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Entry version 103 (13 Feb 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Protein Daple

Gene

Ccdc88c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (PubMed:14750955). May also activate the JNK signaling pathway (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • dynein light intermediate chain binding Source: GO_Central
  • microtubule binding Source: GO_Central
  • PDZ domain binding Source: UniProtKB
  • protein self-association Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Daple
Alternative name(s):
Coiled-coil domain-containing protein 88C
Dvl-associating protein with a high frequency of leucine residues
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccdc88c
Synonyms:Daple
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1915589 Ccdc88c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2007G → A: Abolishes binding to DVL1. 1 Publication1
Mutagenesisi2009V → A: Abolishes binding to DVL1. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002847261 – 2009Protein DapleAdd BLAST2009

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei227PhosphoserineBy similarity1
Modified residuei239PhosphoserineBy similarity1
Modified residuei486PhosphoserineBy similarity1
Modified residuei1435PhosphoserineBy similarity1
Modified residuei1592PhosphoserineBy similarity1
Modified residuei1798PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6VGS5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6VGS5

PeptideAtlas

More...
PeptideAtlasi
Q6VGS5

PRoteomics IDEntifications database

More...
PRIDEi
Q6VGS5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6VGS5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6VGS5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000021182 Expressed in 23 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6VGS5 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer. Interacts with the PDZ domain of DVL1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
212810, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q6VGS5, 3 interactors

Molecular INTeraction database

More...
MINTi
Q6VGS5

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000068629

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6VGS5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6VGS5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 131Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST121

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2007 – 2009DVL1-binding1 Publication3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili247 – 425Sequence analysisAdd BLAST179
Coiled coili456 – 1008Sequence analysisAdd BLAST553
Coiled coili1190 – 1384Sequence analysisAdd BLAST195

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2006 – 2009PDZ-bindingSequence analysis4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCDC88 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4643 Eukaryota
ENOG410YFRJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154785

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112146

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG057867

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6VGS5

Identification of Orthologs from Complete Genome Data

More...
OMAi
YDPTPKK

Database of Orthologous Groups

More...
OrthoDBi
59187at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6VGS5

TreeFam database of animal gene trees

More...
TreeFami
TF320231

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR027719 Daple
IPR008636 Hook-like_fam

