UniProtKB - Q6VE48 (MCP_BOVIN)
Membrane cofactor protein
CD46
Functioni
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).
In case of bovine viral diarrhea virus (BVDV) infection, involved in virus attachment to cells.
By similarityGO - Biological processi
- complement activation, classical pathway Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- negative regulation of complement activation, classical pathway Source: GO_Central
- single fertilization Source: UniProtKB-KW
- T cell mediated immunity Source: GO_Central
Keywordsi
Biological process | Complement pathway, Fertilization, Immunity, Innate immunity |
Names & Taxonomyi
Protein namesi | Recommended name: Membrane cofactor proteinAlternative name(s): CD_antigen: CD46 |
Gene namesi | Name:CD46 Synonyms:MCP |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Other locations
- acrosome inner membrane By similarity; Single-pass type I membrane protein By similarity
Note: Inner acrosomal membrane of spermatozoa.By similarity
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cell surface Source: InterPro
- inner acrosomal membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 43 – 311 | ExtracellularSequence analysisAdd BLAST | 269 | |
Transmembranei | 312 – 332 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 333 – 361 | CytoplasmicSequence analysisAdd BLAST | 29 |
Keywords - Cellular componenti
Cytoplasmic vesicle, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 42 | Sequence analysisAdd BLAST | 42 | |
ChainiPRO_0000238968 | 43 – 361 | Membrane cofactor proteinAdd BLAST | 319 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Disulfide bondi | 107 ↔ 149 | PROSITE-ProRule annotation | |||
Glycosylationi | 122 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Disulfide bondi | 135 ↔ 166 | PROSITE-ProRule annotation | |||
Glycosylationi | 145 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Disulfide bondi | 171 ↔ 219 | PROSITE-ProRule annotation | |||
Disulfide bondi | 200 ↔ 232 | PROSITE-ProRule annotation | |||
Disulfide bondi | 237 ↔ 279 | PROSITE-ProRule annotation | |||
Disulfide bondi | 265 ↔ 292 | PROSITE-ProRule annotation | |||
Glycosylationi | 301 | O-linked (GalNAc...) threonineSequence analysis | 1 | ||
Isoform 3 (identifier: Q6VE48-3) | |||||
Modified residuei | 353 | PhosphotyrosineCurated | 1 | ||
Modified residuei | 356 | PhosphotyrosineCurated | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q6VE48 |
PeptideAtlasi | Q6VE48 |
PRIDEi | Q6VE48 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Interacts with C3b.
Interacts with C4b.
Interacts with moesin/MSN.
By similarityProtein-protein interaction databases
IntActi | Q6VE48, 1 interactor |
STRINGi | 9913.ENSBTAP00000007107 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 43 – 104 | Sushi 1PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 105 – 168 | Sushi 2PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 169 – 234 | Sushi 3PROSITE-ProRule annotationAdd BLAST | 66 | |
Domaini | 235 – 294 | Sushi 4PROSITE-ProRule annotationAdd BLAST | 60 |
Domaini
Keywords - Domaini
Repeat, Signal, Sushi, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QPUC, Eukaryota |
InParanoidi | Q6VE48 |
OrthoDBi | 1239877at2759 |
Family and domain databases
CDDi | cd00033, CCP, 4 hits |
InterProi | View protein in InterPro IPR017341, CD46 IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00084, Sushi, 4 hits |
