I0_HUMAN
Activating transcription factor 7-i...
ATF7IP
132Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE35F8WE35_HUMAN
Activating transcription factor 7-i...
ATF7IP
125Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFA3H0YFA3_HUMAN
Activating transcription factor 7-i...
ATF7IP
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GYR7F5GYR7_HUMAN
Activating transcription factor 7-i...
ATF7IP
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH37312 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AK001001 differs from that shown. Intron retention.Curated
The sequence AK001001 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA91751 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti457L → V in AAH37312 (PubMed:15489334).Curated1
Sequence conflicti1182S → G in AAQ92978 (PubMed:14536086).Curated1
Sequence conflicti1182S → G in BAA91751 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031283278E → K. Corresponds to variant dbSNP:rs2231908Ensembl.1
Natural variantiVAR_031284348N → I1 PublicationCorresponds to variant dbSNP:rs2231909Ensembl.1
Natural variantiVAR_031285530K → R3 PublicationsCorresponds to variant dbSNP:rs3213764Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0559121M → MHQDQRFRM in isoform 3. Curated1
Alternative sequenceiVSP_024035520Missing in isoform 2 and isoform 4. 1 Publication1
Alternative sequenceiVSP_0240381095 – 1106VTVRV…TTTYV → KRFFLYMAPRYM in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0240391107 – 1270Missing in isoform 2. 1 PublicationAdd BLAST164

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY337596 mRNA Translation: AAQ92978.1
AF425650 mRNA Translation: AAO91864.1
AC007782 Genomic DNA No translation available.
AC008114 Genomic DNA No translation available.
AC008814 Genomic DNA No translation available.
AC124892 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96320.1
BC037312 mRNA Translation: AAH37312.1 Sequence problems.
BC063855 mRNA Translation: AAH63855.1
AK001001 mRNA No translation available.
AK001550 mRNA Translation: BAA91751.1 Different initiation.
AJ242978 mRNA Translation: CAB45135.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS66326.1 [Q6VMQ6-4]
CCDS66327.1 [Q6VMQ6-5]
CCDS73449.1 [Q6VMQ6-2]
CCDS8663.1 [Q6VMQ6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001273443.1, NM_001286514.1 [Q6VMQ6-5]
NP_001273444.1, NM_001286515.1 [Q6VMQ6-2]
NP_060649.3, NM_018179.4 [Q6VMQ6-1]
NP_851997.1, NM_181352.1 [Q6VMQ6-4]
XP_006719171.1, XM_006719108.3 [Q6VMQ6-1]
XP_006719172.1, XM_006719109.3 [Q6VMQ6-1]
XP_011519056.1, XM_011520754.2 [Q6VMQ6-1]
XP_011519057.1, XM_011520755.2 [Q6VMQ6-1]
XP_016875127.1, XM_017019638.1 [Q6VMQ6-1]
XP_016875128.1, XM_017019639.1 [Q6VMQ6-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261168; ENSP00000261168; ENSG00000171681 [Q6VMQ6-1]
ENST00000536444; ENSP00000445955; ENSG00000171681 [Q6VMQ6-5]
ENST00000540793; ENSP00000444589; ENSG00000171681 [Q6VMQ6-1]
ENST00000543189; ENSP00000443179; ENSG00000171681 [Q6VMQ6-2]
ENST00000544627; ENSP00000440440; ENSG00000171681 [Q6VMQ6-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55729