The PANTHER Classification System

More...
PANTHERi
PTHR18947:SF31 PTHR18947:SF31, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05622 HOOK, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q6VGS5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVTVSQLVE LFLQSPLVTW VKTFGSFGSG HQDNLTLYMD LVDGIFLNQI
60 70 80 90 100
MLQIDPRPSN QRINKHVNND VNLRIQNLSI LVRNIKTYYQ EVLQQLIVMN
110 120 130 140 150
LPNVLMIGKD PLSGKSMEEI KKVLLLVLGC AVQCERKEEF IERIKQLDIE
160 170 180 190 200
TQAGIVAHIQ EVTHNQENVF DLQWLDLPDV APEELEALSR NMVFHLRRLI
210 220 230 240 250
DERDECTELI VDLTQERDYL QTQQPPSPGK FSSPDSTPSP TSSLSSEDKQ
260 270 280 290 300
HLAVELADTK ARLRRVRQEL EEKTEQLADT RHEVDQLVLE LQKAKQDNIQ
310 320 330 340 350
LAADARSARA YRDELDSLRE KANRVERLEM DLVRCKEKLH DVDFYKARME
360 370 380 390 400
ELREDNIILI ETKAMLEEQL TASRARSDKV HELEKENLQL KSKLHDLELD
410 420 430 440 450
RDADKKQIEK LLEEYMVLEM AQKQSMKESA HLGWELEQLS KNADLSDASR
460 470 480 490 500
KSFVFELNEC ASSRILKLEK ENQSLQSTIQ GLRDTSLALE ESSLKYGELE
510 520 530 540 550
KENQQLSKKI EKLQTQLERE KQSNQDLETL SEELIREKEQ LQSGMEALKA
560 570 580 590 600
DRARQIKDLE QEKGHLHQAV WSLRERPQVN STKDVEKENR ALHQAVTEAG
610 620 630 640 650
SKLSQLELEK QQLHRDLEEA KEKGEQAEAL EKELHRLEKE NEQLTKEVTS
660 670 680 690 700
LKAATEKVEA LEHQSQGLEL ENRSLRKSLD TLQNVSVQLE GLERDKQQLG
710 720 730 740 750
QENLELRKMV EAMRFTSAKM AQIETENRQL EREKEELRRD VELLKTLSKK
760 770 780 790 800
SERLELSYQS VSAENLQLQH SLESSTHKSQ ALQRELSQLE AERQALRRDL
810 820 830 840 850
ETLQLTHKQL EGAEEDRKAL EQEVAQLEKD KKLLEKEARR LWQQVELKDA
860 870 880 890 900
ILDDSAAKLS AAEKESRALD KELARCRDVG SKLKELEKDN RDLTKQVTMH
910 920 930 940 950
TRTLTTLRED LVLEKLKSQQ LSSELDKLSQ ELEKVGLSKD LLLQEDDGHG
960 970 980 990 1000
DGKGKTESAL KTTLAMKEEK IVFLEAQVEE KESLSRQLQI ELQMIKKEHE
1010 1020 1030 1040 1050
QLRQTQEGGD KAQNALKRPP GKVTSHQEKE AWEPSHKEAT MELLRVKDRA
1060 1070 1080 1090 1100
IELERSNAAL QAERQLLKEQ LQHLETQNVS FSSQILTLQK QSAFLQEHTT
1110 1120 1130 1140 1150
TLQTQTAKLQ VENSTLSSQN AALSAQYTVL QSQQAAKEAE HEGLQQQQEQ
1160 1170 1180 1190 1200
LAAVYEALLQ DHKHLGTLYE CQSSEYEALI RQHSCLKTLH RNLELEHKEL
1210 1220 1230 1240 1250
GERHGDLQQR KAELEELEKV LSTEREALER EQKTNAIATS ENQRLRGELD
1260 1270 1280 1290 1300
RISFLHQQLK GEYEELHAHT KELKTSLNNS QLELSRWQVR FDELKEQHQS
1310 1320 1330 1340 1350
MDISLTKMDN HCELLSRLKG NLEEENHHLL SQIQLLSQQN QMLLEQNMES
1360 1370 1380 1390 1400
KEQYHEEQKQ YIDKLNALRR HKEKLEEKIM DQYKFYDPAP KKKNHWIGAK
1410 1420 1430 1440 1450
ALVKLIKPKK EGSRERLKST TDSPPWQLEP SDPASPSPSQ ALRSQTENPD
1460 1470 1480 1490 1500
NPPSGPNCVE ERDTHNGPVG KGPGDLKPKR GSPRGGSVDR TDTSTDPAVK
1510 1520 1530 1540 1550
SWPSEPGSRT FSTSATTAAL SSSTPIPKHL GRTKGCNSDD NLCEPSSEPD
1560 1570 1580 1590 1600
GPYHRQQASR PNSLESSRNA SSNSSPLSLK GSSDHLHSRC ESFSSADLIP
1610 1620 1630 1640 1650
SRDPATLSRD GNTSGRGLLG RHEYPPPRNG PVSQETIQKK GAASTHTGVR
1660 1670 1680 1690 1700
PHSASPSSEM VTLEEFLEES NRGGSPTHDT PSCRDDLLSD YFRKAHDPPA
1710 1720 1730 1740 1750
LGGQPGPPAR KDGAKMPTSF VAPTIKMSIN TSEGQQLKPG HYVKPNLRPS
1760 1770 1780 1790 1800
EAEALAGMPS RQVQPPQSLS LGRPRQTTMT QNCHMPVSRS ASLSRAFSLA
1810 1820 1830 1840 1850
SADLLRASGP EACRPESPQK PGGHEAAGAR ETSTHSLQGS HILARERTPI
1860 1870 1880 1890 1900
VGKADSPSPG QGTRGRPLDT RRFSLAPPKE ERLAPLQQSA TAPALATGCS
1910 1920 1930 1940 1950
SGSNPQIQHF SPTVAPAVRT KSKVPQHSGE VATVAPVRPG LGTSEGDGGP
1960 1970 1980 1990 2000
GHGYSEGLLT KSPGRSSDLP PHVKRGPDDF SQGSSSKSTP ASPEPGGDPQ