PIRSFi | PIRSF037971, TLX_CD46, 1 hit |
SMARTi | View protein in SMART SM00032, CCP, 4 hits |
SUPFAMi | SSF57535, SSF57535, 4 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 4 hits |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRASCTPLKA PLRRPERLAS SGRFAWVLLL APLLLLPTSS DACDDPPRFV
60 70 80 90 100
SMKPQGTLKP SYSPGEQIVY ECHLGFQPVT PGQVLALVCQ DNNTWSSLQE
110 120 130 140 150
GCKKRRCPTL ADPTNGQVIL VNGSTEFGSE VHYVCNNGYY LLGTNISYCE
160 170 180 190 200
VSSGTGVNWS DNPPTCEKIL CQPPPEIQNG KYTNSHKDVF EYNEVVTYSC
210 220 230 240 250
DPSNGPDEYS LVGESKLTCI GNGEWSSQPP QCKVVKCVYP AIEHGTIVSG
260 270 280 290 300
FGPKYYYKAT VVLKCNEGFN LYGNSVVVCG ENSTWEPELP KCIKGHPPRP
310 320 330 340 350
TDASPPNGAE GLGAGYIVLV IVAVLIGVGL LLCLYCCFCR QRKKGIYVTG
360
ESHRQDILFS L
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | R → L in AAP92712 (PubMed:12125738).Curated | 1 | |
Sequence conflicti | 39 | S → C in AAP92712 (PubMed:12125738).Curated | 1 | |
Sequence conflicti | 73 | H → R in AAP92712 (PubMed:12125738).Curated | 1 | |
Sequence conflicti | 104 – 109 | KRRCPT → RRQCPN in AAP92712 (PubMed:12125738).Curated | 6 | |
Sequence conflicti | 124 | S → N in AAR04015 (PubMed:14747544).Curated | 1 | |
Sequence conflicti | 185 | S → N in AAR04015 (PubMed:14747544).Curated | 1 | |
Sequence conflicti | 228 | Q → K in AAP92712 (PubMed:12125738).Curated | 1 | |
Sequence conflicti | 244 | H → Y in AAP92712 (PubMed:12125738).Curated | 1 | |
Sequence conflicti | 272 | Y → Q in AAP92712 (PubMed:12125738).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019033 | 324 – 361 | VLIGV…ILFSL → LLALDYCSACTAVFADRGRK GKQNVALRTPLIRIKQPLQQ NR in isoform 2. 2 PublicationsAdd BLAST | 38 | |
Alternative sequenceiVSP_019034 | 346 – 361 | IYVTG…ILFSL → KAECSATYTTYQDKATTATE QMN in isoform 3. 1 PublicationAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY333119 mRNA Translation: AAP92712.1 AY342429 mRNA Translation: AAR04015.1 |
RefSeqi | NP_001229493.1, NM_001242564.1 NP_898903.2, NM_183080.2 |
Genome annotation databases
GeneIDi | 280851 |
KEGGi | bta:280851 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY333119 mRNA Translation: AAP92712.1 AY342429 mRNA Translation: AAR04015.1 |
RefSeqi | NP_001229493.1, NM_001242564.1 NP_898903.2, NM_183080.2 |
3D structure databases
AlphaFoldDBi | Q6VE48 |
SMRi | Q6VE48 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q6VE48, 1 interactor |
STRINGi | 9913.ENSBTAP00000007107 |
Proteomic databases
PaxDbi | Q6VE48 |
PeptideAtlasi | Q6VE48 |
PRIDEi | Q6VE48 |
Genome annotation databases
GeneIDi | 280851 |
KEGGi | bta:280851 |
Organism-specific databases
CTDi | 4179 |
Phylogenomic databases
eggNOGi | ENOG502QPUC, Eukaryota |
InParanoidi | Q6VE48 |
OrthoDBi | 1239877at2759 |
Family and domain databases
CDDi | cd00033, CCP, 4 hits |
InterProi | View protein in InterPro IPR017341, CD46 IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00084, Sushi, 4 hits |
PIRSFi | PIRSF037971, TLX_CD46, 1 hit |
SMARTi | View protein in SMART SM00032, CCP, 4 hits |
SUPFAMi | SSF57535, SSF57535, 4 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MCP_BOVIN | |
Accessioni | Q6VE48Primary (citable) accession number: Q6VE48 Secondary accession number(s): Q7YRJ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | May 30, 2006 | |
Last modified: | May 25, 2022 | |
This is version 99 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |