Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q6VMQ6 (MCAF1_HUMAN)

Protein

Activating transcription factor 7-interacting protein 1

Gene

ATF7IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells.3 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, Repressor
Biological processHost-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214841 PKMTs methylate histone lysines

Names & Taxonomyi

Protein namesi
Recommended name:
Activating transcription factor 7-interacting protein 1
Alternative name(s):
ATF-interacting protein
Short name:
ATF-IP
ATF7-interacting protein
ATFa-associated modulator
Short name:
hAM
MBD1-containing chromatin-associated factor 1
P621
Gene namesi
Name:ATF7IP
Synonyms:MCAF, MCAF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000171681.12
HGNCiHGNC:20092 ATF7IP
MIMi613644 gene
neXtProtiNX_Q6VMQ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi968D → A: Abolishes the interaction with SUMO. 1 Publication1
Mutagenesisi969L → A: Abolishes the interaction with SUMO. 1 Publication1
Mutagenesisi1224L → R: Abolishes interaction with MBD1 and subsequent transcriptional repression. 1 Publication1

Organism-specific databases

DisGeNETi55729
OpenTargetsiENSG00000171681

Polymorphism and mutation databases

BioMutaiATF7IP
DMDMi317373420

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002817801 – 1270Activating transcription factor 7-interacting protein 1Add BLAST1270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei57PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei118PhosphothreonineCombined sources1
Modified residuei445PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei474PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei479PhosphoserineBy similarity1
Modified residuei496PhosphoserineCombined sources1
Cross-linki558Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei559PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei899PhosphoserineCombined sources1
Cross-linki910Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki938Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6VMQ6
MaxQBiQ6VMQ6
PaxDbiQ6VMQ6
PeptideAtlasiQ6VMQ6
PRIDEiQ6VMQ6
ProteomicsDBi67728
67729 [Q6VMQ6-2]

PTM databases

iPTMnetiQ6VMQ6
PhosphoSitePlusiQ6VMQ6

Expressioni

Tissue specificityi

Detected at low levels in breast, lung and stomach; highly up-regulated in the corresponding cancerous tissues (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000171681 Expressed in 234 organ(s), highest expression level in amniotic fluid
CleanExiHS_ATF7IP
ExpressionAtlasiQ6VMQ6 baseline and differential
GenevisibleiQ6VMQ6 HS

Organism-specific databases

HPAiHPA016578
HPA023505

Interactioni

Subunit structurei

Interacts with MBD1; the interaction is enhanced when MBD1 is sumoylated. Probably forms a complex with SETDB1 and MBD1. Interacts with SUMO ubiquitin-like proteins (SUMO1, SUNO2 and SUMO3), with a preference for SUMO2 and SUMO3. Interacts with SP1, ATF7 and ZHX1. Interacts with the general transcription machinery, including ERCC2, ERCC3, GTF2E1, GTF2E2 and POLR2A. Interacts with Epstein-Barr virus BRLF1/Rta protein, leading to promote and regulate host genes in Epstein-Barr virus-infected cells.8 Publications
(Microbial infection) Interacts with Epstein-Barr virus BRLF1/Rta protein, leading to the regulation of host genes in Epstein-Barr virus-infected cells.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi120849, 39 interactors
CORUMiQ6VMQ6
IntActiQ6VMQ6, 59 interactors
MINTiQ6VMQ6
STRINGi9606.ENSP00000261168

Structurei

3D structure databases

ProteinModelPortaliQ6VMQ6
SMRiQ6VMQ6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6VMQ6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1160 – 1270Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni562 – 817Interaction with SETDB1Add BLAST256
Regioni965 – 975Interaction with SUMO1 PublicationAdd BLAST11
Regioni1154 – 1270Interaction with MBD1Add BLAST117

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili617 – 665Sequence analysisAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi553 – 571Nuclear localization signalBy similarityAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi349 – 580Glu-richAdd BLAST232

Sequence similaritiesi

Belongs to the MCAF family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJ5P Eukaryota
ENOG410XUWA LUCA
GeneTreeiENSGT00530000063707
HOVERGENiHBG087180
InParanoidiQ6VMQ6
OMAiVRQVNPQ
OrthoDBiEOG091G058O
PhylomeDBiQ6VMQ6
TreeFamiTF329427