TVWYEYGCV
Length:2,009
Mass (Da):226,535
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68AB26B288393BD4
GO
Isoform 21 Publication (identifier: Q6VGS5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     509-509: K → KAGSLHLQ

Note: No experimental confirmation available.Curated
Show »
Length:2,016
Mass (Da):227,242
Checksum:i069825088B91C1B2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VLR3A0A1Y7VLR3_MOUSE
Protein Daple
Ccdc88c
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9DCU8Q9DCU8_MOUSE
Protein Daple
Ccdc88c
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2W7U9A0A3B2W7U9_MOUSE
Protein Daple
Ccdc88c
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052377509K → KAGSLHLQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY339881 mRNA Translation: AAR08446.1
AK137260 mRNA Translation: BAE23287.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS26110.1 [Q6VGS5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_080957.2, NM_026681.4 [Q6VGS5-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.156217

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000068411; ENSMUSP00000068629; ENSMUSG00000021182 [Q6VGS5-1]
ENSMUST00000085096; ENSMUSP00000082177; ENSMUSG00000021182 [Q6VGS5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
68339

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:68339

UCSC genome browser

More...
UCSCi
uc007ote.1 mouse [Q6VGS5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY339881 mRNA Translation: AAR08446.1
AK137260 mRNA Translation: BAE23287.1
CCDSiCCDS26110.1 [Q6VGS5-1]
RefSeqiNP_080957.2, NM_026681.4 [Q6VGS5-1]
UniGeneiMm.156217

3D structure databases

ProteinModelPortaliQ6VGS5
SMRiQ6VGS5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212810, 1 interactor
IntActiQ6VGS5, 3 interactors
MINTiQ6VGS5
STRINGi10090.ENSMUSP00000068629

PTM databases

iPTMnetiQ6VGS5
PhosphoSitePlusiQ6VGS5

Proteomic databases

EPDiQ6VGS5
PaxDbiQ6VGS5
PeptideAtlasiQ6VGS5
PRIDEiQ6VGS5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068411; ENSMUSP00000068629; ENSMUSG00000021182 [Q6VGS5-1]
ENSMUST00000085096; ENSMUSP00000082177; ENSMUSG00000021182 [Q6VGS5-2]
GeneIDi68339
KEGGimmu:68339
UCSCiuc007ote.1 mouse [Q6VGS5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
440193
MGIiMGI:1915589 Ccdc88c

Phylogenomic databases

eggNOGiKOG4643 Eukaryota
ENOG410YFRJ LUCA
GeneTreeiENSGT00940000154785
HOGENOMiHOG000112146
HOVERGENiHBG057867
InParanoidiQ6VGS5
OMAiYDPTPKK
OrthoDBi59187at2759
PhylomeDBiQ6VGS5
TreeFamiTF320231

Miscellaneous databases

Protein Ontology

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PROi
PR:Q6VGS5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000021182 Expressed in 23 organ(s), highest expression level in testis
ExpressionAtlasiQ6VGS5 baseline and differential

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR027719 Daple
IPR008636 Hook-like_fam
PANTHERiPTHR18947:SF31 PTHR18947:SF31, 1 hit
PfamiView protein in Pfam
PF05622 HOOK, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDAPLE_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6VGS5
Secondary accession number(s): Q3UVI2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 5, 2004
Last modified: February 13, 2019
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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