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55729

UCSC genome browser

More...UCSCi		uc001rbv.3, human [Q6VMQ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY337596 mRNA Translation: AAQ92978.1
AF425650 mRNA Translation: AAO91864.1
AC007782 Genomic DNA No translation available.
AC008114 Genomic DNA No translation available.
AC008814 Genomic DNA No translation available.
AC124892 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96320.1
BC037312 mRNA Translation: AAH37312.1 Sequence problems.
BC063855 mRNA Translation: AAH63855.1
AK001001 mRNA No translation available.
AK001550 mRNA Translation: BAA91751.1 Different initiation.
AJ242978 mRNA Translation: CAB45135.1
CCDSiCCDS66326.1 [Q6VMQ6-4]
CCDS66327.1 [Q6VMQ6-5]
CCDS73449.1 [Q6VMQ6-2]
CCDS8663.1 [Q6VMQ6-1]
RefSeqiNP_001273443.1, NM_001286514.1 [Q6VMQ6-5]
NP_001273444.1, NM_001286515.1 [Q6VMQ6-2]
NP_060649.3, NM_018179.4 [Q6VMQ6-1]
NP_851997.1, NM_181352.1 [Q6VMQ6-4]
XP_006719171.1, XM_006719108.3 [Q6VMQ6-1]
XP_006719172.1, XM_006719109.3 [Q6VMQ6-1]
XP_011519056.1, XM_011520754.2 [Q6VMQ6-1]
XP_011519057.1, XM_011520755.2 [Q6VMQ6-1]
XP_016875127.1, XM_017019638.1 [Q6VMQ6-1]
XP_016875128.1, XM_017019639.1 [Q6VMQ6-5]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RPQNMR-B938-981[»]
SMRiQ6VMQ6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120849, 43 interactors
CORUMiQ6VMQ6
IntActiQ6VMQ6, 70 interactors
MINTiQ6VMQ6
STRINGi9606.ENSP00000440440

PTM databases

GlyGeniQ6VMQ6, 3 sites, 1 O-linked glycan (3 sites)
iPTMnetiQ6VMQ6
PhosphoSitePlusiQ6VMQ6

Polymorphism and mutation databases

BioMutaiATF7IP
DMDMi317373420

Proteomic databases

EPDiQ6VMQ6
jPOSTiQ6VMQ6
MassIVEiQ6VMQ6
MaxQBiQ6VMQ6
PaxDbiQ6VMQ6
PeptideAtlasiQ6VMQ6
PRIDEiQ6VMQ6
ProteomicsDBi24334
32440
67728 [Q6VMQ6-1]
67729 [Q6VMQ6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12020, 72 antibodies

Genome annotation databases

EnsembliENST00000261168; ENSP00000261168; ENSG00000171681 [Q6VMQ6-1]
ENST00000536444; ENSP00000445955; ENSG00000171681 [Q6VMQ6-5]
ENST00000540793; ENSP00000444589; ENSG00000171681 [Q6VMQ6-1]
ENST00000543189; ENSP00000443179; ENSG00000171681 [Q6VMQ6-2]
ENST00000544627; ENSP00000440440; ENSG00000171681 [Q6VMQ6-4]
GeneIDi55729
KEGGihsa:55729
UCSCiuc001rbv.3, human [Q6VMQ6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55729
DisGeNETi55729
EuPathDBiHostDB:ENSG00000171681.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATF7IP
HGNCiHGNC:20092, ATF7IP
HPAiENSG00000171681, Low tissue specificity
MIMi613644, gene
neXtProtiNX_Q6VMQ6
OpenTargetsiENSG00000171681

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSM2, Eukaryota
GeneTreeiENSGT00530000063707
HOGENOMiCLU_009529_0_0_1
InParanoidiQ6VMQ6
OMAiQVGIPFK
OrthoDBi324622at2759
PhylomeDBiQ6VMQ6
TreeFamiTF329427

Enzyme and pathway databases

PathwayCommonsiQ6VMQ6
ReactomeiR-HSA-3214841, PKMTs methylate histone lysines

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55729, 16 hits in 883 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ATF7IP, human
EvolutionaryTraceiQ6VMQ6

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ATF7IP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55729
PharosiQ6VMQ6, Tbio

Protein Ontology

More...PROi		PR:Q6VMQ6
RNActiQ6VMQ6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171681, Expressed in amniotic fluid and 246 other tissues
ExpressionAtlasiQ6VMQ6, baseline and differential
GenevisibleiQ6VMQ6, HS

Family and domain databases

DisProtiDP01277
Gene3Di2.60.40.10, 1 hit
IDEALiIID00216
InterProiView protein in InterPro
IPR026085, ATF7-int
IPR031870, ATF7IP_BD
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
PANTHERiPTHR23210, PTHR23210, 1 hit
PfamiView protein in Pfam
PF16788, ATF7IP_BD, 1 hit
PF16794, fn3_4, 1 hit
SUPFAMiSSF49265, SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853, FN3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCAF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6VMQ6
Secondary accession number(s): F5GX74
, G3V1U0, Q4G0T9, Q6P3T3, Q86XW5, Q9NVJ9, Q9NWC2, Q9Y4X8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: January 11, 2011
Last modified: August 12, 2020
This is version 157 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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