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR026085 ATF7-int
IPR031870 ATF7IP_BD
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PANTHERiPTHR23210 PTHR23210, 1 hit
PfamiView protein in Pfam
PF16788 ATF7IP_BD, 1 hit
PF16794 fn3_4, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6VMQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSLEEPQKK VFKARKTMRV SDRQQLEAVY KVKEELLKTD VKLLNGNHEN 
        60         70         80         90        100
GDLDPTSPLE NMDYIKDKEE VNGIEEICFD PEGSKAEWKE TPCILSVNVK 
       110        120        130        140        150
NKQDDDLNCE PLSPHNITPE PVSKLPAEPV SGDPAPGDLD AGDPASGVLA 
       160        170        180        190        200
SGDSTSGDPT SSEPSSSDAA SGDATSGDAP SGDVSPGDAT SGDATADDLS 
       210        220        230        240        250
SGDPTSSDPI PGEPVPVEPI SGDCAADDIA SSEITSVDLA SGAPASTDPA 
       260        270        280        290        300
SDDLASGDLS SSELASDDLA TGELASDELT SESTFDRTFE PKSVPVCEPV 
       310        320        330        340        350
PEIDNIEPSS NKDDDFLEKN GADEKLEQIQ SKDSLDEKNK ADNNIDANEE 
       360        370        380        390        400
TLETDDTTIC SDRPPENEKK VEEDIITELA LGEDAISSSM EIDQGEKNED 
       410        420        430        440        450
ETSADLVETI NENVIEDNKS ENILENTDSM ETDEIIPILE KLAPSEDELT 
       460        470        480        490        500
CFSKTSLLPI DETNPDLEEK MESSFGSPSK QESSESLPKE AFLVLSDEED 
       510        520        530        540        550
ISGEKDESEV ISQNETCSPA EVESNEKDNK PEEEEQVIHE DDERPSEKNE 
       560        570        580        590        600
FSRRKRSKSE DMDNVQSKRR RYMEEEYEAE FQVKITAKGD INQKLQKVIQ 
       610        620        630        640        650
WLLEEKLCAL QCAVFDKTLA ELKTRVEKIE CNKRHKTVLT ELQAKIARLT 
       660        670        680        690        700
KRFEAAKEDL KKRHEHPPNP PVSPGKTVND VNSNNNMSYR NAGTVRQMLE 
       710        720        730        740        750
SKRNVSESAP PSFQTPVNTV SSTNLVTPPA VVSSQPKLQT PVTSGSLTAT 
       760        770        780        790        800
SVLPAPNTAT VVATTQVPSG NPQPTISLQP LPVILHVPVA VSSQPQLLQS 
       810        820        830        840        850
HPGTLVTNQP SGNVEFISVQ SPPTVSGLTK NPVSLPSLPN PTKPNNVPSV 
       860        870        880        890        900
PSPSIQRNPT ASAAPLGTTL AVQAVPTAHS IVQATRTSLP TVGPSGLYSP 
       910        920        930        940        950
STNRGPIQMK IPISAFSTSS AAEQNSNTTP RIENQTNKTI DASVSKKAAD 
       960        970        980        990       1000
STSQCGKATG SDSSGVIDLT MDDEESGASQ DPKKLNHTPV STMSSSQPVS 
      1010       1020       1030       1040       1050
RPLQPIQPAP PLQPSGVPTS GPSQTTIHLL PTAPTTVNVT HRPVTQVTTR 
      1060       1070       1080       1090       1100
LPVPRAPANH QVVYTTLPAP PAQAPLRGTV MQAPAVRQVN PQNSVTVRVP 
      1110       1120       1130       1140       1150
QTTTYVVNNG LTLGSTGPQL TVHHRPPQVH TEPPRPVHPA PLPEAPQPQR 
      1160       1170       1180       1190       1200
LPPEAASTSL PQKPHLKLAR VQSQNGIVLS WSVLEVDRSC ATVDSYHLYA 
      1210       1220       1230       1240       1250
YHEEPSATVP SQWKKIGEVK ALPLPMACTL TQFVSGSKYY FAVRAKDIYG 
      1260       1270
RFGPFCDPQS TDVISSTQSS
Length:1,270
Mass (Da):136,394
Last modified:January 11, 2011 - v3
Checksum:i96F6E4FBA1D79385
GO
Isoform 2 (identifier: Q6VMQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     520-520: Missing.
     1095-1106: VTVRVPQTTTYV → KRFFLYMAPRYM
     1107-1270: Missing.

Note: No experimental confirmation available.
Show »
Length:1,105
Mass (Da):118,654
Checksum:i4B84876A207DDC12
GO
Isoform 3 (identifier: Q6VMQ6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHQDQRFRM

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,278
Mass (Da):137,493
Checksum:i3775C6DF7DC731BD
GO
Isoform 4 (identifier: Q6VMQ6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     520-520: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,269
Mass (Da):136,323
Checksum:i220BCFBC8E0AB7A7
GO

Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MV73A8MV73_HUMAN
Activating transcription factor 7-i...
ATF7IP
515Annotation score:
F5H8I0F5H8I0_HUMAN
Activating transcription factor 7-i...
ATF7IP
132Annotation score:
F5H2H9F5H2H9_HUMAN
Activating transcription factor 7-i...
ATF7IP
168Annotation score:
F5H502F5H502_HUMAN
Activating transcription factor 7-i...
ATF7IP
176Annotation score:
F8WE35F8WE35_HUMAN
Activating transcription factor 7-i...
ATF7IP
125Annotation score:
F5H1K9F5H1K9_HUMAN
Activating transcription factor 7-i...
ATF7IP
176Annotation score:
F5H2W9F5H2W9_HUMAN
Activating transcription factor 7-i...
ATF7IP
152Annotation score:
F5GZ10F5GZ10_HUMAN
Activating transcription factor 7-i...
ATF7IP
169Annotation score:
F5GYR7F5GYR7_HUMAN
Activating transcription factor 7-i...
ATF7IP
96Annotation score:
F5H592F5H592_HUMAN
Activating transcription factor 7-i...
ATF7IP
143Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAH37312 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AK001001 differs from that shown. Intron retention.Curated
The sequence AK001001 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91751 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti457L → V in AAH37312 (PubMed:15489334).Curated1
Sequence conflicti1182S → G in AAQ92978 (PubMed:14536086).Curated1
Sequence conflicti1182S → G in BAA91751 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031283278E → K. Corresponds to variant dbSNP:rs2231908Ensembl.1
Natural variantiVAR_031284348N → I1 PublicationCorresponds to variant dbSNP:rs2231909Ensembl.1
Natural variantiVAR_031285530K → R3 PublicationsCorresponds to variant dbSNP:rs3213764Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559121M → MHQDQRFRM in isoform 3. Curated1
Alternative sequenceiVSP_024035520Missing in isoform 2 and isoform 4. 1 Publication1
Alternative sequenceiVSP_0240381095 – 1106VTVRV…TTTYV → KRFFLYMAPRYM in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0240391107 – 1270Missing in isoform 2. 1 PublicationAdd BLAST164

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY337596 mRNA Translation: AAQ92978.1
AF425650 mRNA Translation: AAO91864.1
AC007782 Genomic DNA No translation available.
AC008114 Genomic DNA No translation available.
AC008814 Genomic DNA No translation available.
AC124892 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96320.1
BC037312 mRNA Translation: AAH37312.1 Sequence problems.
BC063855 mRNA Translation: AAH63855.1
AK001001 mRNA No translation available.
AK001550 mRNA Translation: BAA91751.1 Different initiation.
AJ242978 mRNA Translation: CAB45135.1
CCDSiCCDS66326.1 [Q6VMQ6-4]
CCDS66327.1 [Q6VMQ6-5]
CCDS73449.1 [Q6VMQ6-2]
CCDS8663.1 [Q6VMQ6-1]
RefSeqiNP_001273443.1, NM_001286514.1 [Q6VMQ6-5]
NP_001273444.1, NM_001286515.1 [Q6VMQ6-2]
NP_060649.3, NM_018179.4 [Q6VMQ6-1]
NP_851997.1, NM_181352.1 [Q6VMQ6-4]
XP_006719171.1, XM_006719108.3 [Q6VMQ6-1]
XP_006719172.1, XM_006719109.3 [Q6VMQ6-1]
XP_011519056.1, XM_011520754.2 [Q6VMQ6-1]
XP_011519057.1, XM_011520755.2 [Q6VMQ6-1]
XP_016875127.1, XM_017019638.1 [Q6VMQ6-1]
XP_016875128.1, XM_017019639.1 [Q6VMQ6-5]
UniGeneiHs.504856
Hs.591151

Genome annotation databases

EnsembliENST00000261168; ENSP00000261168; ENSG00000171681 [Q6VMQ6-1]
ENST00000536444; ENSP00000445955; ENSG00000171681 [Q6VMQ6-5]
ENST00000540793; ENSP00000444589; ENSG00000171681 [Q6VMQ6-1]
ENST00000543189; ENSP00000443179; ENSG00000171681 [Q6VMQ6-2]
ENST00000544627; ENSP00000440440; ENSG00000171681 [Q6VMQ6-4]
GeneIDi55729
KEGGihsa:55729
UCSCiuc001rbv.3 human [Q6VMQ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY337596 mRNA Translation: AAQ92978.1
AF425650 mRNA Translation: AAO91864.1
AC007782 Genomic DNA No translation available.
AC008114 Genomic DNA No translation available.
AC008814 Genomic DNA No translation available.
AC124892 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96320.1
BC037312 mRNA Translation: AAH37312.1 Sequence problems.
BC063855 mRNA Translation: AAH63855.1
AK001001 mRNA No translation available.
AK001550 mRNA Translation: BAA91751.1 Different initiation.
AJ242978 mRNA Translation: CAB45135.1
CCDSiCCDS66326.1 [Q6VMQ6-4]
CCDS66327.1 [Q6VMQ6-5]
CCDS73449.1 [Q6VMQ6-2]
CCDS8663.1 [Q6VMQ6-1]
RefSeqiNP_001273443.1, NM_001286514.1 [Q6VMQ6-5]
NP_001273444.1, NM_001286515.1 [Q6VMQ6-2]
NP_060649.3, NM_018179.4 [Q6VMQ6-1]
NP_851997.1, NM_181352.1 [Q6VMQ6-4]
XP_006719171.1, XM_006719108.3 [Q6VMQ6-1]
XP_006719172.1, XM_006719109.3 [Q6VMQ6-1]
XP_011519056.1, XM_011520754.2 [Q6VMQ6-1]
XP_011519057.1, XM_011520755.2 [Q6VMQ6-1]
XP_016875127.1, XM_017019638.1 [Q6VMQ6-1]
XP_016875128.1, XM_017019639.1 [Q6VMQ6-5]
UniGeneiHs.504856
Hs.591151

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RPQNMR-B938-981[»]
ProteinModelPortaliQ6VMQ6
SMRiQ6VMQ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120849, 39 interactors
CORUMiQ6VMQ6
IntActiQ6VMQ6, 59 interactors
MINTiQ6VMQ6
STRINGi9606.ENSP00000261168

PTM databases

iPTMnetiQ6VMQ6
PhosphoSitePlusiQ6VMQ6

Polymorphism and mutation databases

BioMutaiATF7IP
DMDMi317373420

Proteomic databases

EPDiQ6VMQ6
MaxQBiQ6VMQ6
PaxDbiQ6VMQ6
PeptideAtlasiQ6VMQ6
PRIDEiQ6VMQ6
ProteomicsDBi67728
67729 [Q6VMQ6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261168; ENSP00000261168; ENSG00000171681 [Q6VMQ6-1]
ENST00000536444; ENSP00000445955; ENSG00000171681 [Q6VMQ6-5]
ENST00000540793; ENSP00000444589; ENSG00000171681 [Q6VMQ6-1]
ENST00000543189; ENSP00000443179; ENSG00000171681 [Q6VMQ6-2]
ENST00000544627; ENSP00000440440; ENSG00000171681 [Q6VMQ6-4]
GeneIDi55729
KEGGihsa:55729
UCSCiuc001rbv.3 human [Q6VMQ6-1]

Organism-specific databases

CTDi55729
DisGeNETi55729
EuPathDBiHostDB:ENSG00000171681.12
GeneCardsiATF7IP
H-InvDBiHIX0010453
HGNCiHGNC:20092 ATF7IP
HPAiHPA016578
HPA023505
MIMi613644 gene
neXtProtiNX_Q6VMQ6
OpenTargetsiENSG00000171681
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ5P Eukaryota
ENOG410XUWA LUCA
GeneTreeiENSGT00530000063707
HOVERGENiHBG087180
InParanoidiQ6VMQ6
OMAiVRQVNPQ
OrthoDBiEOG091G058O
PhylomeDBiQ6VMQ6
TreeFamiTF329427

Enzyme and pathway databases

ReactomeiR-HSA-3214841 PKMTs methylate histone lysines

Miscellaneous databases

ChiTaRSiATF7IP human
EvolutionaryTraceiQ6VMQ6
GeneWikiiATF7IP
GenomeRNAii55729
PROiPR:Q6VMQ6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171681 Expressed in 234 organ(s), highest expression level in amniotic fluid
CleanExiHS_ATF7IP
ExpressionAtlasiQ6VMQ6 baseline and differential
GenevisibleiQ6VMQ6 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR026085 ATF7-int
IPR031870 ATF7IP_BD
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PANTHERiPTHR23210 PTHR23210, 1 hit
PfamiView protein in Pfam
PF16788 ATF7IP_BD, 1 hit
PF16794 fn3_4, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMCAF1_HUMAN
AccessioniPrimary (citable) accession number: Q6VMQ6
Secondary accession number(s): F5GX74
, G3V1U0, Q4G0T9, Q6P3T3, Q86XW5, Q9NVJ9, Q9NWC2, Q9Y4X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: January 11, 2011
Last modified: September 12, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again